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      • KCI등재

        Genome wide survey and analysis of microsatellites in Tombusviridae family

        Biju George,Binu George,Mayur awasthi,Ram Nageena Singh 한국유전학회 2015 Genes & Genomics Vol.37 No.8

        Microsatellites are small repetitive sequences found in all kingdoms of life including viruses. Members of the Tombusviridae family severely affect growth of wide range of plants and reduce economic yield in diverse cropping systems worldwide. Here, we analyzed the nature and distribution of both simple and complex microsatellites present in complete genome of 47 species of Tombusviridae family. Our results showed, in all analyzed genomes, genome size and GC content had a weak influence on number, relative abundance and relative density of microsatellites, respectively. For each genome, dinucleotide repeats followed by mononucleotide repeats were found to be highly predominant. Mononucleotide repeats were found to be underrepresented in majority of Tombusviridae genomes. Poly G and Poly C repeats were more abundant as compared to poly A or poly T nucleotides. TG/GT and AG/CA was the most abundant dinucleotide repeat motif observed in Tombusviridae genomes. Repeats larger than trinucleotide were never found in these viral genomes. Comparative study of relative abundance and density of microsatellite among available RNA and DNA viral genomes indicated that simple repeats were lower than many RNA virus genomes. To our knowledge, this is the first analysis of microsatellites occurring in Tombusviridae genomes. Characterization of such variations in repeat sequences would be important in deciphering the origin, mutational processes, and role of repeat sequences in viral genomes.

      • KCI등재SCIESCOPUS

        Highly asymmetric bipolar resistive switching in solution-processed Pt/TiO<sub>2</sub>/W devices for cross-point application

        Biju, K.P.,Liu, X.,Shin, J.,Kim, I.,Jung, S.,Siddik, M.,Lee, J.,Ignatiev, A.,Hwang, H. Elsevier 2011 Current Applied Physics Vol.11 No.4

        Resistive switching characteristics of Pt/TiO<SUB>2</SUB>/W devices are investigated. TiO<SUB>2</SUB> thin films are grown by a sol-gel spin-coating technique. The crystal structure and chemical bonding states of the TiO<SUB>2</SUB> films are investigated by X-ray diffraction and X-ray photoelectron spectroscopy. The device exhibits reversible and reproducible bistable resistive switching with a rectifying effect. The Schottky contact at the Pt/TiO<SUB>2</SUB> interface limits electron injection under reverse bias and results in a rectification ratio >60 at 2 V in a low-resistance state. The switching mechanisms in our device can be interpreted as oxygen-migration-induced redox reaction at the tungsten bottom electrode (W). The rectifying effect can reduce misreading errors in a cross-point array and provides a feasible way to achieve high memory density.

      • SCIESCOPUSKCI등재

        Tuberculosis of the Spleen as a Cause of Fever of Unknown Origin and Splenomegaly

        ( Biju Pottakkat ),( Ashok Kumar ),( Archana Rastogi ),( Narendra Krishnani ),( Vinay K. Kapoor ),( Rajan Saxena ) 대한소화기기능성질환·운동학회 2010 Gut and Liver Vol.4 No.1

        Background/Aims: Splenic involvement of tuberculosis, which is rare, warrants better definition in the current era of resurgence of tuberculosis. Methods: Out of 339 splenectomies performed between January 1989 and December 2008 for indications other than trauma, histopathologic analysis of the spleen revealed tuberculosis in 8 patients. Results: All eight patients were referred for splenectomy due to fever of unknown origin (FUO). No patient was infected with HIV, and all had at least moderate splenomegaly and hepatomegaly. Three patients had hypersplenism with bleeding manifestations. Radiologic evaluations demonstrated that splenic lesions were present in five patients. Five patients had evidence of tuberculosis manifested as enlarged splenic hilar lymph nodes, cystic lymph nodes, or liver. Two patients exhibited tubercle bacilli in their sputum during the postoperative period. Conclusions: In areas where tuberculosis is prevalent, tuberculosis should be considered in the differential diagnosis of patients presenting with FUO and splenomegaly. Extrasplenic involvement is usually seen in splenic tuberculosis, although it may not be apparent at presentation. Splenic tuberculosis can present in isolation without extrasplenic involvement, and even in immunocompetent individuals. (Gut Liver 2010;4:94-97)

