Meigs Syndrome 1 례

노흥태,윤지열,심재균,손영선 대한산부인과학회 1990 Obstetrics & Gynecology Science Vol.33 No.5

저자들은 본 병원 산부인과에서 흉수와 복수를 동반한 난소섬유종을 제거함으로써 수술후 제9일째의 흉부X-선상 흉수가 완전소실된 Meigs syndrome 1례를 경험하였기에 보고하는 바이다. A case of Meigs syndrome is reported with the brief review of literature. This case, 67-year old multipara, was referred to our hospital due to distended abdomen and palpable mass in lower abdomen. The right hydrothorax was viewed by her chest film. After removal of the tumor, ascites and hydrothorax had been completely disappeared within 9 days postoperatively. Pathologically a fibroma was confirmed.

폐경기 증후군 환자에서 Cyclofenil의 유용성

노흥태,이창환 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

The postmenopausal period is associated with a significant increase in the incidence of agerelated conditions. It is becoming increasingly clear, however, that some of these conditions, specifically osteoporosis and cardiovascular disease, are related to estrogen deficiency as well as to age. For this reason, gynecologic care of postmenopausal women should adress the issue of hormonal replacement therapy. However, estrogen therapy is often responsible for genital or extragenital side effects. Among non-steroid agents, cyclofenil is known to be useful due to action at the level of the hypophyseal and hypothalamic centers. These action is in reducing the secretion of FSH and restoring normal endorphin, dopamine, and norephinephrine activities, thus favorably affecting the entire post-menopausal neurovegetative symptomatology. The purpose of this study was to investigate the clinical efficacy and safety for cyclofenil administered orally at 200mg daily for 8 consecutive weeks in 30 patients with the postmenopausal symptoms. The results were as follows: 1. The distribution of clinical symptoms in the studied patients prior to treatment was: hot Flush, 100.0%; sweating, 86.7%; fatigue, 70.0%; anxiety, 66.7%; depression, 60.0%; headache, 56.7% sleep disturbance 46.7%, and vaginal burning sensation, 40.0%. 2. The efficacy rate after treatment with cyclofenil was 84.7% in the sweat, 75.0% in the vaginal burning sensation, 71.4% in the sleep disturbance and fatigue, 70.0% in the hot flush, 60. 0% in the anxiety, 41.9% in the headache, and 27.8% in the depression. 3, There was no definite evidence of side effects observed during the study. These data suggest that cyclofenil therapy is effective in reducing the incidence of postmenopausal syndrome.

Papanicolaou Smear에서 채취기구에 따른 자궁경부 세포진의 비교검토

노흥태 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

As a population screening test, the Papanicolaou smear has been shown to be effective in reducing the incidence of invasive carcinoma of the cervix. However, one of the problems with screening is the occurence of false negative results with the smear test. Analysis of the reasons behind false negative reports has identified two broad areas where errors are likely to be made : in the laboratory and in the sampling procedure. In order to find out the importance of sampler in cervical cytology to detect early cervical neoplasia, we performed this study on 396 patients by using cervex-brush(105 women), cytobrush(95 women), spatula(96 women), and cotton swab(100 women). Attributes tabulated included the following: background (hemorrhage, cell destruction, mucus) and cell component(squamous & columnar cells, clot, sheet, single) in percent per slide The following results were obtained: 1. In the background, hemorrhage was least in samples using the cotton swab and cell destruction was significantly smaller in samples using cervex-brush and cytohrush than in cotton swab(p 0.05). Mucus was not significant between 4 devices. 2. In the cell component, the incidence for the presence of squamous cells was significantly higher in samples using the cervex brush and spatula than in cotton swab(p 0.05). The incidence for the presence of columnar cells was highest in samples using the cervex-brush, next was cytobrush. 3. In the cell distribution, clot was not significant between 4 devices. Sheet was not significant only between cervex-brush and spatula. Single cell was noted in highest rate in samples using the cervex-brush. But cotton sawb and cytobrush(p=0.2587), cotton swab and spatula (p=0.4326) were not significant. 4. In the analysis of the results over class III Pap smear, cervex brush was higher detection than the cotton swab(p 0.05). From the above results, cervex-brush, as like cytobrush, was important sampler in mass screening of early cervical neoplasia with Pap smear. And the use of cotton swab was not good.

