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Computational design and characterization of a subcritical reactor assembly with TRIGA fuel
Alvie Asuncion-Astronomo,Ziga Stancar,Tanja Goricanec,Luka Snoj 한국원자력학회 2019 Nuclear Engineering and Technology Vol.51 No.2
The TRIGA fuel of the Philippine Research Reactor-1 (PRR-1) will be used in a subcritical reactor assembly(SRA) to strengthen and advance nuclear science and engineering expertise in the Philippines. SRA offersa versatile and safe training and research facility since it can produce neutrons through nuclear fissionreaction without achieving criticality. In this work, we used a geometrically detailed model of the PRR-1TRIGA fuel to design a subcritical reactor assembly and calculate physical parameters of different fuelconfigurations. Based on extensive neutron transport simulations an SRA configuration is proposed,comprising 44 TRIGA fuel rods arranged in a 7 7 square lattice. This configuration is found to have amaximum keff value of 0:95001±0:00009 at 4 cm pitch. The SRA is characterized by calculating the 3-dimensional neutron flux distribution and neutron spectrum. The effective delayed neutron fraction andmean neutron generation time of the system are calculated to be 748 pcm±7 pcm and 41 ms, respectively. Results obtained from this work will be the basis of the core design for the subcritical reactorfacility that will be established in the Philippines.
Kenji Sugimoto,Lorlynn Asuncion Mateo 제어로봇시스템학회 2015 제어로봇시스템학회 국제학술대회 논문집 Vol.2015 No.10
This paper proposes a new scheme of on-line identification for feedforward (FF) learning control of an unknown nonlinear multi-input multi-output (MIMO) plant free of zero dynamics. This is achieved by constructing a FF controller consisting of a bank of linear approximation models for various operating points, which are discretized and called scheduler. Conventional schemes used piecewise constant/linear interpolation techniques to address the discretization. However, the accuracy of response shaping was insufficient. To improve the performance, we propose to take a basis function approach to tune the parameter of the FF controller. To verify the effectiveness of the proposed scheme, numerical simulation is carried out using the motion equation of a two-link manipulator.
Saad Pirzada,Kimberly Boswell,Jerry Yang,Samantha Asuncion,Fernando Albelo,Amanda Tuchler,Lauren Becker,Allison Lankford,Emad Elsamadicy,Quincy K Tran 대한중환자의학회 2024 Acute and Critical Care Vol.39 No.1
Background: Medical complications in peripartum patients are uncommon; however, such events in patients already under biological stress can lead to poor outcomes. Often, these patients are transferred to tertiary care centers, but their conditions and outcomes are not well understood. Our study looked at peripartum patients transferred to an intensive care unit (ICU) at an academic quaternary center.Methods: We reviewed charts of adult, non-trauma, interhospital transfer (IHT) peripartum patients sent to an academic quaternary ICU between January 2017 and December 2021. We conducted a descriptive analysis and used multivariable ordinal regression to examine associations of demographic and clinical factors with ICU length of stay (ICU LOS) and hospital length of stay (HLOS).Results: Of 1,794 IHT peripartum patients, 60 (3.2%) were directly transferred to an ICU. The average age was 32 years, with a median Sequential Organ Failure Assessment (SOFA) score of 3 (1–4.25) and median Acute Physiology and Chronic Health Evaluation (APACHE) II score of 8 (7–12). Respiratory failure was most common (32%), followed by postpartum hemorrhage (15%) and sepsis (14%). Intubation was required for 24 (41%), and 4 (7%) needed extracorporeal membrane oxygenation. Only 1 (1.7%) died, while 45 (76.3%) were discharged. Median ICU LOS and HLOS were 5 days (2–12) and 8 days (5–17). High SOFA was linked to longer HLOS, as was APACHE II score.Conclusions: Transfers of critically ill peripartum patients between hospitals were rare but involved severe medical conditions. Despite this, their outcomes were generally positive. Larger studies are needed to confirm our findings.
