이안류 발생 경보결정 과정체계의 개발

이정렬,Lee, Jeong-Ryeol 한국수자원학회 2014 물과 미래(한국수자원학회지) Vol.47 No.11

흉선지방종 치험 1례 보

이정렬 대한흉부심장혈관외과학회 1984 Journal of Chest Surgery (J Chest Surg) Vol.17 No.4

Thymolipoma is a rare benign tumor consisting of fat and thymic tissue. Approximately 60 case reports have been published. On 1984, one patient with proven mediastinal thymolipoma was treated surgically at the Department of Thoracic & Cardiovascular surgery, Seoul National University Hospital. The following case is the first reported example of thymolipoma occurring in Korea.

심근세포내 칼슘이온 활동도에 미치는 Vanadate의 효과

이정렬 中央大學校 醫科大學 1987 中央醫大雜誌 Vol.12 No.3

主去來銀行制度

李正烈 서울대학교 상과대학 한국경영연구소 1976 經營實務 Vol.10 No.4

토끼 동방결절 활동전압에 대한 Na, K, Ca 및 Mg 이온의 영향

이정렬,엄융의,Lee, Jeong-Ryeol,Eom, Yung-Ui 대한흉부심장혈관외과학회 1985 Journal of Chest Surgery (J Chest Surg) Vol.18 No.1

Isolated sinus node cells of the rabbit were used to assess the effects of extracellular Na, K, Ca and Mg concentrations on cardiac pacemaker activity. With intracellular glass micro-electrodes spontaneous action potentials of SA node were recorded and the effects of various ions and their blockers were analyzed in terms of the cycle length, the amplitude and the duration of action potentials, the results obtained were as follows. 1. Sodium reduction [up to 30%] decreased the amplitude of action potential and lengthened the cycle length. TTX, specific blocker of Na channel slightly lengthened the cycle length. 2. Increasing potassium ion concentration, the duration of action potential decreased and the frequency increased in 6mM, however, spontaneous action potential was stopped in 24 mM. Barium ion known to be decreasing K conductance increased the duration of action potential but no significant change in the cycle length was noticed. 3. Calcium ion has shortening effect on the duration and the cycle length of action potential but not with dose-dependent manner. Cadmium ion .[0.02mM] lengthened cycle length and the duration of action potential. 4. Increasing the concentration of magnesium ion the cycle length was lengthened, significantly.

이소 생쥐심장이식 모델에서 조기 시간경과에 따른 관상동맥의 면역병리학적인 변화

이정렬,임홍국,서정욱 대한흉부심장혈관외과학회 1998 Journal of Chest Surgery (J Chest Surg) Vol.31 No.12

