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Upregulation and secretion of kallikrein-related peptidase 6 (KLK6) in gastric cancer.
Kim, Jin Ju,Kim, Jong-Tae,Yoon, Hyo Ran,Kang, Min Ah,Kim, Joo Heon,Lee, Young-Ha,Kim, Jae Wha,Lee, Seon-Jin,Song, Eun Young,Myung, Pyung Keun,Lee, Hee Gu Saikon Pub. Co 2012 Tumour biology Vol.33 No.3
<P>KLK6 encoding kallikrein-related peptidase 6, a trypsin-like serine protease, has been shown to be upregulated in several cancers, although the tumorigenic role of KLK6 has not been elucidated. In this study, KLK6 was identified as a highly upregulated gene in gastric cancer; therefore, the possibility that KLK6 might be a suitable candidate tumor marker was examined. RT-PCR and immunohistochemical analysis showed overexpression of KLK6 in gastric cancer tissues compared to nontumor regions. Sera from gastric cancer patients had a 1.7-fold increase in KLK6 (373.1 μg/L, P = 0.048) compared to healthy individuals (214.2 μg/L), although there was no significant difference among patients with various tumor stages. Cellular invasiveness decreased by 45% in cells transfected with KLK6-specific small interfering RNA. Exogenous overexpression of KLK6 led to decreased activity of the E-cadherin promoter. This study shows that KLK6 is significantly upregulated and secreted in gastric cancer tissues and sera, suggesting that KLK6 might be used as a potential biomarker and therapeutic target for gastric cancer.</P>
Kim Ju-Ran,Lee Jin-Ha,Jalin Anjela Melinda,Lee Chae-Yeon,Kang Ah-Reum,Do Byung-Rok,Kim Hea-Kwon,Kam Kyung-Yoon,Kang Sung-Goo 한국발생생물학회 2009 발생과 생식 Vol.13 No.3
One of the most extensively studied populations of multipotent adult stem cells are mesenchymal stem cells (MSCs). MSCs derived from the human umbilical cord vein (HUC-MSCs) are morphologically and immunophenotypically similar to MSCs isolated from bone marrow. HUC-MSCs are multipotent stem cells, differ from hematopoietic stem cells and can be differentiated into neural cells. Since neural tissue has limited intrinsic capacity of repair after injury, the identification of alternate sources of neural stem cells has broad clinical potential. We isolated mesenchymal-like stem cells from the human umbilical cord vein, and studied transdifferentiation-promoting conditions in neural cells. Dopaminergic neuronal differentiation of HUC-MSCs was also studied. Neural differentiation was induced by adding bFGF, EGF, dimethyl sulfoxide (DMSO) and butylated hydroxyanisole (BHA) in N2 medium and N2 supplement. The immunoreactive cells for -tubulin III, a neuron-specific marker, GFAP, an astrocyte marker, or Gal-C, an oligodendrocyte marker, were found. HUC-MSCs treated with bFGF, SHH and FGF8 were differentiated into dopaminergic neurons that were immunopositive for tyrosine hydroxylase (TH) antibody. HUC-MSCs treated with DMSO and BHA rapidly showed the morphology of multipolar neurons. Both immunocytochemistry and RT-PCR analysis indicated that the expression of a number of neural markers including NeuroD1, -tubulin III, GFAP and nestin was markedly elevated during this acute differentiation. While the stem cell markers such as SCF, C-kit, and Stat-3 were not expressed after neural differentiation, we confirmed the differentiation of dopaminergic neurons by TH/-tubulin III positive cells. In conclusion, HUC-MSCs can be differentiated into dopaminergic neurons and these findings suggest that HUC-MSCs are alternative cell source of therapeutic treatment for neurodegenerative diseases.
Endovascular Treatment for Lower Extremity Deep Vein Thrombosis: An Overview
Kim Kyung Ah,Choi Sun Young,Kim Ran 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.6
Lower extremity deep vein thrombosis (DVT) is a serious medical condition that can result in local pain and gait disturbance. DVT progression can also lead to death or major disability as a result of pulmonary embolism, postthrombotic syndrome, or limb amputation. However, early thrombus removal can rapidly relieve symptoms and prevent disease progression. Various endovascular procedures have been developed in the recent years to treat DVT, and endovascular treatment has been established as one of the major therapeutic methods to treat lower extremity DVT. However, the treatment of lower extremity DVT varies according to the disease duration, location of affected vessels, and the presence of symptoms. This article reviews and discusses effective endovascular treatment methods for lower extremity DVT.
( Ah Ran Kim ),( Kwang Ha Yoo ),( Kye Young Lee ),( Sun Jong Kim ),( Hee Joung Kim ),( Jun Hyun Kim ),( Yong A Rhyu ) 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
Cryptogenic organizing pneumonia (COP) is an inflammatory lung disease involving the distal bronchioles, respiratory bronchioles, bronchiolar ducts, and alveolae. The etiology is usually unknown; however, there are several known causes and associated systemic diseases. Corticosteroid therapy is the best treatment option and the prognosis of COP is good, with recovery in up to 80% of patients. We described a patient with in-operable hepatocellular carcinoma (HCC) undergoing chemoembolization with doxorubicin in a drug-eluting bead (DEB). COP developed in the patient after chemoembolization but resolved spontaneously in several months.
