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최준식,이진환,이종기,신귀호 한국임상약학회 1991 한국임상약학회지 Vol.1 No.1
This study was attempted to investigate the dissolution rate and bioavailability of commercially available furosemide preparations. A. B. and C. The dissolution test was conducted in an artificial gastric juice using the basket method. and furosemide (40 mg) was administered orally to 8 normal volunteers by cross-over design. The results were as follows: the AUC and dissolution rate in 100 min () were higher in order of preparations. A > C > B. But the peak concentration. time to reach peak concentration , and mean dissolution time (MDT) were in order of preparations. C > A > B. There were significantly linear correlations between the AUC and the , and between the and the MDT. From the results of this experiment. it can be concluded that commercially available preparations bioavailability of furosemide, which may be predicted from the dissolution rate.
최준식,이진환,범진필,Choi, Jun-Shik,Lee, Jin-Hwan,Burm, Jin-Pil 한국약제학회 1990 Journal of Pharmaceutical Investigation Vol.20 No.1
Effect of an angiotensin inhibitor (AAS; loading dose of 25, 50, $100{\mu}g/kg$ and maintenance dose of 12.5, 25,$50{\mu}g/ka/hr$) on the pharmacokinetics of propranolol (4 mg/kg i.v.) was studied in rabbits. Plasma concentrations and relative bioavailability of propranolal increased upto 127-175% by AAS coinjection. The urinary excretion of propranolol decreased by AAS. Dosage regimen of propranolol should be adjusted when it is administered with AAS.
崔俊植 大田工業高等專門學校 1969 論文集 Vol.4 No.-
Accurate judgement cannot be available for the life of reinforced concrete building, to the exclusion of objective opinion on the judgement of its life. That is to say that, even if the life of structural frame of the building is permanent, its substantial functional requirement in connection with planning, equipment or facilities have a strong influence on the life of the building. In addition to the above, it partially depends on the superannuation of the attached structure such as steel sash, anchors, roof drain etc. Thus I have analized the measure on the life of reinforced concrete building and some suggestion are made,
Probenecid와 Nalidixic Acid의 약물상호작용(藥物相互作用) ( II )
최준식,이진환,김용현,이민화,Choi, Jun-Shik,Lee, Jin-Hwan,Kim, Yong-Hyun,Lee, Min-Hwa 한국약제학회 1983 Journal of Pharmaceutical Investigation Vol.13 No.4
The interaction between probencid and nalidixic acid was studied pharmacokinetically in rabbits infused with or without acidic soiution (5% $NH_4Cl$). The results were as fellows. The blood level and the area under the blood concentration curve of nalidixic acid administered intravenously was elevated by coadministration of probenecid and more elevated in rabbits infused with acidic solution. Probenecid inhibited the urinary excretion of nalidixic acid in rabbits infused with adidic solution. Therefore, biolgcal half-life of nalidixic acid was prolonged by coadministration of probencid.
최준식,이진환 대한약학회 2003 약학회지 Vol.47 No.2
The purpose of this study was to investigate the effect of flavone (20 mg/kg) on the pharmacokinetic parameters and the bioavailability of paclitaxel (40 mg/kg) orally coadministered in rats. The plasma concentration of paclitaxel in combination with flavone was increased significantly (coadministration p<0.05, pretreatment p<0.0l) compared to that of control. Area under the plasma concentration-time curve (AVC) of paclitaxel with flavone was significantly (coadministration p<0.05, pretreatment p<0.0l) higher than that of control. Peak concentration (Cmax) of paclitaxel with flavone were significantly increased (coadministration p<0.05, pretreatment p<0.01) compared to that of control. Time to peak concentration (Tmax) of paclitaxel with flavone decreased significantly (p<0.05) than that of control. The total body clearance (CLt) and elimination rate constant ($\beta$) of paclitaxel with flavone were significantly reduced (p<0.05) compared to those of control. Half-life (t$_{1}$2/) of paclitaxel with flavone was significantly prolonged (p<0.05) compared to that of control. Based on these results, it might be concluded that flavone may enhance bioavailability of paclitaxel through the inhibition of cytochrome P450 and P-glycoprotein, which are engaged in paclitaxel absorption and metabolism in liver and gastrogintestinal mucosa, respectively.
최준식,범진필 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1
The pharmacokinetics of orally administered verapamil (10㎎/㎏) was studied in six rabbits after 20 min pretreatment with quercetin and coadministration of quercetin (2.0㎎/㎏, 10㎎/㎏ and 20㎎/㎏, respectively). Pretreatment with quercetin significantly (p<0.01, p<0.05) increased the plasma concentration of varapamil. However, coadministration of quercetin showed no significant effect on the pharmacokinetic parameters of verapamil. The elimination rate constant (K_(el)) of verapamil pretreated with quercetin (10 ㎎/㎏ and 20 ㎎/㎏) was significantly (p<0.05) reduced compared with control. The area under the plasma concentration-time curve (AUC) and the peak concentration (C_(max) of verapamil pretreated with quercetin (2.0 ㎎/㎏, 10 ㎎/㎏ and 20 ㎎/㎏) were increased significantly (p<0.01, p<0.05) compared with control. Pretreatment with quercetin (2.0 ㎎/㎏, 10 ㎎/㎏ and 20 ㎎/㎏) significantly (p<0.01, p<0.05) increased the relative bioavailability of verapamil to 159-219%. These results suggest that quercetin alter disposition of verapamil by inhibition of P-glycoprotein efflux pump and its first-pass metabolism. the dosage fo verapamil should be adjusted when it is administered chronically with quercetin in a clinical situation.