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신장이식환자를 위한 약물교육프로그램이 약물에 대한 지식과 약물복용 이행도에 미치는 효과
장정주(Jang, Jeong Ju),전정애(Jeun, Jeong Ah),박정숙(Park, Jeong Sook),성은혜(Sung, Eun Hae),김혜림(Kim, Hye Rim),조아람(Jo, A Ram) 계명대학교 간호과학연구소 2017 계명간호과학 Vol.21 No.1
Purpose: The purpose of this study was to analyze the effects of the drug educational program on knowledge and medication compliance for kidney transplantation patients. Methods: Kidney transplantation patients were recruited from a transplantation center, at a university hospital located in D city, Korea. Data were collected from June 18m 2016 to september 30, 2016. The research design was a nonequivalent one group pre-posttest. Nineteen subjects participated twice in a drug educational program given by the researcher. Results: After the intervention, the participants showed a significant increase in medication knowledge (t=-7.074, p<.001) and medication compliance (t=-4.553, p<.001) than before the intervention. Conclusion: The research findings suggest that a drug education program can be used as an effective nursing intervention for kidney transplantation patients.
Anti-inflammatory Effect of Columbianetin on Activated Human Mast Cells
Jeong, Hyun-Ja,Na, Ho-Jeong,Kim, Su-Jin,Rim, Hong-Kun,Myung, Noh-Yil,Moon, Phil-Dong,Han, Na-Ra,Seo, Jae-Uk,Kang, Tae-Hee,Kim, Jae-Joong,Choi, Youngjin,Kang, In-Cheol,Hong, Seung-Heon,Kim, You-Ah,Seo, Pharmaceutical Society of Japan 2009 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.32 No.6
<P>In the present study, we extracted <I>Corydalis heterocarpa</I> with various solvents in order to find the bioactive constituents that demonstrated anti-inflammatory effects. We isolated the active compound, Columbianetin. Anti-inflammatory effect of Columbianetin has been reported but the precise effects of Columbianetin in experimental models have remained unknown. In the present study, we investigate the effect of Columbianetin on the production of histamine, interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α and expression of cyclooxygenase-2 (COX-2) by using the human mast cell line (HMC-1). Various concentrations of Columbianetin were treated before the activation of HMC-1 cells with phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore, A23187. PMA plus A23187 significantly increased IL-1β, IL-6, IL-8, and TNF-α production compared with media control (<I>p</I><0.05). We also show that the increased cytokines IL-1β, IL-6, IL-8, and TNF-α level was significantly inhibited by Columbianetin in a dose-dependent manner (<I>p</I><0.05). Maximal inhibition rates of IL-1β, IL-6, IL-8, and TNF-α production by Columbianetin were about 102.6%, 101.1%, 95.8%, and 103.9%, respectively. Columbianetin inhibited expression of COX-2. In addition, the effect of Columbianetin was investigated on the histamine release from HMC-1 stimulated by substance P, which promotes histamine release. Columbianetin also inhibited the histamine release by substance P. In conclusion, these results indicate that Columbianetin may be helpful in regulating mast cell-mediated allergic inflammatory responses.</P>
Jeong-Ju Yoo,Soo Young Park,Ji Eun Moon,Yu Rim Lee,Han Ah Lee,Jieun Lee,Young Seok Kim,Yeon Seok Seo,Sang Gyune Kim 대한간학회 2023 Clinical and Molecular Hepatology(대한간학회지) Vol.29 No.2
Background/Aims: The histologic status of the immune-tolerant (IT) phase of chronic hepatitis B relative to long-term outcomes is unclear. This study aimed to discover how the serological criteria currently in use correspond to histologic criteria in determining the IT phase and indication for liver biopsy. Methods: Patients in the serological IT phase determined by positive hepatitis B e antigen, hepatitis B virus (HBV) DNA ≥106 IU/mL, and normal or minimally elevated alanine aminotransferase (ALT) ≤60 IU/L, who underwent liver biopsy at three different hospitals were included. The distribution of the histologic IT phase, defined as fibrosis of stage 1 or less and inflammation of grade 1 or less, was compared with that of the serological IT phase. The risk factors for the incidence of liver-related events, such as hepatocellular carcinoma, liver cirrhosis, liver transplantation, and death, were also analyzed. Results: Eighty-two (31.7%) out of 259 clinically suspected IT phase patients belonged to the histologic IT phase. Age over 35, high AST, and low albumin were useful for ruling out the histologic IT phase. Risk factors predicting liver-related events were age and significant fibrosis stage. There was no significant difference in the proportion of histologic IT phase and clinical prognosis between normal ALT and mildly elevated ALT groups. However, even in patients with normal ALT, age was an important factor in predicting the presence of the histologic IT phase. Conclusions: A significant number of patients who belonged to the serological IT phase were not in the histologic IT phase. Patients over 35 years and those with high AST, low albumin, and low HBV DNA levels were more likely to experience poor long-term clinical outcomes. Therefore, additional histologic assessment should be considered.
한정아(Jeong-ah Han),주보림(Bo-rim Joo) 한국정보통신학회 2023 한국정보통신학회논문지 Vol.27 No.7
본 연구는 가상 패션에 등장하는 아바타를 중심으로 아바타의 발전단계와 특징 그리고 패션 커뮤니케이션을 주도하는 아바타의 역할 및 패션 아바타의 지속적인 진화 현상에 대해 살펴보고자 하였다. 아바타는 인터넷상의 사용자를 대신하는 형상, 가상공간을 이어주는 주체, 디지털 안의 또 다른 자아를 가진 나(digital-me), 사이버 가상공간의 커뮤니케이션을 이어주는 역할을 성실히 수행하는 다각화된 대리자의 형태로 변화되어 가고 있다. 아바타는 사용자의 선택으로 시각적인 개성을 추구하거나, NFT의 알고리즘에 의해 생성되기도 한다. 패션산업의 영역에서 현실의 나를 대신하는 것만이 아니라 사회적으로 창조된 역할의 가상 모델, 가상 인플루언서 등으로 나타나면서 아바타 개념이 확장되고 있다. 아바타의 발전 방향을 제시해 보자면, 첫째, 기술의 발전과 함께 무한 성장 가능성이 있으며 둘째, 차별적 정체성을 추구하는 소비자의 욕구가 증가함에 따라 다양한 형태가 발전할 것이고. 셋째, 다양한 주체적, 객체적 역할이 요구될 것이다. Focusing on avatars appearing in virtual fashion, this study attempts to examine the development stages and characteristics of avatars, the roles of avatars leading fashion communication, and the constant evolution of fashion avatars. As the forms that replace users on the internet, subjects that connect users to virtual space, and digital-me, avatars are changing into the forms of diversified agents that play faithful roles in linking the communication in cyber space. Avatars may pursue visual personality at the user’s choice or be generated by NFT algorithms. In the field of fashion industry, the concept of avatars is extending as they not only replace ‘me’ in reality but also appear as a virtual model or virtual influencer with socially created roles. Concerning the directions of developing avatars further, first, there is a possibility of their infinite growth along with the development of technology, and second, various forms will develop as consumer needs for differentiated identity increase, and third, various subjective and objective roles will be required.