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홍원규 ( Won Kyu Hong ),송희진 ( Hee Jin Song ),이현숙 ( Hyeon Sook Lee ),이종록 ( Jong Rock Lee ),신정현 ( Jeong Hyun Shin ),최광성 ( Gwang Seong Choi ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.8
Cowden syndrome is a rare autosomal dominant disorder characterized by mucocutaneous alterations including multiple facial trichilemmomas, oral mucosal papillomatosis, and acral keratoses. Extracutaneous lesions include polyposis of the gastrointestinal tract, and other multiple hamartoma of the internal organs. A 39 year-old man presented with multiple verruca-like papules and lichenified patches on the face, one year ago. He had been treated for atopic dermatitis for more than 10 years. Although he had been treated in accordance with atopic dermatitis for 1 year, his skin lesions had not improved, so a skin biopsy was performed. The skin biopsy specimen revealed the typical finding of trichilemmoma. Colonoscopy diagnosed diffuse colorectal polyposis. The clinical and hisopathologic findings were consistent with Cowden syndrome. We, herein, report a case of Cowden syndrome with atopic dermatitis. (Korean J Dermatol 2007;45(8):829∼831)
광범위한 탈모범위를 지닌 난치성 원형 탈모증 환자의Anthralin 국소 치료의 효과
홍원규 ( Won Kyu Hong ),신정현 ( Jeong Hyun Shin ),최광성 ( Gwang Seong Choi ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.5
Background: Extensive alopecia areata (EAA) is resistant to multiple individual treatment modalities and has poor prognosis for cosmetically adequate regrowth. Anthralin is a widely used topical anti-psoriatic drug that may have an immunomodulating effect on AA as is does in psoriasis. But, there has only been small number of clinical trials of anthralin in the treatment of AA. Objective: The purposes of the study were to evaluate the efficacy, prognostic factor, side effects and recurrence rate of topical anthralin therapy in treatment-resistant EAA. Methods: A total of 16 cases of EAA (>50% scalp hair loss) who had failed in previous treatments were subjected in this study. Anthralin in 0.5% concentrations was applied to alopectic lesions for 1 hour daily over 4 weeks, gradually increasing anthralin concentration until low-grade erythema and pruritus develops. Treatment was withdrawn after complete response or if there were no signs of improvement at 6 months. Responders were followed up for 6 months after discontinuation of therapy. Results: The overall response rate was 62.5%, complete response (>90% regrowth or cosmetically acceptable appearance) was obtained in 25% of cases and, good response (50∼99% regrowth) in 39.5% of cases. In this study, among the investigated prognostic factors, there were no statistically significant factors (p<0.05, Fisher exact test). The most frequent side effects were therapeutically induced mild pruritus (93.8%), erythema (93.8%) and scale (56.3%). Other side-effects were transient folliculitis (31.3%) and regional lymph adenopathy (12.5%). Relapse was observed in 60% of responders after 6 month of follow up. Conclusion: Topical anthralin for treatment-resistant EAA is an effective therapy with tolerable side effects. Therefore, we propose the topical anthralin as a reasonable therapeutic option for treatment-resistant EAA. (Korean J Dermatol 2008;46(5):641∼647)
피부 노화 치료로서 저분자콜라겐펩타이드의 피부 항당화와 콜라겐 합성 효과
김홍석 ( Hong Seok Kim ),홍원규 ( Won Kyu Hong ),이문회 ( Mun Hoe Lee ),김형민 ( Hyeong Min Kim ),정희철 ( Hee Chul Chung ),이진희 ( Jin Hee Lee ) 대한화장품학회 2021 대한화장품학회지 Vol.47 No.2
