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      • KCI등재

        A Situational Assessment of Children Living with HIV and AIDS in Bangalore

        Christy Abraham Research Institute of Asian Women Sookmyung Women' 2005 Asian Women Vol.21 No.-

        In its efforts to combat the HIV and AIDS epidemic in India, the National AIDS Control Organization (NACO) in line with Government's efforts has developed an integrated work plan on combating the disease. NACO and the State AIDS Control Societies' primary activity targeting children has been prevention of mother-to-child transmission, which involves administering a short course of antiretroviral drugs to mother and newborn that greatly reduces the risk of HIV transmission during pregnancy and child birth. The most vulnerable group of the population, the HIV positive children and children who are now orphans due to the death of one or both of their parents from AIDS, have received little attention both in terms of practical programs and in sector plans. This is much so because the number of AIDS orphans in the country is not known let alone their living conditions and their needs as other children. This paper assesses the situation of 100 children who are living with HIV and AIDS and who are now orphans due to the death of one or both of their parents from AIDS and the concerns and challeges of positive mothers in Bangalore, India. While 63 children live with their families 36 positive children live in one of the Positive Children's Homes in Bangalore. Out of the 64 positive children, 30 children are paternal orphans, three children are maternal orphans, and nine children are double orphans. Thirteen children are living with their positive parents and the double orphans live with their extended families. The information was gathered in individual therapy sessions, group discussions, and family support sessions with positive children and widows. Out of the 36 Positive Children in the institution, 26 are double orphans and 10 children are either maternal orphans or paternal orphans. The paper also gives an insight on how a Family Support Network, MILANA in Bangalore, India, is addressing and coping with the varied issues and problems faced by orphans and their families. The assessment suggests the need to map out the children orphaned by AIDS, so as to get reliable data on the total number of children orphaned by AIDS, and to frame policies for children orphaned by AIDS, taking into consideration not only the educational, health, and nutritional aspects but also the psycho social and economic aspects.

      • Stabilization of Bacillus subtilis Lipase A by increasing the residual packing

        Abraham1, Tajo,Pil Pack1, Seung,Je Yoo, Young Taylor Francis 2005 Biocatalysis and biotransformation Vol.23 No.3

        <P>Introduction of well-packed residues to the interior of a protein structure could be considered as a stabilization strategy since the reduction of buried cavities might stabilize protein structure. In this study, the less-packed residues with no water-contact were selected as target sites for increasing residual packing. When Lipase A from Bacillus subtilis (179 amino acids) was used as a model system, 43 less-packed residues were initially considered by analyzing their residual packing value and residual exposure ratio. Among the 43 residues, small amino acids such as GLY and ALA were chosen as target sites. Packing increases of ALA to VAL and GLY to ALA were estimated, by molecular modeling, to give 0.5368∼⃒0.7433  kcal mol −1 stabilization. Mutants of Lipase A such as A38V, A75V, G80A, A105V A146V, and G172A were obtained via protein engineering. Thermostability assays revealed that A38V, G80A and G172V were the most stable mutants. This procedure for selecting the target residues for improved thermostability of Lipase A could be applied for improving the thermostability of other proteins and enzymes.</P>

      • KCI등재

        Role of colour and volatile in foraging behaviour of honeybee Apis cerana on Jacquemontia pentanthos

        Anitha Annamma Abraham,Abraham Verghese,Subramanyam Muthangi 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.4

        Floral visual and olfactory cues guide the insect visitors to the source of reward. This work addresses one such interaction between honeybee Apis cerana and a garden climber Jacquemontia pentanthos. Field studies have indicated that A. cerana showed preference to J. pentanthos over the other flowering plants during its visits for foraging. The objectives of the work is to understand the role of colour and scent in the attraction of Apis cerana to the host plant. Bioassays performed emphasized the involvement of colour and volatiles for the visits of A. cerana. Petals show high reflectance to ultraviolet light with ultraviolet absorbing regions in the centre which serve as a nectar guide. Gas chromatography linked electroanntenogram detector (GC-EAD) showed antennal response to the floral volatile of J. pentanthos identified as sesquiterpene β-caryophyllene. Behavioural studies have shown similar preference to β- caryophyllene as that of α-humulene. Our studies suggest an interplay of colour and volatiles cues for A. cerana visitation to Jacquemontia flowers and these findings are further supported by behavioural studies on.

