종설 : 단클론성 항체를 활용한 B 세포 악성 림프종 치료의 신기원: 리툭시맙

조석구 ( Seok Goo Cho ) 대한내과학회 2006 대한내과학회지 Vol.71 No.2

혼합실험계획법에 의한 율무와 밀가루의 압출성형 최적 배합 조건 설정

조석철(Seok-Cheol Cho),강병선(Byung-Sun Kang) 한국식품과학회 2013 한국식품과학회지 Vol.45 No.4

혼합디자인에 의해 설정된 조건하에서 압출성형한 율무와 밀가루의 압출성형물은 율무 첨가에 대해 여러 반응 요인들이 압출성형물의 특성에 영향을 끼치는 것으로 나타났다. 실험조건은 율무 함량 5-75%, 밀가루 25-95%로 결정하였으며, 수분함량은 20.55%로 고정하여 modified distance based mixture design으로 실험설계 및 분석하였다. Bending 파손강도, WAI, a값 등은 유의성이 없는 것으로 나타났으나, 팽화물의 직경, WSI, L값, b값은 율무와 밀가루의 혼합에 의해 유의성이 존재하는 것으로 나타났다. 팽화물의 직경, L값, b값은 선형 모델로 분석할 수 있었으나 WSI는 quadratic 모델로만 설정이 가능한 것으로 나타났다. 율무의 함량이 많아질수록 외관적으로 팽창되어지는 정도가 적어졌으며, 색상도 어두워지는 것으로 나타났다. 율무의 함량이 증가할수록 L값은 77.84에서 72.73, a값은 1.37에서 1.77로, b값은 19.42에서 17.64로 이동되었다. WSI는 율무와 밀가루가 40%:60% 로 혼합되어 압출성형되었을 때 가장 낮게 나타났으며, WAI는 율무와 밀가루 혼합 비율에 대해서는 유의성이 없는 것으로 나타났다. 혼합디자인 계획법은 시리얼류 제품 생산에 적합한 조직형성과 반응량에 유의한 영향을 미치는 요인 등에 대해 적절한 혼합 비율과 가공 조건 등을 제시할 수 있음을 알 수 있었다. Modified distance based mixture design에 의해, 일반 시중 제품과 유사한 조직감을 나타낼 수 있는 율무와 밀가루, 물의 적정 배합비율은 60.12:19.42:20.46으로 나타났다. The aim of this study was to identify the optimal ingredient-mixing ratio of Job’s-tear and wheat flour subjected to extrusion. A modified distance-based mixture design analysis was chosen for the experimental design. The results showed that the bending failure force, the a-value, and the water absorbtion index (WAI) value had no correlation with the mixture ratio of Job’s-tear and wheat flour. However, the diameter of the extrudates, the L- and b-values, and the water solubility index (WSI) value were all found to be correlated to the mixture ratio. While the first three values were determined using a linear model, the WSI value was determined using a quadratic model. The diameter and color had an inverse correlation to the mixture ratio: the higher the ratio of Job’s-tear to wheat flour, the lower the diameter and darker the color. The L- and b-values were found to change in accordance with the mixture ratio of Job’s-tear to wheat flour. The lowest WSI value was obtained at a 40:60 ratio of Job’s-tear to wheat.

옥수수전분 현탁액의 알칼리 호화

조석철(Seok-Cheol Cho),신해헌(Hae-Hun Shin),차윤환(Yun-Hwan Cha),변유량(Yu-Ryang Pyun) 한국식품과학회 2007 한국식품과학회지 Vol.39 No.2

옥수수전분의 알칼리호화는 NaOH 첨가에 의하여 지수적으로 증가하였으며, 호화도가 급격히 증가하기 시작하는 구간을 알칼리호화 개시점으로 추정하였다. 10%(w/w) 옥수수 전분 현탁액의 40℃에서 호화개시점은 24.1 meq NaOH/g starch인 반면에 60℃에서는 9.8 meq NaOH/g starch이었다. 또한 옥수수전분 현탁액의 농도를 40%로 증가시킨 경우 40℃에서 9.5 meq NaOH/g starch에서 호화가 개시되었다. 이와 같은 결과로부터 전분의 알칼리호화 개시농도가 전분 현탁액의 농도와 온도에 반비례하는 것을 알 수 있었다. In this study, we examined the characteristics of alkali gelatinization of corn starch. Here, the degree of com starch gelatinization increased exponentially with the NaOH concentration of the starch slurry. The alkali gelatinization initiation point (AGIP) was obtained from the intersection point of gelatinization slope line, which resulted from the regression of the logarithmic degree of gelatinization, and was markedly changed. The effects of temperature and com starch concentration on alkali gelatinization were studied with a 10%(w/w) corn starch suspension. We found that this corn starch suspension gelatinized in 24.1 meq/g starch of NaOH at 40℃, and in 9.8 meq NaOH/g starch at 60℃. Moreover, a 40%(w/w) corn starch suspension gelatinized with 9.5 meq NaOH/g starch, even at 40℃. These results indicate that the amount of alkali added for the gelatinization of corn starch has an inverse relationship with the temperature and concentration of com starch.

