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김효종(Hyo Jong Kim),김윤화(Youn Hwa Kim),정혜전(Heo Jeon Cheong),동석호(Seok Ho Dong),김배영(Bae Young Kim),김병호(Byung Ho Kim),이정일(Joung Il Lee),장영운(Young Woon Chang),장린(Rin Chang),양문호(Moon Ho Yang) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1
N/A Background/Aims: Multiple genetic alterations in tumor suppressor genes(APC, MCC, DCC, p53) and oncogenes(K-ras) have been implicated in the development of colorectal carcinomas(CRCs). Recently, mutator genes(hMSH2, hMLH1, hPMS1, hPMS2), which are characterized by the development of particular form of genetic instability, termed RER(replication error) was reported in CRCs. It is postulated that RER may be required for multiple genetic alterations in the development of CRCs. But the mode of genetic alterations caused by RER is not certain. To evaluate the mode of genetic alterations caused by RER in multistage carcinogeneis, we compared the frequency of p53 expression, known to be involved in the pathogenesis of CRC, in two groups of tumors. RER(+); those demonstrating RER, and RER( ); those lacking such genetic alterations. Methods: RER test at microsatellite loci; DNA was extracted from normal and tumor tissues using cryostat sectioning method. Purified DNA was subjected to a PCR-based technique in which(CA)n repeat sequence were amplified and RERs were detected when a change in allele length was detected. Immunohistochemical analysis of p53 expression; Deparaffinized section of formalin-fixed tumor tissue samples were immunostained for p53 protein, using a monoclonal p53-specific DO7 antibody. Results: The frequency of RER in sporadic CRC was 40.1%(9/22). P53 expression was observed in 6 of 18 carcinoma(33.3%). The frequency of p53 immunostaining was lower in tumors demonstrating RER(25% vs. 40%). All tumor demonstrating RER at multiple loci did not exhibited p53 immunostaining. Conclusions: These results suggest that RER is likely to play an important role in the pathogenesis of CRCs probably by the different mode of genentic alterations from those lacking RER. (Korean J Gastroenterol 1996;28: 36-46)
부분 비장색전술로 부분관해된 특발성 문맥압항진증 1 예
김수영(Su Young Kim),김병호(Byung Ho Kim),이승훈(Seung Hoon Lee),오주형(Joo Hyeong Oh),이상목(Sang Mock Lee),김교영(Gyo Young Kim),김윤화(Youn Hwa Kim),이주희(Ju Hie Lee),동석호(Seok Ho Dong),김효종(Hyo Jong Kim),장영운(Young Woon ch 대한소화기학회 2001 대한소화기학회지 Vol.38 No.1
Background/Aims: Hepatolithiasis usually causes critical complications. Particularly, recurrent cholangitis is developed even after treatment. In this study, we aimed to find out the risk factors for recurrent cholangitis after management of hepatolithiasis, Methods: We reviewed the medical records of 196 patients with hepatolithiasis who had been diagnosed newly and treated at Seoul National University Hospital between January 1980 and August 2000. Then, the cumulative rate of cholangitis after treatment of hepatolithiasis and the possible risk factors for cholangitis through univariate and multivariate analysis were evaluated. Results: The cumulative rate of cholangitis of all patients was 9.6%/patient-year. Univariate analysis revealed that the presence of residual stone after treatment (p<0.0001), common bile duct stone before treatment (p=0.0066), stone recurrence after treatment (p=0.0014), and disruption of the sphincter of Oddi (p=0.0046) were significantly associated with recurrent cholangitis. By multivariate analysis using Cox model, the presence of residual stones, recurrence of stones, and the disruption of sphincter of Oddi were turned out to be the independent risk factors, but the presence of common bile duct stones was not. Conclusions: Complete removal of bile duct stone, prevention of recurrent stones, and preservation of the sphincter of Oddi can decrease the rate of cholangitis in patients with hepatolithiasis. (Korean J Gastroenterol 2001;38:42-47)
이상길 ( Sang Kil Lee ),김효종 ( Hyo Jong Kim ),지성길 ( Sung Gil Chi ),장재영 ( Jae Young Jang ),남기덕 ( Ki Deok Nam ),김남훈 ( Nam Hoon Kim ),주광로 ( Kwang Ro Joo ),동석호 ( Seok Ho Dong ),김병호 ( Byung Ho Kim ),장영운 ( Youn 대한소화기학회 2005 대한소화기학회지 Vol.45 No.5
Background/Aims: Saccharomyces boulardii (S. boulardii) has been reported to be beneficial in the treatment of inflammatory bowel disease, however, little is known about its mechanism of action. Peroxisome proliferator- activated receptor-γ (PPAR-γ) is re
한국인 염증성 장질환 환자에서의 Natural Resistance-ssociated Macrophage Protein 1 유전자 촉진자의 다형성
이병욱 ( Byoung Wook Lee ),조재호 ( Jai Ho Cho ),이길연 ( Gil Yeon Lee ),김효종 ( Hyo Jong Kim ),지성길 ( Sung Gil Chi ),정용희 ( Yong Hee Jeong ),한요셉 ( Yo Seb Han ),동석호 ( Seok Ho Dong ),김병호 ( Byung Ho Kim ),장영운 ( Youn 대한소화기학회 2003 대한소화기학회지 Vol.41 No.6
