http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
백서에서 양측 난소절제술이 골밀도 및 IL - 6 치에 미치는 영향
한승엽(Seung Yeup Han),김성한(Sung Han Kim),박근용(Keun Yong Park) 대한내과학회 1997 대한내과학회지 Vol.53 No.3
N/A Objective: Estrogen is a major regulator/modulator of bone metabolism, and bone loss in estrogen deficiency is associated with increased bone turnover, But the mechanism for estrogen action on bone metabolism is still unknown. Recent studies have suggested that the increase in bone loss induced by estrogen deficiency is mediated by increased paracrine production of bone resorbing cytokines. Among cytokines, 1nterleukin-6(IL-6) is released from osteoblasts in estrogen deficiency and increases bone resorption by stimulation of osteoclastic activities and recruitment. Thus we performed this study to evaluate the effect of ovariectomies on bone mineral density and IL-6 in cultured monocytes of peripheral blood and bone marrow. Methods: The experimental animals were 13 female Sprague-Dawley rats that were 8 weeks of age and weighed an average of 188.5 gram at the beginning of the study. Bilateral ovariectomies were performed in all rats from a ventral approach. Bone mineral density(BMD) of the total body, spine and level of IL-6 of cultured monocytes of peripheral blood and bone marrow were measured before and 8 weeks after ovariectomy. Results : 1) BMD of total body and spine were lower after ovariectomy(0.257±0.069g/cm2, 0,208±0.005g/cm2) than before ovariectomy (0.276±0.005g/cm2, 0.229±0.011g/cm2), respectively (P<0.01). 2) Although IL-6 level of cultured monocytes in peripheral blood tended to be higher after ovariectomy than before ovariectomy, this difference was not statistically significant (P>0.05). 3) IL-6 level of cultured monocytes in bone marrow was higher after ovariectomy(82.78±4.99pg/ml) than before ovariectomy(48.85±2.42pg/ml)(P<0.05). Conclusion: It is possible that increased production of IL-6 in estrogen deficiency induced by ovariectomy occurs in the local environment of bone or bone marrow rather than in the pheripheral blood and stimulates bone resorption.
전자현미경 검사상 특징적인 기저막 변화를 나타낸 Nail - Patella 증후군 1 예
한승엽(Seung Yeup Han),강민경(Min Kyoung Kang),황은아(Eun Ah Whang),박성배(Sung Bae Park),김현철(Hyun Chul Kim),전시현(Si Hyun Jeon),강유나(Yu Na Kang),박관규(Kwan Kyu Park) 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.5
Nail-patella syndrome is a relatively rare autosomal dominant disorder characterized by dysplastic nail, hypoplastic or absent patella, and dislocation of radial head and iliac horns. In addition, renal abnormalities have been reported. The usual clinical signs of the renal involvement are asymptomatic proteinuria, microscopic hematuria, and in some cases progression to end stage renal disease. We present the case of adult with nail-patella syndrome, who developed proteinuria. Electron microscopy revealed irregular thickening of the glomerular basement membrane with areas of rarefaction, giving rise to a pathognomonic moth-eaten appearance.
