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The Human Skeletal Muscle Transcriptome in Response to Oral Shilajit Supplementation
Amitava Das,Soma Datta,Brian Rhea,Mithun Sinha,Muruganandam Veeraragavan,Gayle Gordillo,Sashwati Roy 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.7
The objective of the present study (clinicaltrials.gov NCT02026414) was to observe the effects of oral supplementation of a purified and standardized Shilajit extract on skeletal muscle adaptation in adult overweight/class I obese human subjects from the U.S. population. Shilajit is a mineral pitch that oozes out of Himalayan rocks. The study design consisted of a baseline visit, followed by 8 weeks of 250 mg of oral Shilajit supplementation b.i.d., and additional 4 weeks of supplementation with exercise. At each visit, blood samples and muscle biopsies were collected for further analysis. Supplementation was well tolerated without any changes in blood glucose levels and lipid profile after 8 weeks of oral supplementation and the additional 4 weeks of oral supplementation with exercise. In addition, no changes were noted in creatine kinase and serum myoglobin levels after 8 weeks of oral supplementation and the additional 4 weeks of supplementation with exercise. The microarray analysis identified a cluster of 17 extracellular matrix (ECM)-related probe sets that were significantly upregulated in muscles following 8 weeks of oral supplementation compared with the expression at the baseline visit. This cluster included tenascin XB, decorin, myoferlin, collagen, elastin, fibrillin 1, and fibronectin 1. The differential expression of these genes was confirmed using quantitative RT-PCR. The study provided maiden evidence that oral Shilajit supplementation in adult overweight/class I obese human subjects promoted skeletal muscle adaptation through upregulation of ECM-related genes that control muscle mechanotransduction properties, elasticity, repair, and regeneration.
Purification and Characterization of Repressor of Temperate S. aureus Phage Φ11
Das, Malabika,Ganguly, Tridib,Chattoraj, Partho,Chanda, Palas Kumar,Bandhu, Amitava,Lee, Chia Yen,Sau, Subrata Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.5
To gain insight into the structure and function of repressor proteins of bacteriophages of gram-positive bacteria, repressor of temperate Staphylococcus aureus phage ${\phi}11$ was undertaken as a model system here and purified as an N-terminal histidine-tagged variant (His-CI) by affinity chromatography. A ~19 kDa protein copurified with intact His-CI (~ 30 kDa) at low level was resulted most possibly due to partial cleavage at its Ala-Gly site. At ~10 nM and higher concentrations, His-CI forms significant amount of dimers in solution. There are two repressor binding sites in ${\phi}11$ cI-cro intergenic region and binding to two sites occurs possibly by a cooperative manner. Two sites dissected by HincII digestion were designated operators $O_L$ and $O_R$, respectively. Equilibrium binding studies indicate that His-CI binds to $O_R$ with a little more strongly than $O_L$ and binding species is probably dimeric in nature. Interestingly His-CI binding affinity reduces drastically at elevated temperatures ($32-42^{\circ}C$). Both $O_L$ and $O_R$ harbor a nearly identical inverted repeat and studies show that ${\phi}11$ repressor binds to each repeat efficiently. Additional analyses indicate that ${\phi}11$ repressor, like $\lambda$ repressor, harbors an N-terminal domain and a C-terminal domain which are separated by a hinge region. Secondary structure of ${\phi}11$ CI even nearly resembles to that of $\lambda$ phage repressor though they differ at sequence level. The putative N-terminal HTH (helix-turn-helix) motif of ${\phi}11$ repressor belongs to the HTH -XRE-family of proteins and shows significant identity to the HTH motifs of some proteins of evolutionary distant organisms but not to HTH motifs of most S. aureus phage repressors.
Gas Metal Arc Lap Joining of Aluminium Alloys and Steel Sheets
Atanu Das,Amitava De 대한용접·접합학회 2018 대한용접·접합학회지 Vol.36 No.5
A coupled experimental and theoretical investigation on joining of aluminium and galvanized sheets in lap joint geometry using an advanced pulsed current gas metal arc based process is presented. The experimental study was focussed on finding suitable processing conditions to restrict the heat input, and minimize the growth of the phase layer thickness and the formation of Fe-Al intermetallic compounds along the joint interface. The theoretical study included the development of a three-dimensional heat conduction model to compute the temperature field and thermal cycles, and estimate the final joint bead profiles and phase layer thickness as a function of processing conditions. The estimated results are tested extensively for a wide range of experimental conditions. The experimentally measured and the corresponding computed results show that the dissimilar material combinations of aluminium and galvanized steel can be joined successfully by pulsed current gas metal arc with a precise control of processing conditions and heat input.
