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- 저자 : Bazzaz, Ehsan (검색결과 14 건)
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Bazzaz, Bibi Sedigheh Fazly,Sarabandi, Sahar,Khameneh, Bahman,Hosseinzadeh, Hossein KOREAN PHARMACOPUNCTURE INSTITUTE 2016 Journal of pharmacopuncture Vol.19 No.4
Objectives: Bacterial resistant infections have become a global health challenge and threaten the society's health. Thus, an urgent need exists to find ways to combat resistant pathogens. One promising approach to overcoming bacterial resistance is the use of herbal products. Green tea catechins, the major green tea polyphenols, show antimicrobial activity against resistant pathogens. The present study aimed to investigate the effect of catechins, green tea extract, and methylxanthines in combination with gentamicin against standard and clinical isolates of Staphylococcus aureus (S. aureus) and the standard strain of Pseudomonas aeruginosa (P. aeruginosa). Methods: The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) values of different agents against bacterial strains were determined. The interactions of green tea extract, epigallate catechin, epigallocatechin gallate, two types of methylxanthine, caffeine, and theophylline with gentamicin were studied in vitro by using a checkerboard method and calculating the fraction inhibitory concentration index (FICI). Results: The MICs of gentamicin against bacterial strains were in the range of $0.312-320{\mu}g/mL$. The MIC values of both types of catechins were $62.5-250{\mu}g/mL$. Green tea extract showed insufficient antibacterial activity when used alone. Methylxanthines had no intrinsic inhibitory activity against any of the bacterial strains tested. When green tea extract and catechins were combined with gentamicin, the MIC values of gentamicin against the standard strains and a clinical isolate were reduced, and synergistic activities were observed (FICI < 1). A combination of caffeine with gentamicin did not alter the MIC values of gentamicin. Conclusion: The results of the present study revealed that green tea extract and catechins potentiated the antimicrobial action of gentamicin against some clinical isolates of S. aureus and standard P. aeruginosa strains. Therefore, combinations of gentamicin with these natural compounds might be a promising approach to combat microbial resistance.
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Bazzaz, Bibi Sedigheh Fazly,Fakori, Mahmoud,Khameneh, Bahman,Hosseinzadeh, Hossein KOREAN PHARMACOPUNCTURE INSTITUTE 2019 Journal of pharmacopuncture Vol.22 No.1
Objective: Antibiotic resistance is a global health problem and threatens health of societies. These problems have led to a search for alternative approaches such as combination therapy. The aim of the present study was to investigate the effect of caffeine and omeprazole in combination with gentamicin or ciprofloxacin against standard and clinically resistant isolates of Staphylococcus aureus and Escherichia coli. Methods: The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of different agents against bacterial strains were determined. The interaction of non- antibiotic drugs with gentamicin and ciprofloxacin was studied in vitro using a checkerboard method and calculating fraction inhibitory concentration index (FICI). Verapamil as efflux pump inhibitor was used to evaluate the possible mechanism of bacterial resistance to antibiotics. Results: The MIC and MBC values of gentamicin against bacterial strains were in the range of $20-80{\mu}g/ml$ and $40-200{\mu}g/ml$, respectively. Caffeine and omeprazole had no intrinsic inhibitory activity against tested microorganisms. However, upon combination of caffeine with antibiotics, the synergistic effects were observed. Verapamil was able to reduce the MIC values of gentamicin (4 folds) only in some bacterial strains. Conclusion: These findings indicated that caffeine was effective in removing bacterial infection caused by S. aureus and E. coli. The relevant mechanisms of antibiotic resistance were not related to the drug efflux.
