Evaluation of Insulin Like Growth Facror-1 Genetic Polymorphism with Gastric Cancer Susceptibility and Clinicopathological Features

Farahani, Roya Kishani,Azimzadeh, Pedram,Rostami, Elham,Malekpour, Habib,Aghdae, Hamid Asadzadeh,Pourhoseingholi, Mohamad Amin,Mojarad, Ehsan Nazemalhosseini,Zali, Mohammad Reza Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.10

Gastric cancer (GC) is one of the most common malignancies in the world. It is the first cause of cancer deaths in both sexes In Iranian population. Circulating insulin-like growth factor-one (IGF-1) levels have been associated for gastric cancer. IGF-1 protein has central roles involved in the regulation of epithelial cell growth, proliferation, transformation, apoptosis and metastasis. Single nucleotide polymorphism in IGF-1 regulatory elements may lead to alter in IGF-1expression level and GC susceptibility. The aim of this study was to investigate the influence of IGF-1 gene polymorphism (rs5742612) on risk of GC and clinicopathological features for the first time in Iranian population. In total, 241 subjects including 100 patients with GC and 141 healthy controls were recruited in our study. Genotypes were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay with DNA from peripheral blood. The polymorphism was statistically analyzed to investigate the relationship with the risk of GC and clinicopathological properties. Logistic regression analysis revealed that there was no significant association between rs5742612 and the risk of GC. In addition, no significant association between genotypes and clinicopathological features was observed (p value>0.05). The frequencies of the CC, CT, and TT genotypes were 97%, 3%, and 0%, respectively, among the cases, and 97.9%, 2.1%, and 0%, respectively, among the controls. CC genotype was more frequent in cases and controls. The frequencies of C and T alleles were 98.9% and 1.1% in controls and 98.5% and 1.5% in patient respectively. Our results provide the first evidence that this variant is rare in Iranian population and it may not be a powerful genetic predisposing biomarker for prediction GC clinicopathological features in an Iranian population.

Effect of process conditions on product yield and composition of fast pyrolysis of Eucalyptus grandis in fluidized bed reactor

Aghdas Heidari,Ralph Stahl,Habibollah Younesi,Alimorad Rashidi,Nicole Troeger,Ali Asghar Ghoreyshi 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4

The fast pyrolysis of eucalyptus wood was conducted in a continuous-feed fluidized bed reactor. The effect of pyrolysis temperature, nitrogen flow rate, biomass feed rate and biomass feed size was investigated. The results showed that with increasing nitrogen flow rate, the bio-oil yield firstly increased from 51.9% to 61.1% and then decreased to 59.9%. The maximum percentage of syringol and guaiacol were 16.27 and 8.98 at temperature of 450 and 600 ℃, respectively. The maximum bio-oil yield was 71.1%. The maximum percentage of CO was 44.1 at a flow rate 11.1 L/min, feed size 1.5 and feeding rate 1.7 g/min.

An efficient approach for optimum shape design of steel shear panel dampers under cyclic loading

Mohsen Khatibinia,Aghdas Ahrari,Sadjad Gharehbaghi,Seyyed Reza Sarafrazi 국제구조공학회 2021 Smart Structures and Systems, An International Jou Vol.27 No.3

The low-cycle fatigue performance of shear panel damper (SPD) highly depends on the geometry of its shape and the criterion considered for its design. The main contribution of the current study is to find the optimum shape of the SPD subjected to cyclic loading by considering two different objective functions. The maximum equivalent plastic strain and the ratio of energy dissipation through plastic deformation to the maximum equivalent plastic strain are selected as the first and second objective functions, respectively. Since the optimization procedure requires high computational efforts, a hybrid computational approach is used to perform two paramount phases of estimating the inelastic responses of the SPD and solving the optimization problem. In the first phase, as an alternative for the time-consuming finite element analysis of the SPD, a weighted-support vector machine model is developed to predict the inelastic responses of the SPDs during the optimization process. In the second phase, the optimum shape of the SPD is found by using the whale optimization algorithm (WOA). The results indicate that both design criteria lead to the optimum-shaped SPDs with a significant improvement in their low cycle fatigue performance in comparing with the initial rectangular shape while a slight reduction in their energy dissipation capacity. Moreover, the second design criterion is slightly better in the performance improvement of the optimum-shaped SPDs compared with the first one. In addition, the weighted-based SVM approach can accurately predict the inelastic responses of the SPDs under cyclic loading, and its combination with WOA results in finding the optimum solutions quickly.

