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Chul Woo Jeong(정철우),Byeng Wha Son(손병화),Jae Du Ha(하재두),Gun-Do Kim(김군도) 한국생명과학회 2011 생명과학회지 Vol.21 No.3
EGFR kinase의 활성을 억제할 수 있는 억제제는 암뿐만이 아니라 성장성 질환에도 효과적인 치료제가 될 수 있다. 본 연구는 새로운 퀴나졸린계 물질인 화합물 63013과 63033의 EGFR kinase 활성억제 효과를 분석하였다. 이들 물질들은 기존의 디알콕시퀴나졸린의 용해성을 증가시키기 위하여 [1,4]-다이옥시노 퀴나졸린 구조를 가지며 알콕시 곁사슬로 연결되어있다. 화합물 63013과 63033은 A431 인간 피부암세포에서 EGF에의해 유도되는 EGFR의 kinase 활성을 저해, 세포 내에서 EGFR 신호체계에 관여하는 MEK1/2, MAPK p44/42, AKT, STAT3과 같은 하위 분자들의 활성저해 효과를 유도하였다. 이러한 활성저해 효과는 현재 상용화되어 있는 Gefitinib (Iressa<SUP>®</SUP>)와의 비교연구에서 화합물 63013과 63033이 보다 더 낮은 처리 농도에서 EGFR kinase의 활성을 저해하며 암세포의 성장을 억제함을 관찰 할 수 있었다. 따라서 본 연구는 이들 신규 물질들의 EGFR-연관 질환에 대한 EGFR kinase 선택적 억제제로서의 이용 가능성을 제시하고 있다. Inhibitors of EGFR (epidermal growth factor receptor) kinase activity may prove useful to therapeutically intervene in cancer and to treat other proliferative diseases. In this study, we investigated the inhibitive effects of two compounds named 63013 and 63033 possess a [1,4]-dioxino quinazoline structure that links the alkoxy side chains together and their structural characteristics are considered to allow better solubility than the dialkoxyquinazoline derivatives. The EGFR kinase activities of A431 human epidermoid carcinoma cells, stimulated by EGF were inhibited by treatment with 63013 and 63033 in a dose-dependent manner respectively. Consistent with the compound-mediated EGFR kinase suppression, the major EGF-related downstream target molecules, such as MEK1/2, MAPK p44/42, AKT and STAT3, were also suppressed by both compounds. Interestingly, both compounds led to cell growth inhibition at a lower concentration than that of Gefitinib (Iressa<SUP>®</SUP>). Collectively, our study showed that both compounds may have good therapeutic potential as an EGFR kinase specific inhibitor to treat EGFR-related diseases.
임상연구 : 삼차원 단층촬영을 이용한 중심정맥의 쇄골상부 도자법에 대한 해부학적 고찰
서정화 ( Jeong Hwa Seo ),이활 ( Whal Lee ),정철우 ( Chul Woo Jung ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.50 No.4
Background: The current study aimed at elucidating the anatomical basis for a supraclavicular approach for central venous catheterization using three-dimensional computed tomography (3D-CT). Methods: Retrospective review of CT images from 60 adult patients with normal body build was performed using 3D-CT reconstruction. Right-sided approach was assumed, and the skin entry point was decided as a point above the subclavian vein at the supraclavicular fossa. Measured parameters were; angles of the clavicle (Aclv) and the subclavian vein (Ascv) to the coronal plane, the distance from the clavisternomastoid angle to the skin entry point (Dse), the optimal angle of needle insertion (Ains) targeting the confluence between the internal jugular vein and the subclavian vein, the distance from the skin entry point to the confluence (Dconf), and the diameter of the confluence (Dia). Descriptive statistics were performed for the measured values. Correlation test was performed between Ascv and Aclv. Results: Measured values were; Aclv = 8.0˚, Ascv = 5.7˚, Dse = 12.5mm, Ains = 40˚, Dconf = 20.5mm, and Dia = 18.1mm. Ascv demonstrated positive correlation with corresponding Aclv (r = 0.494, P < 0.001). Conclusions: Optimal guideline for the supraclavicular approach can be provided via 3D-CT investigation. Forty degrees of needle direction to the sagittal plane and parallel to the posterior surface of the clavicle, at 1.3 cm posterior to the clavisternomastoid angle insures proper puncture of the confluence without anticipated complications. (Korean J Anesthesiol 2006; 50: 373~8)
박정미 ( Jeong Mi Park ),이국현 ( Kook Hyun Lee ),정철우 ( Chul Woo Jung ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.3