디지털 방송 수신을 위한 실시간 오디오 데이터 구현방법에 대한 연구 개발

조석균(Seok-Gyun Cho),김용득(Yong-Deuk Kim) 대한전자공학회 2007 대한전자공학회 학술대회 Vol.2007 No.7

Many new services ard possible with the introduction of digital TV technology, Current trend of broadcasting technology has developed into CATV and DBS and signal transmission is being digitalized. In this paper, a new solution about digital amp is propered to manage about digital amp of BTL solution for the 5.1ch Audio output.

류마티스 관절염 환자의 활액과 활막조직에서의 IL - 6 의 활성도

조석구(Seok Goo CHo),이상헌(Sang Heon Lee),홍연식(Yeon Sik Hong),조철수(Chul Soo Cho),박석영(Seok Young Park),박동준(Dong Jun Park),김호연(Ho Youn Kim),이정용(Jung Young Lee),김상호(Sang Ho Kim),변광호(Kwang Ho Pyun) 대한내과학회 1993 대한내과학회지 Vol.45 No.2

N/A Background: Interleukin-6 (IL-6), previously known as B cell stimulatory factor 2 (BSF-2) is a multifunctional cytokine that is produced by a various cells and plays an important role in the host defence mechanism such as regulation of immune response, acute phase reaction and hematopoiesis. Recent investigations have demonstrated that unregulated expression of IL-6 gene and overproducion of lL-6 were involved in the pathogenesis of cardiac myxoma, Castleman's disease, autoimmune disease, proliferative glomerulonephritis and certain lymphoid malignancies, especially plasmacytoma/multiple myelomas. We tried to evaluate the regulatory effect of IL 6 an the pathogenesis of rheumatoid arthritis (RA) which is characterized by hyperactivation of 8 cells, presence of various autoantibodies and increase in acute phase proteins and platelets. Methods: The IL-6 activity was measured by bioassay using the murine IL-6 dependent hybridoma cell lines (MH60. BSF2), ELISA method and immunohistochemical analysis. Results: 1) IL-6 activity was significantly elevated m synovial fluid from patients with rheumatoid arthritis (RA, n= 25) as compared with osteoarthrits (OA, n=6) and seronegative arthritis (SNA, n=4) (p<0.05). 2) IL-6 activity was also elevated in serum from patients with RA as compared with other disease (P <0.01). 3) High IL-6 activity and destructive changes in affected joints had a tendency to be correlated (r=0.716), And positive correlations between IL-6 activity and C-reactive proteins in serum were observed in patients with RA (r=0.752). 4) Immunohistachemical analysis demonstrated that positive-staining cells were located on the perivascular space. Conclusion: The results suggest that unregulated production of IL-6 may play an important role in the pathogenesis of RA and could explain local as well as generalized symptoms of RA. However, it is not known whether excessive production of IL-6 is a primary event in the disease process, or secondary consequence.

인공 신경망 가속기 온칩 메모리 크기에 따른 주메모리 접근 횟수 추정에 대한 연구

조석재(Seok-Jae Cho),박성경(Sungkyung Park),박성정(Chester Sungchung Park) 한국전기전자학회 2021 전기전자학회논문지 Vol.25 No.1

이미지 인식 및 패턴 감지를 위해 널리 사용되는 알고리즘 중 하나는 convolution neural network(CNN)이다. CNN에서 대부분의 연산량을 차지하는 convolution 연산을 효율적으로 처리하기 위해 외부 하드웨어 가속기를 사용하여 CNN 어플리케이션의 성능을 향상 시킬 수 있다. 이러한 하드웨어 가속기를 사용함에 있어서 CNN은 막대한 연산량을 처리하기 위해 오프칩 DRAM에서 가속기 내부의 메모리로 데이터를 갖고 와야 한다. 즉 오프칩 DRAM과 가속기 내부의 온칩 메모리 혹은 글로벌 버퍼 사이의 데이터 통신이 CNN 어플리케이션의 성능에 큰 영향을 끼친다. 본 논문에서는 CNN 가속기 내의 온칩 메모리 혹은 글로벌 버퍼의 크기에 따른 주메모리 혹은 DRAM으로의 접근 횟수를 추산할 수 있는 시뮬레이터를 개발하였다. CNN 아키텍처 중 하나인 AlexNet에서, CNN 가속기 내부의 글로벌 버퍼의 크기를 증가시키면서 시뮬레이션 했을 때, 글로벌 버퍼 크기가 100kB 이상인 경우가 100kB 미만인 경우보다 가속기 내부와 오프칩 DRAM 간의 접근 횟수가 0.8배 낮은 것을 확인 했다. One widely used algorithm for image recognition and pattern detection is the convolution neural network (CNN). To efficiently handle convolution operations, which account for the majority of computations in the CNN, we use hardware accelerators to improve the performance of CNN applications. In using these hardware accelerators, the CNN fetches data from the off-chip DRAM, as the massive computational volume of data makes it difficult to derive performance improvements only from memory inside the hardware accelerator. In other words, data communication between off-chip DRAM and memory inside the accelerator has a significant impact on the performance of CNN applications. In this paper, a simulator for the CNN is developed to analyze the main memory or DRAM access with respect to the size of the on-chip memory or global buffer inside the CNN accelerator. For AlexNet, one of the CNN architectures, when simulated with increasing the size of the global buffer, we found that the global buffer of size larger than 100kB has 0.8x as low a DRAM access count as the global buffer of size smaller than 100kB.

