http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
원자력발전소 디지털시스템 설계요건(Code & Standard)을 고려한 보안성 평가에 관한 연구
임준희(Jun Hee Lim),김휘강(Huy Kang Kim) 한국정보보호학회 2020 情報保護學會誌 Vol.30 No.2
국내 원자력발전소는 1978년 웨스팅하우스 노형의 고리1호기부터 2019년 APR-1400 노형의 신고리3호기 준공까지 많은 기술의 발전을 이룩하였다. 과거와 비교하여 현재의 원자력발전소는 단순히 발전용량만 증가한 것이 아니라, 안전에 대한 요구가 반영되어 발전하였다. 첫째, 미국 TMI 사고, 우크라이나 체르노빌 사고, 일본 후쿠시마 사고를 겪으며 자연재해, 인적실수 등에 관한 강화된 대책이 적용되었다. 둘째 미국 Browns Ferry 원전 정지, Hatch 원전 정지, 이란 핵시설 스턱스넷 공격 등을 겪으며, 사이버위협에 대응하기 위한 사이버보안 규제요건이 원자력발전소에 적용되었다. 그러나 사이버보안 규제요건과 원자력발전소 설계요건이 상충하는 부분이 일부 존재한다. 본 논문에서는 원자력발전소 사이버보안 규제요건과 상충하는 설계요건(Code&Standard)을 분석하여, 사이버 보안관점에서 요구되는 보안 조치사항을 도출하였다.
Luteolin의 IL-1β에 의한 MCP1 단백질 발현 증가에 미치는 영향
임준희(Jun Hee Lim),권택규(Taeg Kyu Kwon) 한국생명과학회 2009 생명과학회지 Vol.19 No.4
혈관벽에 단핵구, 대식세포 등의 세포와 지질 등의 축적은 중요한 동맥경화 발병 요인이다. 이들 세포의 혈관벽으로의 이동에 있어서 chemokine인 MCP1이 중요한 역할을 한다는 것이 많이 알려져 있다. 본 연구에서는 사람 평활근세포에서 IL-1β의 처리에 의하여 MCP1의 발현이 증가되는 기전을 알아보고자 실험을 진행하였다. IL-1β의 처리는 전사인자 NF-κB의 활성화를 통해 MCP1 발현을 전사단계에서 증가시켰다. 이러한 IL-1β에 의해 증가된 MCP1 발현을 억제하는 물질을 찾기 위해 여러 항염증작용을 하는 물질들을 전처리하여 확인해본 결과 luteolin이 선택적으로 IL-1β에 의해 증가된 MCP1의 발현을 전사단계에서 저해하는 것을 확인하였고 이는 전사인자 NF-κB가 핵으로 이동하는 것을 감소시킴으로써 나타나는 현상임을 확인하였다. Luteolin이 염증작용을 조절하는데 있어서 중요한 전사인자인 NF-κB의 활성을 조절한다는 것을 본 실험을 통해 알 수 있었고 이는 식용식물에서 일반적으로 발견되는 luteolin이 어떠한 기전으로 항 염증작용을 하는지에 대한 이해를 높여줄 것이다. Monocyte chemoattractant protein 1 (MCP1) plays a key role in monocyte/macrophage infiltration to the sub-endothelial space of the blood vessel wall, which is a critical initial step in atherosclerosis. In this study, we examined interleukin-1β (IL-1β) induced MCP1 expressions via activation of transcription factor NF-κB in primary human aorta smooth muscle cells. We determined the effect of several anti-inflammatory agents on IL-1β-induced MCP1 expression. The pretreatment of luteolin significantly suppressed IL-1β-induced MCP1 expressions through blocking activation and translocation of NF-κB to the nucleus.
임준희(June Hee Lim),김성민(Sung Min Kim),김미하(Mi Ha Kim),오수영(Soo Young Oh),문정빈(Jeong Bin Moon),박중신(Joong Shin Park),전종관(Jong Kwan Jun),윤보현(Bo Hyun Yoon),신희철(Hee Chul Syn) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.9
Objective : To evaluate the clinical characteristics, course, and the outcomes of pregnancies with Takayasu's arteritis. Methods : The retrospective study was done by the review of medical records of 14 pregnancies with Takayasu's arteritis found between June, 1989 and December, 1999. Pre-pregnant status and pregnancy outcome were described.Results : Takayasu's arteritis was found in 14 cases among 19,885 women who had delivered at our unit during the study period. There were no maternal or neonatal death. The median age at diagnosis was 24.6 years. Common clinical findings were vascular bruit(58.3%), pulse deficit(50%), and hypertension(50%) at diagnosis. Among the 6 patients who had hypertension, 5(83.3%) showed renovascular hypertension and superimposed preeclampsia developed in 2(33.3%) cases. Marked elevation of systolic blood pressure during labor was associated with 3 pregnancies(25%), including 2 patients who were prepregnant normotensive and without preeclampsia. Cesarean section was performed in 35.7%(5/14) of cases. There were 2 preterm birth(14.3%), 4 growth-restricted newborns(28.6%). Only one was admitted into NICU with 5 Apgar score at 1 minute. Three fourteenths had various postpartum problems, most of which were related to cardiovascular events ; dyspnea, pleural effusion, and transient depressed blood pressure. Conclusion : Because the disorder affects women in childbearing age mainly, it may be recognized the first time during pregnancy. Despite various cardiovascular events which may occur in the perinatal period, the basic disease is usually unaffected by pregnancy and both maternal and fetal clinical outcome may be fair.
