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제주 재래종 감귤 ‘홍귤’, ‘편귤’ 과피 분획물의 항산화, 항염증 효과
현주미(Ju Mi Hyun),박경진(Kyung Jin Park),김상숙(Sang Suk Kim),박석만(Suk Man Park),이영재(Young Jae Lee),안현주(Hyun Joo An) 한국생명과학회 2015 생명과학회지 Vol.25 No.10
한약재로 사용되고 있는 제주 재래 감귤 중 홍귤, 편귤 품종 과피 추출물의 기능성 소재로서의 활용 가능성을 알아보기 위해 용매별 분획물이 보유한 항산화 및 항염증 활성을 조사하였다. 홍귤, 편귤 모두 부탄올 분획물에서 총 페놀성 화합물의 함량이 각각 534.4 mg/g, 342.9 mg/g으로 가장 높았으며, 그 다음으로 에틸아세테이트, 헥산, 그리고 물 분획물 순이었다. 총 플라보노이드 함량에 있어서도 부탄올 분획물에서 홍귤 431.8 mg/g, 편귤 415.7 mg/g으로 가장 높게 나타났다. DPPH 라디칼 소거활성은 부탄올 분획물 1 mg/ml 에서 홍귤(89.2%), 편귤(64.2%) 모두 가장 높았으며, ABTS 라디칼 소거활성에 있어서도 두 품종 모두 부탄올 분획물에서 낮은 농도에서도 매우 우수한 활성을 보였으며 그 뒤로 에틸아세테이트, 헥산, 물 분획물 순이었다. 항염증 효과 측정에서 홍귤, 편귤 에틸아세테이트 분획물 모두 NO, IL-6, iNOS 및 COX-2 단백질 생성 억제 효과를 확인할 수 있었다. 특히 홍귤 에틸아세테이트 분획물 100 μg/ml 농도에서 항염증 효과가 우수하였다. This study investigated the anti-oxidative and anti-inflammatory activity of unripe fruit peel solvent fractions of the native jeju citrus ‘Hongkyool’ (Citrus tachibana Tanaka) and ‘Pyunkyool’ (C. tangerina Hort. ex Tanaka). The total polyphenol content and total flavonoid content were highest in the butanol fraction of both ‘Hongkyool’ (534.4 mg/g, 431.8 mg/g) and ‘Pyunkyool’ (342.9 mg/g, 415.7 mg/g). In both cultivars, the butanol fraction showed the strong antioxidant activity by DPPH radical scavenging and ABTS radical scavenging. The DPPH radical scavenging of the butanol fraction from ‘Hongkyool’ and ‘Pyunkyool’ was 89% and 64% at a concentration of 1 mg/ml, respectively. The ABTS radical scavenging of the butanol fraction from ‘Hongkyool’ and ‘Pyunkyool‘ was 94% and 85% at a concentration of 1 mg/ml, respectively. We investigated the effect of the anti-inflammatory activity of the ethyl acetate fraction from ‘Hongkyool’ and ‘Pyunkyool’ on LPS-induced NO production, IL-6, iNOS, and COX-2 protein expression in Raw 264.7 cells. At concentrations of 50 and 100 μg/ml of the ‘Hongkyool’ ethyl acetate fraction, the anti-inflammatory effect was excellent. These results suggest that ethyl acetate and butanol fractions from ‘Hongkyool’ and ‘Pyunkyool’ could be useful functional materials, with anti-oxidative and anti-inflammatory properties.
