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- 저자 : 전하정 (검색결과 91 건)
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External Beam Radiotherapy in the Management of Low Grade Astrocytoma of the Brain
전하정 대한방사선종양학회 2009 Radiation Oncology Journal Vol.27 No.1
Purpose: This study was designed to evaluate the effectiveness of postoperative radiotherapy for patients with low-grade astrocytomas and to define an optimal radiotherapeutic regimen and prognostic factors. Materials and Methods: A total of 69 patients with low-grade astrocytomas underwent surgery and postoperative radiotherapy immediately following surgery at our institution between October 1989 and September 2006. The median patient age was 36 years. Forty-one patients were 40 years or younger and 28 patients were 41 years or older. Fourteen patients underwent a biopsy alone and the remaining 55 patients underwent a subtotal resection. Thirty-nine patients had a Karnofsky performance status of less than 80% and 30 patients had a Karnofsky performance status greater than 80%. Two patients were treated with whole brain irradiation followed by a coned down boost field to the localized area. The remaining 67 patients were treated with a localized field with an appropriate margin. Most of the patients received a dose of 50∼55 Gy and majority of the patients were treated with a dose of 54 Gy. Results: The overall 5-year and 7-year survival rates for all of the 69 patients were 49% and 44%, respectively. Corresponding disease free survival rates were 45% and 40%, respectively. Patients who underwent a subtotal resection showed better survival than patients who underwent a biopsy alone. The overall 5-year survival rates for patients who underwent a subtotal resection and patients who underwent a biopsy alone were 57% and 38%, respectively (p<0.05). Forty-one patients who were 40 years or younger showed a better overall 5-year survival rate as compared with 28 patients who were 41 years or older (56% versus 40%, p<0.05). The overall 5-year survival rates for 30 patients with a Karnofsky performance status greater than 80% and 39 patients with a Karnofsky performance status less than 80% were 51% and 47%, respectively. This finding was not statistically significant. Although one patient was not able to complete the treatment because of neurological deterioration, there were no significant treatment related toxicities. Conclusion: Postoperative radiotherapy following surgery is a safe and effective treatment for patients with low-grade astrocytomas. The extent of surgery and age were noted as significant prognostic factors in this study. However, further effective treatment might be necessary in the future to improve long-term survival rates.
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전하정,음영지,손진훈,엄진섭 한국감성과학회 2018 감성과학 Vol.21 No.2
The logical assumption of the comparison question test (CQT) is that the guilty person pays more attention to the relevant questions than to the comparison questions, and that the innocent person pays more attention to the comparison questions than to the relevant questions. The purpose of this study was to verify the logic of the comparison question test using functional magnetic resonance imaging (fMRI). The participants were tested for brain responses during a mock crime and performed the CQT under guilty and innocent conditions. After brain imaging, we evaluated the psychological burden of responding to the relevant questions and comparison questions. In the guilty conditions, the degree of burden was higher for the relevant questions than the comparison questions, and there was no significant difference in the innocent conditions. The fMRI results showed that, in the guilty conditions, greater activation was observed in the right superior temporal gyrus and right inferior frontal gyrus when relevant questions were presented relative to comparison questions. Based on these findings, the logical assumption of the CQT was discussed. 비교질문 검사의 논리 가정은 유죄인 조사상자는 비교질문보다 련질문에 주의를 더 기울이고 무죄인 조사상 자는 련질문보다 비교질문에 주의를 더 기울인다는 것이다. 본 연구는 기능자기공명상(fMRI)을 이용하여 비교질 문검사의 논리 타당성을 검증하다. 이를 하여 실험참여자에게 모의 범죄를 수행하도록 한 후 유죄조건과 무죄조건 에서 비교질문검사를 실시하면서 뇌 반응을 측정하다. 뇌 상을 촬한 후에는 련질문과 비교질문에 ‘아니오’라고 응답하는 것이 얼마나 심리으로 부담되는지를 평가하도록 하다. 행동 반응 결과, 유죄조건에서 비교질문보다 련질 문에 ‘아니오’라고 응답하는 것이 더 부담이 되는 것으로 나타났고 무죄조건에서는 두 질문 유형 간에 유의한 차이가 나타나지 않았다. 뇌 반응 결과, 유죄조건에서는 비교질문에 비해 련질문이 제시되었을 때 우측 상측두회와 우측 하두회에서 더 큰 활성화가 찰되었다. 그러나 무죄조건 분석 결과 질문유형에 따른 뇌 역 활성화 차이는 없는 것으로 나타났다. 이러한 결과에 근거하여 유죄조건과 무죄조건에 한 비교질문검사의 논리 가정을 논의하다.
