Assessment of MMP-1, MMP-8 and TIMP-2 in experimental periodontitis treated with kaempferol

Balli, Umut,Cetinkaya, Burcu Ozkan,Keles, Gonca Cayir,Keles, Zeynep Pinar,Guler, Sevki,Sogut, Mehtap Unlu,Erisgin, Zuleyha Korean Academy of Periodontology 2016 Journal of Periodontal & Implant Science Vol.46 No.2

Purpose: The objective of this study was to investigate the effect of a dietary flavonoid, kaempferol, which has been shown to possess antiallergic, anti-inflammatory, anticarcinogenic, and antioxidant activities on the periodontium by histomorphometric analysis and on gingival tissue matrix metalloproteinase-1 (MMP-1), MMP-8, and tissue inhibitor of metalloproteinase-2 (TIMP-2) by biochemical analysis of rats after experimental periodontitis induction. Methods: Sixty Wistar rats were randomly divided into six groups of ten rats each, and silk ligatures were placed around the cervical area of the mandibular first molars for 15 days, except in the healthy control rats. In the experimental periodontitis groups, systemic kaempferol (10 mg/kg/2d) and saline were administered by oral gavage at two different periods (with and without the presence of dental biofilm) to all rats except for the ten non-medicated rats. Alveolar bone area, alveolar bone level, and attachment level were determined by histomorphometric analysis, and gingival tissue levels of MMP-1, MMP-8, and TIMP-2 were detected by biochemical analysis. Results: Significantly greater bone area and significantly less alveolar bone and attachment loss were observed in the kaempferol application groups compared to the control groups (P<0.05). In addition, gingival tissue MMP-1 and -8 levels were significantly lower in the kaempferol application groups compared to the control groups and the periodontitis group (P<0.001). There were no statistically significant differences in TIMP-2 levels between the kaempferol and saline application groups (P>0.05). Conclusions: Kaempferol application may be useful in decreasing alveolar bone resorption, attachment loss, and MMP-1 and -8 production in experimental periodontitis.

Assessment of MMP-1, MMP-8 and TIMP-2 in experimental periodontitis treated with kaempferol

Umut Balli,Burcu Ozkan Cetinkaya,Gonca Cayir Keles,Zeynep Pinar Keles,Sevki Guler,Mehtap Unlu Sogut,Zuleyha Erisgin 대한치주과학회 2016 Journal of Periodontal & Implant Science Vol.46 No.2

Purpose: The objective of this study was to investigate the effect of a dietary flavonoid, kaempferol, which has been shown to possess antiallergic, anti-inflammatory, anticarcinogenic, and antioxidant activities on the periodontium by histomorphometric analysis and on gingival tissue matrix metalloproteinase-1 (MMP-1), MMP-8, and tissue inhibitor of metalloproteinase-2 (TIMP-2) by biochemical analysis of rats after experimental periodontitis induction. Methods: Sixty Wistar rats were randomly divided into six groups of ten rats each, and silk ligatures were placed around the cervical area of the mandibular first molars for 15 days, except in the healthy control rats. In the experimental periodontitis groups, systemic kaempferol (10 mg/kg/2d) and saline were administered by oral gavage at two different periods (with and without the presence of dental biofilm) to all rats except for the ten non-medicated rats. Alveolar bone area, alveolar bone level, and attachment level were determined by histomorphometric analysis, and gingival tissue levels of MMP-1, MMP-8, and TIMP-2 were detected by biochemical analysis. Results: Significantly greater bone area and significantly less alveolar bone and attachment loss were observed in the kaempferol application groups compared to the control groups (P<0.05). In addition, gingival tissue MMP-1 and -8 levels were significantly lower in the kaempferol application groups compared to the control groups and the periodontitis group (P<0.001). There were no statistically significant differences in TIMP-2 levels between the kaempferol and saline application groups (P>0.05). Conclusions: Kaempferol application may be useful in decreasing alveolar bone resorption,attachment loss, and MMP-1 and -8 production in experimental periodontitis.