Background/Aims: Natural resistance-associated macrophage protein 1 (NRAMP1) gene controls the immune response to intracellular microbial pathogens in human. To identify the association between the NRAMP1 gene and susceptibility of inflammatory bowel disease (IBD) in Korean population, we examined three predominant alleles (allele 2, 3, and 7) that have been known to influence the transcriptional activity of the NRAMP1 gene. Methods: Genomic DNA was extracted from blood lymphocytes by standard method in 70 patients with Crohn`s disease (CD), 72 patients with ulcerative colitis (UC), and 52 healthy controls. To detect sequence polymorphisms in the NRAMP1 gene promoter, we performed nonisotopic genomic PCR-SSCP analysis. PCR products with different SSCP patterns were subjected to DNA sequencing analysis to verify sequence polymorphisms. Results: The allele and carrier frequencies of allele 2 and 3 were similar in both patient and healthy control group. Although the statistical significance did not exist, the allele and carrier frequencies of allele 7 had higher tendency in patients with CD (10.7%, 21.4%) and UC (11.1%, 22.2%) than in the healthy control group (4.8%, 9.6%). Conclusions: Our findings suggest that the specific promoter polymorphism of the NRAMP1 gene may influence susceptibility to IBD in the Korean population. Further studies with a group of subjects are required to clarify our observations. (Korean J Gastroenterol 2003;41:465-472)
양문호,장린,박충기,민영일,장영운,방익수,김윤화 대한소화기내시경학회 1985 Clinical Endoscopy Vol.5 No.1
Tuberculosis of the esophagus is rare. We experienced four patients with esophageal tuberculosis proven by esophagoscopic biopsy or surgical specimens. Case 1 was a patient with primary esophageal tabereulosis, case 2 was a patient with teberculous esophagobronchial fistula and case 3,4 were patients with esoyhageal perforation due to tuberculous traetion diverticulum of the esophagus. The clinical, radiological and esapbagoscopic findings may be nonspecific in diagnosis of esophageal tuberculosis. Therefore early diagnosis should be rested on a high index of suapieion and a cautious attention.
김병호,김효종,조진만,김윤화,이정일,동석호,장영운,황일섭,장 린 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.1
Carcinosarcoma of the stomach is regarded as a rare malignant neoplasm composed of both carcinomatous and sarcomatous components in a given tumor. Few cases have been reported since 1904. This is a case of carcinosarcoma of the stomach in a 61-year-old man. He suffered from indigestion, vomiting, and epigastric pain. Endoscopic finding showed a huge protruding mass with intact mucosa on the posterior wall of the antrum up to the pylorus. Surgery was performed and carcinosarcoma with pancreatic invasion was confirmed by pathology.
김병호,김효종,정인경,장린,이정일,동석호,장영운,김광국,황일섭,김윤화 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.1
Although intestinal bleeding is known to occur in amyloidosis, it is rare as a presenting symptom or sole manifestation of the disease. We experienced a case of intestinal hemor-rhage in a 64-year old female patient with primary amyloidosis, kappa type. Antral muco-sal erosions were discovered and one shallow healing ulcer at the angle. Colonoscopy revealed multiple purplish nodules in the sigmoid colon and descending colon, as well as a large shallow ulcer with blood clots in the sigmoid colon which was suspected to be the intestinal hemorrhage site. Endoscopic biopsy established amyloidosis. Polarizing microscopy after Congo red staining and immunohistochemical staining identified primary amyloid, kappa type. A case of intestinal hemorrhage in patients with primary amyloidosis is presented and the literature is reviewed.
종양표지자 CA19- 9 의 현저한 상승을 보인 간내 담관낭선종 1 예
김병호,김효종,김윤화,장린,이정일,동석호,장영운,김희진,박철영,강선우,손상용 대한소화기학회 1999 대한소화기학회지 Vol.33 No.6
A 24-year-old woman who had one month history of right upper quadrant abdominal mass and pain was admitted to our hospital. Examination by abdomen ultrasonography and computerized tomo graphy indicated that it was a large cystic tumor in the liver with multiple internal septation. Thus she received a laparotomy. A 15×12×5 cm cystic mass from left medial segment of the liver wa noted and could be removed by cystectomy and partial segmentectomy. On cut section, yellowish serous fluid containing multilocular cyst surrounded by a smooth and glistening wall was seen Microscopic findings revealed that it is a case of intrahepatic biliary cystadenoma with mesenchyma stroma. This tumor was noted with strikingly elevated serum level of the tumor-associated antigen CA 19-9 (500 U/ml). Twenty days after the surgery, the serum CA 19-9 level returned to normal (29 U/ml). This may be a valuable finding in the differential diagnosis, so we report this case with review of the literatures.