신장 ; ABO 혈액형 부적합 신장이식 환자에서 혈연 간 신장이식과 비혈연 간 신장이식의 성적 비교
박우영 ( Woo Yeong Park ),한승엽 ( Seung Yeup Han ),황은아 ( Eun Ah Hwang ),박성배 ( Sung Bae Park ),박의준 ( Uijun Park ),김형태 ( Hyung Tae Kim ),조원현 ( Won Hyun Cho ) 대한내과학회 2014 대한내과학회지 Vol.87 No.6
목적: 신장이식은 말기 신부전 환자의 치료에 있어 가장 효과적인 신대체 요법이다. 과거 ABO 혈액형 적합 신장이식에서 혈연 공여자 신장이식이 비혈연 공여자 신장이식보다 성적이 좋다고 보고 되었으나 최근에는 성적에 차이가 없다고 보고되고 있다. ABO 혈액형 부적합 신장이식에서 혈연간 신장이식과 비혈연 간 신장이식 성적을 비교하였다. 방법: 2011년 1월부터 2013년 8월까지 ABO 혈액형 부적합 신장이식 19예가 후향적으로 분석되었다. 혈연 간 신장이식은 8예(부모-자식 간 7예, 형제간 1예), 비혈연 간 신장이식은 11예(배우자 간 11예)였다. ABO 혈액형 부적합 신장이식에서 혈연 간 신장이식군과 비혈연 간 신장이식군의 환자 및 이식 신장 생존율, 급성 거부반응, 이식 신장 기능, 합병증에 대해 조사하였다. 결과: Kaplan-Meier 분석에 따라 혈연 간 신장이식군에서 추적 기간 동안 환자 생존율 및 이식 신장 생존율은 각각 87.5%, 87.5%였고 비혈연 간 신장이식군에서 모두 100%였다. 급성 거부반응, 이식 신장 기능, 내외과적 합병증은 양군간에 의미 있는 차이가 없었다. 결론: ABO 혈액형 부적합 신장이식에서 혈연 간 신장이식과 비혈연 간 신장이식 단기 성적의 차이가 없었다. 국내 비혈연 간 신장이식의 대부분은 배우자 간 신장이식으로 배우자는 ABO 혈액형 부적합 신장이식의 주요 공여자가 될 수 있을 것이다. Background/Aims: Kidney transplantation (KT) is the best treatment for end-stage renal disease patients. Although previous studies have demonstrated that the clinical outcome following living related (LR) KT is better than that following unrelated (LUR) KT in ABO-compatible KT recipients, recent studies showed no differences in clinical outcomes between the two treatments. In this study, we compared the clinical outcomes of LR and LUR KT in ABO-incompatible KT recipients. Methods: From January 2011 to August 2013, 19 cases of ABO-incompatible KT were analyzed retrospectively. Eight kidneys (7 cases of parent-offspring and 1 case of siblings, Group 1) were donated from living-related donors and 11 (all spousal donors, Group 2) from living-unrelated donors. We investigated patient survival, graft survival, acute rejection, graft function, and complications. Results: On Kaplan-Meier analysis, patient and graft survival during follow-up were 87.5% and 87.5% in Group 1, both were 100% in Group 2. Acute rejection, graft function, and medical and surgical complications were not significantly different between the two groups. Conclusions: The short-term clinical outcomes between LR and LUR KT in ABO-incompatible KT recipients were equivalent. Most domestic cases of LUR KT are from spousal donors and the spousal donor will be a major donor in ABO-incompatible KT patients. (Korean J Med 2014,87:698-704)
황은아(Eun Ah Hwang),성정훈(Jung Hoon Sung),한승엽(Seung Yeup Han),박성배(Sung Bae Park),김현철(Hyun Chul Kim),김형태(Hyung Tae Kim),조원현(Won Hyun Cho) 대한내과학회 2002 대한내과학회지 Vol.63 No.3
목적 : 복막투석 환자에서 복막염은 복막투석의 실패와 사망에 가장 중요한 합병증의 하나이다. 저자들은 계명대학교 동산의료원에서 복막투석을 시행한 환자들을 대상으로 하여 복막염의 발생 및 역학에 대해 조사하였다. 방법 : 1996년 1월에서 2000년 12월 사이에 계명대학교 동산의료원에서 복막투석을 시행받은 환자들 중 추적기간이 2개월 이상인 238명을 대상으로 하여 후향적으로 조사하였다. 결과 : 5년간의 복막염의 발생율은 평균 0.94회/환자-년(12.8개월당 1회)이었고, 복막염 원인균의 빈도는 그람 양성균이 41.7%, 그람 음성균이 14.1%, 진균이 1% 순이었으며 배양 음성인 경우가 42.7%였다. 그람 양성균 중에는 Staphylococcus aureus가 47.5%로 가장 많았고, 그람 음성균에서는 Acinetobacter가 29.6%를 차지하였다. 균배양 양성율은 Bactec 혈액 배양 방식의 도입 이전 52.5%, 도입 후 72.2%로 균배양 양성율이 유의하게 향상되었다. 복막염은 항생제의 사용으로 치료된 예는 85.6%였고, 11.8%에서는 도관이 제거가 필요하였다. 도관을 제거하였던 경우 출구 감염이 도관을 제거하지 않 았던 군보다 유의하게 많았다(17.4% vs 4.7%). 전체 109명의 환자 중 60예에서 복막투석을 중단하였고, 그 중 28예가 혈액투석으로 전환하였으며 그 원인으로는 복막염이 82.1%로 가장 많았다. 도관 생존율은 복막염을 경험한 환자군에서는 1년, 3년, 5년 도관 생존율이 각각 87.0%, 35.1%, 11.9%였으며 복막염을 경험한 환자군에서는 1년, 3년, 5년 도관 생존율이 각각 81.7%, 58.1%, 54.0%였다. 관찰 기간 동안 6예가 사망하였으며 그 중 절반이 복막염에 의한 패혈증으로 사망하였다. 