선천성 피부 형성부전증 2예

최혜민(Hai Min Choi),명기범(Ki Bum Myung),국홍일(Hong Il Kook) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.1

Aplasia cutis congenita is an anomaly characterized by absence of localized areas of the integument. The most common type of aplasia cutis congenita is a circular or oval, sharply outlined ulcer 1 to 3cm in diameter on the vertex of the scalp at the level of the posterior fontanel. Two cases of aplasia cutis congenita are presented. The first case was in a male newborn infant with a localized defect on his scalp. The second case was also in a male newborn infant who had extensive symmetrical involvement of his heels. No similar conditions and associating other congenital anomalies were found in the family members of reported cases.

Cryosurgery로 호전된 피부 리슈마니아증

최혜민(Hai Min Choi),명기범(Ki Bum Myung),국홍일(Hong Il Kook) 대한피부과학회 1983 대한피부과학회지 Vol.21 No.2

Cutaneous leishmaniasis (oriental sore) is usually a self-limited infection of the skin caused by the protozoan Leishmania tropica. The disease is endemic to the Mediterranean, Asia, Africa, and the Middle East. It has been seen in this country among many Korean technical experts and labourers working in the endemic areas of the disease. Our patient had acquired cutaneous leishmaniasis in Saudi Arabia and it had remained active for six months. He had been treated with antimony and metronidazole but failed because of severe side effects. And then we treated the patient witb cryosurgery and the skin lesions were followed by resolution with cosmetically acceptable scar in 4 months. The brief review of literature on the treatment of cutaneous leishmaniasis was undertaken.

피지선 모반에서 발생한 낭성 기저세포암

오지원,최혜민,함정희 ( Chee Won Oh,Hai Min Choi,Jeong Hee Hahm ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.3

선천성 평활근 과오종

오지원,최혜민,국홍일 ( Chee Won Oh,Hai Min Choi,Hong Il Kook ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.3

We have performed the prick test on 70 patients with atopic lermatitis and at the same time measured the levels of serum IgE and peripheral eosinophil counts. The following results were obtained: 1. Patients with atopic dermatitis showed higher rates of positivty in the prick tests, espe cially to inhalant, allergens. 2. The levels of IgE were increased in these patients and those who were positive to at least one allergen in the prick tests showed higher levels of IgE ha those who were negative in the prick tests. 3. The patients with atopic dermatitis with a past history of allergic rhinitis demonstrated higher rates of skin test positivity. 4. There was no correlation between the levels of serum IgE and the peripheral eosinophil counts in these patients with atopic dermatitis, (Kor J Dermatol 1992; 30(1): 43-50)

다발성 피부평활근종

김홍용(Hong Yong Kim),최혜민(Hai Min Choi),명기범(Ki Bum Myung),국홍일(Hong Il Kook) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.6

We present a case of multiple cutaneous leiomyoma in a 45 year old woman. About 20 years ago, multiple skin colored papules developed on right cheek and man4ibular area. About 10 years after the onset of the disease a uterine myoma developed which wae tree,ted by total hysterectomy. The skin lesions were gradually increasing in number and size, Some larger nodular lesions changed to brown in color and became painful after cold exposure. The histopathologic finding showed typical leiomyoma arieing from arrector pilorum muscle.

한국에서의 외용 약제에 의한 알레르기성 접촉 피부염의 임상적 연구 - 공동연구 -

김홍직 ( Hong Jig Kim ),현경준 ( Kyeong Joon Hyeon ),국홍일 ( Hong Eil Kuk ),최혜민 ( Hai Min Choi ),문기찬 ( Kee Chan Moon ),허충림 ( Choong Rim Haw ),김수찬 ( Soo Chan Kim ),은희철 ( Hee Chul Eun ),김정원 ( Chung Won Kim ),김형 대한피부과학회 1991 大韓皮膚科學會誌 Vol.29 No.1

Korean contact dermatitis research group(KCDRG) investigated 115 cases with suspected allergic contact dermatitis due to topical medicaments who visited 13 university hospitals in Korea during 1986 and 1987. The authors classified the subjects into 10 groups according to the causative medicaments and performed patch tests with as is, standard screening set(HollisterStier) and vehicle sensitivit,y series(Hollister-Stier). The results were as follows : 1. The incidence of investigated cases were shown one peak at third and fifth derades. Z. The cammon sensitizing groups of drugs were antiseptis(26.1%), medicaments for acne vulgaris(19%), medicaments for tissue repair(12.2%) and antibiotics(9.5%). 3. The commonsensitizing drugs were benzoyl peroxide(17.3%), povidone iodide (15.6%), Madecassol(8.7'lo), neomycin(6.9%) and Hygind(6.1% ). 4. The common allergens by patch test were mercuric chloride(14.5%), balsam of Peru(13.1%), cinnamic alcohol(13.1%) and potassium diichromate(11.6%). 5. Ant,iseptics and Madecassol were far more than the other countries. 6. Mercurochrome seems to be deereased and povidone-iodine increased compairing the past r eports. (Kor J Dermatol 29(l): 32 40, 1991)

기저세포 상피암에 대한 임상적 및 조직학적 관찰

최혜민,명기범,국홍일 梨花女子大學校 醫科大學 醫科學硏究所 1984 EMJ (Ewha medical journal) Vol.7 No.1

The clinical and histopathological analysis was done on 28 cases of basal cell epithelioma encountered in the Department of Dermatology, Ewha Womans University Hospital during the past 7 1/2 years period from January 1976 to June 1983. The results obtained were summarized as follows : 1) Of 28 patients, 15 cases were male and 13 cases were female with ratio of 1.16:1. 2) Average age was 53.5 years ranging from 15 to 90 years with the highest incidence rate in the age group 60-69 years. 3) Three cases of basal cell epithelioma in the young age group developed from xeroderma pigmentosum. 4) The average duration of disease was 7.5 years ranging from 1 to 20 years. 5) Twenty seven cases(96.4%) occured on face comprising 11 cases on nose, 8 cases on lower eyelid, 3 cases on cheek, each 1 case on forehead, eyebrow, upper lip, angle of mouth and mandible, and remaining 1 case occured on back. 6) The most common noduloulcerative lesion was observed in 7 cases(25.0%), and then followed by(in order)adenoid type and sclerosing type 6 cases (21.4%) respectively, mixed type 5 cases(17.9%) and keratotic type 4 cases(14.3%).