한국인 산모에서 임신중기 양수내 alpha-fetoprotein치의 정상 범위
윤보현(Bo Hyun Yoon),김미하(Mi Ha Kim),신희철(Hee Chul Syn),문정빈(Jeong Bin Moon),전종관(Jong Kwan Jun),임준희(June Hee Lim),오수영(Soo Young Oh),이용희(Yong Hee Lee),박중신(Joong Shin Park) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.6
Objective: Our purpose was to determine normal amniotic fluid α-fetoprotein level in midtrimester Korean pregnant women whose neonatal outcomes were normal. Methods: Amniotic fluid α-fetoprotein(AFAFP) levels were measured by specific radioimmunoassay (RIA) in midtrimester pregnant women for various indications of amniocentesis from May 1992 to July 1999 at Seoul National University Hospital. Normal ranges were obtained from 640 singleton pregnancies in which neonatal outcomes were normal.Results: Median values of AFAFP in Korean pregnant women were 13,250ng/mL, 12,900ng/mL, 11,150ng/mL, 9,430ng/mL, 8,019ng/mL, 6,800ng/mL, 5,850ng/mL, 5,750ng/mL, 5,210ng/mL, 3,420ng/mL at 15 week, 16 week, 17 week, 18 week, 19 week, 20 week, 21 week, 22 week, 23 week, 24 week, respectively.Conclusion: This determination of the median values and the normal range of AFAFP level by each gestational week in uncomplicated Korean women could be used reference values for prenatal diagnosis of various disorders like open neural tube defect.
조기분만진통 환자의 산전 자궁내 감염 및 주산기 예후 예측에 관한 양수내 Monocyte Chemotactic Protein - 1 측정의 유용성
심순섭(Soon Sup Shim),박현수(Hyun Soo Park),임준희(June Hee Lim),심재윤(Jae Yoon Shim),천대우(Dae Woo Chun),박중신(Joong Shin Park),전종관(Jong Kwan Jun),윤보현(Bo Hyun Yoon),신희철(Hee Chul Syn) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.6
Objective : To examine if amniotic fluid (AF) monocyte chemotactic protein-1 (MCP-1) concentrations are useful in the identification of intrauterine infection and pregnancy outcomes in preterm labor with intact membranes. Methods : The study population consists of 65 patients who received amniocentesis for preterm labor with intact membranes. Amniotic fluid was cultured for aerobic and anaerobic bacteria, as well as mycoplasmas. MCP-1 was determined by a sensitive and specific immunoassay. Fisher`s exact test, Mann- Whitney U test, receiver operating characteristic curve, survival techniques, logistic regression, and Spearman correlation were used for statistical analysis. Results : (1) Patients with a positive amniotic fluid culture had a significantly higher median AF MCP-1 concentration than those with negative results (median, 9.0 ng/mL; range, 0.45-40.5 ng/mL; vs median, 0.82 ng/mL; range, 0.06-30.1 ng/mL; P<.01). (2) Patients with AF MCP-1 concentration of >1.9 ng/mL had a significantly shorter median interval to delivery, the higher rate of histologic chorioamnionitis, preterm delivery within 2 and 5 days, and the occurrence of congenital proven or suspected sepsis than did those with AF MCP-1 concentration of <1.9 ng/mL after adjustment for gestational age (P<.05). (3) There was strong correlation between AF MCP-1 concentrations and AF interleukin-6 concentrations (r=.881, P<.001). Conclusion : AF MCP-1 determinations are useful in the identification of intrauterine infection, preterm delivery, and neonatal infectious complication in preterm labor with intact membranes.
윤상호(Sang Ho Yoon),천은경(Eun Kyung Chun),심순섭(Soon Sup Shim),임준희(June Hee Lim),박중신(Joong Shin Park),전종관(Jong Kwan Jun),윤보현(Bo Hyun Yoon),신희철(Hee Chul Syn) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.7
Objective : To assess the pregnancy outcomes complicated by maternal heart diseases. Methods : From 1994 to 2001, medical records of pregnant women who had reached at least 20 weeks of gestation with maternal heart diseases were reviewed. Results : 224 deliveries of 195 women were enrolled in this study. In 117 (52.2%) cases the heart diseases were of rheumatic origin, in 96 (42.9%) cases congenital, and the remaining 11 (4.9%) cases were miscellaneous group that included arrhythmia, cardiomyopathy, and mitral valve prolapse. There were 2 (0.9%) cases of maternal death related to pregnancy. Majority (91.9%) were in New York Heart Association functional classes I, Ⅱ before, during, and after delivery. Mean gestational age at birth and birth weight were 37.9 weeks and 2883 gm. Perinatal mortality rate was 17.9/1000 and the rate of congenital malformation was 2.7%. Recurrence risk of neonatal congenital heart disease was 2.1%. Conclusion : Most complications were developed in the pregnancies complicated by maternal heart diseases with New York Heart Association functional classes Ⅲ, Ⅳ. Functional status of the pregnant women is the important risk factor in maternal and fetal outcomes.