니코틴이 사람태아골모세포의 광물화 과정에 미치는 영향

임성우,한상헌,이성진,유석주,신형식,유형근,Lim, Sung-Woo,Han, Sang-Heon,Lee, Seong-Jin,You, Suk-Joo,Shin, Hyung-Shik,You, Hyung-Keun 대한치주과학회 2003 Journal of Periodontal & Implant Science Vol.33 No.4

Nicotine is one of the major components of cigarette smoking which causes various systemic and local diseases to human body. The purpose of the present study was to investigate the effects of nicotine on bone mineralization in human fetal osteoblasts cell line(hFOB1). To compare the alkaline ph-osphatase(ALP) synthesis, hFOBl were cultured with DMEM/F-12 1:1 Mixture and 100 pg/ml, 1 ng/ml, 10 ng/ml, 100 ng/ml, 1 ${\mu}g$/ml, 10 ${\mu}g$/ml, 100 ${\mu}g$/ml of nicotine. And to compare the calcium accumulation, hFOB1 cultured for 23 days were quantified and photographed. ALP activity of hFOB1 exposed to nicotine was not significantly changed at a lower concentrations of nicotine, but was significantly decreased at a higher concentrations (10 ${\mu}g$/ml, 100 ${\mu}g$/ml) of nicotine (p<0.05). A quantified calcium acculation in hFOB1 was significantly decreased at 1,10, and 100${\mu}g$/ml of nicotine (p<0.05). Significantly decreased calcium deposition was observed at 1, 10, and 100${\mu}$/ml of nicotine. These results indicate that a higher concentration of nicotine show a negative effects on mineralization of hFOB1.

십이지장 궤양, 출혈성 위염, 미란성 위염 병발 환자의 치험 1례

임성우,Lim, Seong-Woo 대한한방내과학회 1995 大韓韓方內科學會誌 Vol.16 No.1

A previous study suggested that there might be an association between use of herb medicine and peptic ulcer. The past history of patient with perforated duodenal ulcer was treated with herb medicine. We identified that the mucosa of stomach & duodenum were completed healed by herb medicine treatment on the gastro-endoscopy and the systom. Author report ths case with a brief review of literatures.

한약을 이용한 항암 실험 연구의 경향과 연구 방향

임성우,Lim, Seong-Woo 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.1

After examining and analysing the medicinal herbs of fifty-three experimental papers, we studied their effects on immediate tumors in specific cancers. We did not study the influence on the life span of general cancerous cells. We looked to see if the combined usage of medicinal herbs and anticancer agents inhibited the tumor cell's growth. The serum test and blood cell count test showed if the medicinal herbs inhibited the side effects of the anticancer agent. The test showed that more than 80 percent of used medicinal herbs, brought anticancer activities. However, anticancer experimental studies using medicinal herbs have draw-backs. First, it is difficult to choose a prescription using the standards of Oriental Medicine because we are testing a mouse not a man. Second, because we only observed the indirect effect on the whole physiological regulation caused by the synergic effects of the complex prescription, we are not able to understand the detailed mechanism of the herbs. Therefore; if the anticancer effect of the herbs is proved by the experiment, we need to research the concrete medical action of medicinal herbs and the immunological analysis of herbal medicines on the body.

Screening for Various Herb Medicines Extracts against Human immunodeficiency virus & Herpes simplex virus type I and Herpes simplex virus type II

임성우,안덕균,우은란,박호균,Lim, Seong-Woo,Ahn, Duk-Kyun,Woo, Eun-Rhan,Park, Ho-Koon The Society of Korean Medicine 1998 대한한의학회지 Vol.19 No.2

면역 결핍 바이러스와 허피즈 바이러스 -1,2에 대한 한약의 항바이러스 작용을 관찰하기 위하여, 세포 바이러스 검색에 초기 독성과 감염 바이러스의 생존 세포 수를 비교적 단기간내 볼 수 있는 96-well plate를 이용한 MTT assay로 측정하였다. 본 실험은 예비 실험 단계에서 사용된 총 85가지의 한약중 단미제 6가지와 복합처방 44가지를 선정하였으며 복합처방은 유사한 치법으로 분류하였고 한약의 시료 추출은 순수하게 물로 전탕하여 여과하였다. 실험 결과 파두와 맥아가 면액 결핍 바이러스에 대해 감염초기 유의성이 있었으며 호장근, 갈근우방자탕과 형방패독산이 허피즈 바이러스-1,2에 대해 감염초기 유의성이 있었으나 실험의 시간 경과에 따른 지속적인 약효 안정성을 보이지는 못하였다. 이 실험을 통하여 한약을 이용한 우수한 바이러스 치료를 개발하기 위해서는 단미제나 복합 처방에서 항바이러스 작용이 큰 유효성분의 대량 분리와 세포 실험에 있어서 오차를 줄 일 수 있는 세포면역학적 실험의 도입 등이 필요할 것으로 사료된다.

