유성신 (流星身) : 만사업 (萬事業)이 유성양심 (由成養心) - 건봉사학생 (乾鳳寺學生) 정남경 (鄭南耕) ( 조선불교월보 제 18 호 )

정남경 조선불교월보사 1916 朝鮮佛敎月報 Vol.18 No.-

Flow Cytometer를 이용한 뇌종양 환자의 T-세포아군의 분석

정남,김형일,이정청,박래길,정헌택 대한신경외과학회 1989 Journal of Korean neurosurgical society Vol.18 No.7-12

종양의 침입 내지 종양의 성장을 효율적으로 방어하려면 인체의 면역 기능이 잘 유지되어야 하는데 뇌종양 환자에 있어서 어떤 유형의 종양이 면역계의 기능 부전을 초래하는지를 알아 보기위하여 저자는 단크론 항체 및 flow cytometer를 이용하여 종양면역에서 중요한 역활을 하는 T-임파구를 분석해 보았다. 1) 뇌종양 환자는 정상 건강인에 비해 CD3 양성세포군 CD4 양성세포군, CD8 양성세포군의 값이 양성종양이나, 악성종양에 관계 없이 모두 감소된 소견을 보여주었다(p<0.05). 2) 양성 뇌종양 환자에서는 뇌하수체 종양을 제외하고는 정상성인과 큰 차이가 없었다. 뇌하수체종양 환자에서는 시행하부를 침범하거나 혈중 ACTH치가 정상인보다 현저히 증가한 환자에서 유의성 있게 감소하였다. 또한 양성교종 중 결절성 경화증과 동반된 subependymal giant cell astrocytoma의 경우 각 T-세포아군의 값이 현저히 감소된 것을 볼 수 있었다. 3) 악성 신경교종에서는 CD4 양성세포군 및 CD 양성세포군에서는 정상성인에 비해 분석치가 감소된 것을 보여주었고, 전이성종양 환자에서는 CD3 및 CD4 양성 세포군은 정상성인과 큰 차이가 없으나 CD8가 크게 감소되었다(p<0.01). 이러한 단크론 항체 및 flow cytometer를 이용한 T-림프구의 분석을 향후의 면역 요법을 계획하거나 뇌종양 환자를 임상적으로 monitoring하는데 좋은 방법인 것으로 사료되었다. The immunocompetence is important not only to kill the neoplastic cells but also to keep the neoplastic cells from growing further. T lymphocyte is playing the most important role in maintaining the tumor immunity efficiently. T lymphocyte has its specific functions depending in the subset of T lymphocytes. The author analyzed the T lymphocyte subsets in 31 brain tumor patients using anti-CD3, anti-CD4, anti-CD8 monoclonal antibodies and flow cytometry to determine the immunological status of brain tumor patients. All CD3, CD4 and CD8 subsets were reduced in both benign and malignant brain tumor patients but more signigicantly reduced in malignant tumor group. But in benign tumor group, the subtypes of T lymphocytes were not so different from those of normal healthy controls except the pituitary tumor patients, who showed the significant decrease in all the subtypes. In malignant tumor group, each subtype was signigicantly reduced and CD8 subtypes was markedly reduced in metastatic tumor patients, These analyses were considered to have the possibility to be contributable to planning the further immunotherapy and also the possibility to moniter the brain tumor patients clinically.

백서 대뇌 피질에서 Norepinephrine 효과에 대한 Opioids의 영향

정남,정회상,송은석,장광철,김성수,조규박 의과학연구소 1995 全北醫大論文集 Vol.19 No.1

It has been reported that there are differences among the species in the opioid receptor types mediating the inhibitory effect of opioids. Previous studies suggested that the inhibition of high K^+-or elecrically-stimulated release of [^3H]norepinephrine ([^3H]NE) is mediated mainly by μ-opioid receptor. We characterized receptors mediating opioid-induced inhibitation of high potassium(20mM)-evoked release of [^3H]NE from slices of rat cortex incubated in vitro by comparison of the pA_2 values of the competitive antagonists, naloxone, D-Pen-Cys-Try-D-Orn-Thr-Pen_The-NH_2(CTOP), nor-binaltophimine(nor-BNI), naltrindole and bremazocine against the agonists, Tyr-D-Al-Gly-(Me)Phe-(Gly-ol) (DAMGO), Tyr-D-Arg-Phe-Sar(TAPS), [D-Ser^2, Leu^5]enkephaliln-Thr(Ds-LET), β-endorphin(1-31), β-END(1-26) and ethylketocyclazocine(EKC). All the opiod agonists listed above inhibited high potassium-evoked release of [^3H]NE in a dose-dependent manner. (5a, 7a, 8b)-(-)-N-Met-N-(7-[1-py-rolidinyl]-1-oxaspiron [4, 5]-Dec-8-yl)benzenacetamide(U-69,593), a k_1 receptor selective agonisy, and [D-Pen^2, D-Pen^5]enkephalin(DPDPE), a selective δ receptor agonist, did not ingibit[^3H]NE release even in 1μM no more concentration, indicating that δ and k_1 receptors are not involved. DAMGO, TAPS and DSLWT were more sensitively antagonized by μ-preferential opioid antagonists, CTOP and naloxone than other antagonists. TAPS and DSLET showed similar sensitivities to all tested antagonists, suggesting that they act through similar receptors. EKC and β-END(1-31) differed from other agonists and from each other in their sensitivities to most possibly of the k_2 for EKC and of the ε for β-END(1-31) These results suggest that there is heterogeneity in the opioid receptors regulating norepinephrine release in rat cortex.

