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Anna Cho,Danbi Yoon,Jiyoung Park,Jeong Seok Cha,Jiho Yoo 한국구조생물학회 2023 Biodesign Vol.11 No.4
Over 300 polypeptide substrates can undergo catalysis by the constitutively active Ser/Thr kinase, human casein kinase 2 alpha (hCK2α). Quercetin, a naturally occurring polyphenolic compound, is well-known for inhibiting hCK2α, thereby regulating cellular signaling pathways. In this study, we crystallized the hCK2α-quercetin complex to elucidate the inhibitory mechanism of quercetin on hCK2α through the complex structure. The hanging drop vapor diffusion method was employed for crystallizing the hCK2α-quercetin complex, and the resulting crystal diffracted to a resolution of 2.11 Å. X-ray diffraction data analysis revealed that the crystal of the hCK2α-quercetin complex belonged to the P43212 space group, with unit cell dimensions of a = b = 127.604 Å, c = 124.314 Å, and α = β = γ = 90.00°. In an initial density map, quercetin was bound well into hCK2α.
Cho, Young-Chang,Lee, In-Seon,Seo, Huiyun,Ju, Anna,Youn, Deokkyu,Kim, Younghyun,Choun, Jaehee,Cho, Sayeon SPANDIDOS PUBLICATIONS 2014 MOLECULAR MEDICINE REPORTS Vol.10 No.5
<P>Numerous Euphorbiaceae plants have been used for the treatment of diseases, including liver diseases, asthma and rheumatism. The present study evaluated the effect of methanol extracts from Euphorbia cooperi (MEC), a member of the Euphorbiaceae plant family, on the production of inflammatory cytokines interleukin (IL)?6 and tumor necrosis factor (TNF)?α, nitric oxide (NO) as well as the activation of mitogen?activated protein kinase and nuclear factor (NF)?κB signaling. Non?cytotoxic concentrations of MEC significantly reduced the production of NO and IL?6, but not TNF?α, in lipopolysaccharide (LPS)?stimulated RAW 264.7 macrophages. The decreased production of NO by MEC was due to alleviated expression of inducible NO synthase. Reporter assays with cells treated with MEC demonstrated reduced activator protein?1 (AP-1) activity, while NF?κB activity was not reduced. Furthermore, the phosphorylation levels of c?Jun N?terminal kinase (JNK) and p38 were suppressed by MEC while phosphorylation levels of inhibitor of κB were not reduced by MEC, suggesting that MEC?mediated inactivation of JNK and p38 is the underlying regulatory mechanism for inflammatory mediators in LPS?stimulated RAW 264.7 macrophages.</P>
Cho, Anna,Kim, Su Jin,Lim, Byung Chan,Hwang, Hee,Park, June Dong,Kim, Gi Beom,Jin, Dong-Kyu,Lee, Jeehun,Ki, Chang Seok,Kim, Ki Joong,Hwang, Yong Seung,Chae, Jong-Hee SAGE Publications 2012 Journal of child neurology Vol.27 No.3
<P>Pompe disease is an autosomal recessive disorder caused by lysosomal acid α-glucosidase deficiency. Infantile-onset Pompe disease presents with cardiomyopathy and hypotonia, leading to premature death. This article describes 7 infantile Pompe disease cases and provides their molecular bases and clinical outcomes after enzyme replacement therapy for the first time in Korea. Molecular genetic analyses revealed the presence of 9 different mutations, including 5 novel mutations (c.2171C>A, c.2774C>T, c.1582_3de12, c.1261_1263Tms, and c.1322_1326+9de114). The most common mutation in these 7 patients was c.1316T>A (28%). Four patients received intravenous recombinant human acid α-glucosidase therapy for 2 years, on average, without significant side effects during the treatment course. They all exhibited increased muscle power, with considerable improvement in cardiac function. Pompe disease is heterogeneous regarding both clinical features and molecular characteristics. Early identification of Pompe disease is very important, considering that enzyme replacement therapy is a safe and effective treatment for early-onset patients.</P>
Anna Cho,Soo Yeon Kim,Jin Sook Lee,Byung Chan Lim,Hunmin Kim,Hee Hwang,Jong-Hee Chae 대한의학유전학회 2020 대한의학유전학회지 Vol.17 No.2
Purpose: Congenital myasthenic syndrome (CMS) is a clinically and genetically heterogeneous group of disorders characterized by impaired neuromuscular transmission. This study aims to provide the clue for early diagnosis and improved therapeutic strategies in CMS. Materials and Methods: Through the targeted panel sequencing including twenty CMS causative genes, eleven patients were genetically confirmed and enrolled in this study. A retrospective medical record review was carried out for the clinical and laboratory data analysis. Results: The age of patients ranged from 5 to 23 years, with the median age of 16 years. The peak age at onset of symptoms was the neonatal period. Seven out of the eleven patients were symptomatic at birth. The most commonly reported initial finding was generalized hypotonia with poor sucking and crying. Mean time to accurate diagnosis was 9.3±5.0 years. Total fifteen different variants in seven genes associated with CMS (DOK7, AGRN, RAPSN, CHRNE, COLQ, SLC5A7, and GFPT1) were identified. Conclusion: We describe the clinical and genetic characteristics of CMS patients and treatment outcome in a single tertiary center. High clinical suspicion and timely molecular diagnosis is particularly important for the tailored therapy to maximize clinical improvement in CMS.