수종 한약 처방 전탕액(煎湯液)의 허피즈바이러스에 대한 효능 검색

임성우,Lim, Seong-Woo 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.2

Objective : In order to find antiviral compounds against Herpes simplex virus type I(HSV-1) and II(HSV-2) from herb medicines, a convenient virus-induced cytopathic effect(CPE) inhibition assay was introduced. Methods : Fourteen purchased herbal medicines, and their toxicity of infected cell and anti-viral activities were evaluated. Among them, the major part of herbal medicines showed cell stability compared with the contrast. Results : Cytotoxic concentration (CC) of the $H_2O$ extracts of Hyongbangpaedoksan against HSV-1 and HSV-2 was 181.12. This is high level cytotoxic concentration compared with the contrast. Therefore, we assumed that the high level cytotoxic concentration of herbal medicine play a major role in improvement of antiviral activity at the first infective cell. But antiviral effect was unable to figure out for selective index(Sl)=CC50/EC50. The other herbal medicines were unable to showed potent anti-HSV activity. Conclusions : The antiviral activation using herbs in this thesis have unlimited objects, to select research object will help to show the direction of antiviral drug development that have less side effect and more excellent efficiency.

Mouse의 십이지장 점막 염증에 대한 사삼맥문동탕의 면역반응 연구

임성우,최준혁,Lim Seong-Woo,Choi Jun-Hyuk 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.2

Objectives : This study was carried out to investigate the effects of Sasammaickmoondong-tang(SME) on duodenal mucosal lesions induced by indomethacin in mouse. Methods : The normal group is that no inflammation elicitated mouse. Control group is that gastro-inflammation elicitated mouse. Sample group is that SME administered mouseice after gastro-inflammation elicitation. Results : In the common morphology and histochemical change, control group was observed various injury-mucous surface cell, micro-villi, paneth cell, surface epithelial cell, goblet cell-by hemorrhagic erosion, while sample group was as same as normal group. In the immunohistochemical change, the distributions of COX-1, Bcl-2, and BrdU treated with SME noticeably increased than control group(p<0.05). The distributions of TUNEL, $NF-{\kappa}B$, COX-2, $IL-2R-{\alpha}$, NK-1.1, ICAM-1, and CD11b/18 treated with SME noticeably decreased than control group(p<0.05). And the distribution of SBA was as same as normal group. Conclusion : According to the above results, it is supposed that Sasammaickmoondong-tang is applicable to duodenal mucosal lesions.

독일어 입말에서의 반복표현

임성우 ( Seong Woo Lim ) 한국독일어문학회 2011 독일어문학 Vol.55 No.-

In der vorliegenden Arbeit beschaftige ich mich mit den verschiedenen Formen und rhetorisch-pragmatischen Funktionen von Wiederholungen. Zunachst gehe ich von den Formen der Wiederholung aus, bevor ich mich spezieller der Wiederholung in den pragmatischen Funktionen zuwende. Die verstarkende Funktion der Wiederholung kann die haufigste genannt werden, da sie nicht auf einen Ausschnitt des Sprachgebrauchs beschrankt ist, sondern im literarischen Bereich wie auch in anderen Stilen, vor allem aber im alltaglichen Sprachgebrauch eine bedeutende Stellung einnimmt. Die verstarkende Funktion der Wiederholung ist konventionell bei verschiedenen rhetorischen Repetitionsfiguren: Geminatio, Tautologie, Pleonasmus, Hendiadyoin, Prolepse, Nachtrag usw. Eng mit der verstarkenden Funktion von Wiederholung ist die emotionalisierende Funktion verknupft. Emotionalisierung muss jedoch hierarchisch uber der Verstarkung angesetzt werden. Wiederholt wird das, was semantisch und emotional besonders unterstrichen werden soll. Der Ausdruckswert der Wiederholung ist immer der gleiche: hochste Eindringlichkeit. In gesprochener Sprache wird die Funktion von Hervorhebung und Emotionalisierung haufig genutzt. Zum Beispiel wendet sich der Redner in offentlichen Reden nicht nur an die intellektuellen Fahigkeiten, den Verstand der Zuhorer, sondern will den Horer auch emotional auf seine Seite ziehen, uberzeugen, er spricht seine Affekte an. Zusammenfassend ist festzuhalten, dass die rhetorisch-pragmatische Funktion von Wiederholung in allen Bereichen des Sprachgebrauchs ausgenutzt werden kann. Wiederholung ist also ein beliebtes Hervorhebungsmittel, das auch vom durchschnittlichen Sprachbenutzer haufig eingesetzt wird. Dabei ist die Emotionalisierung als spezieller Funktionstyp erkannt worden.