      • SCOPUSKCI등재

        Synthesis of Star-like Random Copolymers from Resorcinarene-Based Octa-Functional Alkoxyamine Initiator via Nitroxide Mediated Free Radical Polymerization

        Abraham, Sinoj,Choi, Jae-Ho,Lee, Jin-Kyu,Ha, Chang-Sik,Kim, Il The Polymer Society of Korea 2007 Macromolecular Research Vol.15 No.4

        An octa-functional alkoxyamine initiator, with the 2,2,6,6-tetramethyl-l-piperidinyloxy (TEMPO) free radical, was synthesized based on resorcinarene, with its efficiency to initiate the nitroxide-mediated free radical copolymerization of styrene and methyl methacrylate (MMA) described. A difunctional analogue of this initiator was also synthesized, using resorcinol as the core molecule. The structures of the resulting initiators were confirmed by homolysis studies based on electron spin resonance spectroscopy and molecular modeling. The polymerization behavior and characteristics of the polymers obtained using these two initiators were also compared. Well-defined star-shaped and linear random copolymers, with low polydispersities and controlled molecular weights, were prepared. The efficiencies of these initiators towards copolymerization, as well as the parameters permitting the formation of well-defined polymers, were also investigated. The reactivity ratios were $r_a=0.42(a=styrene)\;and\;r_b=0.33(b=MMA)$ for the octa-functional initiator system and $r_a=0.45\;and\;r_b=0.39$ for the difunctional initiator system.

      • SCISCIESCOPUS

        Synthesis of Multinuclear Pyridylimine Based Palladium(II) Complexes with a Functionalized Star Polystyrene Core and Evaluation of Their Catalytic Activity Towards Ethylene Oligomerization

        Abraham, Sinoj,Ha, Chang-Sik,Kim, Il WILEY-VCH Verlag 2006 Macromolecular Rapid Communications Vol.27 No.16

        <P>Summary: The synthesis of a novel series of multi-nuclear macroligated pyridylimine based palladium(II) complexes conjugated to a synthetic star polymer core has been well-described. Star shaped polystyrene with a finite number of arms were prepared by atom transfer radical polymerization (ATRP) and the chain ends were chemically modified in order to introduce the desired end functionality. Utilizing this polymer as organic supports for pyridylimine-based ligands, palladium(II) complexes were synthesized. On activating with methylaluminoxane (MAO), this complex showed substantially high activity towards ethylene oligomerization, producing C<SUB>4</SUB> and C<SUB>6</SUB> compositions as major products. The plausible mechanistic insight concerning the process of ethylene oligomerization is also broached.</P><P> <img src='wiley_img/10221336-2006-27-16-MARC200600244-gra001.gif' alt='wiley_img/10221336-2006-27-16-MARC200600244-gra001'> Graphic An example of trinuclear pyridylimine based palladium(II) complex having a functionalized star polystyrene core. </P>

      • Microfluidics assisted synthesis of well-defined spherical polymeric microcapsules and their utilization as potential encapsulants

        Abraham, Sinoj,Jeong, Eun Ho,Arakawa, Takahiro,Shoji, Shuichi,Kim, Kyung Chun,Kim, Il,Go, Jeung Sang Royal Society of Chemistry 2006 Lab on a chip Vol.6 No.6

        <P>In this article, the development of a novel technique to fabricate spherical polymeric microcapsules by utilizing microfluidic technology is presented. Atom transfer radical polymerization (ATRP) was employed to synthesize well-defined amphiphilic block copolymers. An organic polymer solution was constrained to adopt the spherical droplets in a continuous water phase at a T-junction microchannel, and the generation of the droplets was studied quantitatively. The flow conditions of two immiscible solutions were adjusted for the successful generation of the polymer droplets. The morphology of the microcapsules was examined. The efficiency of these polymer microcapsules as containers for the storage and controlled release of loaded molecules was evaluated by encapsulating the microcapsules with Congo-red dye and investigating the release performance using temperature controlled UV-VIS spectroscopy.</P> <P>Graphic Abstract</P><P>The priority of this work is the innovative conjunction of well-defined amphiphilic block copolymers and stable microfluidics to develop the functional spherical microcapsule with quantitative evaluation of its drug release performance, potentially aiming at mass-production. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b518006f'> </P>

      • KCI등재
      • KCI등재

        A Remedy for the World: an Eschatological Dimension of a Quasi-religion, Communism and its Application in a Central European Country, Hungary

        Abraham Kovacs 한국종교학회 2014 宗敎硏究 Vol.74 No.3

        First, (1) a definition of religion is offered in order to articulate what constitutes a quasi-religion, then the study moves on to (2) identifying one of the dimensions of proper religion in Commmunism, and underline the crucial role of doctrine. By appling these two theories, it is possible to make some valuable comparisons between Christian religion and communism. It is also argued that (3) eschatology is one of the most essential aspects of the doctrinal dimension not only of a religion proper, Christianity but that of a quasi-religion, Marxism and its inculturated form communism. My intention is to shed light on how remarkably similar (4) characteristics exist between an atheist ideology, dialectical materialism of communism and theist religion, Christianity. These can be discerned when the researcher scrutinizes their fundamental ‘doctrinal’ teachings about the (4.1) conditions of life and human beings in the world and (4.2.) the kind of solutions both, a religion proper and a quasi-religion offered to save the world from evil in the last days, the eschaton of Time. Some selected texts and songs of international and Hungarian communism will be used to show how they understood (a) crucial issues of life, (b) the role of believers (proletariat or church), and (c) the kind of the solutions they offered as a remedy to the issues they identified as problems. All of these will be placed under the framework of “end of times” notion which may be comparable to Christian eschatological expectation of the end of times.

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