치주염 환자의 혈장과 적혈구내 S.O.D와 Catalase 활성도에 관한 연구

황승환,김병옥,한경윤,Hwang, Seung-Hwan,Kim, Byung-Ok,Han, Kyung-Yoon 대한치주과학회 1995 Journal of Periodontal & Implant Science Vol.25 No.1

It has been believed that the increased release of free oxygen radicals and their tissue damaging potency might be a contributing factor in the pathogenesis of periodontal disease. Antioxidant enzymes such as superoxide dismutase(SOD) and catalase can protect the tissue damage from the free oxygen radicals($O_2^-,H_2O_2$, and $OH^-$). In order to investigate the SOD- and catalase - activity in the blood plasma and red blood cells(RBCs) of the patients with perodontitis, 19 male periodontitis patients($25{\sim}35$ years old) who had good general health, more than 10 teeth with severely inflamed gingiva, attachment loss more than 6mm and bone loss were selected as periodontitis group, and 13 male volunteers($22{\sim}29$ years old) with good general and periodontal health were selected as normal group. After blood plasma and RBC were separated from peripheral blood of 2ml collected from antecubital vein of each subject, SOD- activity in blood plasma and RBCs was measured by the same method that Paoletti et al. did, and catalase - activity in RBC was measured by the same method that Beers et al, did. The difference of SOD- and catalase - activity between the normal and the periodontitis groups was statistically analyzed by Student t-test with SPSS/PC program.The results were as follows : 1. SOD activity in blood plasma was significantly lower in the periodontitis group($1.986{\pm}0.893$) than in the normal group($3.324{\pm}1.044$)(p<0.05). 2. There was no statistical significance in the difference of SOD- activity in RBCs between the periodontitis group($7.753{\pm}3.206$) and the normal group($8.116{\pm}1.192$)(p<O.05). 3. Catalase activity in RBCs was siginficantly lower in the periodontitis group($242.8{\pm}45.6$) than in the normal group($280.2{\pm}32.6$)(p<O.O5). The results, within the limits of the present experiment, suggest that the lowered activity of SOD in blood plasma and catalase in RBCs may be related with periodontal destruction.

자아의 분열인가, 통일성에 대한 욕망인가? -패러다임 변환기의 문화 현상으로서 도플갱어 연구(1)

황승환 ( Seung Hwan Hwang ) 한국독일언어문학회 2014 독일언어문학 Vol.0 No.63

Gebrauchlich ist das ahnliche Aussehen bekannt als ein Doppelganger. Beim literarischen Doppelganger aber handelt es sich nicht nur um die Ahnlichkeit des Aussehens, sondern auch um die Frage der Identitat. Hier deuten sich die Spaltung und die Entfremdung des Ichs an, da der literarische Doppelganger ist eine Gestaltung des Ichs ist, das die Grenze des Individuums uberschreitet. Das Denken-Tat Motiv des Doppelgangers ist ein Extremfall der Autonomie des Subjekts und steht in enger Beziehung zum romantischen Programm.Um 1800 war eine Zeit, in der sich politisch, wirtschaftlich und gesellschaftlich Zerrissenheiten, Spannungen und Widerspruche entwickelten. Viele Romantiker betrachten damalige Zeit als die zerrissene Periode und diese Gefuhle kulminieren in der Ich-Spaltungsgefuhl des Individuums. Die Spaltung des Ichs ist ein Produkt der Selbsrentfremdung, die durch die neuen Normen und Werte der Rationalitat entsteht. Der zerrissenenen und daher widerspruchlichen Wirklichkeit wenden die Romantiker den Rucken zu und versuchen in der poetischen Welt die ursprunhliche Totalitat zu finden. Man kann die Doppelganger in der Romantik fur das Phanomen halten, in dem ein Teil von diesem Versuch konkret reprasentiert wird. So gesehen, haben die Doppelganger eine Funktion, die das Unterdruckte oder das Mangel, das auf den kulturellen Zwangen beruhen, kompensiert.Jonathan Crary hat subjective vision, die um 1800 entstand, als ein wichtiges Moment des Paradigmawechsels gesehen. Goethe hat in seiner Farbenlehre versucht - im Gegensatz zu Newtons wissenschaftlichen Farbenlehren - eine Theorie von der Subjektivitat des Sehens aufzustellen. Dieses subjektive Sehen hat die Basis der aufklarerischen, absoluten Wahrheit gefahrdet und die Relativitat der Wahrheit moglich gemacht. Bei den Romantikern wird das subjektive Sehen zum kreativen Werkzeug, wodurch sie ihre Einbildungskraft sichtbar machen konnen.In den Werken mit Doppelgangermotiv werden die optischen Instrumente wie Brille, Teleskop, Mikroskop und Spiegel, welche die Grenze des menschlichen Wahrnehmungsvermogens erweitern, als ein Vermittlungstrager zwischen Wirklichkeit und Fantasie eingesetzt. Paradoxerweise tragen diese technologischen Gerate der Verzerrung der Realitat bei. Sie beschranken den gesamten Uberblick, wodurch der naturliche Zusammenhang zwischen Objekt und Wirklichkeit verloren geht.Der Doppelganger als Ich-Verdopplung, Ich-Verteilung und Ich-Vertauschung ist mise en abyme wie Spiegel im Spiegel. Wie in Die Elixiere des Teufels vom E. T. A. Hoffmann bricht das einheitliche Subjekt zusammen, und die Grenze zwischen Realitat und Irrealitat, Wirklichkeit und Fantasie, Bewusstsein und Unterbewusstsein verschwinden.Sinnliche Lust, Inzest, Vergewaltigung und Mord, was Medardus und seine Doppelganger zeigen, sind etwas Verdrangtes in der rationalen Wirklichkeit. Doppelganger ist Unsichtbares, Verheimlichtes, d.h. das, was die sozialen Normen als das Bose abgestempelt, sichtbar gemacht. DasBose ist nicht mehr das Ubernaturliche, sondern der verdrangte und unerfullte Wunsch im Unbewusstsein.Nach Freud ist der Doppelganger die Ruckkehr dessen, was im Laufe der kulturellen Entwicklung verdrangt wurde. Das unheimliche Gefuhl entsteht, wenn das Verdrangte wieder auftaucht. Die Herausforderung gegen das Tabu ist eine Provokation und eine Ablehnung gegen die Grenzen, die die zivilisatorische Gesellschaft den Menschen erteilt. Das Doppelgangerphanomen kann man als einen Versuch ansehen, die Differenz und den Zwischenraum zwischen dem Ich und dem Anderen, Subjekt und Objekt, Wirklichkeit und Fantasie, und Realitat und Abwesenheit zu vernichten und zu vereinigen.