THE LONG - RUN EFFECTS OF DEPRECIATION OF THE DOLLAR ON SECTORAL OUTPUT

Oskooee, Mohsen Bahmani,Mirzaie, Aghdas 한국국제경제학회 2000 International Economic Journal Vol.14 No.3

Consumption, Credit, and Macroeconomic Policies: Theory and Evidence from the United States

MAGDA KANDIL,IDA AGHDAS MIRZAIE 연세대학교 동서문제연구원 2011 Global economic review Vol.40 No.3

The paper examines determinants of private consumption in the USA. The empirical model includes disposable income, the University of Michigan consumer sentiment index, the interest rate, and the real effective exchange rate. Anticipated movements in these determinants are likely to affect planned consumption, while unanticipated changes determine cyclical consumption. Fluctuations in private consumption are mostly cyclical with respect to changes in disposable income and the consumers’ sentiment index. In contrast, an increase in the interest rate decreases both planned and cyclical consumption. Fiscal policy has a direct negative effect on cyclical consumption, which is not dependent on the interest rate. Monetary growth, in contrast, increases liquidity to finance both planned and cyclical private consumption.

Protective effects of curcumin on chromatin quality, sperm parameters, and apoptosis following testicular torsion-detorsion in mice

Shahedi Abbas,Talebi Ali Reza,Aghdas Mirjalili,Pourentezari Majid 대한생식의학회 2021 Clinical and Experimental Reproductive Medicine Vol.48 No.1

Objective: The chief outcome of testicular torsion in clinical and experimental contexts is testicular ischemia. Curcumin, a compound with anti-inflammatory and antioxidant properties, has fascinated researchers and clinicians for its promise in the treatment of fertility diseases. Methods: Thirty-five fully grown male mice were randomly classified into five groups: control, sham, testicular torsion, treatment group 1 (testicular torsion+short-term curcumin), and treatment group 2 (testicular torsion+long-term curcumin). Thirty-five days later, spermatozoa from the right cauda epididymis were analyzed with regard to count and motility. Toluidine blue (TB), aniline blue (AB), and chromomycin A3 (CMA3) staining assays were used to evaluate the sperm chromatin integrity. In addition, the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) test was used to assess apoptosis.Result: Treatment group 1 exhibited a remarkably elevated sperm count compared to the testicular torsion group. Additionally, notably lower sperm motility was found in the testicular torsion group compared to the control, treatment 1, and treatment 2 groups. Staining (CMA3, AB, and TB) and the TUNEL test indicated significantly greater testicular torsion in the torsion group compared to the control group (p<0.05). The data also revealed notably lower results of all sperm chromatin assays and lower apoptosis in both treatment groups relative to the testicular torsion group (p<0.05). Significantly elevated (p<0.05) AB and TB results were noted in treatment group 1 compared to treatment group 2.Conclusion: Curcumin can compensate for the harmful effects of testicular ischemia and improve sperm chromatin quality in mice.

Curcumin Can Prevent the Changes in Cerebellar Structure and Function Induced by Sodium Metabisulfite in Rat

Ali Noorafshan,Mohammad Amin Abdollahifar,Aghdas Poostpasan,Saied Karbalay-Doust,Ali Rashidiani-Rashidabadi,Reza Asadi-Golshan 한국뇌신경과학회 2013 Experimental Neurobiology Vol.22 No.4

Sulfites are used as anti-microbial and anti-oxidant agents in the food and pharmaceutical industries. Curcumin, a flavonoid, is anAsian spice that shows neuroprotective activities. The current study aimed to stereologically assess the rats’ cerebellar cortex androtarod performance following sulfite exposure and determine the possible neuroprotective potential of curcumin. The rats weredivided into five groups: distilled water, olive oil, curcumin (100 mg/kg/day), sodium metabisulfite (25 mg/kg/day), and sodiummetabisulfite+curcumin. At 56 days after treatment, rotarod performance was tested, and then the cerebellum was removed forstereological analysis. The study results revealed 31%, 36%, 19% and 24% decrease in the total volume of the cerebellum, cortex, thetotal number of the Purkinje cells and length of the nerve fibers in the cortex per Purkinje, respectively in the sodium metabisulfite-treated rats compared to the distilled water group (p<0.01). The pre-trained animals on the rotarod apparatus were tested first on thefixed speed rotarod protocol followed by the accelerating rotarod protocol two days later. The results showed a significant decreasein the latency to fall in both test in sulfite-treated rats. The sulfite effects on the structural parameters and rotarod performance weresignificantly protected by the concomitant curcumin treatment (p<0.001). Sulfite can induce structural and functional changes inthe rats’ cerebellum and concomitant curcumin prescription plays a neuroprotective role.