강박증 환자에서의 Mismatch Negativity 이상에 관한 연구

장준환,신경순,손준희,권준수,Jang, Joon-Hwan,Shin, Kyung-Soon,Son, June-Hee,Kwon, Jun-Soo 대한불안의학회 2010 대한불안의학회지 Vol.6 No.1

Objective : Mismatch negativity (MMN) provides an electrophysiological index of an involuntary attention switching process. This study investigated MMN anomalies and their relationship to clinical variables in patients with obsessive-compulsive disorder (OCD). Methods : Study participants were 29 OCD patients and 24 normal controls. We used a 128-channel EEG to measure MMN during a passive oddball paradigm. Then we assessed the correlations between MMN amplitudes and clinical measures. Results : The OCD patients exhibited significantly greater MMN amplitude compared to the controls. Also, the right frontal lobe MMN amplitudes correlated significantly to the OCD patients' Yale-Brown Obsessive Compulsive Scale total scores (r=-0.520, p=0.005). Conclusion : These results suggest that MMN anomalies in OCD patients reflect a monitoring circuit dysfunction, raising the possibility that the OCD's pathophysiology includes glutamatergic dysfunction.

전산유체해석을 이용한 Fan Filter Unit(FFU)의 가이드 베인 형상설계

장준환(Jun Hwan Jang),안준(Joon Ahn),명현국(Hyon Kook Myong) 대한기계학회 2013 大韓機械學會論文集B Vol.37 No.7

팬 필터 유닛 (FFU)은 청정실 천정에 설치되어 정화된 공기를 공급하는 장치이다. FFU가 대형화되면서 출구면에서 속도가 불균일해지고 결과적으로 청정실에서 생산되는 제품의 품질 또는 생산성을 떨어뜨리게 된다. 이러한 문제를 해결하기 위해 가이드 베인이 설치되는데 가이드 베인은 속도를 균일하게 하지만 유동저항을 유발하여 동력이 일정하게 주어진 경우 공급되는 유량을 감소시킨다. 따라서 속도 균일성을 확보하면서 유량 감소를 최소화하는 최적설계가 요구된다. 본 연구에서는 FFU의 외벽과 중앙에 설치된 가이드 베인의 각도와 길이를 변경하면서 수치해석을 수행하여 가이드 베인의 성능 개선 방안을 도출하였다. 외벽에 설치된 가이드 베인의 경우, 형상을 변경하여 유량이 1.5% 감소하는 조건에서 속도 균일도를 3.7% 향상시킬 수 있었다. 중앙 가이드 베인의 경우 유량이 0.7% 감소하는 조건에서 속도 균일도를 2.9% 향상시킬 수 있었다. A fan filter unit (FFU) is a device which supplies clean air from the ceiling in a clean room. With an increase in its size, velocity variation occurs within the exhaust plane and this damage the product quality or productivity. Hence, a guide vane is installed inside the device to enhance the velocity uniformity. Because the vane reduces the flow rate for a given pumping power, an optimum design is required to achieve velocity uniformity while minimizing the flow rate reduction at the same time. To find a geometry that satisfies these requirements, a series of numerical simulations has been conducted while changing the angle and length of the guide vanes. By changing the geometry of the side guide vane, the velocity uniformity increased by 3.7% and the flow rate decreased by 1.5%. For the center guide vane, the velocity uniformity increased by 2.9% and the flow rate decreased by 0.7%.

