기저양 모낭 과오종

한은실,서성준,홍창권,송계용,노병인 ( Eun Sil Han,Seong Jun Seo,Chang Kwun Hong,Kye Yong Song,Byung In Ro ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.2

Basaloid follicular hamartoma(BFH) is a benign adnexal tumor with a wide spectrum of clinical appearance and is characterized histologically by the presence of branching cords and thin strands of undifferentiated anasomosing, basaloid proliferations that are embedded in a fibrous stroma. It has been often misdiagnosed and treated as basal cell carcinoma. We report a 57-year-old woman with BFH on the face which is similar to basal cell carcinorna clinically that turned out to be a solitary BFH histologically. There has been no recurrence during one year of follow up after excisional biopsy. (Kor J Dermatol 1997;35(2): 303-306)

최근 10년간 대상 포진 환자의 임상적 관찰

한은실,최흥렬,서성준,홍창권,노병인 ( Eun Sil Han,Heung Ryeol Choi,Seong Jun Seo,Chang Kwun Hong,Byung In Ro ) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.2

대상 포진(Herpes zoster or shingles)은 Varicella Zoster(V-Z) virus에 의해서 발생되며 한개 혹은 수개의 후근 신경절로부터 신경 분포를 따라서 편측성으로 발생하는 수포성 질환이다. 대상 포진의 병인은 확실히 밝혀지지는 않았으나 대체로 과거에 수두를 앓은 후 V-Z virus가 후근 신경절에 잠복해 있다가 이후에 면역성이 저하되거나 그외의 유발인자 즉 물리적 기계적 손상 등을 받게되면 활성화되어 피부의 말초신경에 파급되어 그 분포된 부위의 피부에 포진이 발생하는 것으로 알려져 있으나 재감염이라는 보고도 있다. 본교실에서는 이미 1983년도에 대상 포진의 임상적 관찰에 관하여 보고한 바 있으며, 저자들은 그 이후의 변화 추이를 알아보기 위하여 본 연구를 시행하였다. Background: Herpes zoster is characterized by vesicular skin esions over the unilateral sensory dermatomes being caused by the reactivation of varicella-zoster virus and its incidence seems to be increasing recently. Objective: The purpose of this study was to elucidate the epidemiology and the clinical characteristics of herpes zoster. Methods:The authors observed 877 cases of herpes zoster clinically for annual incidence, age, sex, monthly distribution, predilection site, associated diseases, and compications at the Department of Dermatology in Chung-Ang University Hospital during a 10 years period(1982.9-1992.8). Results: 1) The annual incidence averaged over 10 years was 2.26%(877 cases of total 38,717 outpatients) being on the increase recently. 2) The age distribution was in the range of 2-86 years old being most prevalent in the 6th decade and there was equal sex ratio(444:433). 3) There was no statistically significant monthly or seasonal variation in the incidence of herpes zoster. 4) The most common anatomical distribution was thoracic dermatome(51.7%), followed by trigeminal(17.1%), cervical(16.1%), lumbar(10.6%), sacral(1.4%) and multiple dermatomic involvement(3.1%). Left or right side was affected in about the same ratio(439:437), and bilateral involvement was in 1 case. 5) Associated diseases of herpes zoster were observed in 210 patients(23.9%);hypertension(7.0%), diabetes mellitus(4.1%), tuberculosis(1.8%), postoperative stauts(0.7%), malignancy(0.7%), gastric ulcer(0.7%), and so on. 6) The most common complication of herpes zoster was postherpetie neuralgia(7.4%), followed by eye complication(2.1%), bacterial infection(1.4%), scar formation(0.7%), neurogenic bladder(0.2%), Ramsay-Hunt syndrome(0.2%), motor paralysis(0.1%), herpes zoster generalisatus(0.1%). 7) The incidence of postherpetic neuralgia increased with age and was highest in trigeminal dermatome. 8) Recurrence of herpes zoster was observed in 4 patients(0.5%) Conclusion:According to this study, the annual incidence of herpes zoster showed a tendency to increase recently but there was no significant monthly or seasonal variation. The anatomical distribution was most commom on the thoracic dermatome. The incidence of postherpetic neuralgia increased with age being most common in trigeminal nerve.(Korean J Dermatol 1994;32(2):286~293)