Minoclonal Antibody Ki-67을 이용한 자궁암증식 동태에 관한 연구

노흥태 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

Cell proliferation of normal cervical tissues(5 cases), normal endometrial tissues(5 cases), cervical cancer tissues(8 cases), endometrial cancer tissues(10 cases) were assessed by immunohistochemical method using the monoclonal antibody Ki-67, which reacts with a nucleal antigen only in proliferating cells(late G1, S, M and G2 phase). The percentage of cells recognized with ki-67 (growth fraction) was calculated. Growth fraction was examed in 30.3±4.2% in cervical cancer tissues, 25.1±2.3% in ehdometrial cancer tissues, 19.5±2.9% in normal endometrial tissues and 9.7±2.4% in normal cervical tissues. Growth fraction in malignant cases was higher adenocarcinoma. In endometrial cancer, ki-67 positive cell rate had no relation to histological grade. This technique is quite simple and new to detect cancer cells from the point of growth potential. This result suggests that determination of growth fraction by monoclonal antibody ki-67 is useful in prognostic marker.

膣 트리코모나스 및 칸디다症의 臨床統計的 考察

盧興泰 충남대학교 의과대학 지역사회의학연구소 1977 충남의대잡지 Vol.4 No.2

Clinical study on trichomonas & Candida vaginitis was done on the 400 women who visited the Chungnam Hongseung Province Hospital, Chungnam Hongseung Kun Health Center and Chungnam Cheungyeang Kun Health Center Branch during the 6 Month, from April to September 1977, obtaining the following results: 1. In the Prevalence of Trichomonas & Candida infections on each group, pregnancy group was highest prevalence. 2. In relation to the pregnancy, the prevalence of trichornonas and candida infections was 32.8% and 41.9%, respectively. In relation to the duration of pregnancy, first trimester was highest prevalence of 52.3% in Trichomonas, but in candida, prevalence increased as the duration to the oral pill users, the prevalence of trichornonas & Candida infections was 27.4% & 38.7%, respectively. 4. In loop group, the prevalence of trichomonas & candida infections was slightly higher than that of control. 5. Mixed infections was 4.4%. In classfiying the groups, prostitutes group was highest prevalence of 7.5%. 6. The most commonly affected age group for both trichomonas and candida infections was 30∼34 years. 7. The prevalence of trichomonas & candida infections was higher in the lower education group. 8. The prevalence of trichomonas & candida infections with leukorrhea was 28.1% and 37.3%, respectively. 9. The prevalence of trichomonas & candida infections in persons with no subjective symptom was 10.4% and 13.8%, respectively. 10. In diagnostic methods, wet smear & culture was similar results in trichomonas infections, but in candida, culture was higher than wet smear.

경계성 난소 종양의 임상적 고찰

노흥태,이종범 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.2

Approximately 10 20% of epithelial ovarian tumors are tumor of borderline malignancy or carcinoma of low malignancy potential. Epithelial stratification, cellular atypia, mitotic activity, and absence of ovarian stromal invasion set the histologic criteria for diagnosis. The aim of this study was to analyse the group of patients with borderline ovarian tumors. The analysis included 39 patients, operated for ovarian tumor of borderline malignancy in the Gynecological Department of Chungnam National University Hospital from May 1992 to April 1999. The study takes into account comparison of: age of patients, obstetrical past, clinical signs and symptoms, clinical stage(according to FIGO), type of surgery, tumor pathology, post- surgical treatment. Furthermore, long-term follow-up was assessed. The incidence of borderline malignant ovarian tumor was 28.3%. The mean age was 39.2 years (range, 15 to 79). The most common chief complaint was palpable mass(41.0%). 94.8% of tumors were recognised in stage I (FIGO). 74.4% of the tumors were histological mucinous, 25.6% were serous. All patients were treated by surgery and 17.9% received cisplatin-containing chemotherapy.

