Effect of Aqueous and Ethanolic Extracts of Nigella sativa Seeds on Milk Production in Rats

Hossein Hosseinzadeh,Mohsen Tafaghodi,Mojdeh Jalal Mosavi,Elahe Taghiabadi 사단법인약침학회 2013 Journal of Acupuncture & Meridian Studies Vol.6 No.1

Nigella sativa L. is used as a galactagogue in traditional medicine. Hence, the effects of aqueous and ethanolic extracts of N. sativa seeds on milk production in rats were evaluated. The measurement of milk production was by measuring pup weight during suckling period. The intraperitoneal LD50 values of aqueous and ethanolic extracts of N. sativa were 4.23 and 4.9 g/kg, respectively. The aqueous (0.5 g/kg) and ethanolic extracts (1 g/kg) increased milk production significantly (p < 0.001), producing about 31.3% and 37.6% more milk than control, respectively. During the study period, the pups gained weight with the aqueous (0.5 g/kg, p < 0.01) and ethanolic extracts (1 g/kg,p < 0.05). It is concluded that aqueous and ethanolic extracts of N. sativa can stimulate milk production in rats.

Chitosan/Poly(acrylic acid-co-crotonic acid) Semi-IPN의 합성, 분석 및 팽윤거동

Hossein Hosseinzadeh,Darioush Alijani 한국고분자학회 2014 폴리머 Vol.38 No.5

A semi-interpenetrating polymer network (semi-IPN) hydrogel composed of crosslinked chitosan and poly(acrylic acid-co-crotonic acid) was prepared in the presence of glutaraldehyde (GA) as a crosslinker. Fourier-transforminfrared, thermogravimetric analysis and scanning electron microscopy were employed to confirm the structure of thesemi-IPN hydrogel. The swelling capacity of hydrogel was shown to be affected by the monomers weight ratio, chitosancontent, initiator and GA concentrations. The results also indicated that the semi-IPN hydrogel had different swellingcapacity at various pHs. Additionally, the swelling behavior of the hydrogel was investigated in aqueous solutions of NaCl, CaCl2, and AlCl3.

Antinociceptive, Anti-inflammatory Effects and Acute Toxicity of Aqueous and Ethanolic Extracts of Myrtus communis L. Aerial Parts in Mice

Hossein Hosseinzadeh,Mohammad Khoshdel,Maryam Ghorbani 사단법인약침학회 2011 Journal of Acupuncture & Meridian Studies Vol.4 No.4

Myrtus communis L. aerial parts have been used in traditional medicine for the treatment of inflammatory disease. In this study 350 mice were divided into three main groups:negative (saline), positive (morphine or diclofenac) controls, and test groups. The acute toxicity was assessed for 2 days. Antinociceptive activity was performed using hot plate and writhing tests. The anti-inflammatory effect was investigated using xylene-induced ear edema and a cotton pellet test. According to phytochemical screening, the extracts contained tannins, alkaloids, and flavonoids. The LD50 values of the aqueous and ethanolic extracts were 0.473 and 0.79 g/kg, respectively. In hot plate test, the aqueous and ethanolic extracts showed significant antinociceptive activity that was inhibited by naloxone. The extracts exhibited antinociceptive activity against acetic acideinduced writhing and also showed significant activity against acute inflammation which was dose dependent for aqueous extract. The ethanolic (0.05 g/kg) and aqueous extracts (0.005,0.015, and 0.03 g/kg) demonstrated anti-inflammatory effects against chronic inflammation. The aqueous and ethanolic extracts of the aerial parts of M communis L. showed antinociceptive effects and these may be mediated by opioid receptors.

Protective Effect of Safranal, an Active Constituent of Crocus sativus, on Pentylenetetrazol-Induced Seizures in the Rat

Hossein Hosseinzadeh,Hamid Sadeghnia 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

Anticonvulsant Effect of Berberis integerrima L. Root Extracts in Mice

Hossein Hosseinzadeh,Mohammad Ramezani,Hojjat Shafaei,Elahe Taghiabadi 사단법인약침학회 2013 Journal of Acupuncture & Meridian Studies Vol.6 No.1