조현병 환자에서 장기지속형 항정신병 주사제의 치료 효과와 입원율

황승환(Seung Hwan Hwang),서영은(Young Eun Seo),황현국(Hyun Kuk Hwang),최종혁(Jong Hyuk Choi) 대한사회정신의학회 2022 사회정신의학 Vol.27 No.1

연구목적 : 조현병은 심각한 장애와 높은 개인적 및 사회적 비용 부담을 일으키는 만성 질환이다. 최근 장기 지속형 주사제 항정신병 약물의 종류가 확대되면서 조현병의 만성적인 임상 경과 개선뿐 아니라 사회경제적 비용 부담도 경감시켜줄 것으로 기대되고 있다. 본 연구 에서는 국내 임상 자료를 바탕으로 장기 지속형 주사제인 아리피프라졸 장기 지속형 주사제와 팔리페리돈 장기 지속형 주사제의 임상적 효과뿐 아니라 재입원 횟수 억제 효과 등에 대해서 비교 분석하고자 한다. 방 법 : 본 연구는 후향적 의무기록을 바탕으로 한 연구이며, 대상자는 2015년 4월 이후부터 2021년 4월까지 일 병원 정신건강의학과 외래 또는 입원 진료를 통해서 아리피프라졸 장기 지속형 주사제 또는 팔리페리돈 장기 지속형 주사제를 처방받은 만성 조현병 환자로, 최소 1년 이상 해당 장기 지속형 주사제를 처방받았다. 임상 척도로 간편 정신상태 평정척도(Brief Psychiatric Rating Scale, 이하 BPRS)와 임상 전반적 임상 척도 심각성(Clinical Global Impression Scale-severity, 이하 CGI-S)의 점수를 수집했고, 그 외에 장기 지속형 주사제형 적용 전후 1년간의 입원 일수 및 횟수 등을 확인하였다. 아리피프라졸 투여군과 팔리페리돈 투여군 간의 임상적 효과 및 특징 비교 분석을 위해 Mann-Whitney U 검정과 독립표본 T 검정을 시행하였다. 그리고 각 장기지속형 주사제 투여 전후 임상 효과 및 입원 횟수 등의 비교 분석을 위해 반복측정 분산분석 시행하였다. 결 과 : 총 30명의 조현병 환자를 대상으로 하였으며 아리피프라졸 투여군은 16명, 팔리페리돈 투여군은 14명이었다. 두 투약군 모두에서 장기 지속형 주사제 적용 이후 유의하게 입원 일수와 횟수가 감소하였으며 간편 정신상태 평정척도와 임상 전반적 임상 척도 심각성의 점수가 감소하였다. 하지만 두 투약군 간의 임상 척도상 변화와 입원 일수 및 횟수 감소 효과는 유의한 차이가 발견되지 않았다. 결 론 : 본 연구는 국내에서 아리피프라졸과 팔리페리돈 장기 지속형 주사제의 임상적 효과를 비교한 첫 연구였으며, 두 항정신병 약물 장기 지속형 주사 제형 모두 조현병 환자의 임상 증상을 개선해줬을 뿐 아니라 입원 일수와 횟수를 감소시켰다. 두 약물 제형 간의 총체적인 임상적 효과는 유의한 차이는 없었으나, 각 투약군 간의 병용 약물 개수와 용량 등 임상적 특징의 차이가 있었다. 향후 더오랜 기간 다수의 연구기관에서 더 많은 환자를 대상으로 한 연구가 필요하다. Objectives : Schizophrenia is a chronic disease that causes serious disabilities and a great number of social burdens. Since a variety of long-acting injectable antipsychotics are available now, we have more options to improve the clinical course of schizo-phrenia and reduce the associated socioeconomic burden. In this study, we compared not only the clinical effects of long-acting injectable antipsychotics such as aripiprazole and paliperidone but also their impact on rehospitalization rates. Methods : This was a retrospective study using medical records in a single hospital and participants were patients with chronic schizophrenia who were prescribed the long-acting injectable form of aripiprazole or paliperidone from April 2015 to April 2021. The scores of Clinical Global Impression – Severity (CGI-S) and Brief Psychiatric Rating Scale (BPRS) were collected as clinical scales, and the number of hospitalizations and length of hospitalization were recorded. The MannWhitney U test and t-test were performed to compare the difference in demographic and clinical characteristics between the two groups. In addition, repeated-measures ANOVA was performed for change of clinical effects, the number of rehospitalizations, and admission periods before and after each treatment. Results : A total of 30 patients with schizophrenia were included, with 16 patients in the aripiprazole group and 14 in the paliper-idone group. The number of hospitalizations and length of hospitalization decreased significantly after the application of long-acting injectables, and clinical symptoms improved in both groups. However, no significant differences were found between the two groups. Conclusion : This is the first study that compared the clinical efficacy of aripiprazole and paliperidone