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RISS 인기검색어
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- 저자 : Arumugam, K. (검색결과 142 건)
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Arumugam, Parthasarathy,Song, Joon Myong Oxford University Press 2016 Integrative biology Vol.8 No.6
<P>Elevated expression of drug efflux pumps such as multidrug resistant protein-1 (MDR1/ABCB1) and multidrug resistance associated protein-1 (MRP1/ABCC1) in cancer stem cells (CSCs) among a bulky tumor cell population was attributed to drug resistance. For the first time, we have quantitatively evaluated the cytotoxic profile of camptothecin (CPT) against the CSC. In the present study, a Qdot based total internal reflection fluorescence (TIRF) detection system effectively interpreted that drug resistance to CPT was reduced in the CSC under ABCB1 inhibited conditions. This study revealed that quantitative finding of the EC50 value for apoptosis and necrosis in correlation with the ABC inhibitor and CSC population using TIRF could provide more details of the anti-cancer efficacy of chemotherapeutic agents.</P>
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Arumugam Jayamani,Vijayan Thamilarasan,Venketasan Ganesan,Nallathambi Sengottuvelan 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.12
A nickel(II) complex [Ni(H2biim)2(H2O)2](ClO4)2·H2O (1) of biimidazole ligand has been synthesized and characterized (Where H2biim = 2,2'-biimidazole). The single crystal X-ray diffraction of the complex shows a dimeric structure with six coordinated psudo-octahedral geometry. The cyclic voltammograms of complex exhibited one quasireversible reduction wave (Epc = −0.61 V) and an irreversible oxidation wave (Epa = 1.28 V) in DMF solution. The interaction of the complex with Calf-Thymus DNA (CT-DNA) has been investigated by absorption and fluorescence spectroscopy. The complex is an avid DNA binder with a binding constant value of 1.03 × 105 M−1. The results suggest that the nickel(II) complex bind to CT-DNA via intercalative mode and can quench the fluorescence intensity of EB bind to CT-DNA with Kapp value of 3.2 × 105 M−1. The complex also shown efficient oxidative cleavage of supercoiled pBR322 DNA in the presence of hydrogen peroxide as oxidizing agent. The DNA cleavage by complex in presence of quenchers; viz. DMSO, KI, NaN3 and EDTA reveals that hydroxyl radical or singlet oxygen mechanism is involved. The complex showed invitro antimicrobial activity against four bacteria and two fungi. The antimicrobial activity was nearer to that of standard drugs and greater than that of the free ligand.
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Growth of Bulk Single Crystals of Urea for Photonic Applications
Arumugam Saranraj,Sathiyadhas Sahaya Jude Dhas,Michael Jose,Sathiyadhas Amalapusham Martin Britto Dhas 대한금속·재료학회 2018 ELECTRONIC MATERIALS LETTERS Vol.14 No.1
We report the growth of technologically important urea crystals of record size (48 ×16 × 8 mm3) by doping sulfuric acid and employing slow evaporation technique. Thegrown crystal was identified by single crystal X-Ray diffraction and FTIR spectralanalysis. Optical properties of the grown crystal were analyzed by UV-Vis spectrumand the presence of H2SO4 was confirmed by EDAX analysis. Thermogravimetricanalysis, Differential Scanning Calorimetry and Photo acoustic studies were alsocarried out to determine the thermal properties of the grown crystal. The dielectricproperties for wide range of frequencies (1 Hz to 1 MHz) at different temperatures(35, 40, 60, 80, 100 °C) were analyzed. The second harmonic conversion efficiencyof the grown H2SO4 doped urea crystal was found to be 3.75 times higher than thecommercially available KDP crystals.
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Arumugam, P.,Samson, A.,Ki, J.,Song, J. M. Springer Science + Business Media 2017 Cell biology and toxicology Vol.33 No.3
<P>The existence of a well-established drug resistance mechanism in cancer stem cells (CSC) complicates the cancer treatment. Clusterin (CLU) plays a key role in maintaining the integrity of endoplasmic reticulum (ER) during drug-induced stress. Hence, silencing the CLU could significantly reduce the inherent drug resistance mechanism of CSC. The combination of drug-induced cytotoxicity, as well as the suppression of drug resistance in CSC, could circumvent the recurrence capability of the tumor. In the present study, camptothecin (CPT)-induced apoptosis and necrosis in CSC with and without siCLU treatment were simultaneously measured using Qdot-based total internal reflection fluorescence microscope (TIRF). In addition, to elucidate the mechanism of CPT-induced cytotoxicity in CLU-suppressed CSC, expression of Bcl-2, Bax, Bak, and PARP and mitochondrial permeability transition pore (MPTP) were studied. EC50 values of CPT-induced apoptosis and necrosis were significantly reduced (p < 0.01) in CLU-suppressed MCF-7 and CSC. Significantly increased MPTP (p < 0.001) and cytosolic Ca2+ (p < 0.001) were observed in CPT-treated CLU-suppressed CSC as compared to the normal CSC. Elevated expression of Bax, Bak, and cleaved PARP and reduced expression of Bcl-2 and cytosolic ATP were observed in CPT-treated CLU-suppressed CSC. Observed results indicate that silencing the expression of CLU could improve the anticancer efficacy of CPT at 128.4-nM concentration by equally inducing necrotic signals along with apoptosis. Furthermore, the developed high content TIRF assay based on the CLU-suppressed CSC could be an ideal and beneficial tool for rapidly analyzing the cytotoxicity of anti-cancer agents.</P>
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Arumugam, Nandhini,Kim, JongSung Elsevier 2018 Materials science & engineering. C, Materials for Vol.92 No.-