Berberis integerrima is a member of Berberidaceae family. Berberine is one of the main constituents of this plant, having neuroprotective effect on central nervous system diseases. In this study, the anticonvulsant activity of methanolic extract, and hydromethanolic fraction, and chloroform fraction of B integerrima was assessed. The anticonvulsant effect of B integerrima was investigated using both pentylenetetrazole (PTZ) and maximal electroshock (MES)-induced seizure models. The LD50 value of the methanolic extract was 302.676 mg/kg. In the PTZ test, methanolic extract (140 and 200 mg/kg,i.p., p < 0.01), hydromethanolic fraction (200 mg/kg, p < 0.01), and chloroform fraction (200 mg/kg, p < 0.01) increased the onset time of hind limb tonic extensions (HLTEs). The protective effect against mortality (convulsion survivors/animals tested) was 2/8 in methanolic extract, and 3/8 in hydromethanolic fraction at a dose of 200 mg/kg and in chloroform fraction at a dose of 140 mg/kg. In the MES test, this plant did not display any significant effect in reducing HLTE duration. According to phytochemical screening,methanolic extract contained alkaloids and tannins. The present study, conducted in mice, indicated that B integerrima has anticonvulsant activity in PTZ-induced seizures. It is concluded that B integerrima may be useful in petit mal epilepsy.

Effect of Aqueous and Ethanolic Extracts of Pimpinella anisum L. Seeds on Milk Production in Rats

Hossein Hosseinzadeh,Mohsen Tafaghodi,Shirin Abedzadeh,Elahe Taghiabadi 사단법인약침학회 2014 Journal of Acupuncture & Meridian Studies Vol.7 No.4

Pimpinella anisum L. (P. anisum) is used as a galactagogue in traditional medicine; hence, the effect of aqueous and ethanolic extracts of P. anisum seeds on milk production in rats was evaluated. The milk production was assessed by measuring the pups’ weights during the suckling period. The intraperitoneal LD 50 values of P. anisum aqueous and ethanolic extracts were 4.93 and 3.77 g/kg, respectively. The aqueous (1 g/kg) and ethanolic ex- tracts (1 g/kg) increased the milk production significantly (p < 0.001), with about 68.1% and 81% more milk being produced, respectively, than in the control group. The pups gained weight during the study period with the aqueous (0.5 and 1 g/kg, p < 0.05) and ethanolic (0.5 and 1 g/kg, p < 0.01) extracts. Thus, P. anisum aqueous and ethanolic extracts can increase milk production in rats.

Synthesis and Properties of Partially Hydrolyzed Acrylonitrile-co-Acrylamide Superabsorbent Hydrogel

Pourjavadi, Ali,Hosseinzadeh, Hossein Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.11

In this work, a novel method to synthesis of an acrylic superabsorbent hydrogel was reported. In the two stage hydrogel synthesis, first copolymerization reaction of acrylonitrile (AN) and acrylamide (AM) monomers using ammonium persulfate (APS) as a free radical initiator was performed. In the second stage, the resulted copolymer was hydrolyzed to produce carboxamide and carboxylate groups followed by in situ crosslinking of the polyacrylonitrile chains. The results from FTIR spectroscopy and the dark red-yellow color change show that the copolymerization, alkaline hydrolysis and crosslinking reactions have been do take place. Scanning electron microscopy (SEM) verifies that the synthesized hydrogels have a porous structure. The results of Brunauer-Emmett-Teller (BET) analysis showed that the average pore diameter of the synthesized hydrogel was 13.9 nm. The synthetic parameters affecting on swelling capacity of the hydrogel, such as AM/AN weight ratio and hydrolysis time and temperature, were systematically optimized to achieve maximum swelling capacity (330 g/g). The swollen gel strength of the synthesized hydrogels was evaluated via viscoelastic measurements. The results indicated that superabsorbent polymers with high water absorbency were accompanied by low gel strength. The swelling of superabsorbent hydrogels was also measured in various solutions with pH values ranging from 1 to 13. Also, the pH reversibility and on-off switching behavior makes the hydrogel as a good candidate for controlled delivery of bioactive agents. Finally, the swelling of synthesized hydrogels with various particle sizes obey second order kinetics.

