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조항영,Cho, Han-Yong 대한약리학회 1967 대한약리학잡지 Vol.3 No.1
A colorless needle crystal mass is isolated from rhizom of Cimicifuga heracleifolia Komarov which is used as antipyretic ana antiinflammatory drug. This substance is ientified as 3-hydroxy 4-methoxy cinnamic acid.
조항영(Hang Yung Cho) 한국생약학회 1974 생약학회지 Vol.5 No.3
The yellow needle crystal was isolated from Atractylis Rhizoma, having mp 124∼126℃ (decomp.), the chemical composition C_(16)H_(21)N₃O_6, and its m.w. 251. The pharmacological actions of this alkaloid were studied by various psycopharmacological experiments. 1) In order to see the effect of this Atractylis(= At.) alkaloid on gross general behaviors in mice, a behavioral analysis experiment was adapted. The occurrence number of sleep and lying in At. alkaloidal animals with the doses 10㎎/㎏ or 20 ㎎/㎏ was increased but the number of jumping, exploration, rearing and defecation was significantly decreased than those of placebo. 2) The effect of the At. alkaloid on unlearned emotional behaviors of mice was studied with an open-field method. The At. alkaloidal groups with the doses 20㎎/㎏ or 30 ㎎/㎏ showed less often the frequency of locomotion than that of placebo. 3) To know the effect of the At. alkaloid on the learning, a standard water maze experiment and conditioned avoidance response were conducted. As compared to placebo control, the aquisition rate of the maze learning in the alkaloidal mice with the dose of 10㎎/㎏ or 20㎎/㎏ was significantly impaired and the speed of swimming was also signficantly delayed. In the conditioned avoidance response, the extinction performances of the alkaloidal rats with doses of 20㎎/㎏ or 30㎎/㎏ did not differ significantly than that of placebo.
Rutin 동효물질의 국산천연 약품자원에 관한 연구 (Ⅰ) - Lespedeza 속 식물의 풀라보노이드 검색
조항영(Hang Yong Cho),한성순(Sung Soon Han) 한국생약학회 1973 생약학회지 Vol.4 No.1
In order to detect constituents with similar actions to rutin in the genus Lsepedeza plants growing in Korea, twelve species were collected in Chung Buk and Kyung Ki Provinces and subjected to systematic extraction. When the extract was examined for flavonoid by adding flavonoid reagents, all the species gave positive cofirmatory tests. The examination of the flavonoid consitituents by T.L.C. gave the following results: as rutin-like constituents, quercetin was detected in L. cyrtobotrya, L. maritima and L. bicolor var. melanantha and eriodictin-like constituents were detected in seven species. Of those twelve species, five species, L. cuneata, L. cyrtobotrya, L. maritima, L. bicolor var. melanantha and L. patentibicolor were found to contain kaempferol. All of them appear to contain lespedin and eriodictiol.
Chlorpromazine, Meprobamate 및 Chlordiazepoxide가 마우스의 미로학습에 미치는 영향
朴贊雄,張鉉甲,趙恒英 中央醫學社 1972 中央醫學 Vol.22 No.4
In order to assess the effect of the tranquilizers, i.e. Chlorpromazine, mepro,bamate and chlordiazep oxide on maze learning, mice were tested in a single- T water maze after one of the following drug treatments; physiological saline; .1.25mg/kg of chlorpromazine; 20mg/kg of meprobamate; and 10mg/kg of chlordiazepoxide. The test apparatus was a galvanized steel T-tank 11. 5cm wide and 18cm -deep described by Latz et al. (1967). The maze was filled with 22-24°C water to a depth of 10cm. Drugs were administrated intraperitoneally 20-30min. before test. A session consisted of 3 adaptation and consecutive 20 test trials. The number of correct trials and swimming speed were served as an index of learning performances. The results obtained were as follows; As compared to physiological saline, the number of correct trials were significantly decreased and the swimming speed was significantly delayed after administration of chlorpromazine, but the number of successful trials and swimming time were not changed significantly after administration of mepro bamate and chlordiazepoxide.
감초알카로이드에 관한 연구(제 4 보) -감초 알카로이드 분획의 항궤양작용에 대한 검토-
홍사악,박찬웅,조항영,이철우,Hong, S.A.,Park, C.W.,Cho, H.Y.,Lee, C.W. 대한약리학회 1969 대한약리학잡지 Vol.5 No.2
Anti-ulcer activity of licorice alkaloid fraction, separated from Glycyrrhiza glabra L. by fractionation according to general alkaloid purification procedure, were studied with various experimental gastric ulcers. In Shay ulcer, licorice alkaloid fraction inhibit significantly response rate and severity of ulcer. But there was no significant changes in volume and pH of gastric contents. A male rat was fixed on a board and immersed up to breast in water of $25^{\circ}C$ for 20 hrs. Hemorrhage and erosion develop in all the animals on the mucosa of the glandular portion of stomach. Licorice alkaloid fraction (5 mg/kg, 10 mg/kg) inhibit significantly in the severity of stress ulcer but there was no changes in the response rate. Chlorpromazine produce marked inhibition in the severity and response rate of ulcer It was suggested that at least the anti-ulcer activity of licorice alkaloid fraction was not mediated by central depression.
인삼의 중추신경계에 대한 작용 - 인삼이 흰쥐의 정서반응에 미치는 영향
김응찬(Eung Chan Kim),조항영(Hang Young Cho),김주명(Joo Myung Kim) 한국생약학회 1971 생약학회지 Vol.2 No.1
This study was planned to see whether the Panax Ginseng root has any influence upon the emotionality in rats exposed to a novel open-field and induced by a grid shock. Sixty four male albino rats whose body weight ranged from 130 to 180 gm were used. They were divided into four groups, i.e., placebo control group, 5㎎/㎏ Ginseng ext. group, 10㎎/㎏ Ginseng ext. group, and 20㎎/㎏ Ginseng ext. group. Sixteen rats were subjected in each group. Open-field activity was measured in a 2.20m×2.20m open-field that was divided into 15cm squares. Four novel objects and food pellets were put with an equal distance in the open-field. Locomotion was recorded by entering the number of squares traversed for 4 min. and behaviors which were shown at the 10-sec. period were checked by a modified Jarrad and Bunnel`s observation procedure. Sensitivity to the grid shock was measured in a compartment of shutlle box. 10, 20, 30, 40, 50, 60 and 70 volt ac. 2 sec., electric shock were delivered in each subject by the grid to animal`s feet. Flinch, vocalization and jumping responses were rated in each shock level. The results obtained were as follows: 1.) 5㎎/㎏ and 10㎎/㎏ Ginseng ext. groups were tended to increase the ambulation and exploration compared with placebo control. 2.) All Ginseng extract groups were defecated significantly less often than placebo control in the open-field and shock situation. 3.) Thresholds to the electric shock were tended to elevate in all Ginseng groups. 4.) These results suggest that Ginseng extract has a stimulant action in open-field and a tranqulizing action in feared situation.