Prediction of optoelectronic features and efficiency for CuMX2 (M=Ga, In; X=S, Se) semiconductors using mbj+U approximation

Bikerouin M.,Balli M.,Correa J.D.,Mora-Ramos M.E. 한국물리학회 2021 Current Applied Physics Vol.32 No.-

The optoelectronic properties of a selected group of Cu-III-VI2 chalcopyrites-based materials are deeply investigated by using the modified Becke-Johnson (mBJ) potential, combined with DFT + U approach. The obtained results are further used to calculate these materials’ theoretical efficiency limit for solar cell applications. The bandgap findings indicate a reliable ±0.2 eV agreement. After evaluating the electronic and optical properties, the spectroscopic limited maximum efficiency (SLME) model was used as a metric for the screening. Besides the bandgap value considered in the Shockley–Queisser model, the SLME requires that the absorption spectra, the radiative recombination losses, and the absorber layer thickness must be considered to adequately calculate the efficiency of considered cells. Our findings unveil that some candidates, such as CuInS2, where an SLME of 30.25% is achieved at a film width of 500 nm can be classified in the category of materials with higher power conversion efficiency.

LETTER TO THE EDITOR : Achalasia secondary to lung adenocarcinoma

( Burak Can ),( Fatih Balli ),( Ugur Korkmaz ),( Hasan Yilmaz ),( Fatma Inci Can ),( Altay Celebi ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.2

Evaluation of wind loads and the potential of Turkey's south west region by using log-normal and gamma distributions

Ramazan Özkan,Faruk Sen,Serkan Balli 한국풍공학회 2020 Wind and Structures, An International Journal (WAS Vol.31 No.4

In this study, wind data such as speeds, loads and potential of Muğla which is located in the southwest of Turkey were statistically analyzed. The wind data which consists of hourly wind speed between 2010 and 2013 years, was measured at the 10-meters height in four different ground stations (Datça, Fethiye, Marmaris, Köyceğiz). These stations are operated by The Turkish State Meteorological Service (T.S.M.S). Furthermore, wind data was analyzed by using Log-Normal and Gamma distributions, since these distributions fit better than Weibull, Normal, Exponential and Logistic distributions. Root Mean Squared Error (RMSE) and the coefficients of the goodness of fit (R2) were also determined by using statistical analysis. According to the results, extreme wind speed in the research area was 33 m/s at the Datça station. The effective wind load at this speed is 0.68 kN/m2. The highest mean power densities for Datça, Fethiye, Marmaris and Köyceğiz were found to be 46.2, 1.6, 6.5 and 2.2 W/m2, respectively. Also, although Log-normal distribution exhibited a good performance i.e., lower AD (Anderson – Darling statistic (AD) values) values, Gamma distribution was found more suitable in the estimation of wind speed and power of the region.

Influence of the Timing of Percutaneous Coronary Intervention on Clinical Outcomes in Non-ST-Elevation Myocardial Infarction

Kamuran Tekin,Caglar Emre Cagliyan,Ibrahim Halil Tanboga,Mehmet Balli,Onur Kadir Uysal,Bugra Ozkan,Osman Ziya Arik,Murat Cayli 대한심장학회 2013 Korean Circulation Journal Vol.43 No.11

Background and Objectives: We have intended to investigate the influence of the timing of invasive procedures on all-cause mortality,recurrent myocardial infarction (MI), re-hospitalization due to cardiac causes and left ventricular function over a 3-month period among patients with Non-ST-elevation myocardial infarction (NSTEMI). Subjects and Methods: A total of 131 NSTEMI patients with moderate-high Thrombolysis in Myocardial Infarction risk scores, who had been admitted to our department between July 2011-December 2011 were included in our study. They had been randomized into 2 groups according to the timing of the percutaneous coronary intervention (PCI). Patient undergoing PCI in the first 24 hours of hospitalization were named the “Early Invasive Group” and those undergoing PCI between 24-72 hours of hospitalization were named the “Delayed Invasive Group”. All patients were followed up for 3 months. Results: Third month left ventricular ejection fraction (LVEF) values were higher in the early invasive group (59.9±6.0% vs. 54.1±8.7%;p<0.001). Recurrent MI rates were lower in the early invasive group (2.9% vs. 14.5%; p=0.016). Similarly, hospitalization rates due to cardiac events were lower in the early invasive group (8.7% vs. 30.6%; p=0.001). All cause mortality appeared to be lower in the early invasive group, although not to a statistically significant degree (0% vs. 4.8%; p=0.065). Conclusion: The early invasive strategy appears to be more effective for the reduction of recurrent MI, re-hospitalization due to cardiac events, and the preservation of 3rd month LVEF in patients with moderate-high risk NSTEMI when compared to a delayed invasive strategy.