<P><B>Abstract</B></P> <P>Water-soluble fluorescent carboxyl-functionalized CdSe-ZnS quantum dots (QDs) were immobilized on graphene oxide (GO) and used for sensitive detection of ascorbic acid in aqueous solutions. QDs were attached to the surface of graphene oxide using the EDC/NHS-sulfo coupling reaction. Ascorbic acid is known as an antioxidant. It plays a crucial role in health maintenance, bio synthetic pathways such as formation of collagen and regulates immune system. The photoluminescence (PL) intensity of as-prepared GO-QD hybrids in water was quenched by ascorbic acid at ambient temperature. Based on this photoluminescence quenching phenomenon, a simple, rapid, and sensitive procedure is developed. In this study we are successful in detecting ascorbic acid due to its biological significance and the limit of detection is 568 pM.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Sensing platform based on quantum dots attached to graphene oxide (GO) was established. </LI> <LI> The preparation of GO-QD hybrids is simple and inexpensive. </LI> <LI> As-prepared GO-QD hybrids are successful in detecting ascorbic acid. </LI> <LI> Simple and sensitive detection of ascorbic acid at picomolar level </LI> </UL> </P>
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Selective Detection of Acetylcholine Using Enzyme-Protected Quantum Dot-Attached Graphene Oxide
Arumugam, Nandhini,Kim, Jongsung American Scientific Publishers 2017 Journal of Nanoscience and Nanotechnology Vol.17 No.11
<P>Neurotransmitters are chemical messengers that have the unique function of sending signals from one nerve cell to another. Acetylcholine (ACh) is one of the major neurotransmitter that performs a vital role in regulating the peripheral nervous system and modulating the central nervous system. Several studies have been performed to detect ACh by using electrochemical analysis methods. In this study, we developed an enzyme-protected quantum dot (QD)-attached graphene Oxide (GO) (GO-QDs@Enzyme hybrid) as a biosensor for the detection of ACh. Chymotrypsin, an enzyme that belongs to the serine protease family, was immobilized on the surface of GO-attached QDs using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EDC/NHS) sulfo coupling reaction. The as-synthesized GO-QDs@Enzyme hybrids were characterized using several analytical tools such as scanning electron microscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, and photoluminescence (PL) spectroscopy. The fluorescence of GO-QDs@Enzyme hybrids was quenched by ACh, and the limit of detection was calculated to be as low as 36 nM. The PL intensity of GO-QDs@Enzyme hybrids strongly depends on the various concentrations of ACh.</P>
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Automated Strawberry Flower Detection for Yield Estimation using Machine Vision
( Arumugam Kalaikannan ),( Won Suk Lee ),( Natalia Peres ),( Clyde Fraisse ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
Strawberry is an important horticultural crop in the U.S. Strawberry, which ranks 8th in produce and 4th in fruit with a total value of $2.4 billion annually. Since strawberries are manually harvested and labor shortage is a major concern, yield predictions become extremely important for scheduling labors in harvesting and other field operations as well as marketing. For efficient use of labor resources in harvesting and other operations, strawberry growers in the U.S. will need reliable yield prediction models by utilizing a more feasible and efficient method to count the number of flowers in their fields. Images were acquired from a strawberry field using a consumer grade digital color camera at various working distances, angles and lighting conditions. Various image processing techniques were used to develop automated flower counting algorithms from the images. An accuracy of 88% was achieved by the computer vision algorithm on validation dataset. The number of strawberry flowers obtained from this algorithm will be used to develop a strawberry yield prediction model, which eventually will be used for efficient labor management for harvesting and marketing to increase yield and profit of the strawberry growers.
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Notch signaling and neuronal death in stroke
Arumugam, Thiruma V.,Baik, Sang-Ha,Balaganapathy, Priyanka,Sobey, Christopher G.,Mattson, Mark P.,Jo, Dong-Gyu Elsevier 2018 Progress in neurobiology Vol.165 No.-
<P><B>Abstract</B></P> <P>Ischemic stroke is a leading cause of morbidity and death, with the outcome largely determined by the amount of hypoxia-related neuronal death in the affected brain regions. Cerebral ischemia and hypoxia activate the Notch1 signaling pathway and four prominent interacting pathways (NF-κB, p53, HIF-1α and Pin1) that converge on a conserved DNA-associated nuclear multi-protein complex, which controls the expression of genes that can determine the fate of neurons. When neurons experience a moderate level of ischemic insult, the nuclear multi-protein complex up-regulates adaptive stress response genes encoding proteins that promote neuronal survival, but when ischemia is more severe the nuclear multi-protein complex induces genes encoding proteins that trigger and execute a neuronal death program. We propose that the nuclear multi-protein transcriptional complex is a molecular mediator of neuronal hormesis and a target for therapeutic intervention in stroke.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We review the roles of Notch in the neuropathology of ischemic stroke. </LI> <LI> We discuss the mechanisms for how Notch interacts with other gene transcription regulators such as HIF-1α, NF-κB, p53 and Pin1 following a stroke. </LI> <LI> We introduce a novel concept of a multi-protein complex which controls the expression of genes that determine the fate of neurons in stroke. </LI> <LI> We discuss if and how the multi-protein complex may regulate neuronal plasticity and resilience during the remodeling phase following stroke. </LI> <LI> We conclude with a perspective on how this research may lead to novel approaches for clinical intervention in ischemic stroke. </LI> </UL> </P>
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