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고혈압 허혈성 심질환에서 혈청 Apolipoprotein의 변화에 관한 연구
조승렬,안기완,장경식,정춘해,홍순표,조건국 朝鮮大學校 附設 醫學硏究所 1987 The Medical Journal of Chosun University Vol.12 No.1
The overwhelming evidence that low density lipoprotein (LDL) plays a major role and high density lipoprotein (HDL) plays a preventive role in cardiovascular disease is beyond refutation. Since the protein moiety of HDL and LDL is the most important determinant of its compositional and structural stability, attensions has turned to the estimation of HDL and LDL protein rather than cholesterol as an index of plasma HDL and LDL concentration. We measured and compared the levels of serum apolipoprotein A (apo-A), and apolipoprotein 13 (apo-B), HDL--cholesterol (HDL-C), total cholesterol, and triglyceride in control group and patients with hypertension and ischemic heart disease. The results arc summerized as follows. 1. In hvpetensive patients, the level of apo-A is significantly lower (p < 0. 00l) than control group, other levels shows no significant difference. 2. In patients with ischemic heart disease, the levels of apo-A and HDL-C are significantly lower (p < 0.001, p < 0.005, respectively) and apo-B and apo-B/apo-A are higher (p < 0.005, p < 0.001, respectively) than control group. Other lipid levels shows no significant difference. It seems that apo-A and apo-B/apo-A are more useful than apo-B and HDL-C for identifying ischemic heart disease.