1GHz~18GHz 주파수 범위의 초고속 PIN 다이오드 스위치 개발

조석진(Cho Seok Jin),구본희(Koo Bon Hee),은기찬(En Ki Chan),박병우(Park Byung Woo),이창화(Lee Chang Hwa) 한국통신학회 2014 한국통신학회 학술대회논문집 Vol.2014 No.1

다구획 작업환경에서의 오염농도 예측을 위한 이론적 모델의 개발

조석호 ( Seok Ho Cho ) 한국산업위생학회 2011 한국산업보건학회지 Vol.21 No.4

To predict contaminant concentrations within a multi-zone work environment, an air quality model in the work environment was developed. To do this, airflow equations on the basis of orifice equation were solved by using the Conte and De Boor scheme, and then equations for the conservation of mass on contaminant were solved by using the fourth-order Runge-Kutta algorithm. To validate the accuracy of simulated results, this model was applied to the controlled environment chamber that had been tested in 1998 by Chung KC. The comparison of predicted concentrations by this study with measured concentrations by the Chung KC indicated that the average deviations were 2.66, 3.35, and 3.15% for zone 1, zone 2, and zone 3, respectively. Also, this model was applied to a working plant with four zones. Thus, the results of contaminant concentration versus time were predicted according to the schedule of the openings operation, and case studies were done for four cases of the openings operation to investigate the interaction of airflow and contaminant concentration. The results indicated that opening operation schedules had a significant effect on contaminant removal efficiency. Therefore, this model might be able to apply for the design of ventilation schedules to control contaminants optimally.

하이퍼 퀵 정렬을 이용한 병렬 결합 알고리즘

조석봉(Seok Bong Cho),원영선(Young Sun Weon),홍만표(Man Pyo Hong) 한국정보과학회 1997 정보과학회논문지(B) Vol.24 No.6

대용량 데이타베이스 처리 시스템에서는 효율적인 자료 처리를 위하여 빠른 응답시간을 요구하며, 이를 위해서는 데이타베이스 시스템의 병렬화가 필수적이다. 특히 결합 연산은 비교적 긴 처리 시간을 요구하며, 각 처리기에 릴레이션을 균등하게 분배하는 방법은 시스템의 성능에 커다란 영향을 끼친다. 본 논문에서는 하이퍼큐브 구조에 적합한 하이퍼 퀵 정렬을 이용하여 정렬 병합 알고리즘의 단점인 많은 오버헤드를 해결함과 동시에 각 처리기에서의 부하 균등을 이룸으로써 전체적인 통신 시간을 줄일 수 있는 효율적인 병렬 결합 알고리즘을 제안한다. 또한 제안한 알고리즘의 분석 모델을 통하여 기존의 병렬 결합 알고리즘에 비해 보다 나은 성능을 나타냄을 보인다. Fast response time is required to process data effectively in very large database processing systems. In doing so, parallelization of the system is a prerequisite. In particular, it takes relatively long time to execute the join operation. The method to distribute the relations equally to each processor influences the performance of the system considerably. The current paper proposes an effective parallel join algorithm which contributes to reduce overall communication time through balancing the loads in each processor as well as solving a demerit of sort merge join algorithm, using hyper quick sort algorithm proper to the hyper cube system. This paper also prove that the algorithm outstrips the present parallel join algorithms in its performance analysis.

국소알레르기비염의 최신지견

조석현 ( Seok Hyun Cho ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1991 소아알레르기 및 호흡기학회지 Vol.1 No.4

Rhinitis is a common airway disease that can affect patient’s quality of life and social activities. Rhinitis comprises heterogenous diseases and classified as allergic rhinitis (AR) or nonallergic rhinitis (NAR) based on the clinical history, skin prick test, and serum-specific IgE to aeroallergens. It is important to differentiate between AR and NAR, as management differs for each. However, classification of NAR is controversial and the specific mechanisms responsible for NAR remain unclear. Recently, the entopy of local allergic rhinitis (LAR) has been raised if positive response to nasal provocation test, and elevated specific IgE and inflammatory mediators such as tryptase and eosinophilic cationic peptide in the nasal lavage fluids are shown in patients with NAR. About 47.62.5% of patients previously diagnosed with NAR actually have LAR. LAR shares similar nasal symptoms with AR, such as itching, sneezing, rhinorrhea, and nasal obstruction. LAR shows a good response to nasal corticosteroids and oral antihistamines. However, its natural history and role of immunotherapy need to be elucidated. (Allergy Asthma Respir Dis 2013;1:303-308)