in South Korea. Both these long-acting injectables not only improved clinical symptoms but also reduced the number of hospitalizations and length of hospitalization in patients with schizophrenia. However, no significant differences were found between the groups, al-though some clinical characteristics such as the number of drugs combined or adjunctive differed from one another. Fur-ther investigation with more participants from more sites is warranted for this conclusion.

낭만주의자 헤세와 융 심리학

황승환(Hwang, Seunghwan) 한국카프카학회 2012 카프카연구 Vol.0 No.28

치주염 환자의 혈장과 적혈구내 Superoxide dismutase 와 Catalase 활성도에 관한 연구

황승환(Seung Hwan Hwang),김병옥(Byung Ok Kim),한경윤(Kyung Yoon Han) 조선대학교 구강생물학연구소 1994 Oral Biology Research (Oral Biol Res) Vol.18 No.2

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[연료 및 윤활유부문] 대형 LPG 엔진의 노킹 특성에 관한 연구

황승환(Seunghwan Hwang),이정원(Joungwon Lee),민경덕(Kyoungdoug Min) 한국자동차공학회 2001 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2001 No.11_1

LPG has been well known as a clean alternative fuel for vehicles. Recently, several LPG engines for heavy duty vehicles have been developed, which can replace some diesel engines that are one of the main sources for air pollution in the urban area. Because cylinder bore of heavy duty LPG engine is larger then that of gasoline, The study of knock characteristics of LPG engine are needed.<br/> In this study, The knock characteristics were investigated with various engine speed, air excess ratios and LPG fuel compositions. The Knock occurrence probability decreases when engine speed is higher and propane species of LPG is lower. The Knock occurrence probability is highest at stoichiometry and decreases as the mixture strength became leaner.<br/> <br/>

당근 분말을 첨가한 Sugar Snap-Cookie의 품질 특성에 관한 연구(1)

황승환(Seung-Hwan Hwang),홍진숙(Jin-Sook Hong) 동아시아식생활학회 2010 동아시아식생활학회지 Vol.20 No.1

This study involved the making of sugar snap cookies with the addition of carrot powder at two to twelve percent which furnishes modern people with much lacking and needed dietary fiber. The review of the physiochemical properties, rheology and sensory evaluation of such contents resulted in the following findings: The sedimentation value and Pelshenke value all decreased in weak flour with the addition of more carrot powder, in comparison with the control group. The water retention capacity (WRC) and alkaline water retention capacity (AWRC) all increased in weak flour with the addition of more carrot powder in comparison with the control group. As for the gelatinization properties of the test samples measured by rapid visco-analysis, the addition of more carrot powder resulted in the initial pasting temperatures increasing in the case of weak flour, yet showing no significant difference between the control group and the carrot-added groups, as well as the maximum viscosity, minimum viscosity and final viscosity all showed the tendency of decreasing. The addition of more carrot powder led to the peak times in the mixographs for weak flour all exhibiting the tendency of decreasing, which might be interpreted as gradually weaker physical properties of the dough as well as less stability in the shape of the dough in turn.

