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- 저자 : A. M. Bueno (검색결과 4 건)
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The NER-related gene GTF2H5 predicts survival in high-grade serous ovarian cancer patients
Javier Gayarre,Marta M. Kamieniak,Alicia Cazorla-Jiménez,Ivan Muñoz-Repeto,Salud Borrego,Jesús García-Donas,Susana Hernando,Luis Robles-Díaz,José M. García-Bueno,Ivan Márquez-Rodas,María José Echarri 대한부인종양학회 2016 Journal of Gynecologic Oncology Vol.27 No.1
Objective: We aimed to evaluate the prognostic and predictive value of the nucleotide excision repair-related gene GTF2H5, which is localized at the 6q24.2-26 deletion previously reported by our group to predict longer survival of high-grade serous ovarian cancer patients. Methods: In order to test if protein levels of GTF2H5 are associated with patients' outcome, we performed GTF2H5 immunohistochemical staining in 139 high-grade serous ovarian carcinomas included in tissue microarrays. Upon stratification of cases into high- and low- GTF2H5 staining categories (> and ≤ median staining, respectively) Kaplan-Meier and logrank test were used to estimate patients’ survival and assess statistical differences. We also evaluated the association of GTF2H5 with survival at the transcriptional level by using the on-line Kaplan-Meier plotter tool, which includes gene expression and survival data of 855 high-grade serous ovarian cancer patients from 13 different datasets. Finally, we determined whether stable short hairpin RNA-mediated GTF2H5 downregulation modulates cisplatin sensitivity in the SKOV3 and COV504 cell lines by using cytotoxicity assays. Results: Low expression of GTF2H5 was associated with longer 5-year survival of patients at the protein (hazard ratio [HR], 0.52; 95% CI, 0.29 to 0.93; p=0.024) and transcriptional level (HR, 0.80; 95% CI, 0.65 to 0.97; p=0.023) in high-grade serous ovarian cancer patients. We confirmed the association with 5-year overall survival (HR, 0.55; 95% CI, 0.38 to 0.78; p=0.0007) and also found an association with progression-free survival (HR, 0.72; 95% CI, 0.54 to 0.96; p=0.026) in a homogenous group of 388 high-stage (stages III-IV using the International Federation of Gynecology and Obstetrics staging system), optimally debulked high-grade serous ovarian cancer patients. GTF2H5- silencing induced a decrease of the half maximal inhibitory concentration upon cisplatin treatment in GTF2H5-silenced ovarian cancer cells. Conclusion: Low levels of GTF2H5 are associated with enhanced prognosis in high-grade serous ovarian cancer patients and may contribute to cisplatin sensitization.
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A. M. Bueno,M. J. Gonçalves,I. O. Barcellos,C. K. Souza,L. F. Carvalho,R. B. M. Ibsch,B. R. Warmling,S. L. Bertoli 한국섬유공학회 2020 Fibers and polymers Vol.21 No.1
Due to the large amount of toxic effluents generated by the textile industry using most of synthetic dyes, naturaldyes are increasingly gaining prominence, in keeping with the global trend toward prioritizing the use of cleanertechnologies. However, the application of natural dyes is still restricted, mainly due to their instability in solution and poorfixation onto textile substrates. Thus, research is required to improve the performance of these dyes in order to obtainproducts with the characteristics desired by the industry. In this study, the potential of natural annatto dye in the dyeing ofpolyester (PES) fiber was analyzed and the color and stability parameters in solution were evaluated through twoexperiments. Initially, the stability of the natural annatto dye in solution was determined under different conditions oftemperature, pH, and dye concentration and the application of this dye in conventional PES fiber dyeing was investigated. Subsequently, the influence of the use of a carrier in the dyeing of PES fiber was evaluated. The results indicated that thevariables with the greatest effect on the degradation of the dye are temperature and pH. The natural annatto dye showed goodinteraction with the PES fiber in the conventional dyeing process, presenting good results of color yield and levels of fastness. In the dyeing processes conducted with and without a carrier, the dyeing performed in the latter provided better results, withthe advantage of allowing the application of lower temperatures.
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Torres, I. Zamudio,Dominguez, A. Sosa,Bueno, J.J. Perez,Meas, Y.,Lopez, M.L. Mendoza,Dector, A. Techno-Press 2021 Advances in nano research Vol.10 No.3
The evaluation of the corrosion resistance of titanium with a TiO2 nanotubes top layer was carried out (TiO2 NT). These nanostructures were evolved into anatase nanoparticles without heat treatment in an aqueous medium, which is a novel phenomenon. This work analyzes the layer between the nanotube bottom and the substrate, which is thin and still susceptible to corrosion. The bottom of TiO2 nanotubes having Fluor resulting from the synthesis process changed between amorphous to crystalline anatase with a crystallite size of about 4 nm, which influenced the corrosion rates. Four kinds of samples were evaluated. A) NT by Ti anodizing; B) NTSB for Ti plates, either modifying its surface or anodizing the modified surface; C) NT-480 for anodized Ti and heat-treated (480℃) for reaching the anatase phase; D) NTSB-480 for Ti plates, first, modifying its surface using sandblast, after that, anodizing the modified surface, and finally, heat-treated to 480℃ to compare with samples having induced crystallization and passivation. Four electrochemical techniques were used to evaluate the corrosion rates. The surfaces having TiO2 nanotubes with a sandblast pre-treatment had the highest resistance to corrosion.
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de Oliveira Letícia da S.,Fonseca Lucas P.,de Souza Renato D.,Bueno Cristina de F.,Martins Lucas M.,Scalvi Luis V.A. 한국물리학회 2022 Current Applied Physics Vol.41 No.-
Reduced graphene oxide (rGO) is deposited on glass substrate by dripping and sol-gel-coating methods giving rise to nanostructures. When in combination with thin films of SnO2, they form a heterostructure SnO2:2 at% Eu/ rGO, which alters the surface electrical conductivity. SnO2 and rGO were also combined as a composite, with conductivity strongly affected by ultraviolet excitation, and shows persistent photoconductivity (PPC) phenomenon even very close to room temperature. Both sort o hybrid structures can be applied in electronic devices. The SnO2 films are deposited via chemical route by sol-gel or by a mixed technique that combines powders generated by drying the sol-gel solution with resistive evaporation of this powder. Resistivity measured as a function of temperature show that the SnO2:2 at%Eu sample behaves very similarly to the SnO2:2 at%Eu/rGO heterostructure sample, with the same energy level for the dominant defect, 172 meV, coincident with ionization of oxygen vacancies. Despite not changing the position of this level, the presence of rGO on the surface of the SnO2 film induces a decrease in conductivity in vacuum, demonstrating the surface interaction.
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