Azelaic acid와 Retinoic acid가 자외선 B를 조사한 흑색마우스 표피 색소세포에 미치는 영향

한경원(Kyung Won Han),이기홍(Ki Hong Lee),명기범(Ki Bum Myung) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.4

Increased melanin pigmentation following ultraviolet irradiat.ion is due to increasing tyrosinase activity and multiplicatian of functioning melanocytes. After UV-irradiation, the size of melanocytes increases, and melanocyte dendrites elongatc, and branch. In this experiment, we induced the activation of melanocyts in the epidermis of C57BL black mice by ultraviolet-B(UVB) irradiation and observcd ihe effect of azelaic acid and retinoic acid on the UVB activated epidermal melanocytes. Sixty C57BL black mice were irradiated by UVB 100mJ/cm daily for 10 days, and then azeiaic acid and retinoic acid were topically applied daily for 7 weeks. For the estimation of morphologic change of epidermal melanocytes, light microscopic observation with split DOPA stain was performed at the end of the 1st, 3rd, 5th and 7th week of topical application. The results are summerized as follows : 1. The number, size and circumference of DOPA-positive epidermal melanocytes were significantly decreased in 20% azelaic acid applied group and 30% azelaic acid and 0.05% retinoic acid applied group. 2. In 20% azelaic;i.cid and 0.05% retinoic acid applied group, the number, size and circumference of DOPA-positive epidermal melanocytes were nore significantly decreased than in 20% azelaic acid applied group. In summary, the present study suggets that azelaic acid act as a depigmenting agent on epidermal melanocyte; and such depigmenting effect of azelaic acid was increased by addition of retinoic acid. (Kor J Dermatol 1992;30(4):492-498)

연구논문 : 지역정책의 세계적 동향과 시사점 -장소 기반의 유럽연합 결속정책을 중심으로

한경원 ( Kyung Won Han ) 전남대학교 지역개발연구소 2012 지역개발연구 Vol.44 No.1

이 연구의 목적은 유럽연합 결속정책을 중심으로 지역정책의 세계적 흐름을 고찰하고 정책 시사점을 얻는 데에 있다. 이 논문에서는 주로 World Bank(2009), OECD 보고서, 유럽연합 집행위원회 보고서(2011), 바르카 보고서(2009)를 조사하였다. 조사 결과, 다음과 같은 몇 가지 시사점이 도출되었다. 첫째, 지역발전정책에서 장소 중립적인 견해와 장소 기반의 견해를 절충하는 것이 바람직하다. 둘째, 유럽연합의 차기 결속정책은 장소 기반의 접근 방식을 지향하는데, 효율성 목표와 사회적 포옹 목표라는 분명히 구별되는 두 가지 목표를 추구할 것이다. 셋째, 지역발전정책의 목적-수단 간의 합리성을 확보해야 한다. 넷째, 장소 기반의 지역정책이 성공하려면, 거버넌스 체계 개편이 필요하고, 특히 지역발전위원회의 위상과 역할을 강화할 필요가 있다. The purpose of this study is to examine global trends of regional policies focused on EU cohesion policy and to get policy implications. The paper examines mainly into World Bank report(2009), many OECD reports, and European Commission(2011). Some policy implications are as follow. Firstly, it is desirable that we have an eclectic approach(place-based and spatially blind approaches) to regional policies. Secondly, the next EU cohesion policy will be place-based regional policy and it will have two distinct objectives: increasing efficiency and social inclusion. Thirdly, we should ensure rational nexus between goal and its means in regional policies. Fourthly, to get desired outcomes of regional polices, we need to reform governance system. Above all, it is necessary to strengthen PCRD(presidential committee on regional development) as a center of competence.