Significance of immune checkpoint proteins in <i>EGFR</i>-mutant non-small cell lung cancer
Soo, Ross A.,Kim, Hye Ryun,Asuncion, Bernadette Reyna,Fazreen, Zul,Omar, Mohamed Feroz Mohd,Herrera, Maria Cynthia,Yun Lim, Joey Sze,Sia, Grace,Soong, Richie,Cho, Byoung-Chul Elsevier 2017 Lung cancer Vol.105 No.-
<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P>To characterize the expression of PD-L1, PD-1, cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and T-cell immunoglobulin and mucin-domain containing-3 (TIM3) in epidermal growth factor receptor (<I>EGFR</I>) mutant non-small cell lung cancer (NSCLC).</P> <P><B>Materials and methods</B></P> <P>Samples from 90 patients with newly diagnosed advanced stage NSCLC harboring <I>EGFR</I> mutations and treated with first line EGFR tyrosine kinase inhibitors (TKI) within 3 months of diagnosis were stained for CTLA-4, PD-L1, PD-1, TIM-3 and CD3 expression by immunohistochemistry.</P> <P><B>Results</B></P> <P>PD-L1 was present in at least 1% of immune and tumor cells in 44% and 59% of samples, respectively. In multivariate analysis, increased CD3 immune shaped cell (ISC) counts (HR 2.805, <I>p</I> =0.034) and high PD-L1 tumor H-score (HR 3.805, <I>p</I> =0.022) was associated with a shorter progression free survival and high CTLA-4 ISC counts was associated with borderline overall survival significance (HR 1.054, <I>p</I> =0.061).</P> <P><B>Conclusion</B></P> <P>Tumor PD-L1 expression was significantly associated with a shorter PFS whereas immune cell CTLA-4 may be prognostic for OS. Our findings support the ongoing development of CTLA-4 and PD1/PD-L1 inhibitors in this important molecularly defined subset of lung adenocarcinoma.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Casesof advanced stage EGFR mutant NSCLC were analysed. </LI> <LI> PD-L1, PD-1, CTLA-4 and TIM3 expression were characterized. </LI> <LI> High tumor PD-L1 had a shorter PFS. </LI> <LI> Immune cell CTLA-4 expression was prognostic. </LI> </UL> </P>
Bonifacio O. Pasion,Carolyn DP. Barrias,Milagrosa P. Asuncion,Abelardo H. Angadol,Robert R. Pabiling,Arsenio Pasion Jr.,Archiles A. Braulio,Agaton M. Baysa Jr. 국립중앙과학관 2021 Journal of Asia-Pacific Biodiversity Vol.14 No.1
Riparian zones are a small portion of a watershed but hold a diverse and important ecosystem functioning. We assessed diversity and carbon density of pole (5e10 cm DBH) and canopy (>10 cm DBH)trees along a riparian zone in Pasonanca Natural Park, southern Philippines. We identified 66 species,which included 41 canopy and 54 pole tree species, and comprised 46 indigenous, 18 Philippine endemics,and two exotic species. We recorded eight vulnerable (VU) and two endangered (EN) speciesunder the Philippine Red List, whereas five VU, three EN, and six critically endangered (CR) species wererecorded under the IUCN Global Red List. We estimated the Hill number of canopy trees at 60.91 12.14species and the Shannon diversity H’ was 49.57 5.15, whereas the pole tree was 77.87 12.60 specieswith diversity H’ of 33.07 3.77. The estimated carbon density was 128.42 39.04 MgC ha 1, majorityfrom canopy trees (101.51 63.52 MgC ha 1). We found an asymptotic and strong positive relationship(R2 ¼ 0.81; p ¼ <0.001) between species dominance and carbon density. Our result highlighted the roleof dominant species in maintaining ecosystem function, which can be considered when managing riparianecosystems as they perform better in storing and sequestering carbon.
Dual emission of temperature-induced betacarboline self-associated hydrogen bond aggregates
Hidalgo, Jose,Sanchez-Coronilla, Antonio,Balon, Manuel,Munoz, Maria Asuncion,Carmona, Carmen Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.3
A systematic study of the influence of the gradual temperature decrease on the UV-vis absorption and fluorescence emission spectra of betacarboline, 9H-pyrido[3,4-b]indole, BC, and other model systems, such as BC plus $N_9$-methyl-9H-pyrido[3,4-b]indole, MBC, and BC plus pyridine, PY, has been carried out in 2-methylbutane, 2MB. These studies have allowed the conclusion that the temperature decrease favours the formation of hydrogen-bonded self-associated BC aggregates. The initial red shifts of the absorption and emission bands and the fluorescence quenching have been ascribed to the formation of hydrogen bond BC dimers with a proton transfer structure, PTC. In these adducts, the fluorescence is quenched by an electron-driven proton transfer process. However, because the quenching rate constant decreases upon decreasing the temperature, the emission intensity later increases without modification of the wavelength maxima. At the lowest temperatures, these dimeric PTC complexes further aggregate. We propose that they form ground state cyclic tetrameric adducts in which both nitrogen atoms of each BC unit are hydrogen bonded. The tautomeric forms of these tetrameric complexes, generated by a quadruple proton transfer, emit dual fluorescence, from its locally excited state, LE, and its intramolecular charge transfer state, ICT.
Hila, F.C.,Javier-Hila, A.M.V.,Sayyed, M.I.,Asuncion-Astronomo, A.,Dicen, G.P.,Jecong, J.F.M.,Guillermo, N.R.D.,Amorsolo, A.V. Jr. Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.11
In this paper, the EPICS2017 photoatomic database was used to evaluate the photon mass attenuation coefficients and buildup factors of soils collected at different depths in the Philippine islands. The extraction and interpolation of the library was accomplished at the recommended linear-linear scales to obtain the incoherent and total cross section and mass attenuation coefficient. The buildup factors were evaluated using the G-P fitting method in ANSI/ANS-6.4.3. An agreement was achieved between XCOM, MCNP5, and EPICS2017 for the calculated mass attenuation coefficient values. The buildup factors were reported at several penetration depths within the standard energy grid. The highest values of both buildup factor classifications were found in the energy range between 100 and 400 keV where incoherent scattering interaction probabilities are predominant, and least at the region of predominant photoionization events. The buildup factors were examined as a function of different soil silica contents. The soil samples with larger silica concentrations were found to have higher buildup factor values and hence lower shielding characteristics, while conversely, those with the least silica contents have increased shielding characteristics brought by the increased proportions of the abundant heavier oxides.