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Structural Mechanisms of the Cooling Rate Effect on the Deformation Behaviors in Metallic Glasses
Bian Zhou,Ming‑fei Li,Fan Xiong,Liang Yang 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.5
In this work, the structural mechanisms of the cooling rate effect on the deformation behaviors in metallic glasses (MGs) isstudied, by performing the synchrotron radiation-based experiments coupled with a series of simulations. It is found that aMG prepared at lower cooling rate has the higher yield strength and is more likely to soften itself, resulting in lower plasticity.This is because some atomic-to-cluster level structural factors, such as coordination numbers, atomic packing efficiencies,cluster concentrations and regularities. In addition, a quantitative analysis reveals that higher cooling rate leads to more freevolumes, and significantly affect the evolution of free volumes during the compressive deformation, tuning the formationand the evolution of shear transformation zones, as well as the yield strength and the plasticity.
Evaluating LIMU System Quality with Interval Evidence and Input Uncertainty
Xiangyi Zhou,Zhi-Jie Zhou,Xiaoxia Han,Zhichao Ming,Yanshan Bian 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.11
The laser inertial measurement unit is a precision device widely used in rocket navigation system and other equipment, and its quality is directly related to navigation accuracy. In the quality evaluation of laser inertial measurement unit, there is inevitably uncertainty in the index input information. First, the input numerical information is in interval form. Second, the index input grade and the quality evaluation result grade are given according to different national standards. So, it is a key step to transform the interval information input by the index into the data form consistent with the evaluation result grade. In the case of uncertain input, this paper puts forward a method based on probability distribution to solve the problem of asymmetry between the reference grade given by the index and the evaluation result grade when evaluating the quality of laser inertial measurement unit. By mapping the numerical relationship between the designated reference level and the evaluation reference level of the index information under different distributions, the index evidence symmetrical with the evaluation reference level is given. After the uncertain input information is transformed into evidence of interval degree distribution by this method, the information fusion of interval degree distribution evidence is carried out by interval evidential reasoning algorithm, and the evaluation result is obtained by projection covariance matrix adaptive evolution strategy optimization. Taking a five-meter redundant laser inertial measurement unit as an example, the applicability and effectiveness of this method are verified.
Bian, Jing,Li, Bo,Kou, Xian-Juan,Liu, Tian-Zhou,Ming, Liang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Objective: To explore the predictive value of tumor markers, including cancer antigen 72-4 (CA72-4), cancer antigen 15-3 (CA15-3) and cancer antigen 125 (CA125), in single or combined detection, for the diagnosis of ovarian cancer. Methods: 120 patients diagnosed with ovarian cancer from August 2011 to March 2013 and 80 patients diagnosed with benign ovarian tumors were enrolled in this test, along with 50 health examination women randomly selected from the database as controls. Serum levels of CA72-4, CA15-3 and CA125 in this study were determined by electrochemiluminescence (ECL). Results: Serum levels of CA72-4, CA15-3 and CA125 in ovarian cancer were higher than those in healthy group and benign group (P<0.01).The sensitivity of combined detection of those three tumor markers for diagnosis of ovarian cancer was obviously higher than with single detection with each marker (P<0.01). Conclusions: CA72-4, CA15-3 and CA125 could be a good combination in the diagnosis of ovarian cancer. Patients whose tumor markers continue to increase should be highly suspected of malignancy.
Dandan BIAN,Xiaoming ZHAO,Li CHEN,Jiwu TIAN,Qiuning LIU,Chunlin ZHOU,Boping Tang 한국곤충학회 2018 Entomological Research Vol.48 No.1
Eukaryotic initiation factor 5A (eIF‐5A) is a highly conserved protein found in all eukaryotic organisms that plays a key role in the regulation of many cellular processes including translation elongation, cell proliferation, programmed cell death, mRNA turnover and decay, and abiotic stress responses. In this study, the eIF‐5A gene from the Chinese oak silkworm Antheraea pernyi (Lepidoptera: Saturniidae) was characterized. The full‐length ApeIF‐5A cDNA of 1056 bp includes a 5′‐untranslated region (UTR) of 138 bp, a 3′‐UTR of 435 bp, and an open reading frame of 483 bp encoding a polypeptide of 160 amino acids. The deduced ApeIF‐5A protein shares 99 %, 82 %, and 72 % sequence identity with orthologs in Bombyx mori, Drosophila melanogaster and Homo sapiens, indicating high conservation during animal evolution. Real‐time quantitative reverse transcription PCR revealed expression in all four developmental stages and in all nine tissues tested, consistent with an important role in development. After challenge with lipopolysaccharide, the expression levels of ApeIF‐5A were markedly upregulated. Phylogenetic analysis of amino acid sequences revealed A. pernyi eIF‐5A was closely related to B. mori eIF‐5A, consistent with traditional classification and other molecular data. The results indicate the potential value of eIF‐5A in phylogenetic analysis.