Savita Khanna,Amitava Das,James Spieldenner,Cameron Rink,Sashwati Roy 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.4
The objective of this study (clinicaltrials.gov NCT01858376) was to determine the effect of oral supplementation of a standardized extract of Phyllanthus emblica (CAPROS®) on cardiovascular disease (CVD) risk factors in overweight adult human subjects from the US population. Overweight/Class-1 obese (body–mass index: 25–35) adult subjects received 500 mg of CAPROS supplement b.i.d for 12 weeks. The study design included two baseline visits followed by 12 weeks of supplementation and then 2 weeks of washout. At all visits, peripheral venous blood was collected in sodium citrate tubes. Lipid profile measurements demonstrated a significant decrease in calculated low-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein following 12 weeks of CAPROS supplementation when compared to averaged baseline visits. Circulatory high-sensitivity C reactive protein (hs-CRP) levels were significantly decreased after 12 weeks of supplementation. In addition, both ADP- and collagen-induced platelet aggregation was significantly downregulated following 12 weeks of supplementation. Overall, the study suggests that oral CAPROS supplementation may provide beneficial effects in overweight/Class-1 obese adults by lowering multiple global CVD risk factors.
A Survey on Automatic Twitter Event Summarization
Rudrapal, Dwijen,Das, Amitava,Bhattacharya, Baby Korea Information Processing Society 2018 Journal of information processing systems Vol.14 No.1
Twitter is one of the most popular social platforms for online users to share trendy information and views on any event. Twitter reports an event faster than any other medium and contains enormous information and views regarding an event. Consequently, Twitter topic summarization is one of the most convenient ways to get instant gist of any event. However, the information shared on Twitter is often full of nonstandard abbreviations, acronyms, out of vocabulary (OOV) words and with grammatical mistakes which create challenges to find reliable and useful information related to any event. Undoubtedly, Twitter event summarization is a challenging task where traditional text summarization methods do not work well. In last decade, various research works introduced different approaches for automatic Twitter topic summarization. The main aim of this survey work is to make a broad overview of promising summarization approaches on a Twitter topic. We also focus on automatic evaluation of summarization techniques by surveying recent evaluation methodologies. At the end of the survey, we emphasize on both current and future research challenges in this domain through a level of depth analysis of the most recent summarization approaches.
A Survey on Automatic Twitter Event Summarization
( Dwijen Rudrapal ),( Amitava Das ),( Baby Bhattacharya ) 한국정보처리학회 2018 Journal of information processing systems Vol.14 No.1
Twitter is one of the most popular social platforms for online users to share trendy information and views on any event. Twitter reports an event faster than any other medium and contains enormous information and views regarding an event. Consequently, Twitter topic summarization is one of the most convenient ways to get instant gist of any event. However, the information shared on Twitter is often full of nonstandard abbreviations, acronyms, out of vocabulary (OOV) words and with grammatical mistakes which create challenges to find reliable and useful information related to any event. Undoubtedly, Twitter event summarization is a challenging task where traditional text summarization methods do not work well. In last decade, various research works introduced different approaches for automatic Twitter topic summarization. The main aim of this survey work is to make a broad overview of promising summarization approaches on a Twitter topic. We also focus on automatic evaluation of summarization techniques by surveying recent evaluation methodologies. At the end of the survey, we emphasize on both current and future research challenges in this domain through a level of depth analysis of the most recent summarization approaches.
A fluorescent probe for bisulfite ions: its application to two-photon tissue imaging
Agarwalla, Hridesh,Pal, Suman,Paul, Anirban,Jun, Yong Woong,Bae, Juryang,Ahn, Kyo Han,Srivastava, Divesh N.,Das, Amitava The Royal Society of Chemistry 2016 Journal of Materials Chemistry B Vol.4 No.48
<P>A benzoxazinone based fluorescent probe for the specific and efficient detection of bisulfite ions in aqueous medium is described. The probe formed a bisulfite/sulphite adduct with an associated turn-on fluorescence response in the red wavelength region. No interference was observed in the detection process from all possible competing anions and molecules, including cyanide ion, cysteine, homocysteine and glutathione. In addition, the probe showed a fast response time, low detection limit, and cell membrane permeability. Furthermore, the probe was two-photon excitable, enabling imaging of endogenous bisulfite ions in HeLa cells as well as in deep tissues from different organs of mouse.</P>