학교현장실습을 통한 예비유아교사의 변화 분석: 인식, 교사역량, 교수효능감을 중심으로
조안나(Cho Anna) 학습자중심교과교육학회 2019 학습자중심교과교육연구 Vol.19 No.5
본 연구는 예비유아교사의 학교현장실습 수업을 통해 교육실습 관련 인식, 교사역 량, 교수효능감의 변화를 살펴보고, 그 효과성을 탐색해보는 데 있다. 이를 위해 경기도 소재 4년제 대학교의 교원양성기관에서 유아교육을 전공 중이거나 유아교육 복수 교직과정을 이수중인 4학년 학생 45명을 연구대상으로 하였으며, 2018년 3월부터 6월까지 ‘학교현장실습’ 수업에서 교육실습 관련 이미지 맵을 수집하였고, 교사역 량과 교수효능감 검사 도구를 사용하였다. 수집된 자료는 범주화 과정을 통한 질적 분석과 SPSS 23.0 프로그램을 이용한 대응표본 t-검증을 실시하였다. 연구결과 첫째, 학교현장실습 수업 이후 예비유아교사는 교육실습을 배움과 성장, 대인관계역량의 증진, 진로결정 및 갈등의 시간으로 인식하는 것으로 나타났다. 둘째, 학교현장실습 수업 전후 교사역량의 변화를 살펴본 결과, 교사역량 전체에서는 통계적으로 유의미한 차이가 나타나지 않았으며, 하위요소인 대인관계 및 의사소통 역량에서 유의 미한 차이가 나타났다. 셋째, 학교현장실습 수업 전후로 교수효능감에는 유의미한 차이가 나타나지 않았다. 본 연구의 결과들을 토대로 예비유아교사를 위한 교육실습및 총체적인 학교현장실습 교과의 효율적 운영 방안에 대한 시사점을 논의하였다. This study aimed to investigate the effect of pre-service early childhood teachers perception on teaching practice, teacher competence, and teaching efficacy through practice in school fields. For this purpose, 45 students in 4th grade who have undergone early childhood education or undergraduate curriculum for early childhood education were selected as research subjects at the 4-year university in Gyeonggi- do, and from March to June, 2018, image maps related to teaching practice were collected in the class, and teacher competence and teaching efficacy test tool were used. The collected data were subjected to qualitative analysis through categorization process and the corresponding sample t-test using SPSS 23.0 program. The results of this study were as follows: First, pre-service early childhood teachers perceived teaching practice as learning and growth, interpersonal competence enhancement, and career decision and conflict time. Second, as a result of examining the change of teacher competence before and after the school field practice, there was no statistically significant difference in teacher competence as a whole, and there was a significant difference in interpersonal relationship and communication ability. Third, there was no significant difference in teaching efficacy before and after the school field practice. Based on the results of this study, implications on teaching practice for pre-service early childhood teachers and the effective management of school curriculum were discussed.
언어행위이론의 관점에서 본 하나님 나라의 윤리적 수행을 위한 기독교 생활에서의 도덕적 행위자로서의 성령
조안나 ( Cho Anna ) 한국조직신학회 2018 한국조직신학논총 Vol.51 No.-
이 논문은 언어행위이론을 통하여 성서적 윤리의 해석학적 접근을 소개함으로써 말씀이신 성령 하나님이 어떻게 신자들 안에서 도덕적인 행위자로서 역사하는지, 성령의 사역을 통해 어떻게 그리스도인이 하나님의 말씀에 반응하는지를 보여준다. 이 접근법은 언어행위이론의 관점에서 하나님 나라가 하나님의 자발적 참여 행위와 관련이 있다는 이해에서 출발하여 기독교윤리에서 그리스도인의 삶의 성령의 역사가 하나님의 수행 행위에 대한 신학적 이해와 신자들에게 미치는 영향을 어떻게 설명할 수 있는지에 대해 논의한다. 언어행위이론의 초점은 하나님 나라와 하나님의 백성에 대한 하나님의 통치와 관련하여 “협력적 사회참여”(CSP)의 원칙과 일상생활에서의 윤리적인(신앙적인) 반응으로서의 그리스도인들을 책임을 고려한다. This article presents how the Holy Spirit, the Word of God works in the believers as a moral agent not simply as a helper, and believer’s response to the Word of God through the work of the Holy Spirit in our lives as Christian moral conduct. This approach emerges from an understanding of God’s selfinvolving activity as the presence of the kingdom of God in the present world in the light of speech act theory (abbreviated as SAT). This paper discusses how the work of the Holy Spirit in Christian ethics can enhance theological understanding of God’s performative action and its effects on the believers. The focus in SAT considers the principle of “Co-Operative Social Participation”(CSP) in relation to God’s sovereignty for God’s kingdom and God’s people, and the responsibility of Christians as ethical response in ordinary life.