http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Ardestani, Sussan K. (검색결과 24 건)
- 무료
- 기관 내 무료
- 유료
-
A. Ardestani,R. Yazdanparast,Sh. Jamshidi 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.3
Increased oxidative stress is a widely accepted factor in the development and progression of diabetes and its complications. In this study, we evaluated the antioxidative potential of Teucrium polium (Family Lamiaceae) aqueous extract for protecting rat pancreatic tissue against streptozotocin (STZ)-induced oxidative stress. Diabetes was induced in rats by intraperitoneal injections of at a single dose of STZ at 40 mg/kg. The crude extract (equivalent to 0.5 g of plant powder/kg of body weight) was administered orally (intragastrically) to a group of STZ diabetic rats for 30 consecutive days. Changes in antioxidant status were evaluated by determining catalase (CAT) and superoxide dismutase (SOD) activities and the level of reduced glutathione (GSH) in pancreatic tissue. In addition, serum nitric oxide (NO) concentration, pancreatic tissue malondialdehyde (MDA) (an index of lipid peroxidation) level, and reliable markers of protein oxidation such as protein carbonyl content (PCO) and advanced oxidation protein products (AOPP) were also determined. Under diabetic conditions, blood glucose level, serum NO concentration, and pancreatic MDA, PCO, and AOPP levels were all increased. The diabetic rats also exhibited pancreatic GSH depletion along with significant reductions in activities of CAT and SOD. Rats treated with T. polium extract had significantly higher GSH levels along with enhanced CAT and SOD activities in pancreatic tissue. In addition to suppressed blood glucose levels, serum NO, pancreatic MDA, PCO, and AOPP levels were all lower than in the diabetic group. Our results strongly support the proposal that antioxidative activity of T. polium occurs by quenching the extent of lipid and protein oxidation. Based on these observations, it is concluded that T. polium may have protective effect(s) on pancreatic tissue in STZ-induced oxidative stress due to its high antioxidative potential.
-
-
Mohammad Ardestani 한양대학교 세라믹연구소 2016 Journal of Ceramic Processing Research Vol.17 No.6
Copper/chromium oxide (75%wt) nanocomposite powders were synthesized via chemical precipitation process. The processwas included chemical precipitation of Cr-Cu containing precipitates, calcination and reduction of the precipitates. Based onthermogravimetric analysis of the precipitates, the optimum calcination temperature was determined as 700 oC. Thesynthesized powders were characterized by X-ray diffraction (XRD) and scanning electron microscope (SEM). Theobservations revealed that the powder particles were agglomerated and their shape was mainly spherical. The powders weredensified via spark plasma and presssureless sintering at 1000 oC and 1100 oC, respectively. The microstructural evaluation ofthe spark plasma sintered samples confirmed a near dense structure with a fine dispersion of the constituents. However, themicrostructure of the pressureless sintered specimen showed a large number of pores between the powder particles. Therelative density and micro-hardness of the spark plasma sintered samples were 95.8% and 1600 HV, respectively.
-
Mahnaz Movafaghi Ardestani,Shokouh Mahpishanian,Bahar Forouzesh Rad,Mehran Janmohammadi,Majid Baghdadi 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.6
A facile, effective, and eco-friendly process was developed for the preparation of chemically expanded graphite(CEG) under ambient conditions using natural flake graphite as raw material, potassium permanganate (KMnO4) asan oxidative intercalating agent, and hydrogen peroxide (H2O2) as the reactive species. The results showed that theCEG had an interconnected and highly porous structure, and some oxygen-containing groups were grafted on thegraphite layer by the oxidation-intercalation process. The absence of the graphite diffraction peak at 26o in the XRDpattern of expanded graphite (EG) indicates that the intercalation and expansion processes were complete, and most ofthe starting graphite layers were converted into the graphene sheets. The sulfuric acid concentration was the mosteffective parameter on the expansion, and the maximum expansion occurred at a sulfuric acid concentration of 77.5%. The other optimum preparation conditions were obtained at 1.5 g of KMnO4 and 30mL of H2O2 30%. Under the optimalcondition, the developed room-temperature liquid-phase intercalation and expansion processes led to an expansionvolume of up to 250 times. The potential application of the as-prepared CEG in environmental clean-up wasevaluated by adsorptive removal of methylene blue (MB) from the aqueous solution. The kinetic studies exhibited thatthe MB adsorption onto the CEG followed a pseudo-second-order kinetic model. Equilibrium data were fitted well withthe Langmuir model with a maximum adsorption capacity of 399.08mg g1. The findings indicate that the CEG wouldbe potentially applicable in water purification.
-
Yousefi, Reza,Ardestani, Susan K.,Saboury, Ali Akbar,Kariminia, Amina,Zeinali, Madjid,Amani, Mojtaba Korean Society for Biochemistry and Molecular Biol 2005 Journal of biochemistry and molecular biology Vol.38 No.4
Calcium and zinc binding protein, calprotectin is a multifunctional protein with broad spectrum antimicrobial and antitumoural activity. It was purified from human neutrophil, using a two-step ion exchange chromatography. Since surface hydrophobicity of calprotectin may be important in membrane anchoring, membrane penetration, subunits oligomerization and some biological roles of protein, in this study attempted to explore the effect of calcium in physiological range on the calprotectin lipophilicity. Incubation of human calprotectin ($50\;{\mu}g/ml$) with different calcium concentrations showed that 1-anilino-8-naphthalene sulfonic acid (ANS) fluorescence intensity of the protein significantly elevates with calcium in a dose dependent manner, suggesting an increase in calprotectin surface hydrophobicity upon calcium binding. Our study also indicates that calcium at higher concentrations (6, 8 and 10 mM) induces aggregation of human calprotectin. Our finding demonstrates that the starting time and the rate constant of calprotectin aggregation depend on the calcium concentration.
-
Streptomycin-anionic linear globular dendrimer G2: Novel antibacterial and anticancer agent
Javadi, Sahar,Ardestani, Mehdi Shafiee Techno-Press 2019 Advances in nano research Vol.7 No.4
Recent researches demonstrated well promising anticancer activities for antibiotics. Such effects would be significantly increased while nanoparticle based delivery systems were applied. In this study, the goal was aim to improve anticancer and antitoxic effects of Streptomycin by loading on special kind of dendrimer (anionic-linear-globular second generation). In the current study, Size and zeta potential as well as AFM techniques have been used to prove the fact that the loading was performed correctly. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the drug loaded on dendrimer nanoparticle were determined and compared with both of dendrimer alone and free drug with respect to staphylococcus aureus as the test microorganism. The anticancer activity among three groups including Streptomycin, Streptomycin -G2 dendrimer, and control was measured in vitro. In vitro studies showed that G2 anionic linear-globular polyethylene-glycol-based dendrimer, which loaded on Streptomycin was able to significantly improve the treatment efficacy over clinical Streptomycin alone with respect to proliferation assay. Maximal inhibitory concentration (IC50) was calculated to be $257{\mu}g/mL$ for streptomycin alone and $55{\mu}g/mL$ for Streptomycin -G2 dendrimer. In addition, Streptomycin -G2 dendrimer conjugate prevented the growth of MCF-7 cancerous cells in addition to enhance the number of apoptotic and necrotic cells as demonstrated by an annexin V-fluorescein isothiocyanate assay. Streptomycin -G2 dendrimer conjugate was able to increase Bcl-2/Bax ratio in a large scale compared with the control group and Streptomycin alone. Based on results a new drug formulation based nano-particulate was improved against S. aureus with sustained release and enhanced antibacterial activity as well as anticancer activity shown for functional cancer treatment with low side effects.
-
-
-
-
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