A passive vibration isolator with bio-inspired structure and inerter nonlinear effects
Jing Bian,Xu-hong Zhou,Ke Ke,Michael CH Yam,Yu-hang Wang,Yue Qiu 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.88 No.3
This paper developed and examined a novel passive vibration isolator (i.e., “X-inerter”) motivated by combining a bio-inspired structure and a rack-pinion inerter. The bio-inspired structure provided nonlinear stiffness and damping owing to its geometric nonlinearity. In addition, the behavior was further enhanced by a gear inerter that produced a special nonlinear inertia effect; thus, an X-inerter was developed. As a result, the X-inerter can achieve both high-static-low-dynamic stiffness (HSLDS) and quasi-zero stiffness (QZS), obtaining ultra-low frequency isolation. Furthermore, the installed inerter can produce a coupled nonlinear inertia and damping effect, leading to an anti-resonance frequency near the resonance, wide isolation region, and low resonance peak. Both static and dynamic analyses of the proposed isolator were conducted and the structural parameters' influence was comprehensively investigated. The X-inerter was proven to be comparatively more stable in the ultra-low frequency than the benchmarking QZS isolator due to the nonlinear damping and inertia properties. Moreover, the inertia effect could suppress the bio-inspired structure's super- and sub-harmonic resonance. Therefore, the X-inerter isolator generally possesses desirable nonlinear stiffness, nonlinear damping, and unique nonlinear inertia, designed to achieve the ultra-low natural frequency, the anti-resonance property, and a wide isolation region with a low resonance peak.
Curdione Inhibits Proliferation of MCF-7 Cells by Inducing Apoptosis
Li, Juan,Bian, Wei-He,Wan, Juan,Zhou, Jing,Lin, Yan,Wang, Ji-Rong,Wang, Zhao-Xia,Shen, Qun,Wang, Ke-Ming Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
Background: Curdione, one of the major components of Curcuma zedoaria, has been reported to possess various biological activities. It thus might be a candidate anti-flammatory and cancer chemopreventive agent. However, the precise molecular mechanisms of action of curdione on cancer cells are still unclear. In this study, we investigated the effect of curdione on breast cancer. Materials and Methods: Xenograft nude mice were used to detect the effect of curdione on breast cancer in vivo; we also tested the effect of curdione on breast cancer in vitro by MTT, Flow cytometry, JC-I assay, and western blot. Results: Firstly, we found that curdione significantly suppressed tumor growth in a xenograft nude mouse breast tumor model in a dose-dependent manner. In addition, curdione treatment inhibited cell proliferation and induced cell apoptosis. Moreover, after curdione treatment, increase of impaired mitochondrial membrane potential occurred in a concentration dependent manner. Furthermore, the expression of apoptosis-related proteins including cleaved caspase-3, caspase-9 and Bax was increased in curdione treatment groups, while the expression of the anti-apoptotic Bcl-2 was decreased. Inhibitors of caspase-3 were used to confirm that curdione induced apoptosis. Conclusions: Overall, our observations first suggested that curdione inhibited the proliferation of breast cancer cells by inducing apoptosis. These results might provide some molecular basis for the anti-cancer activity of curdione.
Ke Ke,Jing Bian,Xu-Hong Zhou,Michael C.H. Yam,Yu-Hang Wang,Zi Gu,Miaojun Sun 국제구조공학회 2023 Smart Structures and Systems, An International Jou Vol.31 No.3
A passive prismatic-shaped isolation platform (PIP) is proposed to realize enhanced quasi-zero stiffness (QZS) effect. The design concept uses a horizontal spring to produce a tunable negative stiffness and installs oblique springs inside the cells of the prismatic structure to provide a tunable positive stiffness. Therefore, the QZS effect can be achieved by combining the negative stiffness and the positive stiffness. To this aim, firstly, the mathematical modeling and the static analysis are conducted to demonstrate this idea and provide the design basis. Further, with the parametric study and the optimal design of the PIP, the enhanced QZS effect is achieved with widened QZS range and stable property. Moreover, the dynamic analysis is conducted to investigate the vibration isolation performance of the proposed PIP. The analysis results show that the widened QZS property can be achieved with the optimal designed structural parameters, and the proposed PIP has an excellent vibration isolation performance in the ultra-low frequency due to the enlarged QZS range. Compared with the traditional QZS isolator, the PIP shows better performance with a broader isolation frequency range and stable property under the large excitation amplitude.