시민 참여적 언어비평 활동과 사례분석

임성우(Lim Seong Woo) 서강대학교 인문과학연구소 2014 서강인문논총 Vol.0 No.41

언어비평은 인간의 언어가 가지는 메타언어적 기능에서 비롯된 것인데, 실제 언어비평은 담화비평일 때에만 제 역할을 할 수 있다. 본 연구에서는 공적 의사소통에서 비롯되는 언어현상에 대한 언어비평의 기준들을 살펴보고 각 기준들에 해당하는 사례들을 상세히 검토해 보고자 한다. 독일의 일반 시민들의 참여를 바탕으로 이루어지는 대표적인 언어비평은 ‘올해 최악의 말(UnwortdesJahres)’이다. 본 연구에서는 주로 ‘나쁜 말’또는 ‘몹쓸 말’의 의미를 담고 있는 Unwort의 개념과 매년 선정하여 발표하는 ‘올해 최악의 말’의 언어비평 형식에 대해서 고찰한다. 언어철학자 비트겐슈타인 (Wittgenstein)이 ‘단어의 의미는 곧 단어의 사용’ 에서 비롯된다고 지적한 것처럼, 이러한 언어비평이 단어와 관련지어 이루어진다고 하더라도 단순히 ‘단어’자체에 대한 비평이 아니라 그 단어가 사용된 방식과 사용 의미에 대한 비평임을 간과해서는 안 된다. 본 연구에서는 대중적 언어비평에 대한 선정위원회의 원칙들을 살펴본 후 대표적인 언어비평의 사례인 ‘인적 자원’과 ‘인적 자본’의 선정이유 및 단어 사용의 역사적 배경에 대해서 상세히 기술해 본다. 이러한 논의를 통해 시민들이 적극적으로 참여하는 대중적 언어비평의 대상은 대부분 인간존엄성과 관련된 윤리적이고 도덕적인 원칙에 위배된다고 판단되는 표현들임을 알 수 있다.

설명적 텍스트통사론을 위한 이론적 고찰

임성우 ( Seong Woo Lim ) 한국독일어문학회 2006 독일어문학 Vol.32 No.-

감정 표출의 언어적 실현 양상

임성우 ( Seong Woo Lim ) 한국독일어문학회 2012 독일어문학 Vol.58 No.-

Man kann sich nicht vorstellen, Emotionen aus dem menschlichen Leben wegzudenken. In der vorliegenden Arbeit versuche ich ansatzweise, sprachliche Ausdrucksmittel der Emotionalitat sowohl auf der lexikalischen Ebene als auch auf der syntaktischen Ebene zu erfassen. Nach Buhlers Organonmodell gibt es drei Moglichkeiten, Emotionen sowie Emotionalitat in die Sprache einzubringen. Und zwar: Der Sprecher verwendet sprachliche Zeichen mit unterschiedlichen kommunikativen Funktionen. Der Sprecher kann Emotionen darstellen (deskriptive Funktion), Emotionen ausdrucken (expressive Funktion) und Emotionen erregen (Apellfunktion). Emotionen sind, nach Fiehler(1990), Reaktionen auf wahrgenommenen Gegenstande oder Sachverhalte, die zunachst evaluiert werden. Nach dieser Evaluation kommt ein bestimmtes Gefuhl, das sich als Emotion ausdruckt. Die Emotionen des Sprechers konnen auf verschiedenen Sprachebenen geaußert werden. Auf der lexikalischen Ebene werden die wichtigsten lexikalischen Elemente erfasst, die Emotionen des Sprechers darstellen und seine emotionale Einstellung ausdrucken. Dazu gehoren nicht nur die Worter, die Gefuhle und Emotionen ausdrucken, sondern auch andere aufgelistete Worter wie Partikeln, Interjektionen usw. Der Gefuhlswortschatz des Deutschen wurde relativ haufig in den Fokus linguistischer Arbeiten geruckt. Trotzdem ist der Einfluss der sprachlichen Elemente auf der Satzebene bislang gar nicht geklart. Bei dem emotionalen Außern ist die Syntax von stark empfundenen Gefuhlen beeinflussbar. Dabei handelt es sich um die Satzformen und die Wortstellung (zum Ausdruck von Emotionen). Nach der hier vorgelegte Untersuchung ist festzustellen, dass sich Emotion auf allen Ebenen verbaliseren lasst. Aus dieser Erkenntnis ergibt sich noch, dass die Emotionsanalyse die Erfassung des Kontextes voraussetzt und immer offen fur eine umfassendere semiotische Untersuchung aller Zeichensysteme sein muss.