가족에서 발생한 신경종성 상피병을 보이는 신경섬유종증 2예

한은실(Eun Sil Han),서성준(Seong Jun Seo),홍창권(Chang Kwun Hong),노병인(Byung In Ro) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.4

We reported two cases of elephantiasis neurofibromatosa in a family. The first case was the son of the second case. Both patients showed huge masses and bone changs. They were treated by surgical excision due t,o functional and cosmetic problems. The histopatholog.c findings of the two cases were consistent with neurofibroma, (Kor J Dermatol 1994; 32(4): 724-723)

MIG 헤드의 가상 갭과 금속 두께가 재생 전압 스펙트럼에 미치는 영향에 관한 컴퓨터 시뮬레이션

한은실(Eun Sil Han),조순철(Soonchul Jo) 대한전자공학회 1994 대한전자공학회 학술대회 Vol.1994 No.7

안드로겐성 탈모증의 임상적 고찰

한은실(Eun Sil Han),김명남(Myeung Nam Kim),홍창권(Chang Kwun Hong),노병인(Byung In Ro) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.1

Backpound : Androgenetic alopecia is considered to be a gentially determined disorder influenced by age and andren. The proportion of patients with endrogenetic alopecia among the total number of patients with alpecia seems to be gradually imreasing. Objective : The purpose of this study is to determine the family history, clinical and endocrine status of the patients with androgenetic alopecia. Methods : 387 patients with androgenetic alopecia who had visited the Department of Dermatology, Yongsan Hospital, College of Medicine, Chung-Ang Jniversity during the last 4 years(1990.1-1993.12) were examined. Results : 1) Annual incidence of aodrogenetic alopecia among the to al number of alopecia patients averaged over 4 years was 38.9 having increased recently. 2) There were 286 male and 101 female patients being mosip, evalent in the 3rd decade in both sexes. 3) Patients younger than 30 years old, patients with premat trandrogenetic alopecia, made up 68,5% of the male patients and 56.4% of the female patients with androgenetic alopecia. 4) Of the 73 male patients Hamiltons type III was most cornon (46, 63.0%). 5) Of the 34 female patients Ludwigs type I was most comnorf, 21, 61.2%. 6) There was a family history of baldness in 39.4% of first the gree relatives in male patients and 41.2% of first degree relatives in female patients. 7) Associated diseases were observed in 152 (53.1%) of the male patients and 63 (62.4%) of the female patients, seborrheic dermatitis (36.7%/35.7%), acne vulgaris (5.2%/5.9%), atopic dermatitis, thyroid diseasea, pulmonary tuberculosis, depression, and gastrointestinal diseases. In female patients menstrid irregularity, hypertrichosis, and plycystic ovary disease were also observed. 8) Serum testosterone levels were increased in 24 (8.8%) of male patients and in 17 (17.4%) of female patients. Conclusion : Based on our findings, the development of andrignetic alopecia is significantly related to the positive family history of baldness. Serum test as erone levels in most patients were within normal limit and were increased only in a sm 11 number of the patients with androgenetic alopecia. Therefore, it seems reasonable to suggest that the inhibitory effects of androgens on the dermal papilla cells may be mediated by decreased density and/or functional activity of androgen receptors or through an accelera biom the metabolic activity of androgen. (Kor J Dermatol 1995; 33(1): 44-52)

여러 가지 불소 고분자들의 구조와 특성

한은실(Eun Sil Han),이범재(Bum Jae Lee) 한국공업화학회 1999 공업화학전망 Vol.2 No.2

N/A

MIG 헤드 가상 갭에 의한 재생 전압 스펙트럼 Bump의 컴퓨터 시뮬레이션

한은실(Eun Sil Han),조순철(Soonchul Jo) 한국자기학회 1994 韓國磁氣學會誌 Vol.4 No.2

This paper describes the occurance of bumps in playback spectrum while reading with MIG heads. The amplitudes of the bumps in theoretically predicted frequencies are investigated by computer simulation. Three cases of MIG head structure are simulated, one without pseudo gaps, the other two with pseudo gap thicknesses of 0.02㎛, and 0.2㎛ on both sides of the main gap, respectively. It is assumed that metal powder tapes are used. The results show that the bumps occur at predicted frequencies and the amplitudes of the bumps agree well with predicted values.

