http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Treatment of Malignant Tumor with Dissolving Microneedle Array using Antigens and Immune-modulators
황위보,김다훤,여사연,정지훈 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
Microneedles (MNs) is a therapeutic tool for delivery of drugs to biological tissue. They permit drug delivery at clinically relevant rates across the different layers of skin tissue with minimal damage and pain or irritation. Recently, various types of MNs have been applied for targeting cancer. Among them dissolving MNs have received attention owing to their ability to dissolve quickly after applying to the skin. Imidazoquinoline, one of the therapeutic agents, is used in cancer therapy in a way to modulate immune response. In this study, dissolving MNs were designed by using amphiphilic triblock copolymer generating in situ nano micelles (NMCs). Furthermore, resiquimod (R848) and ovalbumin (OVA) were loaded into the NMC-based MNs to inhibit tumor growth. Therefore, dissolving MNs can be considered as an efficient strategy to deliver therapeutic agents and to improve cancer treatment.
김다훤,황위보,여사연,정지훈 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
Small interfering RNA (siRNA) gene silencing, also known as RNA interference, has been considered as a potential therapeutic strategy for targeting cancer therapy. In this study, a conjugate of the low molecular weight polyethylenimine (PEI), and deoxycholic acid (DA) was further modified with 4-fluorothiophenol (FTP) (TP-DA-PEI) to achieve systemic siRNA delivery. The thiophenol group would be involved with disulfide bonds between the polymer chains and siRNA modified with free thiols (thiol-siRNA) to form and π-π interactions between the pendent aromatic groups and coprostane ring of the bile acid. The TP-DA-PEI conjugates could form stable nanoparticles with thiol-siRNA. The TP-DA-PEI conjugate not only enhanced intracellular uptake, serum stability, and transfection efficiency, but also showed high accumulation of the polyplex nanoparticles and significant tumor growth inhibition effect in tumor-bearing mice after systemic administration.
PEGylated Albumin Nanoparticles for the Delivery of Paclitaxel in Antitumor Treatment
여사연,황위보,김다훤,정지훈 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
Paclitaxel (PTX) has been used as an effective antitumor agent for the treatment of carcinomas including breast, lung, and ovarian cancer. However, the solubility of PTX limits uses of the drug. Oil and methanol mixture was used to improve its solubility in most cases, but they also bring side effects. Herein PEGylated HAS (HAS-PEG) was used for a fabrication of HAS nanoparticles which contains PTX. The HAS-PEG/PTX can be readily self-assembled with film casting and re-hydration. And the PEGylation of HAS would increase the solubility of the protein at the same time. The results suggest that the nanoparticles can be used as a platform with various hydrophobic drugs, which will reduce the formulation-mediated toxicity.