지역간 격차와 박근혜정부 지역발전정책

한경원(Kyung-Won HAN) 조선대학교 지식경영연구원 2013 기업과 혁신연구 Vol.6 No.2

우리나라는 인구, 생산, 고용, 연구개발, 의료서비스의 측면에서 지역간 발전 격차가 심각하다. 박근혜정부는 지역균형발전을 포함한 지역발전정책 과제로서 국민대통합을 위한 지역균형발전, 지방대학지원 확대, 지방재정 확충 및 건전성 강화, 지방분권 강화 및 시민사회·지역공동체 활성화, 지역경제와 산업의 활력 제고 등 5개 과제를 국정과제로 추진하고 있다. 박근혜정부 지역발전정책의 새 기조는 지역주민의 삶의 질 향상에 초점을 맞추며, 지역희망(HOPE) 프로젝트의 비전 하에 지역행복생활권 구현,맞춤형·패키지 지원, 지역 주도 및 협력 강화의 전략을 추진한다. 지역발전위원회에서 발표한 지역희망 프로젝트는 6대분야 17개 실천과제로 추진할 계획이다. 지역정책 수단과 관련된 향후과제는 다음과 같다. 첫째, 지역발전위원회의 컨트롤 타워 기능을 강화해야 한다. 둘째, 광역?지역발전특별회계는 새로운 지역정책을 효과적으로 지원하기 위해 개편되어야 한다. 셋째, 지역행복생활권 시책이 작동할 수 있도록 가이드라인을 마련해 지역에 제공해야 한다. 끝으로, 핵심적인 지역발전 지표를 지속적으로 모니터링하고 지역간 격차를 완화시켜야 한다. There exist serious inter-regional development gap problems in many aspects of population, production, jobs, R&D, and medical services in Korea. This study investigated a list of 140 tasks of Park Geun-hye Administration and 2013 regional development policy reports to President Park Geun-hye. Main findings are as follows. Park"s Administration is implementing five tasks for regional development policies including balance regional development policies as national agenda. Newly announced Park"s regional policy is focused on quality of life of people, its strategies are Regional Human Settlements, customized policy package, and community initiatives & inter-regional cooperation. Presidential committee on regional development will 17 key tasks in 6 policy sectors. The policy implications of these findings include as follows. Firstly, PCRD should play active roles orchestrating regional polices of various government agencies and communicating with local governments and private sectors. Secondly, Regional Development Special Account should be restructured to effectively support new regional development policies. Thirdly, PCRD should provide local governments with user-friendly guideline for Regional Human Settlements. Finally, monitoring key regional development indicators should continue to be implemented to reduce inter-regional development gap in Korea.

자외선 및 광화학 처치에 의한 흑색 마우스의 표피 변화

한경원(Kyung Won Han),한혜기(Hae Ki Han),명기범(Ki Bum Myung),국홍일(Hong Il Kook) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.5

The pretent study was performed to study the epiderrnal changes of ultraviolet irradiation and PUVA treatment in the black mice. The following results were obtained: 1) The histologic changes of the epidermis, number of DOPA positive melanocytes and ultrastructural changes of keratinocytes due to UVB and PUVA were rnore prominent than those of UVA irradiation. 2) The histological changes after 8-MOP photosensitization closely mirnic those of UVR irradiation, and constant, finding was hyperkeratosis. 3) Early histological change after UVL irradiation & IUVA treatment was appearance of dytkeratotic cells. 4) Pro]onged exposure to UVB & PUVA resulted in transient epidermal hyperplasia, and epidermal atrophy occurred 3 weeks after PUVA treatment. 5) Early electron microscopic changes was perinuclear edema, juxtanuclear vacuoles and clumping of tonofilament.

황화수소 화합물이 자외선을 조사한 흑색 마우스의 표피 멜라닌세포내 멜라닌소체의 형태에 미치는 영향

한경원(Kyung Won Han),명기범(Ki Bum Myung),함정희(Jeong Hee Hahm),국홍일(Hong Il Kook) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.5

The present study was performed to evaluate the effect of sulfhydryl compounds, cysteine and glutathione, on the size of melanosomes and the ratio of melanosormai stages of epidermal melanocytes in UV-irradiated black mice. The results were as follows; 1. Both of cysteine and glutathione showed significant diminution in the short axis of melanosomes and the percentage of stage 4 melanosomes of epidermal melanocytes in C57BL black mice skin. 2. The length of short axis of melanosomes in glutathione-treated group is smaller than those in cysteine-treated group at the end of 3rd week of intraperitoneal injection. The percentage of stage IV melanosomes significantly decreased in glutathione-treated group and cysteine-treated group at the end of 3rd week and 5th week respectively. 3. In glutathione-treated group, the short axis of melanosomes and the percentage of stage 4 melanosomes both decreased in proportional to the period of intraperitoneal in]ection.