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Results of Radiation Therapy for Squamous Cell Carcinoma of the Esophagus
전하정,이명자 대한방사선종양학회 2009 Radiation Oncology Journal Vol.27 No.1
Purpose: This study was designed to evaluate the effectiveness and prognostic factors for patients treated with postoperative radiation therapy following surgery or with radiation therapy alone for squamous cell carcinoma of the esophagus. Materials and Methods: We retrospectively analyzed 132 esophageal cancer patients treated with postoperative radiation therapy following surgery or patients who were treated with radiation therapy alone at our institution from 1989 to 2006. Thirty-five patients had stage II disease, 88 patients had stage III disease and nine patients had stage IV disease. Tumors were located at the upper esophagus in 18 patients, the mid esophagus in 81 patients and the distal esophagus in 33 patients. Sixty patients were treated with radiation therapy alone and 72 patients were treated with postoperative radiation therapy following surgery. Eight patients received a dose less than 40 Gy and 78 patients received a dose of 40 to 50 Gy. The remaining 46 patients received a dose of 50 to 60 Gy. The majority of patients who underwent postoperative radiation therapy received a dose of 45 Gy. Results: Actuarial survival rates for all of the patients at two years and five years were 24% and 5%, respectively. The median survival time was 11 months. Survival rates for patients who underwent postoperative RT at two years and five years were 29% and 8%, respectively. The corresponding survival rates for patients who received radiation alone were 18% and 2%, respectively. Survival rates at two years and five years were 43% and 15% for stage II disease, 22% and 2% for stage III disease and 0% and 0% for stage IV disease, respectively; these findings were statistically significant. Two-year survival rates for patients with upper, middle and distal esophageal cancer were 19, 29% and 22%, respectively. Although there was a trend of slightly better survival for middle esophageal tumors, this finding was not statistically significant. Complete response to radiation was achieved in 13 patients (22%) and partial response to radiation was achieved in 40 patients (67%) who received radiation alone. No response to radiation was noted in seven patients (12%). A statistically significant difference in survival rates was seen between patients that had a complete response and patients that had a partial response. Two-year survival rates for patients that had a complete response versus patients that had a partial response were 31% and 17%, respectively. There were no survivors for patients with no response as determined at two-year follow-up. Conclusion: We conclude that radiation therapy is an effective treatment for esophageal cancer. Stage and response to radiation therapy were noted to be prognostic factors. A more effective treatment modality is needed to improve long term survival because of the relatively dismal prognosis for this tumor
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반응양식이 P300 숨긴정보검사의 정확도에 미치는 영향
전하정,손진훈,박광배,엄진섭,Jeon, Hajung,Sohn, Jin-Hun,Park, Kwangbai,Eom, Jin-Sup 한국감성과학회 2017 감성과학 Vol.20 No.3
본 연구에서는 P300 숨긴정보검사에서 관련자극과 무관련자극에 대한 버튼 반응 여부가 P300 진폭과 거짓말 탐지 정확률에 미치는 영향을 검증하였다. 실험참가자들은 두 가지 조건에서 P300 숨긴정보검사를 받았다. 일반응 조건에서는 실험참가자들에게 목표자극이 제시될 때에만 마우스 왼쪽 버튼을 누르도록 지시하였으며, 양반응 조건에서는 제시되는 자극이 목표자극이면 마우스 왼쪽 버튼을 누르고 목표자극이 아니면 마우스 오른쪽 버튼을 누르도록 하였다. 실험 결과, 목표자극에 대한 반응시간은 두 조건에서 유의하게 다르지 않았으며, 양반응 조건에서 관련자극에 대한 반응시간은 무관련자극에 대한 반응시간보다 유의하게 더 길었다. 관련자극에 대한 P300 진폭과 무관련자극에 대한 P300 진폭은 모두 양반응 조건에 비교하여 일반응 조건에서 더 작았다. 그러나 관련자극과 무관련자극 간의 P300 진폭 차이는 두 실험조건에서 유의한 차이가 나타나지 않았으며, 거짓말 탐지율도 두 조건 간에 큰 차이가 없었다. 이러한 결과에 근거하여 버튼 반응이 자극 간 제시간격이 짧은 P300 숨긴정보검사에 미치는 영향을 논의하였다. This study examined the effects of button response to probe and irrelevant stimuli on P300 amplitude and lie detection rate in P300-based concealed information test. Participants underwent the P300-based concealed information test (P300 CIT) in two conditions. In one button condition participants were instructed to press the left mouse button only when the target was present. In two button condition, they were asked to press the left mouse button for target and right button for non-target. The results showed that the response time to target stimulus was not significantly different between the two conditions, and the response time to the probe stimulus was significantly longer than the irrelevant stimulus. The P300 amplitudes for the probe and irrelevant stimulus were all smaller in one button condition compared to two button condition. However, the P300 amplitude difference between the probe stimulus and the irrelevant stimulus did not show a significant difference in the two experimental conditions, and the lie detection rate did not differ significantly between the two conditions. Based on these findings, the effect of button response on P300 CIT with a short inter-stimulus interval was discussed.
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