( Ah Ran Kim ),( Won Hyeok Choe ),( Jeong Han Kim ),( Byung Chul Yoo ),( Sang Woo Park ),( Young Jun Kim ),( Hee Sun Park ),( So Young Kwon ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Background/Aims: Surgical resection or ablation is recommended for treatment of early HCC. However, transcatheter arterial chemoembolization( TACE) is frequently used for this group due to various reasons. We evaluated the clinical effect and safety of radiofrequency ablation( RFA) shortly after TACE in patients who failed to achieve complete response to TACE. Methods: A total of 67 cases of BCLC stage A HCC patients who failed to achieve complete response to TACE as a first treatment and followed by RFA are included from 2005 to 2013 at the Konkuk University Hospital. The evaluation indices included treatment response, overall survival rate, recurrence-free survival and the procedure- related complications. Results: Median follow up was 36.6 months. The Child-pugh classification was A in 54 (80.6%), and B in 13 (19.4%) patients. The modified UICC stage was I in 10 (14.9%) patients, II in 46 (68.7%) patients, and III in 11 (16.4%) patients. The cumulative recurrence-free survival rates were 86.8%, 55.9% and 29.7% at 1, 3 and 5 years, respectively. The overall survival rates were 100%, 93.4% and 83.5% at 1, 3 and 5 years, respectively. Complications were observed in one patients, right inguinal hematoma. There was no treatment-related mortality. Conclusions: RFA is an efficient and safe treatment for patients with early stage HCC patients who failed to achieve complete response to TACE. Combined TACE plus RFA could be considered as a curative option for patients ineligible for surgery or immediate RFA.
Direct potentiation of NK cell cytotoxicity by 8-azaguanine with potential antineoplastic activity
Kim, Nayoung,Choi, Ji-Wan,Song, Ah Young,Choi, Woo Seon,Park, Hye-Ran,Park, Sojung,Kim, Inki,Kim, Hun Sik Elsevier 2019 INTERNATIONAL IMMUNOPHARMACOLOGY Vol.67 No.-
<P><B>Abstract</B></P> <P>This study identified 8-azaguanine (8-AG) as a novel immunomodulatory drug (IMiD) through a high-throughput screen of the Preswick Chemical Library in a model of human NK cell cytotoxicity against blood cancer cells. 8-AG, originally developed as an antineoplastic agent, significantly increased the cytotoxicity of NK cells and was superior in this activity to previously known IMiDs, such as fluoxetine and amphotericin B, identified from the same library. IFN-γ expression was also slightly increased by 8-AG. Mechanistically, 8-AG increased conjugate formation between NK and target cells and subsequent cytolytic granule polarization, but not calcium mobilization, regulation of activating receptors, or expression of perforin or granzyme B. Thus, the antineoplastic activity of 8-AG should be re-evaluated in light of this novel potentiating effect on NK cells.</P> <P><B>Highlights</B></P> <P> <UL> <LI> 8-azaguanine (8-AG) was originally developed as an antineoplastic agent. </LI> <LI> 8-AG was identified by high-throughput screen to increase the cytotoxicity of NK cells. </LI> <LI> 8-AG increased the formation of NK-target conjugates and cytolytic granule polarization. </LI> <LI> 8-AG serves a dual function as antineoplastic and immunomodulatory drug. </LI> </UL> </P>
Sensory Based Feeding Intervention for Toddlers With Food Refusal: A Randomized Controlled Trial
Ah-Ran Kim,Jeong-Yi Kwon,Sook-Hee Yi,Eun-Hye Kim 대한재활의학회 2021 Annals of Rehabilitation Medicine Vol.45 No.5
Objective To investigate the effect of sensory-based feeding treatment for toddlers with food refusal compared with only providing nutrition education. Methods Thirty-two toddlers with food refusal were randomly assigned to an intervention group or the control group. Toddlers in the intervention group received the sensory-based feeding intervention and the duration was for 1 hour for 5 days per week for 4 weeks, and then 1 hour, once a week for 8 weeks. Subjects in both the intervention and control groups received nutritional education once every 4 weeks for 12 weeks. The participants were evaluated at their entry into the study and 12 weeks later based on height, weight, behavior at mealtime using the Behavioral Pediatrics Feeding Assessment Scale (BPFAS), and sensory processing ability using the Infant/Toddler Sensory Profile. Results Sixteen toddlers were included in each group. Two subjects in the intervention group and four toddlers in the control group were excluded from the final analysis. Significant improvements in child or parent subscales of the BPFAS were observed in the intervention group. In contrast, there were no significant improvements in any BPFAS scores in the control group. Conclusion Sensory-based feeding intervention was effective for improving mealtime behavior in toddlers with food refusal. Therefore, a sensory-based feeding intervention could be considered as an intervention approach to address feeding disorders in toddlers.