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2LD-9 Photoelectronic and biomedical applications of porphyrin photosensitizer
최명석 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
Porphyrin is a highly light-sensitive photosensitizer that is widely used in photoelectronic and biological applications. A porphyrin molecule is a heterocyclic macrocycle derived from four pyrroline subunits interconnected through their α-carbon atoms and methine bridges (=CH-). The porphyrin ring structure is aromatic, with a total of 26 electrons in the conjugated system. Porphyrins and their derivatives are relatively non-toxic and promising candidates as a molecular building block for photoelectronic and biomedical applications, due to their unique optical and electrical properties. Herein, we report our recent studies leading to the synthesis of a novel porphyrin derivatives as potential photosensitizer in the field of electronic devices, chemosensor, and photodynamic theraphy.
최명석,Ankush Gupta,서정화,S. Velmathi,James N. Wilson,Jong S. Park 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.1
In this study, we report the efficient identification of proteins using (6-hydroxy-2-naphthyl)ethenyl pyridinium dyes (HNEPs). These dyes exhibited characteristic fluorescence responses, showing enhanced fluorescence with a red shift in the case of bovine serum albumin. The nature of the interaction between the dye and the protein was examined using a combination of various spectroscopic techniques. A time-dependent density functional theory analysis supported the strong environment-dependent fluorescence emission properties of the dyes. The current investigation clearly demonstrates that a selective optical response HNEPs can find potential usefulness as bio-sensing probes.
Efficient Release of Ferulic Acid from Sweet Potato (Ipomoea batatas) Stems by Chemical Hydrolysis
최명석,이종윤,이병현,정강원,Chandrakant S. Karigar,Ji-Hyun Park,Ji Yun Min,Bu-Kug Lim,양재경 한국생물공학회 2008 Biotechnology and Bioprocess Engineering Vol.13 No.3
An efficient method for release of ferulic acid from sweet potato stems was developed. Ferulic acid along with phenolic compounds were released from stems by acid and alkaline treatments. The base hydrolysis with 0.1 N NaOH yielded the highest quantity of total extracts (471.1 mg/g). The stems released more phenolic compounds when 0.0125~0.025 N NaOH was employed. Where as ferulic acid release was maximal with 0.05 N H₂SO₄ (0.32 mg/g). Ferulic acid was separated from phenolics by column chromatography. Among the elution solvents, ethyl acetate fractions (80%) contained ferulic acid. Ethyl acetate eluants were further fractionated with n-hexane/ethyl acetate/formic acid (100/50/0.5, v/v/v). All fractions showed ferulic acid and phenolic compounds. Fraction V among them was ascribed to ferulic acid with an yield of 5.41 mg/g of dry sweet potato tissue.
Production of Ginkgolides and Bilobalide from Optimized the Ginkgo biloba Cell Culture
최명석,김선원,정영관,박용구,Su-Jung Kim,Young-Min Kang,Hee-Young Jung,D. Theertha Prasad 한국생물공학회 2004 Biotechnology and Bioprocess Engineering Vol.9 No.1
The influence of various culture conditions on growth and ginkgolides (GKA and GKB), and bilobalide formation in callus and suspension cultures of Ginkgo biloba were investigated. Callus induced from the leaf petioles exhibited distinct morphological and physiological responses. The cell biomass and ginkgolides content varied among the cell lines; brownish callus lines produced high levels of ginkgolides and bilobalide in spite of poor cell growth. Among the culture media used, MS medium showed significant effect on cell growth and ginkgolides production. Low concentration of sucrose (3%) improved cell growth, while higher sucrose levels (5 and 7%) improved ginkgolides production. Cultivation of callus cultures above 28oC dramatically reduced their growth rate; however the cell lines grown at 36oC showed increased levels of bilobalide content. A 2.5-L balloon type bubble bioreactor (BTBB) was successfully developed for the cell growth and ginkgolides production.
최명석,엄길호,곽관웅,Mai Duc Dai,Alexander Olshevskiy,김창완 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.5
Carbon nanotube (CNT) has recently received much attention due to its excellent electromechanical properties, indicating that CNT can be employed for development of Nanoelectromechanical system (NEMS) such as nanomechanical resonators. For effective design of CNT-based resonators, it is required to accurately predict the vibration behavior of CNT resonators as well as their frequency response to mass adsorption. In this work, we have studied the vibrational behavior of Multi-walled CNT (MWCNT) resonators by using a continuum mechanics modeling that was implemented in Finite element method (FEM). In particular, we consider a transversely isotropic hollow cylinder solid model with Finite element (FE) implementation for modeling the vibration behavior of Multi-walled CNT (MWCNT) resonators. It is shown that our continuum mechanics model provides the resonant frequencies of various MWCNTs being comparable to those obtained from experiments. Moreover, we have investigated the frequency response of MWCNT resonators to mass adsorption by using our continuum model with FE implementation. Our study sheds light on our continuum mechanics model that is useful in predicting not only the vibration behavior of MWCNT resonators but also their sensing performance for further effective design of MWCNTbased NEMS devices.