      • KCI등재SCIESCOPUS

        Bipolar resistance switching in the Pt/WO<sub>x</sub>/W nonvolatile memory devices

        Biju, K.P.,Liu, X.,Kim, S.,Siddik, M.,Shin, J.,Lee, J.,Hwang, H. Elsevier 2011 Current Applied Physics Vol.11 No.2

        We reported the resistive switching behavior in the Pt/WO<SUB>x</SUB>/W memory device fabricated with fully room temperature process. The devices show high resistance ratio (>140), reliable data retention at 85 <SUP>o</SUP>C and fast switching (100 ns). The field-induced resistance change can be explained based on the formation/rupture of the conduction filaments, due to migration of oxygen vacancies under electric field. The dominant conduction mechanisms of low resistance state and high resistance state were verified by ohmic behavior and trap-controlled space charge limited current, respectively. We demonstrate the present device can be used for multi-bit operation either by compliance current or by reset voltage.

      • SCISCIE

        A Eu<sup>III</sup> Tetrakis(β-diketonate) Dimeric Complex: Photophysical Properties, Structural Elucidation by Sparkle/AM1 Calculations, and Doping into PMMA Films and Nanowires

        Biju, Silvanose,Freire, Ricardo O.,Eom, Yu Kyung,Scopelliti, Rosario,Bü,nzli, Jean-Claude G.,Kim, Hwan Kyu American Chemical Society 2014 Inorganic Chemistry Vol.53 No.16

        <P>Reaction of Ln<SUP>III</SUP> with a tetrakis(diketone) ligand H<SUB>4</SUB>L [1,1′-(4,4′-(2,2-bis((4-(4,4,4-trifluoro-3-oxobutanoyl) phenoxy)methyl)propane-1,3-diyl)bis(oxy)bis(4,1-phenylene))bis(4,4,4-trifluorobutane-1,3-dione)] gives new podates which, according to mass spectral data and Sparkle/AM1 calculations, can be described as dimers, (NBu<SUB>4</SUB>[LnL])<SUB>2</SUB> (Ln = Eu, Tb, Gd:Eu), in both solid-state and dimethylformamide (DMF) solution. The photophysical properties of the Eu<SUP>III</SUP> podate are compared with those of the mononuclear diketonate (NBu<SUB>4</SUB>[Eu(BTFA)<SUB>4</SUB>], BTFA = benzoyltrifluoroacetonate), the crystal structure of which is also reported. The new Eu<SUP>III</SUP> dimeric complex displays bright red luminescence upon irradiation at the ligand-centered band in the range of 250–400 nm, irrespective of the medium. The emission quantum yields and the luminescence lifetimes of (NBu<SUB>4</SUB>[EuL])<SUB>2</SUB> (solid state: 51% ± 8% and 710 ± 2 μs; DMF: 31% ± 5% and 717 ± 1 μs) at room temperature are comparable to those obtained for NBu<SUB>4</SUB>[Eu(BTFA)<SUB>4</SUB>] (solid state: 60 ± 9% and 730 ± 5 μs; DMF: 30 ± 5% and 636 ± 1 μs). Sparkle/AM1 calculations were utilized for predicting the ground-state geometries of the Eu<SUP>III</SUP> dimer. Theoretical Judd–Ofelt and photoluminescence parameters, including quantum yields, predicted from this model are in good agreement with the experimental values, proving the efficiency of this theoretical approach implemented in the LUMPAC software (<uri xlink:href='http://lumpac.pro.br' xlink:type='simple'>http://lumpac.pro.br</uri>). The kinetic scheme for modeling energy transfer processes show that the main donor state is the ligand triplet state and that energy transfer occurs on both the <SUP>5</SUP>D<SUB>1</SUB> (44.2%) and <SUP>5</SUP>D<SUB>0</SUB> (55.8%) levels. Furthermore, the newly obtained Eu<SUP>III</SUP> complex was doped into a PMMA matrix to form highly luminescent films and one-dimensional nanowires having emission quantum yield as high as 67%–69% (doping concentration = 4% by weight); these materials display bright red luminescence even under sunlight, so that interesting photonic applications can be foreseen.</P><P>A red-emitting dimeric Eu<SUP>III</SUP> podate based on a tetrakis(β-diketonate) ligand emits highly monochromatic red light and features the highest quantum yield reported so far for dinuclear Eu<SUP>III</SUP> bis(β-diketonates); doping into a PMMA matrix results in thin films and one-dimensional nanowires, the luminescence of which can be seen under sunlight illumination.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/inocaj/2014/inocaj.2014.53.issue-16/ic500966z/production/images/medium/ic-2014-00966z_0012.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ic500966z'>ACS Electronic Supporting Info</A></P>