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Mohammad Bazzaz,Ali Kheyroddin,Mohammad Ali Kafi,Zahra Andalib 국제구조공학회 2012 Steel and Composite Structures, An International J Vol.12 No.5
In order to evaluate the dynamic behavior of passive energy dissipation system, two steps need to be considered for prediction of structural response in the presence of ductile element in an off-centre bracing system. The first is a detailed analysis of the proposed ductile element and the second is the effect of this ductile element on an off-centre bracing system. The use of ductile bracing system is expanding in steel structures in order to increase the force reduction factor. Therefore, regarding the nonlinear behavior of steel material used in an off-centre bracing systems and using ductile element in OBS bracing systems, the seismic evaluation of the mentioned systems seems to be necessary. This paper aims to study linear and nonlinear behavior of steel frames with off-centre bracing system and ductile element, in order to get the best position of these bracing elements. To achieve this purpose, the modeling has been done with ANSYS software. The optimum eccentricity has been obtained by modeling three steel frames with different eccentricities and evaluating the results of them. The analytical results showed that the model OBS-C with 0.3 eccentricities has higher performance among the models.
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Mohammad Bazzaz,Zahra Andalib,Ali Kheyroddin,Mohammad Ali Kafi 국제구조공학회 2015 Steel and Composite Structures, An International J Vol.19 No.4
During a seismic event, a considerable amount of energy is input into a structure. The law of energy conservation imposes the restriction that energy must either be absorbed or dissipated by the structure. Recent earthquakes have shown that the use of concentric bracing system with their low ductility and low energy dissipation capacity, causes permanent damage to structures during intense earthquakes. Hence, engineers are looking at bracing system with higher ductility, such as chevron and eccentric braces. However, braced frame would not be easily repaired if serious damage has occured during a strong earthquake. In order to solve this problem, a new bracing system an off-centre bracing system with higher ductility and higher energy dissipation capacity, is considered. In this paper, some numerical studies have been performed using ANSYS software on a frame with off-centre bracing system with optimum eccentricity and circular element created, called OBS_C_O model. In addition, other steel frame with diagonal bracing system and the same circular element is created, called DBS_C model. Furthermore, linear and nonlinear behavior of these steel frames are compared in order to introduce a new way of optimum performance for these dissipating elements. The obtained results revealed that using a ductile element or circular dissipater for increasing the ductility of off-centre bracing system and centric bracing system is useful. Finally, higher ductility and more energy dissipation led to more appropriate behavior in the OBS_C_O model compared to DBS_C model.
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Mohammad Bazzaz,Mohammad Ali Kafi,Ali Kheyroddin,Zahra Andalib,Hamed Esmaeili 한국강구조학회 2014 International Journal of Steel Structures Vol.14 No.2
Braced structures with concentric braces are among earthquake resistant systems that are widely used in frames with jointconnections. Ductility, dissipation of energy and decreasing in base shear are the benefits of these bracing systems. Despite thebenefits mentioned limited ductility of concentric braces, however, caused poor functionality against earthquake. Therefore inthis paper, new bracing system using circular element (circular dissipater) has been evaluated, in order to replace damagedmember without needing rehabilitation or repair of general system. So using nonlinear software package ANSYS a frame withoff-centre bracing system with optimum eccentricity (OBS-C-O) and another frame with same specifications without circularelement (OBS) has been created. The function of general system has been studied for the first time. Linear and nonlinearbehavior of these two frames compared to each other so the benefits of this circular element in an off-centre bracing systemare highlighted. The analytical results and comparison between plots of these two models showed that the first model has higherperformance than the others.
