Patterns of failure for hypopharynx cancer patients treated with limited high-dose radiotherapy treatment volumes

Adam Burr(Adam Burr ),Paul Harari(Paul Harari ),Aaron Wieland(Aaron Wieland ),Randall Kimple(Randall Kimple ),Gregory Hartig(Gregory Hartig ),Matthew Witek(Matthew Witek ) 대한방사선종양학회 2022 Radiation Oncology Journal Vol.40 No.4

Purpose: Optimal radiotherapy treatment volumes for patients with locally advanced hypopharynx squamous cell carcinoma should ensure maximal tumor coverage with minimal inclusion of normal surrounding structures. Here we evaluated the effectiveness of a direct 3-mm high-dose gross tumor volume to planning target volume expansion on clinical outcomes for hypopharynx cancers. Materials and Methods: We performed a retrospective analysis of patients with hypopharynx carcinoma treated between 2004 and 2018 with primary radiotherapy using a direct high-dose gross tumor volume to planning target volume expansion and with or without concurrent systemic therapy. Diagnostic imaging of recurrences was co-registered with the planning CT. Spatial and volumetric analyses of contoured recurrences were compared with planned isodose lines. Failures were initially defined as in field, marginal, elective nodal, and out of field. Each failure was further classified as central high-dose, peripheral high-dose, central intermediate/low-dose, peripheral intermediate/low-dose, and extraneous. Clinical outcomes were analyzed by Kaplan-Meier estimation. Results: Thirty-six patients were identified. At a median follow-up at 52.4 months, estimated 5-year overall survival was 59.3% (95% confidence interval [CI], 36.3%–74.1%), 5-year local and nodal control was 71.7% (95% CI, 47.1%–86.3%) and 69.9% (95% CI, 57.0%–82.6%), respectively. The most common failure was in the high-dose primary target volume. The gastrostomy tube retention rate at 1 year among patients without recurrence was 13.0% (95% CI, 3.2%–29.7%). Conclusion: Minimal high-dose target volume expansions for hypopharynx cancers were associated with favorable locoregional control. This approach may enable therapy intensification to improve clinical outcomes.

Cariprazine — an Alternative Treatment for Clozapine-resistant Schizophrenia?

Adam Montgomery(Adam Montgomery ),Marianna Rogowska(Marianna Rogowska ),Luiz Dratcu(Luiz Dratcu ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1

Treatment-resistant schizophrenia (TRS) poses a significant therapeutic challenge in psychiatric practice. Clozapine is recognized as a treatment of choice in TRS but is not always effective in alleviating patients’ symptoms. Additionally, clozapine therapy is associated with multiple side effects and monitoring requirements that often limit its use and negatively affect patients’ compliance with the treatment. Although clozapine augmentation options are available, there is currently no alternative monotherapy proven to be effective in TRS. We present a case of a young man with TRS who failed to respond to appropriate trials of risperidone, aripiprazole and also clozapine, and who experienced impairing adverse effects of clozapine that made further clozapine treatment not only futile but also detrimental to his health. He was successfully treated with cariprazine monotherapy, which culminated in the remission of his both positive and negative symptoms of psychosis as well as in the marked improvement in social functioning. Cariprazine, a newer atypical antipsychotic endowed with a D3-preferring mode of action, may offer a better tolerated and more acceptable treatment option for patients with difficult-to-treat psychotic symptoms.

Harmonic Current Compensation Using Active Power Filter Based on Model Predictive Control Technology

Adam, Misbawu,Chen, Yuepeng,Deng, Xiangtian The Korean Institute of Power Electronics 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.6

Harmonic current mitigation is vital in power distribution networks owing to the inflow of nonlinear loads, distributed generation, and renewable energy sources. The active power filter (APF) is the current electrical equipment that can dynamically compensate for harmonic distortion and eliminate asymmetrical loads. The compensation performance of an APF largely depends on the control strategy applied to the voltage source inverter (VSI). Model predictive control (MPC) has been demonstrated to be one of the effective control approaches to providing fast dynamic responses. This approach covers different types of power converters due to its several advantages, such as flexible control scheme and simple inclusion of nonlinearities and constraints within the controller design. In this study, a finite control set-MPC technique is proposed for the control of VSIs. Unlike conventional control methods, the proposed technique uses a discrete time model of the shunt APF to predict the future behavior of harmonic currents and determine the cost function so as to optimize current errors through the selection of appropriate switching states. The viability of this strategy in terms of harmonic mitigation is verified in MATLAB/Simulink. Experimental results show that MPC performs well in terms of reduced total harmonic distortion and is effective in APFs.

Attention to Detail : Learning About Mergers

( Adam L. Aiken ),( Choonsik Lee ) 한국금융연구원 2023 금융연구 working paper Vol.2023 No.7

We study the information gathering process surrounding firms by examining the IP addresses accessing Form 8-K filings for merger agreements. This allows us to measure who pays attention to the announcement, how attention varies across mergers, and if this attention is related to merger outcomes. We link each IP address to a particular firm or institution, as well as track if an IP address shows further interest in other associated filings. Further, we relate soft information about the merger revealed in the text and link specific topics, such as antitrust issues, to the decision to learn. We find that certain attention, such as the search activity of investment management firms, reveals characteristics about the merger, like the withdrawal of the deal or the involvement of an activist.