두피에 발생한 모종

한경원(Kyung Won Han),명기범(Ki Bum Myung),국홍일(Hong Il Kook) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.1

Tricilemmoma is a benign, solitary tumor that may be clinically misdiagnosed as basal cell carcinoma or verruca. It affects frequently the face of elderly rnen. We present herein a case of trichilemrnoma in a 70-year-old Korean wornan who had a slowly growing tumor on the scalp for 50 years. The histopathologic findings revealed lobular acanthosis of glycogeri rich clear cells and palisade of columnar cells resting on prominent basement membrane.

IQ 코릴레이션 기반의 투과파를 이용한 측정 시스템

한경원(Kyung-Won Han) 대한전자공학회 2020 대한전자공학회 학술대회 Vol.2020 No.8

This paper proposes a IQ correlation―based measurement system using an IR―UWB (Impulse Radio Ultra Wideband). In order to compensate for the shortcomings of the conventional contact heart rate measurement method, several non―contact heart rate measurement methods have been proposed, but have a disadvantage of low signal―to―noise ratio. To compensate for this, a system was designed that penetrates the impulse heart and obtains heart rate information through correlation. This system used a method of correlating the transmitted impulse to utilize both the information for each peak and delay of the impulse. The correlation technique shows two correlations, and the system implements a correlator composed of a mixer structure and an integrator, which becomes correlation when the frequency domain characteristics are the same. It is more resistant to noise and interference than the envelope detection method. The proposed system improves the signal―to―noise ratio more than the conventional impulse transmission wave method by utilizing all of the impulse information based on the correlation technique. The data was acquired using a commercial oscilloscope for verification prior to the circuit configuration of the system, and then the results were checked in software and then designed and fabricated using a 65nm CMOS process.

여자 외음부에 발생한 아포크린 한선낭종

한경원(Kyung Won Han),명기범(Ki Bum Myung),국홍일(Hong Il Kook) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.1

A 31-year-old female patient has had a translucent cystic papule on the genitalia since 2 years ago. The diagnosis was confirmed by clinical and histopathological findings. This is the rare case of apocrine hidrocystoma occring in the fernale genitalia in the literature.

양구백자박물관 융합체험교육프로그램 연구

한경원(Han, Kyung Won),최병건(Choi, Byong Keon) 한국전시산업융합연구원 2016 한국과학예술융합학회 Vol.24 No.-