Synchronous liver and kidney transplantation (SLK) is considered a treatment of choice for an end-stage liver disease patient with irreversible kidney disease. Several perioperative renal supportive treatments, especially continuous renal replacement therapy (CRRT), have contributed to the effective control of hypervolemia and electrolytes and acid-base disturbances leading to high success rate in adults. However, anesthesia for SLK in children is frequently difficult since the CRRT is seldom available because of difficulty in securing large venous lines. In addition, conventional techniques such as venovenous bypass and side-clamping of the inferior vena cava are less applicable in small children causing difficult volume control. Herein, we report a case of SLK in a child with glycogen storage disease type I with a review of literature. (Korean J Anesthesiol 2009;57:381∼6)
초임계 이산화탄소에 의한 시멘트 페이스트의 중성화 반응 메커니즘
박정원 ( Park Jeong-won ),김지현 ( Kim Ji-hyun ),이민희 ( Lee Min-hee ),정철우 ( Chung Chul-woo ) 한국건축시공학회 2018 한국건축시공학회지 Vol.18 No.5
Recently, needs for utilization of recycled aggregate have been increasing. However, its utilization has been limited due to its high alkalinity, which mostly came from the unremoved cement paste particles that were attached at the surface of recycled aggregate. Various efforts has been made to reduce its alkalinity by using CO<sub>2</sub>, but currently available methods that uses CO<sub>2</sub> generate the problem with pH recovery. Considering the fact that supercritical CO<sub>2</sub> (scCO<sub>2</sub>) can provide more rapid carbonation of cement paste than by normal CO<sub>2</sub>, scCO<sub>2</sub> was utilized in this work. The reaction between scCO<sub>2</sub> and hydrated cement paste has been systematically evaluated. According to the results, it was found that powder type showed higher carbonation compared to that of cube specimens. It seems the carbonation by scCO<sub>2</sub> has occurred only at the surface of the specimen, and therefore still showed some amount of Ca(OH)<sub>2</sub> calcium aluminates after reaction with scCO<sub>2</sub>. With powder type specimen, all Ca(OH)<sub>2</sub> was converted into CaCO<sub>3</sub>. Moreover, additional calcium that came from both calcium aluminate hydrates and calcium silicate hydrates reacted with scCO<sub>2</sub> to form CaCO<sub>3</sub>. After carbonation with scCO<sub>2</sub>, the powder type specimen did not show pH recovery, but cube specimens did show due to the presence of portlandite.
물시멘트비가 다른 원전 콘크리트의 염화물 침투저항성 비교평가
손정진 ( Son Jeong Jin ),김지현 ( Kim Ji-hyun ),정철우 ( Chung Chul-woo ) 한국건축시공학회 2023 한국건축시공학회 학술발표대회 논문집 Vol.23 No.1
In the present investigation, the chloride ion penetration resistance of nuclear power plant concrete with varying water-to-cement ratios was assessed. A comparative analysis was conducted on concretes that do not incorporate supplementary cementitious materials, such as fly ash, using permanently decommissioned nuclear structures as a reference. The objective is to employ this acquired data as a fundamental resource for the evaluation of the residual service life of nuclear power plant structures in subsequent studies.
디스크형 시편을 활용한 화해를 입은 구조물 국부적 열화 평가
손정진 ( Son¸ Jeong Jin ),김지현 ( Kim¸ Ji-hyun ),정철우 ( Chung¸ Chul-woo ) 한국구조물진단유지관리공학회 2023 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.27 No.2
두께가 비교적 두꺼운 대형 콘크리트 구조물이 화재에 의한 피해을 받는 경우 구조물에 국부적인 손상이 발생한다. 국부적인 손상에 따른 잔존강도 평가를 위한 구체적인 방법에 관한 연구가 미흡한 실정이다. 이에 본 연구에서는 디스크형 시편을 활용하여 화해에 의해 국부적인 열화가 발생한 구조물 평가 방법을 제안하고자 한다. 국부적인 열화를 모사하기 위해 200×200×300(㎜) 박스형 시편을 제작하여 600℃에 노출 시켰으며, 이후 코어링을 진행하여 10㎜ 디스크형 시편으로 절삭한 후 동탄성계수 측정을 통해 열화정도를 비교하였다. 본 연구 결과 600℃ 노출면과 멀어질수록 동탄성계수가 증가하는 경향을 확인하여 추후 디스크형 시편을 활용한 화해를 입은 구조물 국부적 열화 평가가 가능할 것으로 판단된다.
함수상태와 크기에 따른 콘크리트 시편 공진주파수 및 동탄성계수 변화
손정진 ( Son¸ Jeong Jin ),김지현 ( Kim¸ Ji-hyun ),정철우 ( Chung¸ Chul-woo ) 한국구조물진단유지관리공학회 2023 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.27 No.2
안정성 평가에 대한 요구가 증가함에 따라 콘크리트 구조물의 안정성 및 잔존강도를 파악하기 위한 비파괴 검사에 대한 연구가 활발히 진행중에 있다. 공진주파수를 활용한 충격방향기법은 비교적 간단한 측정방법으로 활발히 활용되고 있다. 이 방성인 콘크리트 시편의 공진주파수는 시편 상태 및 조건에 따른 영향을 많이 받을 것으로 판단된다. 하지만 콘크리트 함수 상태에 따른 공진주파수 차이에 관한 연구는 미흡한 실정이다. 따라서 본 연구의 목적은 함수상태에 따른 공진주파수 및 동탄성계수 차이를 확인하여 함수상태에 따른 보정계수 값을 추정하는 것으로 두었다.