배정: 연구자 등은 본 연구에서 가속화된 이식동맥 경화증의 조기 진행경과를 규영하기 위하여 제1분류 주 조직적합성항원(빠IC class 1)의 한지 라만 다른 생쥐 종조합을 이용하여 이소심장이식을 시행하고 이식성장 의 관상동맥에서의 주조직적합성항원(MHC), 세포간부착분자-1(ICAM-l), 혈관세포부착분자-1 (VCAM-l), 인터 루킨-6의 발현 및 조직병리학적 병변의 변화 양상이 이식 후 4주 이내의 조기에 시간 경과에 따라 어떻게 변화하는지를 관찰하였다, 대상 및 방법; 생후 7-10주된 BIO.A 생쥐를 공여심장으로, BIO.BR 생쥐를 피이식 생쥐로 이용하였다. 이식후 피이식생쥐에 면역억제요법은 사용하지 않았으며 군을 7일, 15일, 21일, 30일 등 네 군으로 분류하여 각각 해당되는 날짜에 공여심장과 피이식생쥐의 심장을 적출하였다. 성장조직표본은 면역조직화학법, 현미경적소견, 형태학적 측정법으로 분석하였으며 평가는 중복관찰을 통한 경, 중등, 강의 등 급체계로 반정량적인 방법으로 평가하였다 결과: 제1분류 주조직적합성항원의 발현은 7일 경과 표본에서 이미 강하게 발현되기 시작하였으며 그 후에도 계속 높은 수준으로 유지되었다. 제2분류 주조직적합성항원 의 발현은 모든 군에서 미미하거나 발현이 되지 않았다, 세포간부착분자-1 발현은 7일 경과 표본부터 경도 내지 중등도로 관상동맥내펴세포에서 발현되었으나 혈관중층세포에서의 발현은 관찰되지 않았다. 혈관세포 부착분자-1 발현은 네군 모두에서 헐관내피세포 및 중층세포에서 강하게 발현되었다. 인터루킨-6의 발현은 모든 군에서 중등도로 발현이 되었다. 조직병리학적 소견의 변화양상은 혈관내피세포의 증식을 보이는 혈관 이 7일 경과 표본에서는 관찰혈관 중 평균 10%에서 보이다가 30일 경과 표본에서는 50%의 혈관에서 관찰되었다. 그 결과 혈관 내강의 면적의 감소가 20%에서 40%로 증가하였다. 혈관중층펑활근의 증식여부를 관찰 하기 위한 트로포마이오신 염색의 결과는 적어도 30일까지는 경도 이하로 관찰이 되었으며 중층완전성도 역시 잘 유지되었다. 혈관주변 단핵세포 침윤은 7일 경과 표본에서 중등도 정도로 관찰되다가 이후 점진적으로 증가하는 양상을 보였다. 피이식생쥐의 심장표본에서는 네군 모두에서 연역병리학적인 소견이 전혀 관찰 되지 않았다 결론: 본 연구에서 이소 생쥐심장이식 모델에서 공여심장의 관상동맥에서 발현되는 부착물질 및 싸이토카인 등이 이미 7일 이내의 조기부터 발현되기 시작하는 것을 규명하였으며 혈관내막세포증식, 혈관주변세포침윤 등 조직영리학적인 병변의 진행양상 역시 30일이 경과하는 사이에도 점진적으로 진행하는 양상이라는 사실을 발견하였다. 연구자 등은 연구 결과를 토대로 기속화된 이식동맥 경화증이 급작스런 현상이 아닌 만성적인 면역반응의 결과일 가능성이 높다고 추론하였다. Background: In this study, we investigated the early time course of expression of the major histocompatibility(MHC) antigens, intercellular adhesion molecule-1(ICAM-1), vascular cell adhesion molecule-1(VCAM-1), interleukin-6 and the histopathological changes in the coronary arteries of cardiac allografts exchanged between inbred mice strains that differ in one loci of class I major histocompatibility antigen (B10.BR to B10.A). Material and Method: No immunosuppressive therapy was used. Both allografts and the hearts of the recipients were harvested at 7(group 1, n=6), 15(group 2, n=6), 21(group 3, n=6), and 30(group 4, n=6) days after transplantation. They were examined by immunohistochemistry, microscopy and morphometry. All allografts had contractions at the time of harvest. Result: A strong MHC class I antigen expression was present on the endothelial and medial cells of the coronary arteries in group 1 and remained unchanged in the rest of the groups. However, MHC class II reactivity was none or very little at any time. Mild to moderate ICAM-1 expression was observed on the endothelial cells, but not on the medial cells at any time by 30 days. VCAM-1 expression was strong both on the endothelial and medial cells at any time. Moderate degree expression of interleukin-6 was observed from 7 to 30 day specimens. Histopathologically, percentage of affected vessels(vessels with intimal thickening) was less than 10 % in 7 day group and increased up to 50 % at 30 days. Mean percent narrowing of the lumen of the affected vessels revealed less than 20 % at 7 days and 40 % at 30 days. The area occupied by tropomyosin positive cells in the intimal lesion, graded from 0 to 3, showed gradual increase but remained between grade 0 to 1 by 30 days. Medial integrity was also well preserved at any time. Moderate perivascular mononuclear cell infiltration was observed at 7 days and it was progressively increased upto 30 days. Recipients' heart revealed no positive immunopathologic findings. Conclusion: In this study, the early time course of progression of the transplantation vasculopathy was demonstrated in the murine heterotopic heart transplant model.

