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Gitelman 씨 증후군으로 오진된 Pseudo - Bartter 씨 증후군 1 예
이동규(Dong Kyu Lee),정재면(Jae Myun Jung),강준구(Jun Goo Kang),김태엽(Tae Yeob Kim),김태종(Tae Jong Kim),오호석(Ho Suk Oh),최창렬(Chang Youl Choi),한상웅(Sang Woong Han),김호중(Ho Jung Kim) 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.3
A 31-year-old woman had a history of fatigue and hypokalemia and metabolic alkalosis and hypocalciuria. The patient had a subtotal thyroidectomy and denied ingestion of diuretic medication. Her clinical and laboratory findings were consistent with Gitelman`s syndrome. Normal blood pressure, hypokalemic metabolic alkalosis, hypocalciuria were present. She confessed to us that she had been taking a pill due to constipation for 7 years. She was afraid that her husband know it. But we don`t know the reason why she had concealed it Surreptious ingestion of diuretics must be excluded in any adult patient in whom a diagnosis of Bartter`s or Gitelman`s syndrome is considered.
1,2-Dimethylhydrazine에 의해 유발된 Colonic Aberrant Crypt Foci에 대한 마늘추출물의 암예방효과
김태명(Tae Myoung Kim),류재면(Jae Myun Ryu),권현정(Hyun Jung Kwon),황인국(In Guk Hwang),반정옥(Jung Ok Ban),정헌상(Heon Sang Jeong),홍진태(Jin Tae Hong),김대중(Dae Joong Kim) 한국독성학회 2007 Toxicological Research Vol.23 No.2
Garlic (Allium sativum L.) with the food supplement material and medicine was used traditionally in Asia and Europe. Epidemiological studies revealed that the intake of garlic reduced incidences of various cancer including digestive system. The present study was designed to investigate the effect of garlic ethanol extract on the development of colonic aberrant crypt foci (ACF) induced by 1,2-dimethylhydrazine (DMH) in male F344 rats. Five-week-old rats were given four times for two weeks to subcutaneous injections by DMH (30 ㎎/㎏ body weight) to induce ACF. The animals were divided into groups that fed diet containing garlic ethanol extract at five different doses (0.1, 0.2, 0.5, 2, 5%), respectively, animals were evaluated for the total number of ACF and total aberrant crypts (AC) per colon detected from methylene blue-stained rat colon. ACF were formed in animals in DMH-treated group. The feeding suppressed potently the appearance ACF in the colon of rats. Especially, fed diet containing garlic ethanol extract at intermediate dose (0.5%) significantly reduced the number of ACF and AC per colon (p < 0.05). Garlic ethanol extract inhibited DMH-induced overexpression of Activator Protein-1 (AP-1) and β-catenin genes related to cell proliferation that also upregulated the expression of p21Waf1/Cip1 mRNA, a cell cycle-regulating gene. These results suggested that garlic ethanol extract may inhibit ACF formation, β-catenin gene as the early preneoplastic marker of malignant potential in the process of colon carcinogenesis.
사람 대장암 세포주에서 Diallyl Disulfide의 세포증식억제 및 Apoptosis 유도 효과
김태명(Tae Myoung Kim),류재면(Jae Myun Ryu),권현정(Hyun Jung Kwon),우관식(Koan Sik Woo),정헌상(Heon Sang Jeong),홍진태(Jin Tae Hong),김대중(Dae Joong Kim) 한국독성학회 2005 Toxicological Research Vol.21 No.4
Epidemiological and laboratory studies provide insight into the anti-carcinogenic potential of garlic and its constituent compounds. Garlic is appealing as an anti-carcinogenic agent due to its ability to induce apoptosis in vitro. Diallyl disulfide (DADS) is one of the major components of garlic that used to determine inhibition of cell proliferation and induced apoptosis in human colon cell lines. In this study, human colorectal cancer cell lines (LOVO, HCT-116, SW-480) were exposed to DADS. The inhibitory effects of DADS dose level more than 50 μM in the cell viability of all cell lines. Cell growth activity inhibits of human colon cancer cell lines. The inhibitory effects of DADS dose level more than AFG₁5~50 μM in the cell growth using MTT assay. We found that DADS may have the apoptosis action (chromatin condensation, DNA fragmentation) using DAPI staining and increased the expression of caspase-3 at the dose level more than 100 μM, decreased the expression level of β- catenin at dose dependent in the western blotting. We suggest that DADS may have a potential candidate as cancer chemopreventive agents.