The impact of incontinence etiology on artificial urinary sphincter outcomes

Adam R. Miller,Brian J. Linder,Laureano J. Rangel,David Y. Yang,Daniel S. Elliott 대한비뇨의학회 2017 Investigative and Clinical Urology Vol.58 No.4

Purpose: To evaluate the impact of incontinence etiology on artificial urinary sphincter (AUS) device outcomes. Materials and Methods: We identified 925 patients who underwent primary AUS placement from 1983 to 2011. The etiology of incontinence was categorized as radical prostatectomy alone, radical prostatectomy with radiation, benign prostate resection, and those with cryotherapy as a salvage prostate cancer treatment. Hazard regression and competing risk analyses were used to determine the association of the etiology of incontinence with device outcomes. Results: The distribution of the 4 etiologies of incontinence included: 598 patients (64.6%) treated with prostatectomy alone, 206 (22.2%) with prostatectomy and pelvic radiation therapy, 104 (11.2%) with benign prostate resection, and 17 (1.8%) with prior cryotherapy. With a median follow-up of 4.9 years (interquartile range, 1.2–8.8 years), there was significant difference in the cumulative incidence of device infection/urethral erosion events between the four etiologies (p=0.003). On multivariable analysis, prior cryotherapy (reference prostatectomy alone; hazard ratio [HR], 3.44; p=0.01), older age (HR, 1.07; p=0.0009) and history of a transient ischemic attack (HR, 2.57; p=0.04) were associated with an increased risk of device infection or erosion. Notably, pelvic radiation therapy with prostatectomy was not associated with an increased risk of device infection or erosion (reference prostatectomy alone, p=0.30). Conclusions: Compared to prostatectomy alone, prior treatment with salvage cryotherapy for recurrent prostate cancer was associated with an increased risk of AUS infection/erosion, whereas radiation (in addition to prostatectomy) was not.

Endoscopic Hemostasis for Non-Variceal Upper Gastrointestinal Bleeding: New Frontiers

Adam Kichler,Sunguk Jang 대한소화기내시경학회 2019 Clinical Endoscopy Vol.52 No.5

Non-variceal upper gastrointestinal bleeding (NVUGIB) refers to blood loss from the gastrointestinal tract proximal to the ligamentof Treitz due to lesions that are non-variceal in origin. The distinction of the bleeding source as non-variceal is important in numerousaspects, but none more so than endoscopic approaches for successful hemostasis. When a patient presents with acute overt bloodloss, NVUGIB is a medical emergency, which requires immediate intervention. There have been major strides in pharmacologic andendoscopic interventions for successful induction and remission of hemostasis in the last two decades. Despite achieving tangibleimprovements, the burden of the disease and the consequent mortality remain high. To address endoscopic outcomes better, severalnew technologies have emerged and have been subsequently incorporated to the armamentarium of hemostatic tools. This study aimsto provide a succinct review on novel technologies for endoscopic hemostasis.

Automated Height Adjustable Prosthetic Leg(AHAPL)

Adam Chung 한국콘텐츠학회 2018 ICCC International Digital Design Invitation Exhib Vol.2018 No.12

Race and Legitimacy in Acts 17:26: An Approach from Political Theology

Adam F. Braun 연세대학교 신과대학(연합신학대학원) 2021 신학논단 Vol.106 No.-

더글라스(Frederick Douglas)는 자신의 유명한 편지에서 사도행전 17장 26절에 기대어 “노예들에게 독립기념일이란 무엇인가?”라고 질문한다. 더글라스는 “당신들은 ‘인류의 모든 족속을 한 혈통으로 만드사 온 땅에 살게 하심’을 믿는다고 고백했다”라고 지적함으로써, 자신의 반대 세력들의 믿음을 인용하여 자신의 주장에 대한 정당성을 확보하고자 한 것이었다. 본 논문은 사도행전 17장 26절을 노예폐지론자, 다문화주의자, 그리고 인종분리주의자들이 어떻게 수용하였는지 살펴본다. 이 과정에서 본 논문은, 코츠코(Adam Kotsko)의 신자유주의 이론 모델처럼, 인종문제를 정치신학적 관점에서 접근하고자 한다. 따라서 필자는 사도행전 17:26에서 인종 담론은 차이점들을 지우고 모두가 동일하게 보이게 만든다는 점을 지적하고자 한다. Frederick Douglass appeals to Acts 17:26 in his famous letter, “What to the slave is the Fourth of July?” Douglass intends to gain legitimacy to his argument by conjuring the beliefs of his opponents, when he says, “You profess to believe ‘that, of one blood, God made all nations of men to dwell on the face of all the earth.’” While Acts certainly relies on political theology to legitimize “men” in the face of “all nations,” this paper will concern itself with recent invocations of this form of legitimization of the human, one which is made up of different races. In particular, I want to look at the series of essays from The Gospel Coalition"s Tim Keller and his treatment of race. This paper will analyze uses of Acts 17:26 in so-called “multiculturalist” discourses and Tim Keller’s work on The Gospel Coalition. Through this analysis, this paper will consider race, like Kotsko"s neoliberalism, as its own legitimizing political theology. Race legitimates all into a sameness that erases difference.

Capitalism, Rationality and Justice

Adam Przeworkski 고려대학교 노동문제연구소 1991 노동연구 Vol.9 No.-

Automated Height Adjustable Prosthetic Leg(AHAPL)

Adam Chung 한국콘텐츠학회 2018 한국콘텐츠학회 ICCC 논문집 Vol.2018 No.12