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좌골신경 손상 모델에서 보양환오탕 처리에 의한 축삭 재생반응성 분석
장인애 ( Chang In Ae ),김기중 ( Kim Ki Joong ),남궁욱 ( Namgung Uk ) 대전대학교 한의학연구소 2016 한의학연구소 논문집 Vol.25 No.1
While axons in the peripheral nerve can regenerate and lead to functional recovery to a certain extent after injury, its efficacy varies depending on the severity and duration of the injury. Here, we investigated the effects of Boyanghwano-tang (BYHOT) treatment on the regenerative responses in the sciatic nerves after prolonged transection and coaptation surgery. In mice given crush injury, axonal regeneration was completed when analyzed 1 week later and did not show any difference in regenerative reponses in the distal portion of the nerve between saline- and BYHOT-treated groups. In animal models with transection and reconnection, axonal regeneration was markedly retarded compared to animals with crush injury. Regenerating axons were extended into the reconnected distal portion of the nerve more actively in animals treated with BYHOT than saline controls. Cdc2 protein was similarly induced in nerves with crush injury and with transection and recollection, and its level was lower in BYHOT-treated animal than saline control when measured 2 weeks after nerve reconnection. These results suggest that BYHOT may be useful to promote axonal regeneration in the peripheral nerve after severe injury.
Yim, Eun-Kyoung,Chang, In-Ae,Lee, Jin-Sang,Kim, Yoon-Won,Woo, Soo-Dong,Ahn, Jee-Yin,Park, Seung-Kee,Cho, Min-Kee 대한감염학회 2004 감염과 화학요법 Vol.36 No.2
배경 : 1984년 한국에서 처음으로 렙토스피라증 환자가 확진된 이래 환자와 들쥐로부터 많은 수의 렙토스피라균이 분리되었으며 혈청학적 방법에 의해 혈청형이 동정된 바 있으나 혈청형 동정에 도움이 되는 것으로 알려진 pulsed-field gel electrophoresis (PFGE)가 시행된 바는 없다. 이에 국내에서 분리된 균주들의 PFGE 양상을 파악하고 그 결과를 고전적인 혈청형 동정방법과 비교하고자 하였다. 방법 : 표준균주 29와 한국에서 분리된 분리균주 29주의 렙토스피라균을 대상으로 이들 균주들의 chromosome을 Not I 제한효소로 처리하여 contous-clamped omogeneous field (CHEF) 전기영동장치(CHEF-DRII, Bio-Rad)를 사용하여 Pulsed-Field Gel Electrophoresis를 실시하였다. 결과 : 혈청군 Icterohemorrhagiae에 속하는 17 혈청형 표준균주의 Not I 제한효소 절단양상은 각기 다르게 나타났으며, 국내 분리균주들(29주)은 세 가지의 다른 PFGE 양상을 보였다. 혈청학적인 방법에 의해 혈청형 Iai로 동정되었던 국내 분리균주들은 표준균주 Iai와 똑같은 PFGE 양상을 보였다. 혈청학적 방법으로는 혈청형 Iai와 구분되었던 AP31, CH89-19 및 N13균주도 표준균주 Iai와 같은 PFGE 양상을 보였으나, 혈청형 Iai로 동정된 바 있는 HY2 균주와 혈청형 Iai와 구분되었던 30R 균주는 표준균주 Iai와 약간 다른 PFGE 양상을 보였다. 결론 : 혈청형 Iai로 동정된 한국 분리균주들의 대부분은 표준균주 Iai와 같은 PFGE 양상을 보였다. DNA의 Not I 절단에 의한 PFGE는 분리균주의 혈청형 동정에 크게 도움이 될 뿐 아니라, 서로 관련된 혈청형 내의 유전적 다양성을 조사하는데 좋은 방법이라는 것을 확인할 수 있었다. Background : Many strains of Leptospira interrogans have been isolated in Korea since 1984. Most isolates were identified as serovar lai by serological methods. The pulsed field gel electrophoresis (PFGE) patterns of Korean isolates have not been investigated currently. Methods : 29 reference strains and 29 Korean isolates of Leptospira interrogans were characterized by PFGE. Chromosomes were digested by the Not Ⅰ restriction enzyme and subsequently PFGE was performed in CHEF-DRⅡ(Bio Rad Lab) with 3 pulse times (30 seconds 13 hours. 60 seconds 13 hours, 120 seconds 14 hours) at 150 V (4.3 V/㎝). Results : 12 serogroup reference strains and most 17 serovars reference strains in the serogroup Icterohaemoffhagie showed the unique Not I restriction patterns. Most isolates identified serologically as serovar lai showed the same PFGE patterns as the serovar lai reference strain. The strain HM3 and 18R identified serologically as new serovars yeonchon and hongchon respectively showed the same PFGE patterns as serovar lai. The strain AP31, CH88-19 and NR13 that were different from serovar lai by serological methods showed the PFGE patterns indistinguishable from serovar lai reference strain. The strain HY2 that was identified as serovar lai, and the strain 30R that was different from serovar lai serologically showed the PFGE patterns slightly different from serovar lai reference strain. Conclusion : The PFGE profile of most Korean isolates Leptospira interrogans serologically identified as serovar lai is identical to the reference strain serovar lai. PFGE analysis thus may be applied to identify serovar of isolates and to investigate the genetic diversity of related serovar.