      • KCI등재

        Performance Analysis of Diabetic Retinopathy and Hemorrhages Segmentation System Using Enhanced Visual Geometry Group (EVGG) Architecture

        Biju J.,Shanthi D. 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.5

        In this article, the retinal images are classifi ed into either healthy or DR using the proposed EVGG deep learning architecture. This proposed method consists of Gabor transform module, data augmentation module, classifi cation module along with hemorrhages segmentation module. The Gabor transform is used to transform the spatial pixel coordinates into multi resolution pixel coordinates. Then, the data augmentation methods are applied on the Gabor image to increase the image counts. The EVGG architecture is proposed in this work to classify the retinal image into either healthy or DR. Finally, the hemorrhages are segmented in DR retinal images. The proposed DR image classifi cation system is applied and tested on the retinal images on DIARETDB1 and HRF datasets. The performance of the proposed hemorrhages segmentation algorithm is evaluated in terms of sensitivity, specifi city and accuracy. The experimental results of the proposed method stated in this article are signifi cantly compared with other similar works.

      • KCI등재후보

        Review on the comparison of effectiveness between denosumab and bisphosphonates in post-menopausal osteoporosis

        Biju Benjamin,Mridula Ambwani Benjamin,Myint Swe,Sandheep Sugathan 대한골다공증학회 2016 Osteoporosis and Sarcopenia Vol.2 No.2

        Objective: Osteoporosis is a rapidly rising cause of concern for elderly patients. Various classes of drugs are available in the market. Bisphosphonates are considered as a first-line therapy for the prevention and treatment. Denosumab is an antiresorptive agent which is a RANK ligand inhibitor. There is a scarcity of comparison between these two classes of drugs. The aim of this study is to compare efficacy of Bisphosphonates and Denosumab in various parameters. Materials and methods: Literature search was done for randomized controlled trials (RCTs) comparing bisphosphonates with denosumab. RCTs with a treatment period of at least one year with a baseline bone mineral density (BMD) and bone turnover markers (BTM) and follow up values at one year were included in the study. All included studies were also analysed for complications. The study has also been registered in PROSPERO International prospective register of systematic reviews. Results: A total of five RCTs were identified providing data on 3751 participants. In all five studies, the BMD changes at both hip and spine were statistically significant in favour of denosumab. Result was similar in three studies that studied BMD changes at the wrist. Denosumab also produced significant reduction in BTM as early as one month, but at one year there was no difference compared to the bisphosphonates. There was no statistically significant differences in the complication rates. Conclusion: Though both bisphosphonates and denosumab were effective with similar side effects, the latter was statistically superior in increasing the BMD and reducing the BTM. © 2016 The Korean Society of Osteoporosis. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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