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Bibi Sedigheh Fazly Bazzaz,Sahar Sarabandi,Bahman Khameneh,Hossein Hosseinzadeh 대한약침학회 2016 Journal of pharmacopuncture Vol.19 No.4
Objectives: Bacterial resistant infections have become a global health challenge and threaten the society’s health. Thus, an urgent need exists to find ways to combat resistant pathogens. One promising approach to overcoming bacterial resistance is the use of herbal products. Green tea catechins, the major green tea polyphenols, show antimicrobial activity against resistant pathogens. The present study aimed to investigate the effect of catechins, green tea extract, and methylxanthines in combination with gentamicin against standard and clinical isolates of Staphylococcus aureus (S. aureus) and the standard strain of Pseudomonas aeruginosa (P. aeruginosa). Methods: The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) values of different agents against bacterial strains were determined. The interactions of green tea extract, epigallate catechin, epigallocatechin gallate, two types of methylxanthine, caffeine, and theophylline with gentamicin were studied in vitro by using a checkerboard method and calculating the fraction inhibitory concentration index (FICI). Results: The MICs of gentamicin against bacterial strains were in the range of 0.312 - 320 μg/mL. The MIC values of both types of catechins were 62.5 - 250 μg/ mL. Green tea extract showed insufficient antibacterial activity when used alone. Methylxanthines had no intrinsic inhibitory activity against any of the bacterial strains tested. When green tea extract and catechins were combined with gentamicin, the MIC values of gentamicin against the standard strains and a clinical isolate were reduced, and synergistic activities were observed (FICI < 1). A combination of caffeine with gentamicin did not alter the MIC values of gentamicin. Conclusion: The results of the present study revealed that green tea extract and catechins potentiated the antimicrobial action of gentamicin against some clinical isolates of S. aureus and standard P. aeruginosa strains. Therefore, combinations of gentamicin with these natural compounds might be a promising approach to combat microbial resistance.
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Bibi Sedigheh Fazly Bazzaz,Mahmoud Fakori,Bahman Khameneh,Hossein Hosseinzadeh 대한약침학회 2019 Journal of pharmacopuncture Vol.22 No.1
Objective: Antibiotic resistance is a global health problem and threatens health of societies. These problems have led to a search for alternative approaches such as combination therapy. The aim of the present study was to investigate the effect of caffeine and omeprazole in combination with gentamicin or ciprofloxacin against standard and clinically resistant isolates of Staphylococcus aureus and Escherichia coli. Methods: The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of different agents against bacterial strains were determined. The interaction of non- antibiotic drugs with gentamicin and ciprofloxacin was studied in vitro using a checkerboard method and calculating fraction inhibitory concentration index (FICI). Verapamil as ef-flux pump inhibitor was used to evaluate the possible mechanism of bacterial resistance to antibiotics. Results: The MIC and MBC values of gentamicin against bacterial strains were in the range of 20- 80 μg/ml and 40-200 μg/ml, respectively. Caffeine and omeprazole had no intrinsic inhibitory activity against tested microorganisms. However, upon combination of caffeine with antibiotics, the synergistic effects were observed. Verapamil was able to reduce the MIC values of gentamicin (4 folds) only in some bacterial strains. Conclusion: These findings indicated that caffeine was effective in removing bacterial infection caused by S. aureus and E. coli. The relevant mechanisms of antibiotic resistance were not related to the drug efflux.
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Within and Between Species Ecological Variation in Polygonum Pensylvanicum and Polygonum virginianum
Lee, Hee Sun,Bazzaz, Fakhri A. 西原大學校 1985 西原大學 論文集 Vol.15 No.-
