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Anti-inflammatory effects of diphenyleneiodonium in LPS-induced acute lung injury in rats
전호욱,고유미,송소향,김치홍,유진영,김성경 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Background: NADPH oxidase (NOX) plays an important role in inflammatory responses by producing reactive oxygen species and the inhibition of NOX has been shown to participate in anti-inflammatory action in some inflammatory models. The aim of this study was to investigate the effects of diphenyleneiodonium( DPI), a NOX inhibitor, on lipopolysaccharide (LPS)-induced acute lung injury (ALI) model. Methods: Sprague Dawley rats were intraperitoneally administered DPI (5 mg/kg) 30 minutes after intratracheal instillation with LPS (3 mg/kg). After 6 hours, bronchoalveolar lavage fluid (BALF) and lung tissue were collected. The numbers of inflammatory cells and cytokine release (TNF-α, IL-1β, and IL-6) in BALF were detected by cell counting and ELISA. In lung tissues, NF-κB and myeloperoxidase (MPO) activity and ALI score were measured. Inducible nitric oxide synthase (iNOS) was examined by immunohistochemistry. To identify the anti-inflammatory mechanism of DPI, activation of MAPK and NF-κB pathways was measured by western blot analysis. Results: DPI-treated rats showed significantly reduced numbers of inflammatory cells, production of inflammatory cytokines (TNF-α, IL-1βand IL-6) in BALF compared to LPS-treated rats. In lung tissues, NF-κB and MPO activity, ALI scores, and iNOS expression were significantly decreased in DPI-treated rats compared to LPS-treated rats. Western blot analysis demonstrated that DPI significantly suppressed LPS-induced activation of MAPK and NF-κB pathways. Conclusions: Our results suggest that DPI may have an anti-inflammatory effect on LPS-induced ALI via suppression of the activation of MAPK and NF-κB pathways. DPI could be a useful therapeutic agent of ALI treatment.
3관능성 BPA-3MA를 기질로한 광중합형 치면열구전색재의 물성 연구
박경준,김경남,안광덕,김광만,한동근,전호욱 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.2
The BPA-3MA(bisphenol-A trimethacrylate) in which one of two hydroxy group was substituted by methacrylate was synthesized by reaction of Bis-GMA with methacryloyl chloride. To investigate the possibility to apply BPA-3MA as matrix of composite resin or pit and fissure sealant, BPA-3MA(3MA) or Bis-GMA(GMA) as matrix, TEGDMA as diluent, CQ as photosensitizer, EDMAB as photoinitiator and 5㎛ pyrogenic silica as filler were used for making experimental sealants. In addition, these experimental sealants were compared to a commercial Concise L/C White sealant(CLW, 3M Co, U.S.A.) for flexural strength, diametral tensile strength, amount of abrasion, surface hardness, water sorption and solubility, and degree of conversion. The flexural strength of CLW was the highest value but there was not significant difference with 3MA. Diametral tensile strength of all 3 groups were similar(p>0.05) and the amounts of abrasion of 3MA and GMA were less than that of CLW(p<0.05). The surface hardness of 3MA was higher than that of GMA(p<0.05) but similar to that of CLW. The water sorption of 3MA was less than that of GMA and CLW(p<0.05) and the solubilities of 3MA and CLW were than that of GMA(p<0.05). GMA and CLW were relatively polymerized well as compared to 3MA. From these results, pit and fissure sealant using trifunctional BPA-3MA as matrix had superior physical and mechanical properties to existing Bis-GMA sealant. Furthermore, it will be possible to develop composite resin having superior properties to existing composite resin.
전호욱 ( Ho Wook Jeon ),김대현 ( Daehyun Kim ),이화민 ( Hwa Min Lee ) 한국정보처리학회 2013 한국정보처리학회 학술대회논문집 Vol.20 No.2
현대사회에 들어 네트워크의 발달과 스마트 폰 시대에 들어옴에 따라 기존 SMS시스템보다 메신저의 기능이 활발해졌고, 무료로 사용하는 메신저의 비중이 굉장히 높아지고 사용량 또한 높아져 다양한 메신저 어플리케이션이 시장에 유통되었으나 커플들만의 1:1 어플리케이션은 크게 발달하지 못하였는데, 이번 어플리케이션은 현 사용자의 위치를 기반으로 하여 그들만의 새로운 데이트 장소 및 맛 집 등을 기록하고, 다른 커플들끼리 공유하여 데이트 및 새로운 지역 이동시 사전 조사하여야 하는 불편함을 없앨 수 있도록 어플리케이션을 구성하였다.