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2-bromopropane이 Sprague-Dawley 랫트의 blood-testis barrier에 미치는 영향
손화영,강부현,조성환,윤원기 충남대학교 수의과대학 동물의과학연구소 1997 動物醫科學硏究誌 Vol.5 No.-
This study was carried out to investigate the effect of 2-bromopropane, which recently caused occupational intoxication in Korea, on blood-testis barrier of Sprague-Dawley rats. 10 weeks old male Sprague-Dawley rats were treated with 3.5g/㎏ of 2-bromopropane for 3 consecutive days orally. 2-bromopropane treatment induced degeneration of spermatogonia but spermatocytes, spermatids, Sertoli cells and interstitial cells showed normal appearance. There was no effect observed on the Blood-testis barrier examination by hypertonic fluid or lanthanum was normal.
열탈착 분석법에 의한 Pt(111) 표면위의 NO와 CO의 흡착
이순보,박종윤,곽현태,부진효,강용철 성균관대학교 1992 論文集 Vol.42 No.2
The adsorptions of nitric oxide and carbon monoxide on Pt(111) surfaces have been studied by using LEED, AES, and TDS(Thermal Desorption spectroscopy). The adsorbed species of NO is predominantly molecular on the Pt(111) surface at room temperature. A main desorption peak of TDS is attributed to the molecular adsorption at 360K. With increasing No exposures, a shoulder peak at 480K which may be attributed to the defect site adsorption is appeared. The desorption rate order for No desorption is 1st order and the desorption energy for NO calculated by Redhead equation assuming pre-exponential factor v_1=10^13 sec^-1 is 21.7Kcal/mol. The adsorption of carbon monoxide is also molecular on Pt(111) surface at room temperature. The TDS results showed only a single broad peak at 460K, which is attributed to molecular adsorption. The desorption order for CO desorption is 1st order as well as NO and the desorption energy for CO is 28Kcal/mol.
두릅나무와 황백피의 혼합추출물 P55A 의 랫트 및 개에 대한 경구투여 급성독성
강부현(Boo Hyon Kang),손화영(Hwa Young Son),송시환(Si Whan Song),차신우(Shin Woo Cha),서동욱(Dong Oook Seo),이상봉(Sang Bong Lee),정영신(Young Sin Jung),홍은경(Eun Kyung Hong),김해리(Har Riet Kim),김성진(Sung Jin KIm) 한국응용약물학회 1999 Biomolecules & Therapeutics(구 응용약물학회지) Vol.7 No.2
The current study was performed to determine the acute oral toxicity of P55A, a crude extract of 1:1 mixture of Phellodendron amurense cortex and Aralia elate cortex, in SD rats and beagle dogs. 5 rats of each sex were treated with a single dose of P55A orally at doses of 0 and 5,000 mg/kg respectively. Also 2 dogs of each sex were treated with a single dose of P55A orally at doses of 0 and 2,000 mg/kg, respectively. After the treatment, clinical signs, and body weight change were observed for 14 days. All rats survived during the study and did not show any clinical sign. Body weight gain showed no significant difference between the control and treated rats. Grossly, no lesion was observed in the rats. All dogs survived during the study. In clinical signs, dark stool was observed in the 2,000 mg/kg treated dogs at day 1 after administration. The animals recovered from general signs at day 2 after administration. Body weight gain showed no significant difference between the control and treated dogs. Grossly, no lesion was observed in the dogs. It is suggested that the LD_(50) of P55A by oral administration was estimated to be over 5,000 mg/kg in both sexes of rats and 2,000 mg/kg in both sexes of beagle dogs.
Sprague-Dawley(SD) 랫드를 이용한 2주와 4주 반복투여 독성시험에 대한 혈액, 혈액생화학 및 장기중량 기초자료
강부현(Boo-Hyon Kang),김용범(Yong-Bom Kim),이현숙(Hyun-Sook Lee),김영희(Young-Hee Kim),임완중(Wan-Jung Im),하창수(Chang-Su Ha) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.2
We present background data of Sprague-Dawley (SD) rats from the control groups of 2 weeks and 4 weeks repeated-dose toxicity studies performed in our laboratory during 2002-2003. These include hematology, blood biochemistry and organ weights. These data can be used as background data for the interpretation of data from repeated-dose toxicity studies of drugs or chemicals in SD rats.
Ktc:Sprague-Dawley 랫드의 장기중량치의 자료분석
강부현,김일환,김용범,김영희,이현숙,하창수 한국수의병리학회 2001 한국수의병리학회지 Vol.5 No.2
A reference range data base containing organ weight values on animals used in 4 week and 13 week toxicity tests is described. Data listed include the values of minimum, maximum, mean and standard deviation for each of the following organ weights. Organs: Briain, heart, liver, spleen, kidney, adrerial gland, testis, ovary. This study was undertaken to determine organ weight reference values of Ktc: SD rats.