전환된 각질형성세포주에 의한 마우스 Dendritic Epidermal T Cell ( V 5/V 1 + T 림프구 ) 의 활성화 반응

서성준(Seong Jun Seo),한은실(Eun Sil Han),김명남(Myung Nam Kim),홍창권(Chang Kwun Hong),노병인(Byung In Ro) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.11

Background:Dendritic epidermal T cells(DETC) are skin specific members of the epithelial γδ-T cell family that reside normally in mouse epidermis. Although the mechanisms of antigen recognition by αβ-T cells have become better defined, the physiological role of the γδ-T cells and ligands they recognize are still poorly understood. Object:In the present study we sought to elucidate the antigen specificity and whether the DETC recognize transformed keratinocyte derived antigen. Method:We used a DETC and TCR(-) DETC which were obtained by 1600R γ-irradiation and sorting, in addition to transformed keratinocyte cell lines. We performed coculture experiments of DETC/transformed keratinocyte cell lines to detect direct evidence that DETC recognize the keratinocyte-derived antigen. Result:1. TCR negative variants of DETC do not respond to concanavalin(Con)-A, but respond to phobol myristate acetate(PMA)/ionomycin. 2. PAM 212, UV-irradiated PAM 212 and heat shocked PAM 212 cells stimulate DETC. PAM 212 cells could perform as stimulator of DETC even in the absence of stress signal. 3. UV irradiated XB2 cells stimulate DETC, but XB2 and heat shocked XB2 cells could not stimulate DETC. 4. DETC do not respond to fibroblast, UV-irradiated fibroblast and heat shocked fibroblast 5. TCR negative variants of DETC are no longer stimulated by PAM 212 cells, suggests that PAM 212 cells mediate their effects through the TCR Conclusion:The above results strongly suggest that DETC recognize specific, transformed and stressed keratinocyte-derived antigens and may play a role as an immune surveillant for cellular damage. Therfore, DETC may play critical roles during the induction of immune reaction in the skin. (Korean J Dermatol 2000;38(11):1444~1452)

A Clinical and Mycological Study of Superficial Fungal Diseases (Ⅷ)

Han, Eun Sil,Seo, Seong Jun,Kim, Myeung Nam,Hong, Chang Kwun,Ro, Byung In 대한의진균학회 1996 대한의진균학회지 Vol.1 No.1

Background: Superficial fungal infections are common diseases in the dermatologic conditions. The prevalence of superficial fungal diseases is not static but change under the influence of various factors such as climate, migration of people, and development in prophylaxis and therapy. Objective: The authors performed this study to investigate the present status of superficial dermatophytoses and some changes on the frequency of the diseases, sex distributions and varieties of the causative organisms. Methods: The clinical and mycological study of superficial fungal diseases on 2,115 patients who had visited Department of Dermatology, University Hospital and Yongsan Hospital, College of Medicine, Chung Ang University between July 1992 and June 1994 were performed. Results: 1) The incidence of superficial fungal diseases to total number of outpatients(8,048) was 26.3%(2,115 cases). 2) Superficial fungal diseases showed high incidence in fourth (22.3%), third(22.2%), and fifth decade(17.9%). 3) The ratio of male to female was 2.3: 1(1,478:637). Especially in patients with tinea(T.) cruris, which was the most prominent disease showing male predominance, the sex ratio was 15.9:1. 4) The monthly prevalences of superficial fungal diseases were high in July(16.5%), June(13.1%), and August(12.3%), respectively. 5) The incidence of each type of superficial fungal disease was the highest in T. pedis(21.4%), followed by T. cruris(17.6%), candidiasis(17.6%), T. corporis(13.5%), T. unguium(13.3%), T versicolor(9.6%), T. manus(5.1%), and T capitis(1.9%). 6) There were coexisting fungal infections in 426 patients(20.1%), and the case of T. pedis with T. unguium was the most common. 7) The positive rate of KOH scraping was 57.4% and the positive rate of culture on ordinary Sabouraud's dextrose agar media was 48.6%. 8) The most common cultured organism was Trichophyton(T.) rubrum(39.1%), followed by Candida species(34.6%), T. mentagrophytes(23.0%), Microsporum canis(2.0%), Epidermophyton floccosum(1.2%), and T. ferrugineum(0.2%). Conclusion: These results are not significantly different from those of previous studies. But the incidence of the superficial fungal diseases(26.3%) was higher than previous studies and showed a high incidence in young male patients and in warm season. The positive rate of KOH scraping(57.4%) was lower than previous studies. The most common causative organism was T. rubrum.