Valued Daughters: First-Generation Career Women

Anshu Singh 숙명여자대학교 아시아여성연구원 2018 Asian Women Vol.34 No.2

Osteochondral Lesion in Diffuse Pigmented Villonodular Synovitis of the Knee

Anshu Shekhar,Savneet Singh,Shantanu Sudhakar Patil,Sachin Ramchandra Tapasvi 대한슬관절학회 2019 대한슬관절학회지 Vol.31 No.1

Pigmented villonodular synovitis (PVNS) is a rare benign condition that is locally aggressive and may destructively invade the surrounding soft tissues and bone causing functional loss of the joint and the limb. The knee is the most affected joint (range, 28% to 70%) but involvement of the bone is not a common feature seen at this site. We present a rare case of diffuse PVNS of the knee associated with subchondral cyst of the lateral femoral condyle. This posed a diagnostic dilemma because of bone invasion. The radiological image of synovitis was pathognomonic of PVNS but etiology of the osteolytic lesion was confirmed only on histopathology. The large osteochondral defect was eventually managed in a staged manner with bone grafting and osteochondral autograft transfer.

Peptide Enriched Functional Food Adjunct from Soy Whey: A Statistical Optimization Study

Anshu Singh,Rintu Banerjee 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.suppl1

Soy whey is generated as a process waste while preparing soy based food products tofu, causing environmental pollution and also representing an economic penalty against the industrial process. Therefore, its valorization is of prime importance to the industry. The present investigation aims to convert this proteinaceous waste into bioactive peptide enriched hydrolysate. Soy whey protein was enzymatically treated with the Aspergillus awamori nakazawa protease. Respective protease was efficient to produce antioxidant peptide beholding radical scavenging ability of 40-50% at normal conditions. Remarkable increase in the radical scavenging activity upto 70% was noticed at the response surface methodology (RSM) based optimized condition: temperature 40oC, salt concentration (NaCl) 0.05 M, surfactant concentration (Triton-X 100) 0.0075%, hydrolysis time 80 min, and enzyme to substrate concentration 164 IU/g of soy whey protein. The present study emphasizes the biotransformation of proteineceous waste into antioxidant peptide rich soy whey protein hydrolysate to be considered as additives for food preparation and formulation.

Secure Multi-party Communication in Data-mining Applications

Anshu Chaturvedi,D.N. Goswami,Rishi Soni,Brijesh Kumar Chaurasia 보안공학연구지원센터 2015 International Journal of Database Theory and Appli Vol.8 No.4

Data mining extracts knowledge or patterns from a large amount of data. Secure communication is an issue of shared database applications. Fundamentally, secure multi party computation is to enable a number of networked parties to carry out distributed computing tasks on sensitive information. In this paper, we have proposed two techniques for multi party communication one is for third party assisted and another without third party. Third party assisted technique uses Group based approach and in case of without third party mechanism ECC based approach is used. Simulation results show that the time taken by the schemes are significantly less as compared to other schemes and this proves the efficacy of the proposed scheme which makes it viable for multi party communication in data mining applications.

ZBTB16-RARa variant of acute promyelocytic leukemia with tuberculosis: a case report and review of literature

Anshu Palta,Pratibha Dhiman,Sanjay D. Cruz 대한혈액학회 2012 Blood Research Vol.47 No.3

A 23- year-old male presented with pulmonary tuberculosis and swelling of both lower limbs. He was put on antitubercular treatment. Hemogram showed mild anemia and Pseudo Pelger-huet cells. The bone marrow (BM) examination showed 52% promyelocytes with regular round to oval nuclei, few granules and were positive for CD13 and CD33, and negative for HLA-DR. Cytogenetic analysis of the BM aspirate revealed an apparently balanced t(11;17)(q23;q21). Final diagnosis rendered was acute promyelocytic leukemia (APL) with t(11;17)(q23;q21); ZBTB16/RARA. APL is a distinct subtype of acute myeloid leukemia. The variant APL with t(11;17)(q23;q21) cases that are associated with the ZBTB16/RARA fusion gene have been reported as being resistant to all-trans-retinoic acid (ATRA). Therefore, differential diagnosis of variant APL with t(11;17)(q23;q12) from classical APL with t(15;17)(q22;q12); PML-RARA is very important. Here we have discussed the importance of distinct morphology of variant APL and also significance of rare presentation with tuberculosis.

Molecular Characterization of Nippostrongylus brasiliensis (Nematoda: Heligmosomatidae) from Mus musculus in India

Anshu Chaudhary,Urvashi Goswami,Hridaya Shanker Singh 대한기생충학열대의학회 2016 The Korean Journal of Parasitology Vol.54 No.6

A comparative study of methylergonovine and 15-methyl prostaglandin F2α in active management of third stage of labor