대전시내 여학생의 초경에 관한 연구

노흥태 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.2

Menarche is an important life event in girls biologically and the onset of the menarche differs with the individual and is affected by such variables as climate, genetics, socio-economic status, ethnicity, geographical location and general physical condition. In an effort to evaluate the experience rate of menarche, the age of menarche, the relation between menarche and height, the knowledge concerning menarche and emotional responses for menarche, the author conducted surveys for 1490 girls, who are primary, middle, high school girls, college and business women. The results obtained from the surveys are as follows. 1. Experience rate of menarche was 12.6% in primary school, 66.8% in the middle school, 99.0% in the high school, 98.9% in the college girls, 100% in the business women. 2. The mean age at menarche was 13.9±1.4 years. The earliest age of menmche was 9 and the latest age 18. 3. According to age group, menarche occurs sooner by degrees. 4. The shorter girls had earlier menarche and the taller girls had later. 5. Knowledge concerning menarche was obtained mostly from school teacher and friends or sisters. 6. 84.5% of total number experienced fear and anxiety at the occurrance of menarche.

가속도 기반 분산 멀티미디어 동기화

노흥태,배종식,배인한 대구효성가톨릭대학교 응용과학연구소 1995 응용과학연구논문집 Vol.4 No.-

Multimedia synchronization techniques are an important field in the implementation of multimedia applications. We study multimedia synchronization schemes and suggest an ac-celeration-based multimedia synchronization scheme. In this scheme, if the slave device of the receiver detects asynchrony between master and slave media, the slave device ac-celerates or decelerates slave media presentation speed.

자궁 경부암 Ib기 환자에서 Peritoneal Cytology의 유용성

노흥태,유병대 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

To determine the incidence of positive peritoneal cytology and to evaluate its usefulness in the management of patients with early-stage cervical cancer, peritoneal cytology was studied in 61 women undergoing primary surgical exploration for International Federation of Gynecology and Obstetrics stage Ib cancer of the cervix between January, 1987 and December, 1992. Charts were reviewed retrospectively for clinicopathologic data concerning patient's age, pathologic type, invasion depth, lymphovascular and lymph node involvement. The results were following : 1. There was no positive peritoneal cytology in the carcinoma of cervix, stage Ib. 2. The peritoneal cytology was riot related with patient's age, pathologic type, invasion depth, lymphovascular and lymph node involvement. 3. The routine collection of cytologic specimens at laparotomy should he abandoned in this setting.

人蔘이 Vinblastine을 投與한 家兎의 肝機能에 미치는 影響

盧興泰 충남대학교 의과대학 지역사회의학연구소 1980 충남의대잡지 Vol.7 No.2

Vinblastine, an oncolytic agent isolated from the plant Catharantus roseus G. Don(Vinca rosea Linn.) of the family Apocynaceae, is now used commonly in clinical cancer therapy. But it has some adverse effects, which include depression of bone marrow, impairments of renal and hepatic function as well as congenital malformation of the fetus. In this investigation, the mixture of ginseng extract-vinblastine was administered intravenously to rabbits to compare the effects on the liver function with those of liver function injected vinblastine alone. Experiments were done in three groups : one day group where vinblastine (0.3mg/kg) and ginseng extract(80mg/kg) were given in a single dose, 5 days group where vinblastine (0.05mg/kg with daily increase of 0.05mg/kg) and ginseng extract (10mg/kg with daily increase of 10mg/kg) were given for 5 days, and 15 days group in that the way of 5 days group were repeated with 5 days resting interval. The results were summarized as follows : 1. Plasma concentrations of albumin and globulin after administration of vinblastine alone showed much lower value than those of control, and the values of albumin and globulin after administeration of ginseng extract-vinblastine showed higher value, nearly to control. 2. Plasma levels of GOT and GPT after administration of vinblastine alone were significantly elevated compare to those of control, but the value after administration of ginseng extract as well showed lower ones which were nearly as control. 3. Plasma concentrations of B. S. P. retended after administration of vinblastine alone showed much higher value than those of control, but the value was not significantly different when ginseng extract was added. 4. Plasma bilirubin level showed higher value with the administration of vinblastine alone, but as ginseng extract was added, the value was not significantly different from that of control. 5. Plasma concentration of cholesterol after administration of vinblastine alone showed much higher value than that of control, but as ginseng extract was given together with vinblastine, it showed as nearly low as control.