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RISS 인기검색어
- 검색키워드
- 저자 : 정해철 ( Hae Chul Chung ) (검색결과 4 건)
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정정명(Jung Myung Chung),정해철(Hae Chul Chng),설상영(Sang Yeong Seol),정승진(Seung Jin Jeong),최석렬(Seok Reyol Choi),최하진(Ha Chin Choe) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.1
N/A Although several classifications of esophageal varices are reported at present monent, none of them seems to be perfect in terms of clinical applicability. Some are too simple to cover the whole features of varices, or too much complicated to apply practically to clinical practices. Recent remarkable advances of endoscopy has let more precise serial observations and prognostic evaluation of varices be possible without great difficulties. Having observed 373 cases of esophageal varices from Jan. 1981 to June. 1984 at Paik Hospital, In-Je Medical College, we have tried a new classification of esophageal varices, according to not only their shape, size, numbers, colors and locations, but having particular consideration on their bleeding episodes. Endoscopic grades of esophageal varices are classified into following 4 grades, Grade I: One or two tiny tortuous, blue colored varices, less than 2 mm in diameter, being localized in lower esophagus. Grade II: Bead-like tortuosity, blue colored varices, mostly 2-4 mm in diameter being localized in lower esophagus. Grade III: Varices on the top of the varices, red colored, mostly more than 4 mm in diameter with spreading up to mid esophagus. Grade IV: Grade III varices with spreading through the entire esophagus and or down to the fundus of stomach. Bleeding tendency was most frequently observed in Grade IV varices.
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B형 만성 간질환 환자들의 간조직내 HBV precore 돌연변이종에 관한 관찰
정해철,박영홍,정정명 대한간학회 1996 Clinical and Molecular Hepatology(대한간학회지) Vol.2 No.2
Background/Aims:In order to determine the relationship between the HBV precore mutant and the severity of liver disease in Korea, we performed liver biopsies in patients with HBV related chronic liver disease and compared the types of mutations and histologic findings in the same liver tissue simultaneously. Methods:HBV DNA in liver tissues was amplified by polymerase chain reaction (PCR). The precore mutants were detected by PCR-SSCP(single strand conformation polymorphism), cloning the amplified PCR products and direct sequencing for them. Results:1. HBV DNA was detected in liver tissues of 28 cases among 30 patients with PCR. And with SSCP, the most cases were mixed type infections. 2. The HBV precore mutants were found in 12 cases among the total number of 28 cases(42.9%) and all mutations were G to A change at nucleotide 1896, creating a stop codon at codon 28. However, 10 cases among 12 mutants were associated with simultaneous another mutation at different positions or regions;9 cases at core gene region, 2 cases at nucleotide 1856(C to T change at codon 15), one case at core promoter, and one case with double mutations at nucleotide 1837 and 1846 respectively. Also, all HBV precore mutants were combined with wild type HBV sequence. 3. The relationship between HBV precore mutants and HBeAg status revealed that 4 cases from 13 HBeAg positive(30.8%) and 8 from 15 HBeAg negative or Anti-Hbe positive(53.3 %) were mutants. 4. In analysis of the types of mutants and histopathological findings of liver diseases, 6 among 15 chronic active hepatitis(40.0%), all 3 cases with hepatocellular carcinoma(100,0 %), 2 among 4 asymptomatic carriers with minimal histopathologic changes(50.0%) and a case with chronic lobular heaptitis(100.0%) showed precore region mutation. Conclusion:The patterns of HBV precore mutants in Korea could be summarized as followings. Firstly, most of the mutations are composed of G to A change at nucleotide 1896. Secondly, the most of the mutants at nuclmtide 1896 have been associated with simultaneous mutations at core promoter, core gene, and rarely at other positions, and manifested usua'ly mixed type viremic conditions. Thirdly, although precore mutation could be occurred in asymptomatic carrier, this type of mutation might be closely related with chronic or severe liver disease. However, it needs further investigations hereafter.
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복부 초음파검사 및 간주사를 통한 위암 환자의 기 및 수술 여부 결정
김성록,정해철,문기석,최원락,김병제,박주열 인제대학교 1986 仁濟醫學 Vol.7 No.2
저자들은 1981년 1월부터 1985년 6월까지 인제의과대학 부산백병원에 입원하여 위내시경검사 및 직시하 생검에서 위선암으로 확인된 총 130예를 대상으로 근치적 절제술의 효과를 높이기 위하여 수술 전에 간주사법 및 복부초음파 검사를 시행한 61예와 둘 다 시행하지 않았던 69예를 대상으로 개복수술 시행 후 아래와 같은 성적을 얻었기에 문헌 고찰과 함께 이를 보고한다. The reliablity of physical examination, liver scan and abdominal ultrasonography in detecting Cancer metastasis has been evaluated 130 patients with histologically proven stomalch Cancer(61 cases was performed Liver scan and abdominal ultrasonography.) who had admitted to InJe Medical College, Pusan Paik Hospital from January 1981 to June 1985. Confirmation on Laparotomy showed the following results. 1) Ninety nine cases out of one hundred and thirty were over the age of 41 years (76.2%). 2) Liver scan and abdominal ultrasonography were 93.4% accurate and 90.2% accurate, respectively, in detecting liver metastasls. 3) Abdominal ultrasonography were 39.3% accurate in detecting lymph node Metastasis. 4) Abdominal ultrasonography were 65.6% accurate in detecting other organs' metastasis. 5) In a composite analysis on hepatic metastasis, the diagnostic accuracy was not improved by combining abdominal ultrasonography and liver scan examination. 6) The additional benefit of abdominal ultrasonography when liver scan was in error was an increase in accuracy of 9.8% for liver scan alone. 7) Borrmann's type IV had the highest incidence of TMN classification stage IV(75.7%). Those who had palpable epigastric mass show higher incidence of TMN classification stage IV compaired with these who had not. 8) Comparison of TMN classification between normal and not taken group of Liver scan and ultrasonograpny showed the highest incidence of TMN classification stage IV in broth groups.
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