통일대비 : 기획시리즈 ; 내가 본 남한사회 : 지하철 속에서 만난 사람들, 그 모습도 달라

정남 평화문제연구소 2002 통일한국 Vol.219 No.-

통일대비 : 기획시리즈 ; 내가 본 남한사회 : 탈선(脫線) 청소년들, "타인을 배려할 줄 알았으면"

정남 평화문제연구소 2002 통일한국 Vol.223 No.-

대인관계 형용사척도(KIAS-40) 타당화 연구

정남운 한국상담심리학회 2005 한국심리학회지 상담 및 심리치료 Vol.17 No.3

본 연구의 목적은 대인관계 원형모델에 입각하여 구성된 형용사척도(정남운, 2004)가 이론에서 제시된 대로 원형구조를 가지는지 알아보고, 형용사척도가 원형모델의 두 차원(친애와 통제)을 잘 반영하는지를 다른 척도들과의 상관분석을 통하여 알아봄으로써 척도의 타당도를 확인하려는 것이다. 이를 위하여 두 집단의 대학생 피험자들(n=503)에게 대인관계 형용사척도와 NEO 인성검사의 외향성, 친화성 척도, 그리고 대인관계 문제척도를 실시하였다. 주성분분석 결과 두 집단 모두에서 대인관계 원형모델의 두 차원에 해당하는 2개의 요인을 확인하였으며, 하위척도들의 요인부하량을 이용하여 평면상에 척도들을 배열한 결과 적절한 원형구조를 이루고 있음을 확인할 수 있었다. 또한 형용사 척도의 각 하위척도들과 외향성 척도의 하위척도들 및 친화성 척도의 하위척도들 간의 관계를 살펴본 결과 내용상 유사한 척도들 사이에 상관이 높음을 볼 수 있었으며, 대인관계 문제척도의 문항과 형용사 척도 간의 관계에서도 의미상 일치하는 방향으로 상관이 높게 나오는 것을 관찰할 수 있었다. 이것은 형용사 척도가 친애와 통제의 두 차원이 체계적으로 조합된 대인관계 척도임을 보여주는 것이다. 이러한 결과와 함께 연구의 의의와 한계, 앞으로의 연구 방향 등을 논의하였다. The aim of the present study was to validate a Korean version of the Interpersonal Adjective Scales (KIAS-40). Two samples of university undergraduates (n1=229, n2= 274, total= 503) were used for this purpose of the study. The eight 5-item scale scores were intercorrelated and subjected to a series of principal component analyses in which two interpersonal factors (Affiliation and Control) were extracted. Post hoc chi-square tests developed by Fisher(1983) were used to evaluate the circumplex structure of the KIAS-40 in two different samples. These tests suggested a high degree of convergence between the empirical locations of the KIAS-40 scales and the locations predicted by circumplex theory. Correlational and factor analyses of Extraversion and Agreeableness Domains of NEO-PI-R and KIAS-40 showed that the interpersonal circumplex occupied the two-dimensional plane defined by Extraversion and Agreeableness. The IIP-C items also confirmed the KIAS-40 had good concurrent validity. The implications and limitations of the study were discussed along with some suggestions for future researches.

통일대비 : 기획시리즈 ; 내가 본 남한사회 : 선후배가 모여 회포푸는 즐거운 졸업식

정남 평화문제연구소 2005 통일한국 Vol.254 No.-

환경 보전 대책과 방향

정남 淑明女子大學校 藥學大學 1976 藥硏 Vol.12 No.1

뇌전산화 단층촬영에 의한 뇌동맥류의 수술전 진단

정남,조기홍,김한규,조경기 대한신경외과학회 1985 Journal of Korean neurosurgical society Vol.14 No.4

The authors analyzed the computed tomography (CT) findings in 69 patients with intracranial aneurysm. The indirect evidences for the diagnosis of an aneurysm in this series consisted of subarachnoid hemorrhage (53/69), intracerebral hematoma (24/69), dilatation of ventricle (19/69). infarction (8/69), intrventricular hematoma (7/69), and subdural hematoma (1/69). Visualization of aneurysms were possible in 6 out of 69 patients. In sites of blood by CT, the suprasellar cistern was most common and the sylvian cistern next Ventricular dilatations were seen in the patients with aneurysm of internal carotid artery most commonly and next in those with anterior communicating artery The higher the CT grade was, the poorer the clinical grade was and the more severe the vasospasm. Close correlation was present between the blood in CT and vasospasm.

두개기저골 골절 160예에 대한 임상적 고찰 : Clinical Analysis of 160 Cases

정남,조기홍,김한규,조경기 대한신경외과학회 1985 Journal of Korean neurosurgical society Vol.14 No.4

Although the presence of a linear skull fracture involving the cranial vault is very often of no clinical significance, the same is not true of fracture of the base. The authors analyzed 160 cases of basal skull fracture treated in the department of Neurosurgery, presbyterian Medical center from May 1980 to Apr 1985. Clinical features and radiological findings were reviewed, analyzed and correlated each other. The result of the analysis are summarized as follow: 1) The basal skull fractures were more common in man than woman the ratio of 13:3. 2) Clinical features were otorrhea (61.2%), racoon eye (22.5%), and hearing loss (20%) etc in decreasing order. 3) Combined pathologies were skull fracture (45%), subdural hematoma (13.7%), epidural hematoma(11.2%), and pneumocephalus(10%) etc. in decreasing order. 4) The facial nerve, vestibule- cochlear nerve, and olfactory nerve were most common cranial nerves injured. 5) Among the visible fractures in simple X-ray, longitudinal fractures were more common than transverse fractures. 6) CSF leakage were noted in 126 cases, and among them immediate type was far more common (93.6%) than delayed type. 7) Incidence of meningitis was 5%, and most of them were associated with CSF leakage. 8) The infection rate was higher when the CSF leak persisted over 7 days.