( Anshu Gupta ) 대한산부인과학회 2013 Obstetrics & Gynecology Science Vol.56 No.5

Objective Postpartum hemorrhage is most common cause of maternal mortality. Active management of third stage of labor minimizes the risk of postpartum hemorrhage. To compare the effect of methylergonovine and 15-methyl prostaglandin F2α (15-methyl PGF2α) in active management of third stage of labor. Methods A randomized open labelled parallel study with 50 women in normal labor, 25 in each group were included. The drugs methylergonovine (0.2 mg) intravenous and 15-methyl PGF2α (250 μg) intramuscular were administered at the time of delivery of anterior shoulder. Main outcomes measured were amount of blood loss during the first four hours of delivery and objective measurement of hemoglobin and hematocrit levels before delivery and third day postpartum. Results There was no statistically significant difference in the blood loss between the two groups at delivery (P = 0.130), at 1 hour of delivery (P = 0.453). The blood loss with 15-methyl PGF2α was significantly less as compared to that of blood loss with methylergonovine at four hours of delivery (P = 0.014) and the total, i.e., during first four hours, amount of blood loss was significantly less with 15-methyl PGF2α (P = 0.026). There was no statistically significant difference in the hemoglobin and hematocrit levels measured predelivery and postpartum third day between both the drugs. Conclusion Both the drugs were effective in controlling the amount of blood loss during the third stage of labor, 15-methyl PGF2α being more efficacious.

Superantigen SpeA attenuates the biofilm forming capacity of Streptococcus pyogenes

Anshu Babbar,Israel Barrantes,Dietmar H. Pieper,Andreas Itzek 한국미생물학회 2019 The journal of microbiology Vol.57 No.7

Beta haemolytic Group A streptococcus (GAS) or Streptococcus pyogenes are strict human pathogens responsible for mild to severe fatal invasive infections. Even with enormous number of reports exploring the role of S. pyogenes exotoxins in its pathogenesis, inadequate knowledge on the biofilm process and the potential role of exotoxins in bacterial dissemination from matured biofilms has been a hindrance in development of effective and targeted treatments. Therefore, the present study was aimed in investigating the uncharted role of these exotoxins in biofilm process. Through our study the putative role of ciaRH in the SpeA dependent ablation of biofilm formation could be speculated and thus helping in bacterial dissemination. The seed-dispersal effect of SpeA was time and concentration dependent and seen to be consistent within various streptococcal species. Transcriptome analysis of SpeA treated S. pyogenes biofilms revealed the involvement of many transcriptional regulators (ciaRH) and response genes (luxS, shr, shp, SPy_0572), hinting towards specific mechanisms underlying the dispersal effect by SpeA. This finding opens up a discussion towards understanding a new mechanism involved in the pathogenesis of Streptococcus pyogenes and might help in understanding the bacterial infections in a better way.

An Efficient Method for Protecting High Utility Itemsets in Utility Mining

Anshu Chaturvedi,D. N. Goswami,Rishi Soni 보안공학연구지원센터 2016 International Journal of Database Theory and Appli Vol.9 No.7

Privacy preserving data mining (PPDM) has become a popular research direction in data mining. Privacy preserving data mining is an approach to develop algorithms by which we can modify the utility values of original data using some techniques in order to protect sensitive information from unauthorized user. Protecting data against illegal access becomes a serious issue when this data is required to be shared onto the network due to some reasons. To hide the sensitive information, many approaches have been proposed. In this study, we are proposing an efficient method, for protecting high utility itemsets using distortion technique where the values for high utility items are altered to achieve the privacy. Algorithm is designed in such a way so as to handle privacy without disclosure of sensitive information. The algorithm can completely hide any given utility items by scanning data iteratively. The results when compared with existing one show significant reduction in execution time.

Influence of Age and Type 1 Diabetes Mellitus on Serological Test for Celiac Disease in Children

Maheshwari, Anshu,He, Zhaoping,Weidner, Melissa Nicole,Lin, Patrick,Bober, Ryan,Del Rosario, Fernando J. The Korean Society of Pediatric Gastroenterology 2021 Pediatric gastroenterology, hepatology & nutrition Vol.24 No.2

Purpose: Serological tests of tissue transglutaminase (TTG) and deamidated gliadin (DGP) antibodies for celiac disease diagnosis show conflicting correlation with histology in young children and in type 1 diabetes mellitus (T1DM). Tests' ability to predict histology and cutoff values based on age and T1DM was evaluated. Methods: A retrospective study of children who had celiac serological tests between 6/1/2002 and 12/31/2014 at a pediatric hospital. Results: TTG IgA displayed similar results in predicting histology between <4.0 and ≥4.0 years age groups with sensitivity 98% and 93%, and specificity 88% and 86%, respectively. In children <4.0 years old, sensitivity for DGP antibodies was 100% and specificity 94%; in ≥4.0 years age groups, sensitivity was 60%, 88% for DGP IgA and IgG and specificity 95%, 96%, respectively. TTG IgA had low specificity in patients with T1DM compared with non-T1DM, 42% vs. 91%. Positive TTG IgA with normal histology was associated with higher T1DM prevalence at 36% compared with negative tests at 4%. Finally, the TTG IgA cutoff value was higher in T1DM at 36 vs. 16.3 units in non-T1DM. DGP IgG cutoff showed similar values between age groups; TTG IgA and DGP IgA cutoffs were lower in <4.0 years at 8.3 and 11.9 units than ≥4.0 years at 23.4 and 19.9, respectively. Conclusion: TTG IgA is sufficient for the <4.0 years age group and DGP antibodies had no advantage over TTG IgA in older children. The cutoff value to determine a positive TTG IgA should be higher for children with T1DM.