Synthesis and Properties of Partially Hydrolyzed Acrylonitrile-co -Acrylamide Superabsorbent Hydrogel

Ali Pourjavadi,Hossein Hosseinzadeh 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.11

In this work, a novel method to synthesis of an acrylic superabsorbent hydrogel was reported. In the two stage hydrogel synthesis, first copolymerization reaction of acrylonitrile (AN) and acrylamide (AM) monomers using ammonium persulfate (APS) as a free radical initiator was performed. In the second stage, the resulted copolymer was hydrolyzed to produce carboxamide and carboxylate groups followed by in situ crosslinking of the polyacrylonitrile chains. The results from FTIR spectroscopy and the dark red-yellow color change show that the copolymerization, alkaline hydrolysis and crosslinking reactions have been do take place. Scanning electron microscopy (SEM) verifies that the synthesized hydrogels have a porous structure. The results of Brunauer-Emmett-Teller (BET) analysis showed that the average pore diameter of the synthesized hydrogel was 13.9 nm. The synthetic parameters affecting on swelling capacity of the hydrogel,such as AM/AN weight ratio and hydrolysis time and temperature, were systematically optimized to achieve maximum swelling capacity (330 g/g). The swollen gel strength of the synthesized hydrogels was evaluated via viscoelastic measurements. The results indicated that superabsorbent polymers with high water absorbency were accompanied by low gel strength. The swelling of superabsorbent hydrogels was also measured in various solutions with pH values ranging from 1 to 13. Also, the pH reversibility and on-off switching behavior makes the hydrogel as a good candidate for controlled delivery of bioactive agents. Finally, the swelling of synthesized hydrogels with various particle sizes obey second order kinetics.

Some bounds for total communicability of graphs

Das, Kinkar Ch.,Hosseinzadeh, Mohammad Ali,Hossein-Zadeh, Samaneh,Iranmanesh, Ali Elsevier 2019 Linear algebra and its applications Vol.569 No.-

<P><B>Abstract</B></P> <P>In a network or a graph, the total communicability (<I>TC</I>) has been defined as the sum of the entries in the exponential of the adjacency matrix of the network. This quantity offers a good measure of how easily information spreads across the network, and can be useful in the design of networks having certain desirable properties. In this paper, we obtain some bounds for total communicability of a graph <I>G</I>, T C ( G ) , in terms of spectral radius of the adjacency matrix, number of vertices, number of edges, minimum degree and the maximum degree of <I>G</I>. Moreover, we find some upper bounds for T C ( G ) when <I>G</I> is the Cartesian product, tensor product or the strong product of two graphs. In addition, Nordhaus–Gaddum-type results for the total communicability of a graph <I>G</I> are established.</P>

Review on the Potential Therapeutic Roles of Nigella sativa in the Treatment of Patients with Cancer: Involvement of Apoptosis - Black cumin and cancer -

Mollazadeh, Hamid,Afshari, Amir R.,Hosseinzadeh, Hossein KOREAN PHARMACOPUNCTURE INSTITUTE 2017 Journal of pharmacopuncture Vol.20 No.3

Nigella sativa (N. sativa, family Ranunculaceae) is a medicinal plant that has been widely used for centuries throughout the world as a natural remedy. A wide range of chemical compounds found in N. sativa expresses its vast therapeutic effects. Thymoquinone (TQ) is the main component (up to 50%) in the essential oil of N. sativa. Also, pinene (up to 15%), p-cymene (40%), thymohydroquinone (THQ), thymol (THY), and dithymoquinone (DTQ) are other pharmacologically active compounds of its oil. Other terpenoid compounds, such as carvacrol, carvone, 4-terpineol, limonenes, and citronellol, are also found in small quantities in its oil. The main pharmacological characteristics of this plant are immune system stimulatory, anti-inflammatory, hypotensive, hepatoprotective, antioxidant, anti-cancer, hypoglycemic, anti-tussive, milk production, uricosuric, choleretic, anti-fertility, and spasmolytic properties. In this regard, we have searched the scientific databases PubMed, Web of Science, and Google Scholar with keywords of N. sativa, anti-cancer, apoptotic effect, antitumor, antioxidant, and malignancy over the period from 2000 to 2017. The effectiveness of N. sativa against cancer in the blood system, kidneys, lungs, prostate, liver, and breast and on many malignant cell lines has been shown in many studies, but the molecular mechanisms behind that anti-cancer role are still not clearly understood. From among the many effects of N. sativa, including its anti-proliferative effect, cell cycle arrest, apoptosis induction, ROS generation, anti-metastasis/anti-angiogenesis effects, Akt pathway control, modulation of multiple molecular targets, including p53, p73, STAT-3, PTEN, and $PPAR-{\gamma}$, and activation of caspases, the main suggestive anti-cancer mechanisms of N. sativa are its free radical scavenger activity and the preservation of various anti-oxidant enzyme activities, such as glutathione peroxidase, catalase, and glutathione-S-transferase. In this review, we highlight the molecular mechanisms of apoptosis and the anti-cancer effects of N. sativa, with a focus on its molecular targets in apoptosis pathways.