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흰쥐 내후야의 아미노산 함량에 대한 복측 또는 배측 뇌 해마 제거 영향
최석형,김종규,양훈모,민영기 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2
This study was planned to analyze amino acids in the entorhinal cortex of dorsal and ventral hippocampectomized rats by high performance liquid chromatography (HPLC). Male albino rats were used. Under chloral hydrate anesthesia (20%, 2 ㎖/㎏ body weight), a hole was made in each parietal bone about 4 mm lateral to the sagittal suture, and 4 mm rostral to the lambda suture. The cortical tissue on each side was removed and, through this opening, the hippocampal tissue anterodorsal and posteroventral to the hippocampal flexures on both sides was removed by aspiration. This preparation served as the dorsal and the ventral hippocampal animals, respectively. The cortical control animal received the same surgery short of hippocampectomy. The normal rats served as normal control animal. One week later, the animals were sacrificed by decapitation in the cold room. Two to three milligrams of tissue was obtained from the entorhinal cortex in one side of the brain. The tissue samples were homogenized and centrifuged. Then content of each amino acid was measured by HPLC from the brain tissue. 1) The contents of aspartate were decreased significantly more in the dorsal and ventral hippocampal groups than in the normal and the cortical control groups, while there were no significant differences between the 2 hippocampal and 2 control groups. 2) The contents of glutamate were decreased significantly more in the dorsal hippocampal group than in the normal and the cortical control groups. The contents of glutamate were increased significantly more in the ventral hippocampal group than in the dorsal hippocampal, the normal control, and cortical control groups. while there was no significant difference between the 2 control groups. It is inferred from the above mentioned results that glutamate and aspartate of many amino acids may he used as a excitatory transmitter in entorhinal cortex, and that the dorsal hippocampus may be facilitatory to the entorhinal cortex, but the ventral hippocampus would be inhibitory/facilitatory to the cortex.
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이남규,박영호,최석형 순천향대학교 1994 논문집 Vol.17 No.4
Prostatic specipic antigen(PSA), neutral serine protease secreted exclusively by prostatic epithelial cell, has a number of application in the diagnosis of men with prostatic carcinoma. It is widely recognized that elevated PSA correlates with the presence of carcinoma. We measured serum PSA levels in normal controls, patients with benign prostate hyperplasia symptoms because to evaluate diagnostic value of PSA as a tumor marker for prostatic cancer. Mean values of serum PSA in normal controls and patients with BPH symptoms were 2.83±4.02, 23.48±62.17ng/ml, respectively(p<0.01). We conclude that serum PSA offers simple and objective tumor maker but interpretation of significance of a specific level measured is inexact.
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부록: 멘토링 프로그램 참가 후기 : 멘토링 프로그램: 의예과생을 위한 줄기세포 연구 프로그램
최석형 ( Suk Hyung Choe ),구승엽 ( Seung Yup Ku ) 서울대학교 인구의학연구소 2012 人口醫學硏究論集 Vol.25 No.-
Stem cell research mentoring is a newly introduced program of Seoul National University (SNU) College of Medicine this year. Many SNU medical students were given the chance to participate in the variety of medical research field, such as cancer, Stem cell, neurology, immunology, pharmacology, regenerative medicine, etc. Embryonic stem cell research is one of the leading groups of medical research, because human embryonic stem cell could differentiate into many types of cells and tissues that could be used for currently unconquered human diseases. Through this mentoring program, not only can medical students experience the methods of stem cell medical research, but they can also be acquainted with the incredible medicine of the 21st century.
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긴장성 요실금에 대한 Modified pereyra procedure 치험1례
박영호,최석형,이상대 순천향대학교 1989 논문집 Vol.12 No.3
We report a case of Grade Ⅱ stress incontinence in 55 years old female treated by modified Pereyra procedcure with the review of literatures.
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박영호,김민의,최석형,남윤재,이동화 순천향대학교 1992 논문집 Vol.14 No.4
신장의 낭성신세포암은 신세포암의 드문 변종으로 그 구성형태 및 혈성 또는 괴사된 조직 등 내용물의 성질에 따라 분류되어 왔으며 그 생물학적 특성은 일반적으로 신세포암과 유사하다. 따라서 단순낭종과 감별이 임상적으로 매우 어려우며 조직학적으로만 확진이 가능하다. 또한 낭성신암은 대다수가 Robson의 분류에 따라 1기에 속하여 증상에 있어서도 신세포암의 일반적 증상 모두를 포함하고 있다. 최근 본 교실에서 우연히 정기검진중 초음검사상 종물을 포함한 신낭종의 소견을 보인 41세 남자환자에서 신낭종을 천자하여 세포검사상 음성으로 나타나 단순신낭종 절제를 시행하였으나 조직검사상 grade Ⅱ의 낭성신세포암으로 진단되어 광범위 신적출술을 시행한 환자를 치험하였기에 문헌고찰과 함께 보고하는 바이다. Cystic renal cell carcinorma is a relatively rare tumor. The radiolographic and pathologic findings of cystic renal cell carcinoma are often more confusing and less specific than the finding of solid renal cell carcinoma. We report a case of cystic renal cell ca in 41 years old man confirmed by pathologic finding, who was treated by radical nephrectomy but was misdiagnosed of simple renal cyst by ultrasonography initially.
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