4단 화격자 목재 펠릿 보일러의 부분부하 연소해석

안준(Joon Ahn),장준환(Jun Hwan Jang) 대한기계학회 2014 大韓機械學會論文集B Vol.38 No.4

본 연구에서는 4단 화격자로 구성된 목재 펠릿 보일러의 연소실에 대하여 수치해석을 수행하였다. 목재 펠릿의 화염은 화격자에서 연소실 출구까지 신장되는 데 이 현상이 균질 반응에 기반한 수치해석 기법으로 잘 예측되었다. 수치해석으로 구한 유동장을 보면 연소실 상류에서 출구쪽으로 강한 재순환 유동이 형성되는데 이 유동을 따라 화염이 신장된다. 이와 같은 유동 및 연소 형태는 부분부하 조건에 대하여 수치해석을 수행하였을 때도 유지되었다. 따라서 연소실의 체적을 변경하는 것보다 연소실의 구조를 변경하는 것이 연소 효율을 개선하는 데 도움이 될 것으로 보인다. 본 연구에서는 수치해석 결과를 바탕으로 연소 효율을 높이기 위하여 연소실 출구 위치 변경하거나 화격자 개수를 늘이는 방안 또는 격벽과 같은 내부 구조물을 설치하는 방안을 제안하였다. A numerical simulation was conducted for the combustion chamber of a 4-step grate-firing boiler for wood pellet fuel. The flame is extended to the exit of combustion chamber, which is reproduced by present numerical method based on a homogeneous reaction model. Flow field from the simulation shows a strong recirculation flow at the upstream corner of the chamber, along which the flame is extended to the exit. These combustion and flow characteristics remain unchanged for partial load operations, which suggest modification of the combustion chamber structure rather than resizing should be effective to improve combustion characteristics. Possible modifications for combustion chamber are suggested such as relocating its exit, increasing the number of grate steps or installing internals such as guide baffles.

강박장애 환자에서의 성격 5요인 모델 분석

허민정,변민수,김성년,김의태,장준환,권준수,Huh, Min Jung,Byun, Min Soo,Kim, Sung Nyun,Kim, Euitae,Jang, Joon Hwan,Kwon, Jun Soo 대한불안의학회 2012 대한불안의학회지 Vol.8 No.2

Objective : The aim of this study is to evaluate the five-factor model of personality in patients with obsessive-compulsive disorder (OCD) related to obsessive-compulsive symptom severity and the distinct symptom subgroups. Methods : We recruited 95 patients with OCD and 116 normal controls in the study. We used the short version of Revised NEO Personality Inventory and the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) for the assessment. Results : Patients with OCD showed significantly higher scores in neuroticism than normal controls. On multiple linear regression analysis, we found that agreeableness and conscientiousness were associated with the total Y-BOCS scores. On subscale analysis, agreeableness and neuroticism were associated with the obsession subscale scores and only conscientiousness was associated with the compulsion subscale scores. Furthermore, we found that patients who have contamination/cleaning or symmetry/ordering/counting/arranging as a main symptom presentation had significantly higher mean scores in conscientiousness than patients who have harm due to injury/violence/aggression as a main symptom presentation. Conclusion : In this study, we found that specific personality factors are associated with the obsessive-compulsive symptom severity. In addition, this is the first study to investigate the relationship between the personality factors in the five-factor model and the distinct symptom subgroups in OCD.

병적 도박 환자에서의 회백질 부피 변화 분석 : 화소 기반 형태분석 방법을 이용한 예비 연구

최정석,신영철,정위훈,정명훈,장준환,강도형,최치훈,권준수,이준영,Choi, Jung-Seok,Shin, Young-Chul,Jung, Wi Hoon,Jung, Myung Hun,Jang, Joon Hwan,Kang, Do-Hyung,Choi, Chi-Hoon,Kwon, Jun Soo,Lee, Jun-Young 대한생물정신의학회 2009 생물정신의학 Vol.16 No.3

Objectives : The purpose of this study was to examine structural abnormalities of brain in patients with pathological gambling(PG) using voxel-based morphometry. Methods : We compared gray matter(GM) volumes between 10 patients with PG and 14 age- and IQ-matched healthy controls and examined the relationship of GM volumes with clinical variables in patients with PG. Results : We found significant increase of GM volume in the superior, middle, and inferior frontal gyri, the midbrain, the middle temporal gyrus, the precuneus, and the fusiform gyrus of patients with PG. A significant decrease of GM volume was observed in the parahippocampal gyrus and the lingual gyrus of the patient group. In addition, GM volumes in some of these regions were positively associated with South Oaks Gambling Screen score and negatively with age of onset in patients with PG. Conclusion : Current findings indicate that structural abnormalities in the fronto-temporal cortex, the midbrain, and the precuneus might be involved in the pathophysiology of PG, and contribute to some of the behavioral changes observed in patients with PG.

