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Preparation of PEGlated Conjugated Polymer Nanoparticles for Photoconversion in Bio Application
팜티투이동,박주현,알렉스,팜티투이동,전예지,신용훈,임기환,이다빈 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
Conjugated polymers (CP) had gradually been admitted as promising materials in various applications these days. Their versatile properties such as high brightness, high photostability, and low cytotoxicity have transformed them into alternatively multifunctional biomaterials. However, these organic-based materials were limited by the lack of hydrophilicity and bioavailability. Recently, the incorporation of functionalized polyethylene glycol (PEG) has been found as efficient solution to overcome these obstacles. This research provides a view of different techniques in the fabrication of structural PEGlated CPNs. The difference in PEG-linked methods results in the changing of assembled molecular structures, thus giving a significant effect on the NIR absorption and photothermal properties for theranostic applications.
팜티투이동,박주현,이다빈,박한음 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
To fulfill the technological requirements these days, nanomaterials have been developed as a tremendous potential in various fields, especially in the role of multifunctional applications in one-step process for bio-medical theragnosis. In this study, by harvesting near infrared energy, we focused on using of two materials as hybrid nanoparticles (HNs) for magnetic resonance imaging and photoacoustic - photothermal therapy simultaneously. Inside, conjugated polymer recognized through electro-optical characteristics combined to magnetically contrast terms of magnetic nanoparticles. Our water-dispersed HNs were assembled successfully by forming the phase-separated thin film of a conjugated polymer, phospholipids and iron oxide nanocrystals, followed by shattering the film with water penetration into the polar region of the phase-separated film under ultrasonication. The specific characteristics were observed in optimal mixing ratio, presenting simultaneous multifunctionalities.