국력 강화는 산업장 건강증진 향상으로

이정렬,Lee, Jeong-Ryeol 대한산업보건협회 2005 산업보건 Vol.208 No.-

4년제 간호대학(과) 지역사회간호학 실습교육의 현황분석

이정렬,이향련,김광숙,강경아 지역사회간호학회 2006 지역사회간호학회지 Vol.17 No.1

Purpose: This study was to investigate the current situation of communtiy health nursing practicum in bachelor programs. Method: Data were collected using a questionnaire consistiong of questions on education goals, teaching items, teaching methods, and evaluction methods and items, Forty five nursing schools in Korea or 84.9% of four-year nursing schools in Korea responded to the survey, Result: Nursing process application and understanding about the role and function of community health nurses were major goals of practice education, Community health centers were the most significant practice fields because all nursing schools mentioned them as places for practice. All nursing schools used a specific evaluation tool to measure students outcomes and utilized guidebooks to help students. Condlusion: The results of this study suggest that the goals of practice education should be standardzed to improve the quality of education Besides, evaluation tods that can be used commonly at all nursing schools should be developed to measure the effectiveness of practice education of cmmunity health nursing.

한국산 잡견에서의 실험적 심장 이식술 (II)

이정렬 대한흉부심장혈관외과학회 1990 Journal of Chest Surgery (J Chest Surg) Vol.23 No.5

We have performed 27 cases of orthotopic homologous cardiac transplantation using Korean mongrel dogs and one case of sham operation for the evaluation of harmful effect of cardiopulmonary bypass itself on the dog from April, 1989 to June, 1990. Our previous reports have already demonstrated basal hemodynamic and hematologic data on the canine homologous heart transplantation and the fundamental principles of transplantation of the heart. The mean body weight of recipients was 13.2$\pm$1.2kg with a rage of 11 ~ 15kg, and the hemodynamic and hematologic pictures were almost same as the result of previous reports from our hospital, except marked decrease in postoperative platelet count[from 3.18 $\pm$0.80x106/mm3 to 1.41$\pm$0 37x 106/mm3]. Mean survival time was 24.82$\pm$49.40 hours with the longest survival of 264 hours. Donor cardiectomy included coronary vasodilatation with diltiazem, potassium arrest, and the rapid cooling of the heart suspending in the specially designed ice-bath. Median sternotomy provided excellent exposure of the surgical field. 6 \ulcorner0 prolene suture was used for the anastomosis of both atrial cuffs and the great arteries, and we found the fact that stenosis, bleeding, thrombus formation around the anastomotic site could be decreased with the use of everted horizontal mattress suture techniques. Immunosuppression was done with a combination of lower dose Cyclosporin-A, Azathioprine, methyl-prednisolone, but our cases still showed too short survival to worry about graft rejection. Still poor was our quality control of experimental animal, we had much difficulties in postmortem evaluation of the dogs. Low cardiac output due to biventricular failure, intractable supraventricular or ventricular tachyarrhythmia, postoperative massive bleeding, sepsis were most frequent findings that could be thought as a cause of death. A few cases showed subendocardial patch hemorrhage in both ventricular cavity or atrial septum at autopsy, suggesting acute subendocardial infarction. Although our team overcome most of the technical problems of orthotopic heart transplantation, we should pile up further knowledges about donor heart preservation, quality control of animal, infection, rejection, the effect of the cardiopulmonary bypass to improve the results.

군병원에서의 심혈관계 수술 114례에 대한 임상적 고찰

이정렬 대한흉부심장혈관외과학회 1988 Journal of Chest Surgery (J Chest Surg) Vol.21 No.4

One hundred and fourteen patients were underwent cardiovascular operation from the 11th June 1985 to 12th July 1988 in the department of cardiovascular surgery of Seoul District Hospital. There were one hundred and one open heart surgery patients and thirteen non-open heart surgery patients. Of open heart surgery cases, seventy-four were acyanotic, twenty four were cyanotic congenital heart disease and three were acquired valvular heart disease. VSD was most common[55 cases] among acyanotic group and TOF[21 cases] was most common among cyanotic group. Of non-open heart patients, there were eleven cases of PDA and two cases of shunt[modified Blalock-Taussig shunt using PTFE graft] for TOF. There were one operative death[0.9%] due to inadequate relief of right ventricular outflow tract obstruction and peripheral pulmonary artery stenosis for TOF patient. No Patients were dead during follow-up.