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무선재추출법에 기초한 사건관련전위 자료분석에 대한 탐색적 고찰
현주석 ( Joo-seok Hyun ) 한국감성과학회 2017 감성과학 Vol.20 No.2
가설검증 과정에서 자료 분석 결과 산출된 통계치에 대한 해석은 몇 가지 통계학적 이론을 토대로 분석 결과 산출된 관련 통계치의 이론적 확률 분포에 의해 좌우된다. 예를 들어 실험 조건 간 측정치의 평균 차이에 대한 통계적 유의미성은 대개 전집 특성에 대한 몇 가지 이론적 가정에 기초해 구성된 해당 평균 차이값의 확률 분포(예: Student`s t)에 기초해 결정된다. 본 연구는 이러한 이론적 통계치의 분포가 아닌 실측정 자료의 무선 재구성을 통해 얻어진 경험적통계치의 분포에 기초해 가설 검증을 시도하는 무선재추출법의 기본 논리와 장점을 살펴보고 사건관련전위 분석 상황에서의 응용 가능성을 모색하였다. 더 나아가 무선 추출 원리에 기초한 무선치환법이 적용된 구체적 사례를 소개하고 ERP 자료 분석에 있어서 경험적 통계 분석 적용에 앞서 유의할 점을 살펴봄으로써 뇌파 연구자들의 무선재추출법에 대한 정확한 이해를 도모하였다. In hypothesis testing, the interpretation of a statistic obtained from the data analysis relies on a probabilistic distribution of the statistic constructed according to several statistical theories. For instance, the statistical significance of a mean difference between experimental conditions is determined according to a probabilistic distribution of the mean differences (e.g., Student`s t) constructed under several theoretical assumptions for population characteristics. The present study explored the logic and advantages of random-resampling approach for analyzing event-related potentials (ERPs) where a hypothesis is tested according to the distribution of empirical statistics that is constructed based on randomly resampled dataset of real measures rather than a theoretical distribution of the statistics. To motivate ERP researchers` understanding of the random-resampling approach, the present study further introduced a specific example of data analyses where a random-permutation procedure was applied according to the random-resampling principle, as well as discussing several cautions ahead of its practical application to ERP data analyses.
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현주정(Hyun Joo Jung),안길영(Ahn Gil Young),고선혜(Ko Sun Hye) 한국여성체육학회 1998 한국여성체육학회지 Vol.12 No.-
Relationship between training anxiety and sports injuries of table tennis player in order to examine the relationship between the characteristics of ping-pong player`s movement and sports injuries, I conducted a survey based upon a randon sampling with 300 athelets, 50 athelets form each sex and each high school, college, and adult group. The result is as following : 1. There are three forms of sports injuries according to sex. The first one in skin injuries such as abrasion, blisters and boils. The second in muscle and tendon injuries such as cramps and bruise. The third one in injuries related to nerve and sensory organs like neuralgra and sight disorder. According to age, blisters mainly appeared as skin injuries, neuralgra and sight disorder as injuries related to nerve and sensory organs. There are also specified injuries according to the paddle holding style. Boils mostly appeared as a main skin inquiry, cramps and destruction of subcutaneous tissue as a main muscle and tendon injuries. The statistics showed significant differences among surveyed groups according to sex, age and the paddle holding style mentioned above. 2. There were sports injuries related to intensity and frequency, respectively. According to frequency, there were abrasion, blisters, boils, rooting-out of fingernail and toenails for skin injuries. For muscle and tendon injuries, there were cramps and contusions, for joints, dislocation, damage of cartilage, arthritis and chronic joint distortion. In the nerve and sensory organs frequently appeared concussion of the brain, neuralgra, sight disorder and paralysis. According to intensity, all the sysmptoms and injuries appeared from all the three surveyed groups. 3. In the comparison by sex age, there were statistically noticeable differences in the level of p$lt;.01, p$lt;.001. The differences by sex revealed in the abdomen and the difference by age revealed in knee joints and feet. 4. In the comparison by the paddle holding style, there were statistically conspicuous differences in the level of p$lt;.05. The differences appeared in upper limbs specifically arms and in lower specifically thigh. 5. In the comparison by intensity and frequency, there showed statistically noticeable differences in the head, upper limbs, lower limbs and feet.