Fanconi 증후군으로 발현한 Chinese Herb Nephropathy - 서양형과 동양형의 차이 비교 -
최창렬 ( Chang Ryeol Choi ),윤여욱 ( Yeo Wook Yun ),이동규 ( Dong Kyu Lee ),정재면 ( Jae Myun Jung ),홍택원 ( Taeck Won Hong ),한상웅 ( Sang Woong Han ),백승삼 ( Seung Sam Paik ),박문향 ( Moon Hyang Park ),김호중 ( Ho Jung Kim 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.1
We encountered one case of Chinese Herb Nephropathy in Korea. But clinical feature of our case was different from those of CHN in Belgium. The purpose of this case report was clarified the features of CHN in Asia. The subjects consisted of a patient diagnosed as interstitial nephritis in Hanyang University Hospital and of those reported in the literature in Asia and Belgium. We investigated the clinical and histological features of CHN patients in Asia and compared them with the Belgian cases. The renarkable differences were as follows; (1) relatively high prevalence in males compared with Belgian cases, (2) digestion with multiple object and mode in Asia, (3) Most of renal failure in Asia were improved or were in stable status, (4) Fanconi`s syndrome was found in most cases of Asia. In conclusion, CFN in Asia has some characteristics distinguished from Belgian Chinese Hreb Nephropathy. These findings could indicate that susceptibility to aristolochic acid may be different among races. Furthermore, it is likely that different components of AA could cause different features, that the amount of ingested AA, mode in digestion, or interaction with other components except nephrotoxic agent such as AA might reflect clinical pictures. Other hypothesis may be some other toxic substances affecting the clinical findings although they are not identified at present. further studies must be underaken to clarify these diferences.
윤영섭 ( Yeong Seop Yun ),권순효 ( Soon Hyo Kwon ),정재면 ( Jae Myun Jung ),전진석 ( Jin Seok Jeon ),노현진 ( Hyun Jin Noh ),한동철 ( Dong Cheol Han ) 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.1
목적: 국외의 경우 사전의사결정서와 투석 보류 및 중단지침을 통해 환자와 의료진 모두 투석 중단에 대한 갈등과 고민을 최소화하고자 하고 있다 그러나 아직 국내에서는 투석 중단에 대한 연구가 거의 없다. 이에 저자들은 신장내과 의사들의 투석 보류와 중단에 대한 태도를 알아보고자 본 연구를 시행하였다. 방법: 2006년 1월부터 2008년 1월까지 내과의원, 종합병원 대학병원에서 투석환자를 진료하는 내과의사 45명을 대상으로 투석 보류와 중단에 대한 설문 조사를 시행하였다. 투석 보류와 중단에 대한 항목은 Likert식의 5점 척도로 구성되었고 투석 치료에 관한 사전의사결정서 작성과 투석중단 가이드라인 필요성에 대한 항목은 3점 척도로 구성되었다. 결과: 투석 보류와 중단 모두의 경우에서 치매 환자보다 식물상태 환자에서 더 강하게 동의하는 것으로 나타났다. 의식 상태가 명료한 말기 신질환 환자가 투석을 원하지 않을 경우 투석을 중단하는 것에 동의하는 것보다 시작을 보류하는 것에 더 강한 동의를 보였다. 하지만 치매나 식물상태의 경우에는 투석 보류와 중단 요구간에 대상자의 태도에는 의미 있는 차이가 없었다. 투석 시작 전 투석 중단에 관한 사전 의사 결정서에 대해서는 반대의견이 더 많았으나 투석 보류와 중단 가이드라인 제정에 대해서는 대부분 찬성하였다. 결론: 환자의 신경학적 이상에 따라 투석유보와 중단에 대해서 상반된 태도를 보였으나 투석 보류와 중단에 대한 지침의 필요성에서 대부분 찬성하였다. Purpose: In many countries, patients and dialysis unit physicians attempt to address issues regarding withholding and withdrawing dialysis through advance directives and clinical guidelines for dialysis utilization. However, there are only a few reports of withholding and withdrawing dialysis in Korea. This study was developed to investigate the attitudes of dialysis unit physicians regarding withholding and withdrawing dialysis in Korea. Methods: A questionnaire survey was conducted among 45 dialysis unit physicians