뇌과학의 발전과 형법적 패러다임 전환에 관한 연구(II)

탁희성(Tak Hee Sung),이인영(Lee In Young),권준수(Kwon Jun Soo),강도형(Kang Do Hyung),장준환(Jang Joon Hwan),박상옥 한국형사법무정책연구원 2014 형사정책연구원 연구총서 Vol.- No.-

에너지기술에서 스마트 기기(IOS) 어플리케이션(App) 개발

강새별(Sae Byul Kang),김종진(Jong Jin Kim),최규성(Kyu Sung Choi),오홍영(Hong Young Oh),심봉석(Bong Suk Sim),장준환(Joon Hwan Jang) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.12

Nowadays, most people carry a smart device that is a smart phone or a smart pad. Usually with a smart phone, we can use it as a phone, a calculator, a scheduler and even as a navigator. There are 2 types of smart device, one is an Android(http://developer.android.com/) platform and the other is as IOS(http://developer.apple.com/) platform. Application developing language is different from each other. Programmer for android has to use Java<SUP>tm</SUP> and one for IOS has to us Objective-C language. We make applications(App) for smart device, especially for IOS such as iPhone and iPad. One of the applications is in the form of ICT(Information and Communications Technology). With the program, we can monitor an electric power consumption of building. We can check current electric power usage, today electricity charge, electric usage pattern and so on. Another is for technical calculation applications, such as calculation for boiler efficiency, calculation for fuel heating value, boiler operation monitoring and so on.

음성 증상이 주된 조현병 환자에서 Aripiprazole의 효과에 대한 52주의 전향적 연구

김혜수,김성년,장준환,권준수 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

p<.0001), and 41.03% of patients appeared to respond according to CGI-I. Conclusion:Aripiprazole may be as much efficacious against negative symptoms as positive symptoms in schizophrenia. This suggests the possibility clinicians can consider aripiprazole as a drug of choice in the chronic schizophrenic patients with prominent negative symptoms before trying switching other antipsychotics with clozapine. 본 연구는 aripiprazole이 만성 조현병 환자의 선택 약제로 사용될 수 있는 작은 가능성을 제시하였다고 평가할 수 있겠다. 많은 종류의 항정신병약물이 조현병의 치료를 위해 쓰여지고 있는 현 상황에서, 병의 경과 상 다양한 시점에 놓인 각각의 환자군에 대한 보다 많은 종류의 항정신병약물 효과에 대한 비교 연구가 축적된다면, 임상의사의 약물 선택에 대한 시행착오가 지금보다는 줄어들 수 있을 것이다. Objectives:This study was done to evaluate the efficacy of aripiprazole in the schizophrenic patients with prominent negative symptoms. Methods:This study was a prospective, multicenter, single-group, 52-week open study of patients with schizophrenia, schizophreniform disorder and schizoaffective disorder. A total of 300 Korean patients participated in the study. Among them, 39 patients with prominent negative symptoms were initially administered 15mg/day of aripiprazole for the first 2 weeks, and then treated with 10-30mg/day. The efficacy measures included the Positive and Negative Syndrome Scale(PANSS) total, positive and negative subscale scores, the Clinical Global Impression-Severity of Illness(CGI-S), and the CGI-Global improvements(CGI-I). Results:The significant improvements were observed in all 3 PANSS parameters total(-35.72 p<.0001), positive subscale(-7.41 p<.0001), and negative subscale scores(-11.56 p<.0001). The difference between positive and negative subscale scores was significantly decreased from baseline to week 52. CGI-S was also decreased (-1.67