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현주,박태관,장지호,온영훈,Joo Hyun,MD,Tae Kwann Park,MD,PhD,Jee Ho Chang,MD,PhD,Young-Hoon Ohn,MD,PhD 대한안과학회 2012 대한안과학회지 Vol.53 No.7
Purpose: To report specific spectral domain OCT findings of Oguchi disease diagnosed with fundoscopic examination and electrophysiological study. Case summary: A 14-year-old patient visited our clinic with a complaint of night blindness for ten years. Fundoscopic examination showed a golden-yellow fundus reflex. After three hours of dark adaptation, the fundus color returned to normal (Mizuo-Nakamura phenomenon). In full-field ERG, rod b-wave was not detectable. The a-wave amplitude in maximal combined response increased after three hours of dark adaptation, although the b-wave amplitude was similar to the amplitude before dark adaptation, demonstrating a negative waveform. In the spectral domain OCT images of the perifoveal area, no gap between the retinal pigment epithelium and the inner segment/outer segment (IS/OS) junction was detected before prolonged dark adaptation, and a highly reflective band was shown. However, the gap appeared after three hours of dark adaptation, and two highly reflective bands were detected in the OCT images. Conclusions: The characteristic OCT finding in addition to the specific fundoscopic finding and full-field ERG results may be useful to diagnose Oguchi disease. J Korean Ophthalmol Soc 2012;53(7):1041-1045
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현주미 ( Ju Mi Hyun ),김정은 ( Jung Eun Kim ),염현숙 ( Hyun Sook Yeum ),송정민 ( Jung-min Song ),김미량 ( Mi Ryang Kim ),이남호 ( Nam Ho Lee ) 대한화장품학회 2016 대한화장품학회지 Vol.42 No.3
본 연구에서는 세토카 가지 정유의 주요 성분을 분석하고 이들의 항균, 항염 및 세포독성 실험을 진행하였다. 세토카는 제주도에서 널리 재배되고 있는 감귤류의 품종이다. 세토카 나무의 가지는 간벌 작업으로 인해 대부분 폐기되고 있고, 이러한 폐자원의 활용은 최근 많은 관심을 받고 있다. 정유 성분은 세토카 가지의 에탄올추출물을 호호바오일로 처리하여 얻었다. 세토카 정유의 주요 성분은 ethyl linoleate (64.1%), ethyl palmitate (16.5%), neophytadiene (11.1%) 및 β-citronellol (5.1%)임을 확인하였다. 이들의 항균활성을 확인하기 위하여 피부 관련 미생물에 대한 paper disc 확산법을 실시한 결과 Staphylococcus aureus 및 Propionibacterium acnes에서 좋은 항균활성을 보였다. 또한 항염활성을 확인하기 위해 lipopolysaccharide (LPS)로 염증이 유도된 대식세포에서 nitric oxide (NO) 생성량을 측정한 결과 세토카 정유 성분은 농도의존적으로 NO 생성을 저해하였다. WST-1 분석법을 이용하여 세포독성을 측정한 결과 RAW 264.7 macrophage 및 HaCaT 각질형성세포에서 세포생존율이 무처리 대조군과 비슷한 결과를 보였다. 이러한 결과를 바탕으로 세토카 가지 정유는 세포독성이 없으면서 염증억제 및 항균효과가 있음을 확인하였으며, 이를 응용한 화장품소재로써의 개발이 가능할 것으로 여겨진다. This study was designed to analyze the chemical compositions of ‘Setoka’ branch essential oils (SEBO) and to test their biological activities. ‘Setoka’ is a Citrus species widely cultivated in Jeju Island. At the present, ‘Setoka’ branches produced by thinning process were mostly discarded as a waste. Therefore, utilization of this branch waste has received much attention. ‘Setoka’ branch essential oils (SBEO) were prepared by treatment of its ethanol extracts with jojoba oil. SBEO were chemically analyzed using gas chromatograph-mass spectrometry (GC-MS), and following components were identified; ethyl linoleate (64.14%), ethyl palmitate (16.50%), neophytadiene (11.06%) and beta-citronellol (5.09%). The anti-inflammatory activity in the SBEO was examined using RAW 264.7 murine macrophage cells stimulated with LPS. As a result, the SBEO inhibited nitric oxide (NO) productions with a dose-dependent manner. In addition, SBEO showed good anti-microbial activities against drug-susceptible and -resistant skin pathogens such as Staphylococcus aureus and Propionibacterium acnes, which are acne-causing bacteria. Based on these results, we suggest that SBEO has the possibility for use as an anti-inflammatory and anti-microbial agent in cosmetic applications.
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