from January, 2006 to January, 2008. Physicians were asked about their decision making process to withhold and withdraw dialysis, and their opinions regarding the necessities of advance directives and guidelines for withholding and withdrawing dialysis. Results: Analysis of surveys revealed that physicians agreed more about whether to withhold and withdraw dialysis in vegetative patients compared to patients with dementia (p<0.001, p<0.001). There were more agreements about whether to withhold dialysis than whether to withdraw dialysis in patients with unimpaired cognition (p<0.037). However, there were no differences in agreements between withholding and withdrawing dialysis in patients with severe neurological impairments. There appeared to be a general consensus regarding the need for guidelines addressing withholding and withdrawing dialysis (84.4%). However, opinions supporting the necessity for advance directives were not strongly favored (33.3%). Conclusion: Conflicting opinions are present among dialysis unit physicians regarding whether to withhold and withdraw dialysis according to a patient`s neurological impairments. However, most dialysis unit physicians were of one accord regarding the need of guidelines for withholding and withdrawing dialysis.
복막투석 환자의 예후를 예측하는 인자로서 총 단백 복막 청소율의 의의
이설희 ( Sul Hee Yi ),이호영 ( Ho Young Lee ),김정현 ( Jung Hyun Kim ),정재면 ( Jae Myun Jung ),권순효 ( Soon Hyo Kwon ),전진석 ( Jin Seok Jeon ),한동철 ( Dong Cheol Han ),노현진 ( Hyun Jin Noh ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.6
Purpose: It has been reported recently that peritoneal protein clearance (Pcl) is a marker of endothelial dysfunction and cardiovascular disease in peritoneal dialysis patients. We evaluated whether baseline or longitudinal follow-up Pcl is a factor to consider in predicting the outcome in peritoneal dialysis patients for the follow-up period. Methods: Patients who initiated continuous ambulatory peritoneal dialysis at our center from September 1994 to January 2006 and had a baseline peritoneal equilibration test, measurement of dialysis adequacy, and 24-h dialysate Pcl (24hr dialysate protein loss/ [serum albumin/0.4783]) were included. Demography, comorbidities, and biochemical data were retrospectively collected. Follow-up was until death or the end of the period studied (November 2009). Results: A total of 203 patients (56% men, mean age 55.0±12.5; 55.2% with diabetes; 22.2% with cardiovascular disease) were included. The mean follow up period was 38 months (3-170 months). Baseline Pcl was 128.2 ml/day. Follow up data of Pcl were not changed from baseline period. Cox`s analysis revealed the predictors of mortality (and technical failure) were age and diabetes mellitus but not dialysate/plasma creatinine ratio (D/Pcr) and Pcl. On multivariate analysis, Pcl was negatively correlated with serum albumin and triglyceride and positively correlated with D/Pcr and peritoneal creatinine clearance. Conclusion: Our study showed that the changes in Pcl over time were not significant from baseline up to 53 months. Neither baseline nor mean Pcl during the follow-up period were independent predictors for technical or patient survival.