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Improving and Assessing the Impact of e-Navigation applications
Michael BALDAUF,Sun-Bae HONG 국제이네비해양경제학회 2016 International Journal of e-Navigation and Maritime Vol.4 No.1
The scope of this paper is implementation issues of the e-Navigation concept of the International Maritime Organization (IMO). IMO has adopted the e-Navigation strategic implementation plan (SIP) in 2014. This plan, i.a., bases on estimating the effect of e-Navigation applications on reducing navigational accidents, including collisions and groundings of ships falling under the International Convention for the Safety of Life at Sea (SOLAS) by approximately 65 per cent. However, IMO Member States are responsible for safety of navigation and efficient vessel traffic at international but also on national levels. Regarding the introduction of new concepts and innovative systems into vessel traffic there is a need to comprehensively assess potential effects not only for SOLAS ships but also for non-SOLAS ships. This paper aims at a more comprehensive and theoretically sounded estimation of e-Navigation potentials by investigating and applying IMO’s methodology for quantification of those effects also to the implementation of e-Navigation solutions to ships not falling under the SOLAS convention (non-SOLAS ships). The authors carried out a case study using the SMART-Navigation concept of Korea as model case for impact assessment. For the mentioned purpose, this paper identifies main tool kits of IMO e- Navigation, proposes and applies a set of formulas to comprehensively assess and quantify effects of new functions or services based on IMO’s methodological approaches. From gained results authors suggest investigations not only taking into account expert opinions but also simulation trials to identify factors and coefficients for thorough calculations. From the results the authors conclude and recommend to extend the impact assessment of e-Navigation also to vessel traffic involving non-SOLAS ships as a general and global recommendation to coastal states. Further, results are provided as a potential model case for IMO Member States’ reference for their statespecific individual situation and conditions.
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The wide utility of rabbits as models of human diseases
Pedro J. Esteves,Joana Abrantes,Hanna-Mari Baldauf,Lbachir BenMohamed,Yuxing Chen,Neil Christensen,Javier González-Gallego,Lorenzo Giacani,Jiafen Hu,Gilla Kaplan,Oliver T. Keppler,Katherine L. Knight 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Studies using the European rabbit Oryctolagus cuniculus contributed to elucidating numerous fundamental aspects of antibody structure and diversification mechanisms and continue to be valuable for the development and testing of therapeutic humanized polyclonal and monoclonal antibodies. Additionally, during the last two decades, the use of the European rabbit as an animal model has been increasingly extended to many human diseases. This review documents the continuing wide utility of the rabbit as a reliable disease model for development of therapeutics and vaccines and studies of the cellular and molecular mechanisms underlying many human diseases. Examples include syphilis, tuberculosis, HIV-AIDS, acute hepatic failure and diseases caused by noroviruses, ocular herpes, and papillomaviruses. The use of rabbits for vaccine development studies, which began with Louis Pasteur’s rabies vaccine in 1881, continues today with targets that include the potentially blinding HSV-1 virus infection and HIV-AIDS. Additionally, two highly fatal viral diseases, rabbit hemorrhagic disease and myxomatosis, affect the European rabbit and provide unique models to understand co-evolution between a vertebrate host and viral pathogens.
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Precision cluster mass determination from weak lensing
Mandelbaum, Rachel,Seljak, Uroš,Baldauf, Tobias,Smith, Robert E. Blackwell Publishing Ltd 2010 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.405 No.3
<P>ABSTRACT</P><P>Weak gravitational lensing has been used extensively in the past decade to constrain the masses of galaxy clusters, and is the most promising observational technique for providing the mass calibration necessary for precision cosmology with clusters. There are several challenges in estimating cluster masses, particularly (a) the sensitivity to astrophysical effects and observational systematics that modify the signal relative to the theoretical expectations, and (b) biases that can arise due to assumptions in the mass estimation method, such as the assumed radial profile of the cluster. All of these challenges are more problematic in the inner regions of the cluster, suggesting that their influence would ideally be suppressed for the purpose of mass estimation. However, at any given radius the differential surface density measured by lensing is sensitive to all mass within that radius, and the corrupted signal from the inner parts is spread out to all scales. We develop a new statistic ϒ(<I>R</I>; <I>R</I><SUB>0</SUB>) that is ideal for estimation of cluster masses because it completely eliminates mass contributions below a chosen scale (which we suggest should be about 20 per cent of the virial radius), and thus reduces sensitivity to systematic and astrophysical effects. We use simulated and analytical profiles including shape noise to quantify systematic biases on the estimated masses for several standard methods of mass estimation, finding that these can lead to significant mass biases that range from 10 to over 50 per cent. The mass uncertainties when using the new statistic ϒ(<I>R</I>; <I>R</I><SUB>0</SUB>) are reduced by up to a factor of 10 relative to the standard methods, while only moderately increasing the statistical errors. This new method of mass estimation will enable a higher level of precision in future science work with weak lensing mass estimates for galaxy clusters.</P>
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A Cenozoic record of the equatorial Pacific carbonate compensation depth
P채like, Heiko,Lyle, Mitchell W.,Nishi, Hiroshi,Raffi, Isabella,Ridgwell, Andy,Gamage, Kusali,Klaus, Adam,Acton, Gary,Anderson, Louise,Backman, Jan,Baldauf, Jack,Beltran, Catherine,Bohaty, Steven M.,Bo Nature Publishing Group, a division of Macmillan P 2012 Nature Vol.488 No.7413
Atmospheric carbon dioxide concentrations and climate are regulated on geological timescales by the balance between carbon input from volcanic and metamorphic outgassing and its removal by weathering feedbacks; these feedbacks involve the erosion of silicate rocks and organic-carbon-bearing rocks. The integrated effect of these processes is reflected in the calcium carbonate compensation depth, which is the oceanic depth at which calcium carbonate is dissolved. Here we present a carbonate accumulation record that covers the past 53 million years from a depth transect in the equatorial Pacific Ocean. The carbonate compensation depth tracks long-term ocean cooling, deepening from 3.0??3.5??kilometres during the early Cenozoic (approximately 55??million years ago) to 4.6 kilometres at present, consistent with an overall Cenozoic increase in weathering. We find large superimposed fluctuations in carbonate compensation depth during the middle and late Eocene. Using Earth system models, we identify changes in weathering and the mode of organic-carbon delivery as two key processes to explain these large-scale Eocene fluctuations of the carbonate compensation depth.
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