일광차단제도포후 자외선 조사에 의한 표피색소 세포의 변화에 관한 연구

최혜민,국홍일,박윤기 梨花女子大學校 醫科大學 醫科學硏究所 1988 EMJ (Ewha medical journal) Vol.11 No.3

Over-exposure to sunlight may result in sunburn, pigmented skin lesions, solar keratosis, premature aging of skin, or cancer in human skin. Sunscreens protect the structure and function of the human integument from the actinic damage. This protective effect is afforded by active ingredients of sunscreens through absorption, reflection, and/or scattering of the solar radiation impinging on the skin. There are oral and topical sunscreens. Para-aminobenzoic acid(PABA), PABA esters, benzophenones(BZ), cinnamates, salicylates and anthranilates are the topical sunscreens absorbing solar radiation. Most of them absorb UVB, but BZ absorb both UVB and UVA. These investgators observed the effect of the sunscreens by calculating sun protection factor(SPF) before and after application of the sunscreens in human skin. To my knowledge, there are no papers which evaluate morphological changes in the epidermal melanocytes after UVB or UVA irradiation following application of the sunscreens. In this experiment, a total of 150 adult male black mice(C57BL) was used. The animals were divided into one control (application of hydrophilic ointment base) and four experimental(application of PABA, Cinnamate, BZ or homomenthylsalicylate (HMS)) groups. Each group was irradiated by UVB and UVA, respectively. Each of the 5 groups were divided into 5 subgroups according to the days of UV light irradiation ; subgroup A for 2 days, B for 4 days, C for 6 days, D for 8days and E for 10 days. The daily doses of UVB and UVA were 50mJ/cm^2 and 5J/cm^2 respectively. YS UVB-400 and Waldmann UV 800 were used as a light source of UVB and UVA. Skin specimens were taken from both ears of the animals 24h after the last irradiation. The split-DOPA preparation was carried out for observation of the numbers and morphological changes of the epidermal melanocytes. The results are summarized as follows; 1. Changes in the numbers of the epidermal melanocytes : The numbers of the epidermal melanocytes markedly decreased in the experimental groups, especially in the group of PABA application(p<0.01), compared in the control group under UVB irradiation (p<0.01). However, only the group of BZ application showed a significant decrease in the numbers compared to the control group under UVA irradiation(p<0.01, p<0.05). 2. Changes in the size of the epidermal melanocytes ; Each experimental group, especially the group of PABA application (p<0.01), showed a significant decrease in the sizes of the epidermal melanocytes under UVB irradiation(p<0.01, p<0.05). On the other hand, only the group of BZ application showed a significant decrease in the sizes compared to the control group under UVA irradiation(p<0.05) From the results, it seems to be sure that PABA, Cinnamate, BZ, HMS can protect UVB from sunlight in the skin of black mice. Furthermore, BZ was effective for protection of UVB and UVA together.

CO_2 레이저의 피부과적 응용 : 색소성 및 혈관성 피부질환에서의 치료 효과 Therapeutic Effects in the Cutaneous Pigmented and Vascular Lesions

최혜민 梨花女子大學校 醫科大學 醫科學硏究所 1990 EMJ (Ewha medical journal) Vol.13 No.4

Carbon dioxide(CO_2) laser is the the most commonly used laser in the treatment of cutaneous disorders of the skin. CO_2 laser emits invisible far-infrared radiation of 10,600nm wavelength. This radiation is totally absorbed in a depth of only 0.1~0.2mm of water. Cutaneous tissue has a similar coffficient of absorption since it is 85~90% water. The internal scatter of the laser beam in water is minimal. These two factors, low penetration and minimal scatter, make the CO_2 laser a highly localized tissue-destructive modality. This study was undertaken to evaluate the therapeutic effect and complication of the CO_2 laser on the cutaneous pigmented and vascular lesions. The data of the 110 patients who were treated between October, 1987 and March, 1989 and could be followed up over 3 months at the Department of Dermatology. Ewha Womans University Hospital were analyzed. Patients were treated with Pfizer Laser System Model 20-C CO_2 laser. The power ranges were between 2 and 10W using continuous wave accrding to the size and the shape of the lesions. The CO_2 laser was more effective modality in the treatment of the pgmented lesions. especially lentigenes and solar lentigo than cutaneous vascular lesions. In the cutaneous vascular lesions, CO_2 laser was effective for rosacea and senile angioma.

피지선 증식증 1예

최혜민,명기범,국홍일,유경 梨花女子大學校 醫科大學 醫科學硏究所 1983 EMJ (Ewha medical journal) Vol.6 No.3

Sebaceous hyperplasia, also called senile sebaceous hyperplasia refers to a benign enlargement of normal sebaceous unit in the old age group. The lesions, single or multiple, elevated, cream to yellowish colored round papules with frequent central umbilication have a predilection for the forehead and cheeks. We present an atypical case of sebaceous hyperplasia on a 31-year-old man. About 15 years ago, a small skin colored papule developed on his right cheek without pre-existing skin eruption or trauma history. The asymptomatic papule enlarged slowly reaching up to a walnut sized plaque.