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서영거(Young Ger Suh),전라옥(Ra Ok Jeon) 대한약학회 1999 약학회지 Vol.43 No.6
The first and versatile total synthesis of isopimarol diterpene has been achived via stereoselective construction of C-13 quanternary carbon unit as a key step. Isopimarol diterpene was systhesized from the known decalone in 17% overall yield of 16 steps.
유레아 및 티오유레아 유도체의 합성과 활성화된 대식세포의 NO 생성 저해효과
김윤정,천예진,임효진,류재하,전라옥,Kim, Yoon-Jung,Cheon, Ye-Jin,Lim, Hyo-Jin,Ryu, Jae-Ha,Jeon, Ra-Ok 대한약학회 2007 약학회지 Vol.51 No.4
Several ureas and thioureas were designed and synthesized and their inhibitory activities of NO production in lipopolysaccharide-activated macrophages were evaluated. Among these compounds, indole-containing thiourea 6e was the most potent showing 17.4 ${\mu}M$ of $IC_{50}$ value.
Porphyrin-4`-bromoacetophenone Conjugates의 설계, 합성 및 DNA 절단 활성
김효진,전라옥 숙명여자대학교 약학연구소 2010 약학논문집-숙명여자대학교 Vol.25 No.-
Photodynamic therapy, in which light activates a photosensitizing drug, is a type of cancer therapy based on the selective uptake and retention of photosensitizers such as porphyrins in tumor tissues. These compounds display cytotoxic effects when activated by light of particular wavelength. Porphyrin sensitizers have been a subject of intense research in the past decades because of their unique photophysical and pharmacokinetic properties. In order to increase the biological effectiveness and reduce toxicity of porphyrin as a sensitizer, their conjugation to various molecules, such as peptides, oligonucleotides, proteins, monoclonal antibodies, and small DNA cleaver have been investigated in recent years. With the aim to develop efficient photoinducible cytotoxic agent, porphyrin-4'-bromoacetophenone conjugates were designed as new photoinducible DNA cleavers. (Tri-p-tolyl)-(4-hydroxyphenyl) porphyrin and tetrakis( 4-hydroxyphenyl) porphyrin were synthesized and conjugated to 4'-bromoacetophenone, which can generate active carbon radicals upon irradiation and cleave DNA strand, through the appropriate linker. We describe the photolytic behavior of 4'-bromoacetophenone. The effect of the irradiation time of the compound on the photolysis was examined in order to optimize photoreaction condition. The photo cleaving activity of porphyrin-4'-bromoacetophenone conjugates were evaluated using the supercoiled plasmid pBR322 in the presence and absence of light.