결론 : 앞으로 복막염의 발생을 감소시키기 위해서는 투석액 교환시 감염 및 도관 주위감염에 대한 적극적인 치료와 주기적인 환자 교육이 필요할 것으로 생각된다. Background : Peritonitis is one of the major complication leading to mortality and technique failure in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). We have examined the incidence and etiology of CAPD peritonitis at Keimyung University Dongsan medical center. Methods : Between January 1996 and December 2000, 238 new patients received peritoneal dialysis and were reviewed retrospectively. Results : In 238 patients, 109(45.8%) patients experienced peritonitis and a total of 192 episodes of peritonitis has occurred during study period. The overall incidence of peritonitis during CAPD averaged 0.94/patient-year and there was no essential change during the last five years. The most common causative organism was Gram positive organism (41.7%), followed by Gram negative organism (14.1%), and fungus (2%). In Gram positive organism, Staphylococcus aureus (47.5%) was the most common microorganism, followed by coagulase negative Staphylococcus (23.5%), Streptococci (7.5%), and Enterococci (5.5%). Gram negative organism were Acinetobactor (29.6%), Escherichia coli (18.5%), Klebsiella (18.5%) and Pseudomonas (7.4%) in decreasing order of frequency. With the use Bactec blood culture system for peritoneal fluid culture since April 2000, the culture yield has been improved significantly than before (52.5% vs 72.2%, p<0.05). Peritonitis was cured in 164 cases (85.6%) with the administration of antibiotics. However catheters had to be removed in 23 cases (11.8%). Exit-site infection was more frequent in catheter removal group than in catheter retaining group (17.4% vs 4.7%, p<0.05). The CAPD failure occured in 28 patients during study period, and peritonitis was the major reason for technique failure (82.1%). The catheter removal rate was significantly higher in the patients with peritonitis than those without peritonitis (55.0% vs 30.2%, p<0.05). There were six deaths during study period. Septicemia associated with peritonitis accounted for the half of the mortality. Conclusion : Better exit-site care and continuing patient education is needed the incidence of peritonitis and peritonitis related mortality in CAPD patient.(Korean J Med 63:314-321, 2002)
황은아(Eun Ah Whang),성정훈(Jung Hoon Sung),한승엽(Seung Yeup Han),박성배(Sung Bae Park),김현철(Hyun Chul Kim),강민경(Min Kyung Kang) 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.5
Posttransplant diabetes mellitus, a complication due to corticosteroids and the calcineurin inhibitors, cyclosporine and tacrolimus, is commonly regarded as a form of type 2 diabetes mellitus. Diabetes ketoacidosis, which requires relative insulin deficiency to impair fatty acid metabolism, is a complication of type 1 diabetes mellitus. We report two patients who presented with diabetic ketoacidosis after kidney transplantation. Two patients presented with severe hyperglycemia, significant ketosis and metabolic acidosis of variable severity. One patient was treated with a cyclosporine-based regimen, and the other with a tacrolimus-based regimen. Both were found to have moderate to high serum levels of calcineurin inhibitors on presentation. Our experience suggests that post-transplant diabetes mellitus, in association with calcineurin inhibitor, may result in ketoacidosis either secondary to relative beta cell dysfunction, peripheral insulin resistance, or a combination of the two effects. Post transplant diabetes mellitus can be an atypical form of adult-onset diabetes with features of both type I and type 2 diabetes mellitus.