http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 한광협(Kwang Heup Han) (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
이광재(Kwang Jae Lee),한광협(Kwang Heup Han),전재윤(Jae Yun Chun),문영명(Young Myoung Moon),이상인(Sang In Lee),박인서(In Suh Park),김호근(Ho Guen Kim),박찬일(Chan Il Park),오희철(Hee Chul Oh) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.3
N/A Background/Aims: Chronic hepatitis type B is highly-prevalent in Korea. However, few studies about its natural history and prognostic factors have been presented until now. The natural course and long-term prognosis of chronic hepatitis type B varies greatly, and this diversity makes it difficu]t to predict the clinical course of individual patients. The histologic finding is known to be a important prognostic factor. Thus we conducted this study to evaluate the natural history and prognostic factors of chronic hepatitis type B in Korea. Methods: The authors analyzed the clinical courses of 147 patients with clinicopathologically proven chronic hepatitis type B through long-term follow-up from the time of the initial biopsy according to histologic classification. 15 patients had chronic persistent hepatitis(CPH). 61 patients had chronic active hepatitis without bridging necrosis(CAH-BN). 46 patients had chronic hepatitis with bridgung necrosis(CAH+BN). 25 patients had chronic active hepatitis with early cirrhotic change(CAH+LC). They were followed for 24 to 150 months(mean 70.8(+25.8)). Results: The probability of developing cirrhosis in chronic hepatitis type B was 0%, 2%, 10%, 18%, 23%, 28%, 37%, 49%, 54% in 1 year to 9 years, respectively. The 5-year cumulative probability of developing cirrhosis was 9% in CPH, 14% in CAH-BN, 22% in CAH+BN, and 55% in CAH+LC. The significant prognostic factors of developing cirrhosis were age(p<0.01) and histologic classification(p<0.001). The probability of developing decompensated cirrhosis in chronic hepatitis type B was 0%, 0%, 0%, 1%, 5%, 13%, 17%, 28%, and 32% in 1 year to 9 years, respectively. The probability of developing hepatocellular carcinoma(HCC) in chronic hepatitis type B was 0%, 0%, 0%, 1%, 3%, 3%, 6%, 8% and 8% in 1 year to 9 years, respectively. The significant prognostic factor of developing HCC was age. Conclusions: The results of this study explored the natural history and prognostic factors of chronic hepatitis type B. 5-year cumulative probability of developing cirrhosis, decompensated cirrhosis and HCC was 23%, 5% and 3%, respectively. Histologic classification and age were significant prognostic factors for the development of cirrhosis. Age was a significant prognostic factor for the development of HCC. (Korean J Gastroenterol 1997;29:343 - 351)
-
간 , 담도 및 췌장 : 정상인 및 간경변증에 있어서 Doppler 복부 초음파검사에 의한 문맥계의 혈역학적 연구
강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),박인서(In Suh Park),문영명(Young Myoung Moon),김원호(Won Ho Kim),정재복(Jae Bok Chung),한광협(Kwang Heup Han) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
N/A Portal systemic bleod flow can be measured quantitatively by the recently developed pulsed Doppler flowmetry system that consist of a mechanical sector scanner and a pulsed Doppler flowmeter. Since both modes are displayed in real time, Doppler signals can be retrieved at will from any depth. The blood flow velocity determined by the Doppler spectrogram and the vascular cross-sectional area measured from the B-mode tomographic image enables the quantitiative calculation of the blood flow volume. To evaluate the changes of portal hemodynamics in liver cirrhosis, we observed the cross-sectional area, blood flow velocity and blood flow volume of portal vein, splenic vein and superior mesenteric vein in 22 healthy adults as control and 21 patients with liver cirrhosis by the pulsed Doppler flowmetry system. The results obtained are as follows: 1) The cross-sectional area of the portal vein was significantly enlarged in patients with liver cirrhosis (1.19+-0.32 cm) cornpared with controls (0.81+-0.16 cm'), and the blood flow velocity was significantly reduced in patients with liver cirrhosis (11.46+-2.08 cm/sec) compared with controls (16.47+-3.82 cm/sec). But the blood folw volume of the portal vein was not significantly different in patients with liver cirrhosis (817.4+-265.2 ml/min) from controls (790.2+-207.2 ml/min) 2). The cross-sectional area of the splenic vein was significantly enlarged in patients with liver cirrhosis (0.54+-0.30 cm2) compared with controls (0.35+-0.12 cm), and the blood flow velocity was significantly reduced in patjents with liver cirrhosis (13.81+-5.13 cm/sec) compared with controls (22.15+-10.83 cm,'sec). But the blood flov; volume of the splenic vein was not significantly different in patients with liver cirrhosis (423.5+-220.2 ml/min) from controls (389.0+-90.4 ml-min). 3) The cross-sectional area of the superior mesenteric vein was significantly enlarged in patients with liver cirrhosis (0.59+-0.18 cm) compared with controls (0.37+-0.12 cm), and the blood flow velocity was significantly reduced in patients with liver cirrhosis (13.30+-4.98 cm/sec) compared with controls (20.21+-5.65 cm/sec). But the blood flow volume of the superior meseteric vein was not significantly different in patients with liver cirrhosis (436.4+-115.1 ml/min) frorn controls (393.3+-107. 0 ml/min). 4) In patients with liver cirrhosis, there was no significant hemodynamic change according to the presence or absence of ascites and the degree of esophageal varices. But the cross-sectional area and the blood flow volume of the splenic vein was significantly larger in patients with severe splenomegaly than in patients with mild splenomegaly. These results suggest that the pulsed Doppler flowmetry system is simple, non-invasive and particularly useful method in studying the changes of portal hemodynamics.
-
강진경,박인서,전재윤,송시영,이동기,최흥재,한광협 대한소화기학회 1992 대한소화기학회지 Vol.24 No.5
Mentally retarded children (MRC) are easily predispose to hepatitis B infection due to their special problems, especiaIly in case of institutionalization. So in these children, vaccination against hepatitis B infection is very important. The aim of the present study is to compare the immune response to hepatitis B vaccine between MRC and normal children and to investigate the presence of any difference of immune response according to various factors in MRC. The vaccination was done 0, 1, 2 method with Hepaccine on the deltoid area intramuscularly. Anti HBs titer was cheked one month after each vacinations with radioimmunoassay. The vaccine responder was defined as vaccine recipient whose level of anti HBs over 10 RU after vaccination. At 1month after 1st vaccination, the frequency of responder was lower in group II(31.3%) than in group I (62.5%) and group III(63.3%). But the difference was abscent after 3rd vaccination in each group. The anti-HBs titer shows no difference in each group after 1st and 3rd vaccination. The cause of mental retardation had no effect on frequency of respoder and titer of anti-HBs. Also the sex, age and duration of institutionalization did not influence the immune response in MRC. This results suggest that the immune response of MRC was not so different with healthy children.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
