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- 저자 : 추원오(Won Oh Choo) (검색결과 4 건)
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동위원소 ( 99mTc - DTPA ) 를 이용한 신사구체 여과율 측정의 유용성
추원오(Won Oh Choo),우제영(Je Young Woo),김용수(Yong Soo Kim),구완서(Wan Suh Koo),장윤식(Yoon Sik Chang),윤영석(Young Suk Yoon),방병기(Byung Kee Bang),정수교(Soo Kyo Chung) 대한내과학회 1992 대한내과학회지 Vol.43 No.6
Background: Although creatinine clearance is most commonly used to evaluate renal function, it overestimates glomerular filtration rate and needs 24 hour urine collection. In the last several years, it was reported that glomerular filtration rate using radioisotope has advantages of creatinine clearance. Methods: Glomerular filtration rate estimated by fractional accumulation of 99mTc-DTPA (CDTPA), creatinine clearance (Ccr), predicted creatinine clearance estimated by the formula devised by Cockcroft and Gault (PCcr) and 100/serum creatinine (100/Scr) were measured simultaneously in 89 medical outpatients whose serum creatinines ranged from 0. 6 mg/dl to 11, 2 ma/dl. Results: 1) CDTPA were closly correlated to Ccr (r=0.84), PCcr (r=0.88) and 100/Scr (r=0.86). 2)CDTPA were inversely correlated to Scr. 3) In patients with normal renal function (Scr<1.2 mg/dl) or mild to moderate renal insufficiency (1,2< Scr < 4. 0 mg/dl), CDTPA A were significantly lower than Ccr and 100/Scr, and simmilar to PCcr. 4) In patients with severe renal insufficiency (Scr>4. 0 mg/dl), CDTPA were significantly higher than Ccr, PCcr and 100/Scr. 5) Cm of left kidney were closely correlated to those of right kidney (r=0.91). The absolute differences of CDTPA between right and left kidneys were 5,1±4.9ml/ min/l. 73 M2, which were not significant statistically. 6) In 4 patients who had a past history of unilateral nephrectomy, DDTPA were measured falsely by 7.4±4.9 ml/min/1,73 M2 in nephrectomized side. 7) This procedure needs only 6 minutes of patient time. Conclusion: These observations suggest that determining glomerular filtration rate using 99mTc-DTPA is a rapid, accurate method in patients with normal or mild to moderate renal insufficiency, both as a total value and individually for each kidney. But it overestimates glomerular filtration rate in patients with severe renal insufficiency.
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폐손상의 후유증을 남기고 생존한 파라콰트 음독환자 1례
추원오,이세훈 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.2
파라콰트 한두모금을 음독한 환자에서 자외선 분광분석기로 체내농도를 검사하고 Proudfoot등이 제시한 생존 가능곡선과 비교하여 생존 가능성이 50%를 상회하여 고식적 치료로도 제한성 폐기능장애만을 남기고 생존한 한 증례를 문헌 고찰과 함께 보고하는 바이다. The rapid qauntification of paraquat in body fluids is of undoubted value in both initial assessment as well as the immediate prognosis of acutely poisoned patients. A 20-year-old woman ingested a mouthful of paraquat. Serum and urine paraquat levels were measured colorimetrically for 48 hours after identifying the presence of paraquat in her urine by a Paraquat test kit. At that time her survivability was considered to be over 50% according to Proudfoot's scale of time related measured serum paraquat levels. Five days after admission, she began to cough but her chest x-ray picture was normal. However, she persisted to cough and subsequent chest x-rays showed fine reticulonodular densities in both upper and lower lobes. Twenty days after admission, she was clinically well, and not deteriorated radiologically. Therefore, respiratory function tests were undertaken. They showed reduced lung volume, moderate reduction in ventilatory capacity, and a diffusion defect (DLco: 27% predicted value). Twenty four days after admission, the patient was discharged in good condition except for the sequale of lung involvement. Six months later, she was re-examined and found to be healthy with a large regression of lung lesions on her chest x-ray.
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몇 가지 항진균제가 호중구의 화학주성 및 식균작용에 미치는 영향
김양리,양시영,강동현,추원오,신완식,최정현,강문원 대한감염학회 1991 감염 Vol.23 No.4
The in vitro effects of some antifungal agents on the chemotaxis and phagocytosis of human neutrophils have been studied. Human neutrophils were incubated with amphotericin B, flucytosine, ketoconazole, fluconazole and itraconazole at different concentrations. The effect on the chemotaxis was measured by counting the number of migrated neutophils in 10 microscopic fields by modified Boyden chamber method using 48-well microchamber and the effect on the phagocytosis was measured by the number of phagocytizing neutrophils and engulfed Candida albicans. The results were as follows; 1) Ampohericin B suppressed the chemotaxis over the concentration of 1.0 ㎍/㎖ (p<0.05) and phagocytosis over the concentration of 5.0 ㎍/㎖ (p<0.01). 2) Flucytosine did not affect the chemotaxis and phagocytosis within the experimental concentrations. 3) Ketoconazole enhanced chemotaxis in the treated group (p<0.05), but did not affect the phagocytosis. 4) Fluconazole did not affect the chemotaxis but suppressed the phagocytosis over the concentration of 20 ㎍/㎖ (p<0.05). 5) Itraconazole suppressed the chemotaxis over the concentration of 10 ㎍/㎖ (p<0.05), and phagocytesis over the concentration of 5.0 ㎍/㎖ (p<0.05).
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임응훈,김성수,김치홍,추원오,김용수,박인석,구완서,장윤식,방병기,송경섭,박영하 대한내과학회 1992 대한내과학회지 Vol.42 No.2
저자들은 혈액투석을 시행하고 있는 다낭신 환자에서 발생한, 수혈을 요하는 대량혈뇨를 신동맥색전술을 이용하여 성공적으로 치료한 2예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Polycystic kidney disease is one of the most common inherited autosomal dominant disease with variable clinical prsentations. The disease may manifest abdominal pain, bilateral flank masses, hypertension, hematuria, nephrolithiasis and azotemia. Massive hematuria may occur in polycystic kidney requiring transfusions or rarely surgical intervention. However, renal arterial embolization has been applied for the control of massive hematuria recently. We have experienced two cases of massive hematuria in polycystic kidney disease controlled by percutaneous renal arterial embolization successfully without any serious complications.
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