콜라겐 가수 분해물(collagen hydrolysate, CH)은 피부 진피 섬유아세포를 자극하여 콜라겐과 엘라스틴 같은 세포 외 기질 합성을 촉진함으로써 피부 노화 방지에 도움을 주는 것으로 알려져 있다. 최근 피부 노화를 일으키는 다양한 요인 중 최종당화산물(advanced glycation end products, AGEs)이 주목을 받고 있음에도 불구하고, 아직까지 CH가 AGE축적에 미치는 영향은 연구된 바 없다. CH는 피부 구조단백질의 생성을 촉진하여 AGE 축적에 영향을 줄 수 있으므로, 이를 확인하기 위해 트리펩타이드25%, Gly-Pro-Hyp 4%를 함유한 CH인 저분자콜라겐펩타이드(low molecule weight collagen peptide, LMCP)를 이용하여 임상시험을 수행하였다. 피부 조직 내 AGE 축적량을 평가하기 위해 AGE reader를 사용하여 피부자가형광(skin autofluorescence, SAF) 값을 측정하였다. 0.5%와 1.0% LMCP 용액을 8 주 동안 피험자의 전박에 도포한 결과, 시험부위의 SAF값이 대조부위에 비해 유의하게 감소하였다. 추가적으로, LMCP에 의한 피부섬유아세포의 콜라겐 합성 촉진을 평가하기 위해 CCD-986sk를 이용하여 in vitro test를 수행하였다. 그 결과, 800 μg/mL의 LMCP는 CCD-986sk의 human pro-collagen Iα1(COL1A1) 합성을 증가시켰다. 본 연구를 통해 LMCP도포가 콜라겐 합성을 촉진하여 항당화 효과에 도움을 줄 수 있다는 것을 확인하였으며, 이는 LMCP가 노화 방지 화장품 원료로써 잠재력이 있음을 시사한다. Collagen hydrolysate (CH) is known to prevent skin aging by stimulating skin dermal fibroblasts to promote synthesis of extracellular matrix such as collagen and elastin. Recently, among the various factors that cause skin aging, advanced glycation end products (AGEs) have received particular attention. However, the effect of CH on AGE accumulation has not been studied. Since CH could affect AGE accumulation by promoting production of skin structural proteins, clinical trial was performed using low molecule collagen peptide (LMCP), which were CH containing 25% tripeptide and 4% Gly-Pro-Hyp. Skin autofluorescence (SAF) values were measured using an AGE reader to evaluate accumulation of AGE in skin. As a result of applying 0.5% and 1.0% LMCP solutions to the subject's forearm for 8 weeks, the SAF value at the test site significantly decreased compared to the control site. Additionally, in vitro test was performed using CCD-986sk to evaluate the promotion of collagen synthesis in skin fibroblasts by LMCP. As a result, 800 μg/mL of LMCP significantly increased synthesis of human pro-collagen Iα1 (COL1A1) in CCD-986sk. Through this study, we have confirmed that tropical LMCP applications can promote collagen synthesis to help anti-glycation effects, suggesting that LMCP has potential as an anti-aging cosmetic material.
이혜영 ( Hye Young Lee ),홍원규 ( Won Kyu Hong ),신정현 ( Jeong Hyun Shin ),노주영 ( Ju Young Roh ),이종록 ( Jong Rok Lee ) 대한피부과학회 2006 대한피부과학회지 Vol.44 No.11
An umbilical omphalomesenteric duct polyp arises from remnants of the omphalomesenteric duct, which connects the midgut to the Yolk sac of the embryo and is closed completely at 7 weeks. Persistence of the omphalomesenteric duct shows various clinical manifestations of embryologic anomalies such as umbilical enteric fistula, Meckel`s diverticulum or vitelline cysts. In particular, the umbilical omphalomesenteric duct polyp should be clinically discerned from persistent granulation tissue or pyogenic granuloma and attention should be given to external openings with discharge, which can be suggestive of underlying anomalies. We herein report an case of an umbilical omphalomesenteric duct polyp in a 10-year-old male who had no underlying anomalies. (Korean J Dermatol 2006;44(11): 1342~1344)
PC 네트워크에서의 화일전송 프로토콜의 설계 및 구현에 관한 연구
한선영(Sunyoung Han),김찬우(Chan Woo Kim),홍원규(Won Kyu Hong) 한국정보과학회 1988 정보과학회논문지 Vol.15 No.6
본 논문에서는 호스트 컴퓨터에 연결되어 쓰이는 PC들 사이의 파일전송을 위한 파일전송 프로토콜을 설계하고 구현하였다. 호스트 컴퓨터에 Routing 기능을 둠으로써 근원지 노드에서 목적지 노드로의 파일전송이 가능토록 설계하였다. 본 논문에서는 PC간의 파일전송을 위하여 각종 PC를 포함하여 다양한 컴퓨터에 구현이 되어있는 Kermit 프로토콜을 이용하였다. Kermit은 소스 프로그램이 공개되고 있기 때문에 쉽게 그 수정이 용이하고 이식성도 매우 높기 때문에 본 연구에서는 Kermit을 이용하였다. 그러나 Kermit 프로토콜은 Routing 기능을 제공하지 못하고 있다. 본 논문에서는 Routing과 Addressing 기능등을 추가하여 Packet과 그 프로토콜을 설계하였다. UNIX운영체제를 갖는 VAX 11/750 컴퓨터에 MS-DOS 운영체제의 PC/XT들이 Star Topology로 연결되어 있는 환경에서 설계된 프로토콜이 구현된다. This paper presents the design and implementation of a file transfer protocol between PC's which are connected via a host computer system. The host computer has a routing function so that a source node may transfer files to a destination node. In designing the protocol we use Kermit Protocol which supports a file transfer between various heterogeneous computers including several kinds of PC's. Kermit Protocol does not support routing function. We extended the Kermit Protocol to have routing function. The designed Protocol was implemented under UNIX which has connections to PC/XT under MS-DOS with Star topology.