지방자치단체 간의 문화적 경쟁의 쟁점은 지역이 가진 고유한 정체성을 기반으로 어떤 문화적 이미지를 구축하고 활용 하는가 이다. 양구백자박물관은 조선왕조 500년간 왕실관요에 쓰였던 백토의 주요산지로서의 양구군의 역사와 문화를 잘 보여 주는 문화적이 공간이다. 이에 본 논문은 양구백자박물관의 홍보와 나아가 지자체의 홍보에도 도움이 될 수 있도록 스토리텔링과 접목시킨 교육프로그램을 제작하는 것을 목적으로 한다. 연구방법으로는 첫째, 문헌연구, 인터넷 검색, 전문가 면담을 통한 박물관의 이론적 고찰과 개념을 정립하였다. 둘째. 박물관과 지역의 자원인 백자의 역사를 활용하여 스토리를 개발하였다. 셋째, 국내 타 도자박물관의 다양한 체험교육프로그램의 사례를 통하여 그 유형을 분석하였다 넷째. 양구백자를 소재로 하는 공감형 스토리텔링 연구를 통하여 교육프로그램 모형과 교수학습지도안, 활동지 모형을 백자박물관 수업에 실행 가능하도록 제시하였다. 본 연구에서 제시된 양구백자박물관의 융합체험교육프로그램을 통해 지역의 역사를 담은 스토리텔링이 박물관 전시물의 이해와 관람객의 공감대 형성에 큰 역할을 할 것으로 기대한다. 특히 소원성취부(所原成就符)의 이성계 백자발원문은 스토리텔링의 모티브로서 관람객의 동기유발과 자발적 참여를 가져오리라 기대한다. 또한, 양구백자박물관의 교육프로그램 홍보는 지역의 마케팅 효과로 이어져 지역의 정체성 강화와 긍정적인 이미지를 구축할 것이다. 스토리텔링과 접목한 체험교육은 타 지역, 타 박물관과 차별화된 백자박물관의 융합 교육적 전략이 될 것이다. 이를 토대로 백자박물관은 양구가 가진 정체성을 대변하는 지역의 유형, 무형문화재를 지속적으로 발굴하여 스토리텔링으로 개발해 나간다면 지역문화를 선도하는 글로벌 박물관으로 자리매김 할 것이라 사료된다. The issue of cultural competition among the local governments is to establish and utilize which cultural image based on the intrinsic identity of the region. Yanggu White Porcelain Museum is a cultural space which well shows history and culture of Yanggu-gun as the major producer of white clay that had been used for royal porcelain during the 500 years of Joseon Dynasty. Here, this research aimed at producing educational program combined with storytelling to be helpful for PR for local government along with PR for the local government. As the research method, first, this research established theoretical consideration and concept of the museum through literature research, internet search, and expert interview. Second. this research developed a story by utilizing the history of white porcelain, the resource of the museum and the region. Third, this research analyzed the type through the cases of various experience education programs of other porcelain museums in Korea. Fourth, this research suggested educational program model, teaching learning guide, and activity model to be practiced for white porcelain museum class through the empathic storytelling research based on Yanggu white porcelain. The researcher expects the storytelling included with regional history through the convergence experience education program of Yanggu White Porcelain Museum suggested in this research could take a great role in comprehension of museum exhibits and formation of the audience’s bond of sympathy. Particularly, the researcher expects that Yi, seonggye’s white porcelain prayer of wish-fulfillment would bring motivation and voluntary participation of the audience as the motif of storytelling. Also, PR for educational program of Yanggu White Porcelain Museum would enhance identity of the region and establish positive image by being connected with regional marketing effect. Convergence experience education combined with storytelling would be a differentiated educational strategy of white porcelain museum from other region and other museums. Based on this, the researcher considers, white porcelain museum would be a global museum that leads the regional culture if it is developed with storytelling by continuously discovering regional tangible, intangible cultural assets that represent identity of Yanggu.

방사성폐기물 처분장 주변에서 정상상태의 지하수 수치 모델 개발

서경석,이한수,한경원,Suh, Kyung Suk,Lee, Han Soo,Han, Kyung Won 대한토목학회 1989 대한토목학회논문집 Vol.9 No.4

방사성 폐기물 처분장 주변의 지하수 유동 현상을 이해하기 위해 정상상태에서의 지하수 수치모델을 수립하였다. 지하수 수치모델은 절점과 부재로 구성된 network에 의해 균질, 비균질, 다층매질에서 지하수 흐름을 조사하는데 이용되었고 모델의 수치해는 해석해와 일치하는 결과를 가졌다. 또한 지하매질의 수리학적 특성과 균열지역의 영향에 의한 지하수 유동의 물리적 변화현상도 조사되었다. 처분장 주변의 지하매질에 대해 구성된 network과 계산된 지하수 속도의 방향을 이용하여 지하수의 가능한 이동경로를 산정하는 방법이 개발되어 방사성 폐기물 처분장에서 생태계로의 가능한 지하수의 이동속도 및 시간을 예측하였다. A numerical model for Steady state groundwater flow has been established to understand the groundwater flow phenomena near a radioactive waste repository. The integrated finite difference method based on a network composed of nodes and members was applied to investigate groundwater flow in homogeneous, heterogeneous and layered media. Its numerical solution was in good agreement with analytic solution. Physical phenomena associated in the groundwater flow depending on both hydraulic characteristics and effects of fractured zone were also investigated. A method by which feasible groundwater flow paths can be identified was developed. This method used the composite network for the geologic media near a repository and the direction of computed groudwater velocity. Groundwater velocity and travel time were predicted for the possible pathway form a repository to a biosphere.