자아의 분열인가, 통일성에 대한 욕망인가? - 패러다임 변환기의 문화 현상으로서 도플갱어 연구(2)

황승환 ( Seung Hwan Hwang ) 한국독어독문학회 2014 獨逸文學 Vol.129 No.-

In der kulturhistorischen Entwicklung gibt es große Ahnlichkeit zwischen amEnde des 18. Jahrhunderts und des 19. Jahrhunderts. Wenn am Ende des 18. Jahrhunderts die die Irrationalitat und die Absolutheit der Einbildungskraft betonteRomantik entstand, erscheinen im ausgehenden 19. Jahrhundert die geistigen undasthetischen Stromungen, die die Subjektivitat hervorheben. Es ist der Unterschied,dass sich Ich-Spaltung umfangreich und tief entfaltet. In einem Wort wird dieKultur der Jahrhundertwende fur die Hinwendung zum Inneren gehalten. Dementsprechend erscheint das Doppelgangermotiv der Jahrhundertwende vielmannigfaltiger und neuformiger im Vergleich zu dem der Romantik. Wie die Aufklarung im 18. Jahrhundert, die Rationalitat und Vernunfthervorgehoben hat, hat das 19. Jahrhundert die Ideologie des militaristischenAutoritarismus, des Nationalismus, des empirischen Positivismus und derTechnologie beherrscht. In dieser Atmosphare hat die kollektive Koharenz gestarkt,aber die individuellen Naturtriebe mussten zum Vorteil und zur Stabilitat der Gruppenunterdruckt werden. Dies ware ein Grund fur die Ruckkehr des Doppelgangersmit dem neuen Eintritt der Subjektivitat an der Wende des Jahrhunderts. Freudhat Doppelganger als die Ruckkehr des Unterdruckten im Laufe der zivilisatorischenEntwicklung angesehen. Krakauer hat Doppelganger im Weimarer Film als die Externalisierung desphilistrosen Inneres von der Mittelklasse betrachtet. Er hat Doppelganger-Film vordem Ersten Weltkrieg nur die Vorahnung des 20er Doppelganger-Films gesehen. Nach den neuen Forschungen seien aber vor dem Ersten Weltkrieg schon vieleDoppelganger-Filme vorhanden. Infolgedessen ist Doppelgangermotiv fur diekulturelle Gestalt zu halten, die nicht nur der Zeitgeist der Weimarer Republik,sondern fur die des breiteren Spektrums, d.h. einer ganzen Jahrhundertwendereprasentativ. Der literarische Doppelganger ist in Analogie zu der multiplenPersonlichkeitsstorung im Bereich der Psychopathologie. PathologischeForschungen zeigen, dass im Wandel der Zeit die Zahl der Personlichkeiten imPhanomen der multiplen Personlichkeiten standig zugenommen haben. DiesesErgebnis scheint in Korrelation zu dem Phanomen, in denen neuartige DoppelgangerFormen in den Literaturen und Filmen erschienen, zu stehen. Die Kunst ist einProdukt des Zeitgeistes, wie Krakauer ahnlich gesagt hat. Doppelgangermotive sind in den Filmen der Jahrhundertwende aufgebluht. Undnoch ein Grund dafur ist das, was Filmmedien einige Merkmale mit demDoppelganger teilen. D.h. wie Doppelganger haben Filmmedien auch die Charaktereder Unheimlichkeit, der Ich-Verdopplung, der Ich-Verteilung und derIch-Vertauschung.

증례 : 비케톤성 고삼투압성 혼수로 인해 늦게 진단된 비경련성 간질중첩증 1예

황승환 ( Seung Hwan Hwang ),홍세인 ( Se In Hong ),조동혁 ( Dong Hyeok Cho ),강호철 ( Ho Cheol Kang ),정동진 ( Dong Jin Chung ),정민영 ( Min Young Chung ) 대한내과학회 2006 대한내과학회지 Vol.71 No.1S

사회적 갈등과 글쓰기에 대한 성찰

황승환(Hwang, Seunghwan) 한국카프카학회 2016 카프카연구 Vol.0 No.36