遷移 初期種인 Polygonum pensylvanicum L.와 遷移後期種인 Polygonum virginianum L.을 材料植物로 하여 土壤含水量, 肥沃度 및 光度 勾配에 따른 生態的 變異를 조사했다. P.pensylvanicum은 種子에서 發芽한 個體를 사용했고 P.virginianum은 種子와 根莖에서 發芽한 個體를 各各 사용했다. 環境勾配에 따른 Niche breadth는 P.pensylvanicum이 P.virginianum 보다 컸으며, 두 種 共히 形態的 變異에 비해 生植的 變異가 더 컸다. P.virginianum은 種子에서 發芽한 個體의 Niche breadth가 根莖에서 發芽한 個體보다 컸다. 同一 屬(Genus)에 속하며 遷移段階가 다른 이 두 種의 種子에서 發芽한 個體들은 環境勾配에 따라 種間生態的 變異가 컸으며 P.virginianum의 種子와 根莖에서 各各 發芽한 個體들의 種內 生態的 變異도 이와 비슷했다. 대체적으로 種子에서 發芽한 이 두 種의 個體들은 環境에 대한 生態的 反應의 樣狀이 비슷했으나 오히려 P.virginianum의 種子와 根莖에서 發芽한 個體間의 生態的 反應의 樣狀이 서로 차이가 있었다. The responses of Polygonum pensylvanicum L., an early successional annual, and of Polygonum virginianum L., a late successional perennial, were examined along discontinuous gradients of soil moisture, light and nutrient availability. In the case of P. virginianum both individuals grown from seed and individuals grown from rhizoms were examined. The results show that variation in the response of conspecific individuals of different age to environmental variation is as great as that found between congeneric species of different successional habitat, In general, individuals of the two species were more similar to one another, ecologically, when both were started from seed, than were individuals of P.virginianum grown from seeds and from fhizomes. Potential differences in stored reserves between rhizomes and seeds appeared to have little effect upon responses to resource availability. Instead a number of plant characters were found to vary along gradients in ways that were unique to individuals differing in age. These characters in cluded aspects of leaf size, shape and orientation as well as whole plant architecture. Many if not all of these characters are likely to have significant affects upon the functioning of plants.
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Dehghan-Noudeh Gholamreza,Housaindokht Mohammadreza,Bazzaz Bibi Sedigeh Fazly The Microbiological Society of Korea 2005 The journal of microbiology Vol.43 No.3
Bacillus subtilis ATCC 6633 was grown in BHIB medium supplemented with $Mn^{2+}$ for 96 h at $37^{\circ}C$ in a shaker incubator. After removing the microbial biomass, a lipopeptide biosurfactant was extracted from the supernatant. Its structure was established by chemical and spectroscopy methods. The structure was confirmed by physical properties, such as Hydrophile-Lipophile Balance (HLB), surface activity and erythrocyte hemolytic capacity. The critical micelle concentration (cmc) and erythrocyte hemolytic capacity of the biosurfactant were compared to those of surfactants such as SDS, BC (benzalkonium chloride), TTAB (tetradecyltrimethylammonium bromide) and HTAB (hexadecyltrimethylammonium bromide). The maximum hemolytic effect for all surfactants mentioned was observed at concentrations above cmc. The maximum hemolytic effect of synthetic surfactants was more than that of the biosurfactant produced by B. subtilis ATCC 6633. Therefore, biosurfactant would be considered a suitable surface-active agent due to low toxicity to the membrane.
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Sabzichi, Mehdi,Mohammadian, Jamal,Khosroushahi, Ahmad Yari,Bazzaz, Roya,Hamishehkar, Hamed Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.12
Objective: Targeted-drug-delivery based lipid nanoparticles has emerged as a new and effective approach in cancer chemotherapy. Here, we investigated the ability of folate-modified nanostructured lipid carriers (NLCs) to enhance letrozol (LTZ) efficacy in MCF-7 breast cancer cells. Methods: New formulations were evaluated regarding to particle size and scanning electron microscope (SEM) features. Anti-proliferative effects of LTZ loaded nanoparticles were examined by MTT assay. To understand molecular mechanisms of apoptosis and cell cycle progression, flow cytometric assays were applied. Results: Optimum size of nanoparticles was obtained in mean average of $98{\pm}7nm$ with a poly dispersity index (PDI) of 0.165. The IC50 value was achieved for LTZ was $2.2{\pm}0.2{\mu}M$. Folate-NLC-LTZ increased the percentage of apoptotic cells from 24.6% to 42.2% compared LTZ alone (p<0.05). Furthermore, LTZ loaded folate targeted NLCs caused marked accumulation of cells in the subG1 phase. Conclusion: Taken together, our results concluded that folate targeted LTZ can be considered as potential delivery system which may overcome limitations of clinical application of LTZ and improve drug efficacy in tumor tissue.
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